CN1473047A - 治疗男性勃起功能障碍和增强性冲动的方法 - Google Patents
治疗男性勃起功能障碍和增强性冲动的方法 Download PDFInfo
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- CN1473047A CN1473047A CNA018172660A CN01817266A CN1473047A CN 1473047 A CN1473047 A CN 1473047A CN A018172660 A CNA018172660 A CN A018172660A CN 01817266 A CN01817266 A CN 01817266A CN 1473047 A CN1473047 A CN 1473047A
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| US09/651,777 US6503894B1 (en) | 2000-08-30 | 2000-08-30 | Pharmaceutical composition and method for treating hypogonadism |
| US70375300A | 2000-11-01 | 2000-11-01 | |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091079B (zh) * | 2005-06-03 | 2014-03-12 | 艾克若克斯Dds有限公司 | 用于透皮给药的方法和组合物 |
| CN112020361A (zh) * | 2018-02-02 | 2020-12-01 | 阿克罗斯生物制药公司 | 睾酮治疗方法 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
| MY139721A (en) | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| AUPS317302A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Metastable pharmaceutical compositions |
| JP5160018B2 (ja) | 2002-06-25 | 2013-03-13 | アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド | 非晶質医薬組成物を用いる経皮送達速度調節 |
| IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
| US8883769B2 (en) | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| RS52945B (sr) | 2004-05-11 | 2014-02-28 | Emotional Brain B.V. | Farmaceutske formulacije i njihova primena u lečenju ženske seksualne disfunkcije |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| CA2610708C (en) * | 2005-06-03 | 2013-10-08 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| CA2624788C (en) | 2005-10-12 | 2011-04-19 | Unimed Pharmaceuticals, Llc | Improved testosterone gel and method of use |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US8613360B2 (en) | 2006-09-29 | 2013-12-24 | M-I L.L.C. | Shaker and degasser combination |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| GB2461725B (en) | 2008-07-10 | 2012-06-13 | United Wire Ltd | Improved sifting screen |
| US20100022991A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and device for maintaining physiological levels of steroid hormone in a subject |
| US20110190201A1 (en) * | 2008-07-24 | 2011-08-04 | Searete Llc | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
| US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
| BR112012028782A2 (pt) | 2010-05-12 | 2017-06-13 | Guy Pomerleau Daniel | sistemas e métodos para a secagem de cascalhos de perfuração |
| RU2474424C2 (ru) * | 2010-09-24 | 2013-02-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин |
| US9642863B2 (en) | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
| US9795639B1 (en) * | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
| US8785426B1 (en) | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
| EP4054549A4 (en) | 2019-11-06 | 2023-12-06 | Smartech Topical, Inc. | TOPICAL FORMULATIONS OF CYCLO-OXYGENASE INHIBITORS AND THEIR USE |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496556A (en) * | 1982-08-16 | 1985-01-29 | Norman Orentreich | Topical applications for preventing dry skin |
| US4855305A (en) * | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| TW224048B (enExample) * | 1992-03-30 | 1994-05-21 | Hoechst Roussel Pharma | |
| AU677206B2 (en) * | 1992-06-11 | 1997-04-17 | Theratech, Inc. | The use of glycerin in moderating transdermal drug delivery |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| JP4036496B2 (ja) * | 1995-10-24 | 2008-01-23 | リンテック株式会社 | ゲル製剤の製造方法 |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5730987A (en) * | 1996-06-10 | 1998-03-24 | Omar; Lotfy Ismail | Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9700878D0 (en) * | 1997-01-17 | 1997-03-05 | Scherer Ltd R P | Dosage forms and method for ameliorating male erectile dysfunction |
| JP2001512440A (ja) * | 1997-02-07 | 2001-08-21 | セラテック・インコーポレーテッド | テストステロンの欠乏症状を持つ女性のテストステロン補充のための組生物および方法 |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| KR100648536B1 (ko) * | 1997-11-10 | 2006-11-24 | 셀러지 파마세우티칼스, 인크 | 침투 보강 및 자극 감소를 위한 계 |
| PL345087A1 (en) * | 1998-06-25 | 2001-12-03 | Lavipharm Lab | A device and method for the treatment of erectile dysfunction |
| JP2000225116A (ja) * | 1998-12-04 | 2000-08-15 | Eisai Co Ltd | 陰茎径の測定法 |
| JP2000212080A (ja) * | 1999-01-26 | 2000-08-02 | Hiroshi Azuma | 勃起機能不全改善剤 |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| ATE252380T1 (de) * | 1999-02-05 | 2003-11-15 | Cipla Ltd | Topische sprays enthaltend eine filmbildende zusammensetzung |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091079B (zh) * | 2005-06-03 | 2014-03-12 | 艾克若克斯Dds有限公司 | 用于透皮给药的方法和组合物 |
| CN112020361A (zh) * | 2018-02-02 | 2020-12-01 | 阿克罗斯生物制药公司 | 睾酮治疗方法 |
Also Published As
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|---|---|
| DK1315502T3 (da) | 2010-07-19 |
| NO332649B1 (no) | 2012-11-26 |
| ES2341090T3 (es) | 2010-06-15 |
| SI1315502T1 (sl) | 2010-07-30 |
| KR100861603B1 (ko) | 2008-10-07 |
| DE60141587D1 (de) | 2010-04-29 |
| EP2283865A1 (en) | 2011-02-16 |
| AU2001286995B2 (en) | 2006-11-30 |
| KR20030043949A (ko) | 2003-06-02 |
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| NO20030955L (no) | 2003-04-28 |
| AU8699501A (en) | 2002-03-13 |
| BR0113651A (pt) | 2004-11-09 |
| IL154692A0 (en) | 2003-09-17 |
| EP1315502B1 (en) | 2010-03-17 |
| EP1315502A1 (en) | 2003-06-04 |
| NO20030955D0 (no) | 2003-02-28 |
| CA2746787A1 (en) | 2002-03-07 |
| CA2420895A1 (en) | 2002-03-07 |
| PT1315502E (pt) | 2010-05-06 |
| JP2004524267A (ja) | 2004-08-12 |
| NZ524601A (en) | 2006-04-28 |
| MXPA03001858A (es) | 2004-05-21 |
| PL366037A1 (en) | 2005-01-24 |
| ATE460939T1 (de) | 2010-04-15 |
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| PL205279B1 (pl) | 2010-03-31 |
| US20050054623A1 (en) | 2005-03-10 |
| WO2002017927A1 (en) | 2002-03-07 |
| TR200300776T2 (tr) | 2005-10-21 |
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