JP2004522461A5 - - Google Patents
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- Publication number
- JP2004522461A5 JP2004522461A5 JP2002519020A JP2002519020A JP2004522461A5 JP 2004522461 A5 JP2004522461 A5 JP 2004522461A5 JP 2002519020 A JP2002519020 A JP 2002519020A JP 2002519020 A JP2002519020 A JP 2002519020A JP 2004522461 A5 JP2004522461 A5 JP 2004522461A5
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- artificial implant
- support
- implant according
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 description 11
- 239000013543 active substance Substances 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 230000002785 anti-thrombosis Effects 0.000 description 6
- 239000003146 anticoagulant agent Substances 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000002318 adhesion promoter Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- SJECZPVISLOESU-UHFFFAOYSA-N 3-trimethoxysilylpropan-1-amine Chemical compound CO[Si](OC)(OC)CCCN SJECZPVISLOESU-UHFFFAOYSA-N 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 102000001788 Proto-Oncogene Proteins c-raf Human genes 0.000 description 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000001621 anti-mitogenic effect Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- GPUADMRJQVPIAS-QCVDVZFFSA-M cerivastatin sodium Chemical compound [Na+].COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 GPUADMRJQVPIAS-QCVDVZFFSA-M 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000003961 organosilicon compounds Chemical class 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117191A EP1179353A1 (de) | 2000-08-11 | 2000-08-11 | Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff |
| EP00117191.7 | 2000-08-11 | ||
| PCT/EP2001/008913 WO2002013882A1 (de) | 2000-08-11 | 2001-08-01 | Implantate mit phosphazenhaltiger beschichtung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004522461A JP2004522461A (ja) | 2004-07-29 |
| JP2004522461A5 true JP2004522461A5 (enExample) | 2008-10-23 |
| JP4886156B2 JP4886156B2 (ja) | 2012-02-29 |
Family
ID=8169492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002519020A Expired - Lifetime JP4886156B2 (ja) | 2000-08-11 | 2001-08-01 | ホスファゼン含有コーティングを有するインプラント |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20030157142A1 (enExample) |
| EP (2) | EP1179353A1 (enExample) |
| JP (1) | JP4886156B2 (enExample) |
| KR (1) | KR100809134B1 (enExample) |
| CN (1) | CN100467073C (enExample) |
| AT (1) | ATE374626T1 (enExample) |
| AU (2) | AU9544701A (enExample) |
| BR (1) | BR0113184B1 (enExample) |
| CA (1) | CA2424359C (enExample) |
| DE (1) | DE50113094D1 (enExample) |
| DK (1) | DK1337285T3 (enExample) |
| ES (1) | ES2296811T3 (enExample) |
| WO (1) | WO2002013882A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1274471B1 (de) | 2000-04-11 | 2007-01-03 | Polyzenix GmbH | Verwendung von Folien aus Poly-Tri-Fluor-Ethoxypolyphosphazenen zur Umhüllung von medizinischen Vorrichtungen |
| US20090004240A1 (en) * | 2000-08-11 | 2009-01-01 | Celonova Biosciences, Inc. | Implants with a phosphazene-containing coating |
| US9080146B2 (en) | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
| DE10100961B4 (de) | 2001-01-11 | 2005-08-04 | Polyzenix Gmbh | Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten |
| DE10202467A1 (de) * | 2002-01-23 | 2003-07-24 | Polyzenix Gmbh | Vorrichtung auf Basis von Nitinol, ein Verfahren zu dessen Herstellung sowie dessen Verwendung |
| US20080228284A1 (en) * | 2001-01-11 | 2008-09-18 | Celonova Biosciences, Inc. | Specific Polyphosphazene-Containing Three-Dimensional Bone Support Implants and Methods for Their Use |
| DE50208282D1 (de) | 2001-08-17 | 2006-11-09 | Polyzenix Gmbh | Vorrichtung auf basis von nitinol mit polyphosphazenüberzug |
| US20050136093A1 (en) * | 2002-07-05 | 2005-06-23 | Polyzenix Gmbh | Implant for transport and release for pharmacologically active agents as well as a process for producing the same |
| US20080138433A1 (en) * | 2002-07-05 | 2008-06-12 | Celonova Biosciences, Inc. | Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use |
| ES2311733T3 (es) * | 2002-07-05 | 2009-02-16 | Celonova Biosciences Germany Gmbh | Implante para el transporte y liberacion de agentes farmacologicamente activos, asi como un procedimiento para producir los mismos. |
| KR20050120665A (ko) * | 2003-03-26 | 2005-12-22 | 폴리제닉스 게엠베하 | 코팅된 치과용 임플란트 |
| US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
| BRPI0518383A2 (pt) * | 2004-10-25 | 2008-11-18 | Polyzenix Gmbh | partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas |
| US9107850B2 (en) | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
| US9114162B2 (en) | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
| ES2378905T3 (es) | 2006-10-10 | 2012-04-19 | Celonova Biosciences, Inc. | Válvula cardiaca bioprotésica con polifosfaceno |
| CN101032473B (zh) * | 2007-04-05 | 2010-04-07 | 上海交通大学 | 三明治型药物缓释膜及其制备方法 |
| JP2010526625A (ja) * | 2007-05-15 | 2010-08-05 | カメレオン バイオサーフェセズ リミテッド | 医療器具へのポリマー・コーティング |
| JP2010534266A (ja) | 2007-07-25 | 2010-11-04 | セロノバ バイオサイエンシーズ， インコーポレイテッド | 治療および／または診断用途のための、色分けされ、大きさによって分けられた充填可能なポリマー粒子、ならびにそれらを調製し、そして使用する方法 |
| DE102007038799A1 (de) * | 2007-08-17 | 2009-02-19 | Biotronik Vi Patent Ag | Implantat aus einer biokorrodierbaren Magnesiumlegierung und mit einer Beschichtung aus einem biokorrodierbaren Polyphosphazen |
| WO2009058145A1 (en) * | 2007-10-31 | 2009-05-07 | Celonova Biosciences, Inc. | Vasodilator eluting luminal stent devices with a specific polyphosphazene coating and methods for their manufacture and use |
| EP2219701A2 (en) * | 2007-10-31 | 2010-08-25 | CeloNova Biosciences, Inc. | Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use |
| EP2252218A4 (en) * | 2008-02-11 | 2012-06-06 | Celonova Biosciences Inc | FABRIC FASTENERS AND DEVICES AND RELEVANT PROCEDURES |
| US20100047324A1 (en) * | 2008-02-22 | 2010-02-25 | Celonova Biosciences, Inc. | Multi-Functional Wound Dressing Matrices and Related Methods |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| EP2616131A4 (en) * | 2010-09-16 | 2014-12-03 | Univ Kyoto | STATIN LOADING COILS TO ACCELERATE THE REORGANIZATION AFTER THE ENDOVASCULAR EXPLOITATION OF ANEURYSMS |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| WO2013166358A1 (en) * | 2012-05-03 | 2013-11-07 | Indiana University Research And Technology Corporation | Surface coatings for biological implants and prostheses |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| CN108601645B (zh) | 2015-12-15 | 2021-02-26 | 内奥瓦斯克迪亚拉公司 | 经中隔递送系统 |
| EP4183372A1 (en) | 2016-01-29 | 2023-05-24 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
| CN113893064A (zh) | 2016-11-21 | 2022-01-07 | 内奥瓦斯克迪亚拉公司 | 用于快速收回经导管心脏瓣膜递送系统的方法和系统 |
| US10856984B2 (en) | 2017-08-25 | 2020-12-08 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| EP3876870B1 (en) | 2018-11-08 | 2023-12-20 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
| AU2020233892A1 (en) | 2019-03-08 | 2021-11-04 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
| CN113811265B (zh) | 2019-04-01 | 2024-11-29 | 内奥瓦斯克迪亚拉公司 | 能够以可控的方式部署的假体瓣膜 |
| AU2020271896B2 (en) | 2019-04-10 | 2022-10-13 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
| US11779742B2 (en) | 2019-05-20 | 2023-10-10 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
| EP3986332A4 (en) | 2019-06-20 | 2023-07-19 | Neovasc Tiara Inc. | FLAT ARTIFICIAL MITRAL VALVE |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311736A (en) * | 1979-03-19 | 1982-01-19 | The Kendall Company | Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making |
| US4341844A (en) * | 1979-10-25 | 1982-07-27 | The Kendall Company | Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making |
| US4318947A (en) * | 1979-12-26 | 1982-03-09 | The Kendall Company | Polymer coating and curing process for catheters |
| US4424395A (en) * | 1982-03-11 | 1984-01-03 | The Dow Chemical Company | Carbamates of biphenyls |
| US4451647A (en) * | 1982-06-21 | 1984-05-29 | Research Corporation | Heparinized polyorganophosphazenes |
| US4480642A (en) * | 1982-07-26 | 1984-11-06 | Health Products Research, Inc. | Dilation device for the cervix |
| JPS6038307A (ja) * | 1983-08-11 | 1985-02-27 | Nippon Daigaku | 充填用複合材 |
| US4883699A (en) * | 1984-09-21 | 1989-11-28 | Menlo Care, Inc. | Polymeric article having high tensile energy to break when hydrated |
| US4911691A (en) * | 1984-09-21 | 1990-03-27 | Menlo Care, Inc. | Assembly for adminstering IV solution |
| US4592755A (en) * | 1985-06-11 | 1986-06-03 | Ethyl Corporation | Mammary implant |
| US4798876A (en) * | 1985-11-12 | 1989-01-17 | Tyndale Plains-Hunter Ltd. | Hydrophilic polyurethane composition |
| US4880622A (en) * | 1986-05-20 | 1989-11-14 | Research Corporation Technologies, Inc. | Water-soluble phosphazene polymers having pharmacological applications |
| US5634946A (en) * | 1988-08-24 | 1997-06-03 | Focal, Inc. | Polymeric endoluminal paving process |
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| FR2679466B1 (fr) * | 1991-07-25 | 1994-04-15 | Ceramique Technique | Membrane de filtration et procede de fabrication. |
| DE4138513A1 (de) * | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
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| ATE154757T1 (de) * | 1993-07-19 | 1997-07-15 | Angiotech Pharm Inc | Anti-angiogene mittel und verfahren zu deren verwendung |
| CA2187355C (en) * | 1994-04-08 | 2009-10-13 | Richard L. Dunn | An adjunctive polymer system for use with medical device |
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| US5548060A (en) * | 1994-08-08 | 1996-08-20 | Penn State Research Foundation, Inc. | Sulfonation of polyphosphazenes |
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| DE19613048C2 (de) * | 1995-03-30 | 1997-12-18 | Michael Prof Dr Grunze | Künstliche Implantate mit antithrombogenen Eigenschaften und Verfahren zu deren Herstellung |
| US5914388A (en) * | 1995-04-26 | 1999-06-22 | The Penn State Research Foundation | Synthesis polyphosphazenes with controlled molecular weight and polydisperity |
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| EP1312635B1 (en) * | 2000-03-18 | 2005-08-24 | Polyzenix GmbH | Dental implants having bacterial resistance |
| EP1274471B1 (de) * | 2000-04-11 | 2007-01-03 | Polyzenix GmbH | Verwendung von Folien aus Poly-Tri-Fluor-Ethoxypolyphosphazenen zur Umhüllung von medizinischen Vorrichtungen |
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| US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
| AU2002340749A1 (en) * | 2001-05-04 | 2002-11-18 | Concentric Medical | Coated combination vaso-occlusive device |
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| US20030065345A1 (en) * | 2001-09-28 | 2003-04-03 | Kevin Weadock | Anastomosis devices and methods for treating anastomotic sites |
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| US6887270B2 (en) * | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
-
2000
- 2000-08-11 EP EP00117191A patent/EP1179353A1/de not_active Withdrawn
-
2001
- 2001-08-01 CA CA2424359A patent/CA2424359C/en not_active Expired - Lifetime
- 2001-08-01 AU AU9544701A patent/AU9544701A/xx active Pending
- 2001-08-01 BR BRPI0113184-2A patent/BR0113184B1/pt not_active IP Right Cessation
- 2001-08-01 ES ES01976054T patent/ES2296811T3/es not_active Expired - Lifetime
- 2001-08-01 KR KR1020037001952A patent/KR100809134B1/ko not_active Expired - Fee Related
- 2001-08-01 DE DE50113094T patent/DE50113094D1/de not_active Expired - Lifetime
- 2001-08-01 DK DK01976054T patent/DK1337285T3/da active
- 2001-08-01 AU AU2001295447A patent/AU2001295447B2/en not_active Expired
- 2001-08-01 US US10/344,216 patent/US20030157142A1/en not_active Abandoned
- 2001-08-01 WO PCT/EP2001/008913 patent/WO2002013882A1/de not_active Ceased
- 2001-08-01 CN CNB018173063A patent/CN100467073C/zh not_active Expired - Lifetime
- 2001-08-01 AT AT01976054T patent/ATE374626T1/de active
- 2001-08-01 JP JP2002519020A patent/JP4886156B2/ja not_active Expired - Lifetime
- 2001-08-01 EP EP01976054A patent/EP1337285B1/de not_active Expired - Lifetime
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