ES2296811T3 - Implantes con un recubrimiento que contiene fosfaceno. - Google Patents

Implantes con un recubrimiento que contiene fosfaceno. Download PDF

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Publication number
ES2296811T3
ES2296811T3 ES01976054T ES01976054T ES2296811T3 ES 2296811 T3 ES2296811 T3 ES 2296811T3 ES 01976054 T ES01976054 T ES 01976054T ES 01976054 T ES01976054 T ES 01976054T ES 2296811 T3 ES2296811 T3 ES 2296811T3
Authority
ES
Spain
Prior art keywords
phosphacene
implants
coating
substrate
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01976054T
Other languages
English (en)
Inventor
Stefan Nagel
Michael Boxberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celonova Biosciences Germany GmbH
Celonova Bioscience Inc
Original Assignee
Polyzenix Gesellschaft fuer Medizin Technische Materialien und Vorrichtungen mbH
Celonova Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyzenix Gesellschaft fuer Medizin Technische Materialien und Vorrichtungen mbH, Celonova Bioscience Inc filed Critical Polyzenix Gesellschaft fuer Medizin Technische Materialien und Vorrichtungen mbH
Application granted granted Critical
Publication of ES2296811T3 publication Critical patent/ES2296811T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)

Abstract

Implante artificial que comprende un material de implante como el substrato y un recubrimiento biocompatible aplicado, al menos parcialmente, a la superficie del substrato, cuyo recubrimiento comprende un polímero antitrombogénico que tiene la siguiente fórmula general (I) R¹ R² R³ *- P = N -- P = N - P = N -- n- (I), * R4 R5 R6 en la que R1 a R6 son iguales o diferentes y representan un resto alcoxi, alquilsulfonilo, dialquilamino o ariloxi, o un resto alquilo heterocíclico o un resto heteroarilo, que comprende al nitrógeno como heteroátomo y, al menos, otro agente farmacológicamente activo.
ES01976054T 2000-08-11 2001-08-01 Implantes con un recubrimiento que contiene fosfaceno. Expired - Lifetime ES2296811T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00117191A EP1179353A1 (de) 2000-08-11 2000-08-11 Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff

Publications (1)

Publication Number Publication Date
ES2296811T3 true ES2296811T3 (es) 2008-05-01

Family

ID=8169492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01976054T Expired - Lifetime ES2296811T3 (es) 2000-08-11 2001-08-01 Implantes con un recubrimiento que contiene fosfaceno.

Country Status (13)

Country Link
US (1) US20030157142A1 (es)
EP (2) EP1179353A1 (es)
JP (1) JP4886156B2 (es)
KR (1) KR100809134B1 (es)
CN (1) CN100467073C (es)
AT (1) ATE374626T1 (es)
AU (2) AU9544701A (es)
BR (1) BR0113184B1 (es)
CA (1) CA2424359C (es)
DE (1) DE50113094D1 (es)
DK (1) DK1337285T3 (es)
ES (1) ES2296811T3 (es)
WO (1) WO2002013882A1 (es)

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US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US20080228284A1 (en) * 2001-01-11 2008-09-18 Celonova Biosciences, Inc. Specific Polyphosphazene-Containing Three-Dimensional Bone Support Implants and Methods for Their Use
EP1432380B1 (de) 2001-08-17 2006-09-27 Polyzenix GmbH Vorrichtung auf basis von nitinol mit polyphosphazenüberzug
CA2491282C (en) * 2002-07-05 2013-02-12 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents incorporated within polyphosphazenes and related methods
US20080138433A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use
US20050136093A1 (en) * 2002-07-05 2005-06-23 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
DE602004030892D1 (de) * 2003-03-26 2011-02-17 Celonova Biosciences Germany Gmbh Beschichtete dentalimplantate
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
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WO2009058145A1 (en) * 2007-10-31 2009-05-07 Celonova Biosciences, Inc. Vasodilator eluting luminal stent devices with a specific polyphosphazene coating and methods for their manufacture and use
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US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
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US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9550011B2 (en) 2012-05-03 2017-01-24 Indiana University Research And Technology Corporation Surface coatings for biological implants and prostheses
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
CN113633435A (zh) 2016-01-29 2021-11-12 内奥瓦斯克迪亚拉公司 用于防止流出阻塞的假体瓣膜
CN113893064A (zh) 2016-11-21 2022-01-07 内奥瓦斯克迪亚拉公司 用于快速收回经导管心脏瓣膜递送系统的方法和系统
CA3073834A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
WO2020210652A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
CA3140925A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
AU2020295566B2 (en) 2019-06-20 2023-07-20 Neovasc Tiara Inc. Low profile prosthetic mitral valve

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Also Published As

Publication number Publication date
KR100809134B1 (ko) 2008-02-29
CA2424359A1 (en) 2003-02-06
US20030157142A1 (en) 2003-08-21
AU2001295447B2 (en) 2007-01-04
BR0113184B1 (pt) 2014-12-02
ATE374626T1 (de) 2007-10-15
AU9544701A (en) 2002-02-25
WO2002013882A1 (de) 2002-02-21
JP2004522461A (ja) 2004-07-29
EP1179353A1 (de) 2002-02-13
DE50113094D1 (de) 2007-11-15
CA2424359C (en) 2012-03-20
CN1469759A (zh) 2004-01-21
CN100467073C (zh) 2009-03-11
JP4886156B2 (ja) 2012-02-29
KR20030061780A (ko) 2003-07-22
DK1337285T3 (da) 2008-02-11
EP1337285A1 (de) 2003-08-27
BR0113184A (pt) 2003-07-01
EP1337285B1 (de) 2007-10-03

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