JP2004513107A5 - - Google Patents
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- Publication number
- JP2004513107A5 JP2004513107A5 JP2002539304A JP2002539304A JP2004513107A5 JP 2004513107 A5 JP2004513107 A5 JP 2004513107A5 JP 2002539304 A JP2002539304 A JP 2002539304A JP 2002539304 A JP2002539304 A JP 2002539304A JP 2004513107 A5 JP2004513107 A5 JP 2004513107A5
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- alkanoyl
- salt
- composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 7
- -1 alkanoyl L-carnitine Chemical compound 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 3
- 125000001589 carboacyl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- WCBVOPMSONYWEB-UHFFFAOYSA-N 2-aminoacetyl chloride Chemical compound NCC(Cl)=O WCBVOPMSONYWEB-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000567A IT1317924B1 (it) | 2000-10-31 | 2000-10-31 | Composizioni solide atte alla somministrazione orale comprendenti salinon igroscopici della l-carnitina e delle alcanoil l-carnitine con |
| PCT/IT2001/000503 WO2002036543A1 (en) | 2000-10-31 | 2001-09-28 | Solid compositions suitable for oral administration containing non-hygroscopic salts of l-carnitine and the alkanoyl l-carnitines with taurine chloride and glycine chloride |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513107A JP2004513107A (ja) | 2004-04-30 |
| JP2004513107A5 true JP2004513107A5 (enExample) | 2006-01-05 |
| JP4181406B2 JP4181406B2 (ja) | 2008-11-12 |
Family
ID=11454973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539304A Expired - Fee Related JP4181406B2 (ja) | 2000-10-31 | 2001-09-28 | Ｌ−カルニチンおよびアルカノイルｌ−カルニチンとタウリンクロリドおよびグリシンクロリドとの非吸湿性塩を含有する経口投与に好適な固形組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7858820B2 (enExample) |
| EP (1) | EP1330428B1 (enExample) |
| JP (1) | JP4181406B2 (enExample) |
| KR (1) | KR100764155B1 (enExample) |
| CN (1) | CN1219748C (enExample) |
| AT (1) | ATE312810T1 (enExample) |
| AU (2) | AU9589301A (enExample) |
| BR (1) | BRPI0115019B1 (enExample) |
| CA (1) | CA2427482C (enExample) |
| CY (1) | CY1106062T1 (enExample) |
| CZ (1) | CZ302802B6 (enExample) |
| DE (1) | DE60115944T2 (enExample) |
| DK (1) | DK1330428T3 (enExample) |
| ES (1) | ES2253430T3 (enExample) |
| HU (1) | HU229989B1 (enExample) |
| IT (1) | IT1317924B1 (enExample) |
| MX (1) | MXPA03003799A (enExample) |
| NZ (1) | NZ525333A (enExample) |
| PL (1) | PL205801B1 (enExample) |
| RU (1) | RU2270191C2 (enExample) |
| SI (1) | SI1330428T1 (enExample) |
| SK (1) | SK287133B6 (enExample) |
| WO (1) | WO2002036543A1 (enExample) |
| ZA (1) | ZA200303328B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005031705A1 (de) * | 2005-07-05 | 2007-01-18 | Henkel Kgaa | Mittel, enthaltend L-Carnitin oder L-Carnitinderivate und mindestens eine weitere Substanz ausgewählt aus Taurin und dessen Derivaten und mindestens einem Wirkstoff, erhältlich aus Pflanzen der Gattung Echinacea |
| KR101007927B1 (ko) | 2008-12-24 | 2011-01-14 | 주식회사 셀트리온제약 | 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| JP5451558B2 (ja) * | 2010-08-27 | 2014-03-26 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 美容活性成分の送達に有用なゲル |
| CN104276986B (zh) * | 2013-07-12 | 2016-07-06 | 辽宁科硕营养科技有限公司 | 左旋肉碱牛磺酸盐的制备方法 |
| JP6473352B2 (ja) * | 2015-03-10 | 2019-02-20 | 利幸 糸井 | 虚血性疾患治療薬 |
| CN107325013B (zh) * | 2016-04-28 | 2019-04-12 | 辽宁科硕营养科技股份有限公司 | 一种合成甘氨酸丙酰左旋肉碱盐酸盐的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3463261D1 (en) | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
| CA2030310A1 (en) * | 1989-12-22 | 1991-06-23 | Ronald E. Macleay | Derivatives of n-hals-substituted amic acid hydrazides |
| IT1291126B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizioni solide atte alla somministrazione orale comprendenti sali non igroscopici della l-carnitina e delle alcanoil l-carnitine |
| IT1306147B1 (it) * | 1999-05-28 | 2001-05-30 | Biosalts Srl | Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali |
-
2000
- 2000-10-31 IT IT2000RM000567A patent/IT1317924B1/it active
-
2001
- 2001-09-28 NZ NZ525333A patent/NZ525333A/en not_active IP Right Cessation
- 2001-09-28 DK DK01976633T patent/DK1330428T3/da active
- 2001-09-28 HU HU0302294A patent/HU229989B1/hu not_active IP Right Cessation
- 2001-09-28 RU RU2003116133/04A patent/RU2270191C2/ru active
- 2001-09-28 US US10/415,472 patent/US7858820B2/en not_active Expired - Lifetime
- 2001-09-28 ES ES01976633T patent/ES2253430T3/es not_active Expired - Lifetime
- 2001-09-28 CA CA2427482A patent/CA2427482C/en not_active Expired - Fee Related
- 2001-09-28 AU AU9589301A patent/AU9589301A/xx active Pending
- 2001-09-28 SI SI200130462T patent/SI1330428T1/sl unknown
- 2001-09-28 CZ CZ20031041A patent/CZ302802B6/cs not_active IP Right Cessation
- 2001-09-28 DE DE60115944T patent/DE60115944T2/de not_active Expired - Lifetime
- 2001-09-28 WO PCT/IT2001/000503 patent/WO2002036543A1/en not_active Ceased
- 2001-09-28 SK SK501-2003A patent/SK287133B6/sk not_active IP Right Cessation
- 2001-09-28 MX MXPA03003799A patent/MXPA03003799A/es active IP Right Grant
- 2001-09-28 EP EP01976633A patent/EP1330428B1/en not_active Expired - Lifetime
- 2001-09-28 KR KR1020037005596A patent/KR100764155B1/ko not_active Expired - Fee Related
- 2001-09-28 AU AU2001295893A patent/AU2001295893B2/en not_active Ceased
- 2001-09-28 JP JP2002539304A patent/JP4181406B2/ja not_active Expired - Fee Related
- 2001-09-28 CN CNB018182941A patent/CN1219748C/zh not_active Expired - Lifetime
- 2001-09-28 BR BRPI0115019A patent/BRPI0115019B1/pt not_active IP Right Cessation
- 2001-09-28 PL PL364823A patent/PL205801B1/pl unknown
- 2001-09-28 AT AT01976633T patent/ATE312810T1/de active
-
2003
- 2003-04-30 ZA ZA200303328A patent/ZA200303328B/en unknown
-
2006
- 2006-01-19 CY CY20061100074T patent/CY1106062T1/el unknown
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