JP2004511527A - ワクチン - Google Patents
ワクチン Download PDFInfo
- Publication number
- JP2004511527A JP2004511527A JP2002535687A JP2002535687A JP2004511527A JP 2004511527 A JP2004511527 A JP 2004511527A JP 2002535687 A JP2002535687 A JP 2002535687A JP 2002535687 A JP2002535687 A JP 2002535687A JP 2004511527 A JP2004511527 A JP 2004511527A
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- Prior art keywords
- neu
- prostase
- antigen
- cpg
- adjuvant
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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| US09/690,921 US6544518B1 (en) | 1999-04-19 | 2000-10-18 | Vaccines |
| GB0025574A GB0025574D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| GB0025573A GB0025573D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| PCT/EP2001/011984 WO2002032450A2 (en) | 2000-10-18 | 2001-10-16 | Vaccines |
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| JP2008126888A Division JP2008285487A (ja) | 2000-10-18 | 2008-05-14 | ワクチン |
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| JP2004511527A true JP2004511527A (ja) | 2004-04-15 |
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| JP (1) | JP2004511527A (https=) |
| KR (1) | KR100860893B1 (https=) |
| CN (1) | CN100548373C (https=) |
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| BR (1) | BR0114786A (https=) |
| CA (1) | CA2425358C (https=) |
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| ES (1) | ES2295229T3 (https=) |
| HU (1) | HU229642B1 (https=) |
| IL (1) | IL155282A0 (https=) |
| MX (1) | MXPA03003408A (https=) |
| NO (1) | NO335919B1 (https=) |
| NZ (1) | NZ525320A (https=) |
| PL (1) | PL208755B1 (https=) |
| SI (1) | SI1326638T1 (https=) |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008506789A (ja) * | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
| JP2008531637A (ja) * | 2005-03-03 | 2008-08-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 水疱−帯状疱疹ウイルスワクチン |
| JP2016503029A (ja) * | 2012-12-13 | 2016-02-01 | アデュロ バイオテック，インコーポレイテッド | 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法 |
| JP2016534977A (ja) * | 2013-09-19 | 2016-11-10 | ゾエティス・サービシーズ・エルエルシー | 油性アジュバント |
| US10131686B2 (en) | 2013-04-29 | 2018-11-20 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1104306E (pt) | 1998-08-10 | 2006-05-31 | Antigenics Inc | Composicoes de cpg e adjuvantes de saponina e seus metodos |
| ES2572834T3 (es) | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| US20060210555A1 (en) | 2001-12-21 | 2006-09-21 | Antigenics, Inc. | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| BR0311995A (pt) * | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
| WO2004019975A2 (en) * | 2002-08-30 | 2004-03-11 | Glaxo Group Limited | Il-14 vaccine for the treatment of asthma and atopic disorders |
| EP1678303A2 (en) | 2003-10-30 | 2006-07-12 | Coley Pharmaceutical GmbH | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
| WO2006050116A1 (en) * | 2004-11-02 | 2006-05-11 | Biomedical Research Models, Inc. | Methods of cancer treatment/prevention using cancer cell-specific surface antigens |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| PL2068918T5 (pl) | 2006-09-26 | 2024-12-02 | Access To Advanced Health Institute | Kompozycja szczepionki zawierająca syntetyczny adiuwant |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
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| EA027236B1 (ru) | 2011-04-08 | 2017-07-31 | Иммьюн Дизайн Корп. | Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| EP2751570A4 (en) * | 2011-08-31 | 2015-08-12 | Oncocyte Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF CANCER |
| HRP20181102T1 (hr) | 2012-05-16 | 2018-09-07 | Immune Design Corp | Cjepiva za hsv-2 |
| CA2879066C (en) * | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| EP2777711A1 (en) | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| MX370573B (es) | 2013-04-18 | 2019-12-17 | Immune Design Corp | Monoterapia con glucopiranosil lipido a para usarse en el tratamiento del cancer. |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| CN112972671B (zh) | 2019-12-13 | 2024-04-19 | 远大赛威信生命科学(南京)有限公司 | 药物组合物及其用途 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186921A (ja) * | 1982-10-18 | 1984-10-23 | ブロル・モレイン | 免疫原性複合物 |
| JPH11504020A (ja) * | 1995-04-25 | 1999-04-06 | スミスクライン・ビーチャム・バイオロジカルス （ソシエテ・アノニム） | サポニンおよびステロールを含有するワクチン |
| WO1999040188A2 (en) * | 1998-02-05 | 1999-08-12 | Smithkline Beecham Biologicals S.A. | Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccinations |
| WO1999061056A2 (en) * | 1998-05-22 | 1999-12-02 | Loeb Health Research Institute At The Ottawa Hospital | Methods and products for inducing mucosal immunity |
| WO2000009159A1 (en) * | 1998-08-10 | 2000-02-24 | Aquila Biopharmaceuticals, Inc. | Compositions of cpg and saponin adjuvants and methods thereof |
| WO2000044899A1 (en) * | 1999-01-29 | 2000-08-03 | Corixa Corporation | Her-2/neu fusion proteins |
| JP2002542203A (ja) * | 1999-04-19 | 2002-12-10 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2397374A1 (en) * | 2000-01-13 | 2001-07-19 | Antigenics Inc. | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
| ES2307568T3 (es) * | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
-
2001
- 2001-10-16 AU AU2002244337A patent/AU2002244337B2/en not_active Ceased
- 2001-10-16 DK DK01987671T patent/DK1326638T3/da active
- 2001-10-16 KR KR1020077026150A patent/KR100860893B1/ko not_active Expired - Fee Related
- 2001-10-16 WO PCT/EP2001/011984 patent/WO2002032450A2/en not_active Ceased
- 2001-10-16 ES ES01987671T patent/ES2295229T3/es not_active Expired - Lifetime
- 2001-10-16 EP EP07121675A patent/EP1889630B1/en not_active Expired - Lifetime
- 2001-10-16 PL PL365598A patent/PL208755B1/pl unknown
- 2001-10-16 CA CA2425358A patent/CA2425358C/en not_active Expired - Fee Related
- 2001-10-16 BR BR0114786-2A patent/BR0114786A/pt not_active IP Right Cessation
- 2001-10-16 SI SI200130800T patent/SI1326638T1/sl unknown
- 2001-10-16 NZ NZ525320A patent/NZ525320A/en not_active IP Right Cessation
- 2001-10-16 MX MXPA03003408A patent/MXPA03003408A/es active IP Right Grant
- 2001-10-16 HU HU0402067A patent/HU229642B1/hu not_active IP Right Cessation
- 2001-10-16 JP JP2002535687A patent/JP2004511527A/ja active Pending
- 2001-10-16 IL IL15528201A patent/IL155282A0/xx unknown
- 2001-10-16 AU AU4433702A patent/AU4433702A/xx active Pending
- 2001-10-16 EP EP01987671A patent/EP1326638B9/en not_active Expired - Lifetime
- 2001-10-16 CZ CZ20031093A patent/CZ302449B6/cs not_active IP Right Cessation
- 2001-10-16 CN CNB018206611A patent/CN100548373C/zh not_active Expired - Fee Related
-
2003
- 2003-04-11 NO NO20031705A patent/NO335919B1/no not_active IP Right Cessation
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186921A (ja) * | 1982-10-18 | 1984-10-23 | ブロル・モレイン | 免疫原性複合物 |
| JPH11504020A (ja) * | 1995-04-25 | 1999-04-06 | スミスクライン・ビーチャム・バイオロジカルス （ソシエテ・アノニム） | サポニンおよびステロールを含有するワクチン |
| WO1999040188A2 (en) * | 1998-02-05 | 1999-08-12 | Smithkline Beecham Biologicals S.A. | Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccinations |
| WO1999061056A2 (en) * | 1998-05-22 | 1999-12-02 | Loeb Health Research Institute At The Ottawa Hospital | Methods and products for inducing mucosal immunity |
| WO2000009159A1 (en) * | 1998-08-10 | 2000-02-24 | Aquila Biopharmaceuticals, Inc. | Compositions of cpg and saponin adjuvants and methods thereof |
| WO2000044899A1 (en) * | 1999-01-29 | 2000-08-03 | Corixa Corporation | Her-2/neu fusion proteins |
| JP2002542203A (ja) * | 1999-04-19 | 2002-12-10 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008506789A (ja) * | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
| JP2008531637A (ja) * | 2005-03-03 | 2008-08-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 水疱−帯状疱疹ウイルスワクチン |
| JP2016503029A (ja) * | 2012-12-13 | 2016-02-01 | アデュロ バイオテック，インコーポレイテッド | 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法 |
| JP2018135367A (ja) * | 2012-12-13 | 2018-08-30 | アデュロ バイオテック，インコーポレイテッド | 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法 |
| US10414789B2 (en) | 2012-12-13 | 2019-09-17 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| US10131686B2 (en) | 2013-04-29 | 2018-11-20 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| US10385091B2 (en) | 2013-04-29 | 2019-08-20 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| US11014956B2 (en) | 2013-04-29 | 2021-05-25 | Memorial Sloan Kettering Cancer Center; The Rockefeller | Compositions and methods for altering second messenger signaling |
| JP2016534977A (ja) * | 2013-09-19 | 2016-11-10 | ゾエティス・サービシーズ・エルエルシー | 油性アジュバント |
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| SI1326638T1 (sl) | 2008-04-30 |
| KR100860893B1 (ko) | 2008-09-29 |
| PL208755B1 (pl) | 2011-06-30 |
| ES2295229T3 (es) | 2008-04-16 |
| CZ20031093A3 (cs) | 2003-08-13 |
| EP1326638A2 (en) | 2003-07-16 |
| HU229642B1 (en) | 2014-03-28 |
| WO2002032450A3 (en) | 2002-10-10 |
| HUP0402067A3 (en) | 2012-09-28 |
| CA2425358A1 (en) | 2002-04-25 |
| EP1889630A1 (en) | 2008-02-20 |
| CN100548373C (zh) | 2009-10-14 |
| CA2425358C (en) | 2012-08-21 |
| HUP0402067A2 (hu) | 2005-01-28 |
| CZ302449B6 (cs) | 2011-05-25 |
| AU2002244337B2 (en) | 2005-08-11 |
| CN1481255A (zh) | 2004-03-10 |
| KR20070114230A (ko) | 2007-11-29 |
| EP1889630B1 (en) | 2011-11-23 |
| DK1326638T3 (da) | 2008-03-25 |
| PL365598A1 (en) | 2005-01-10 |
| WO2002032450A2 (en) | 2002-04-25 |
| NZ525320A (en) | 2004-10-29 |
| NO20031705L (no) | 2003-06-14 |
| NO335919B1 (no) | 2015-03-23 |
| IL155282A0 (en) | 2003-11-23 |
| BR0114786A (pt) | 2003-08-12 |
| MXPA03003408A (es) | 2005-06-30 |
| NO20031705D0 (no) | 2003-04-11 |
| EP1326638B1 (en) | 2007-11-28 |
| EP1326638B9 (en) | 2008-02-20 |
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