JP2004510701A5 - - Google Patents
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- Publication number
- JP2004510701A5 JP2004510701A5 JP2002510040A JP2002510040A JP2004510701A5 JP 2004510701 A5 JP2004510701 A5 JP 2004510701A5 JP 2002510040 A JP2002510040 A JP 2002510040A JP 2002510040 A JP2002510040 A JP 2002510040A JP 2004510701 A5 JP2004510701 A5 JP 2004510701A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- embedded image
- compound according
- pyridyl
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 38
- 125000004076 pyridyl group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 7
- 125000004122 cyclic group Chemical group 0.000 description 6
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- -1 R 3 is H Chemical group 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30419100P | 2000-05-09 | 2000-05-09 | |
| US60/304,191 | 2000-05-09 | ||
| PCT/US2001/014721 WO2001095858A2 (en) | 2000-05-09 | 2001-05-08 | Piperazinedione compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510701A JP2004510701A (ja) | 2004-04-08 |
| JP2004510701A5 true JP2004510701A5 (https=) | 2008-04-17 |
| JP5101781B2 JP5101781B2 (ja) | 2012-12-19 |
Family
ID=23175471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510040A Expired - Fee Related JP5101781B2 (ja) | 2000-05-09 | 2001-05-08 | ピペラジンジオン化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6635649B2 (https=) |
| EP (1) | EP1282609B1 (https=) |
| JP (1) | JP5101781B2 (https=) |
| KR (1) | KR100852965B1 (https=) |
| CN (1) | CN100522949C (https=) |
| AT (1) | ATE417614T1 (https=) |
| BR (1) | BR0110745A (https=) |
| CZ (1) | CZ301743B6 (https=) |
| DE (1) | DE60137037D1 (https=) |
| HU (1) | HUP0302358A3 (https=) |
| NO (1) | NO326341B1 (https=) |
| RU (1) | RU2269520C2 (https=) |
| WO (1) | WO2001095858A2 (https=) |
| ZA (1) | ZA200209917B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
| CN100553636C (zh) | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| WO2004030522A2 (en) * | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
| EP2517718B1 (en) | 2003-05-15 | 2016-03-02 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
| CA2538352A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize n-acyl-l-aspartic acid |
| AU2005212399B2 (en) * | 2004-02-04 | 2011-09-22 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| CN102131775B (zh) * | 2008-08-22 | 2015-12-16 | 不列颠哥伦比亚癌症局分支机构 | 雄激素受体n-末端活化的小分子抑制剂 |
| CN102395581A (zh) * | 2009-04-16 | 2012-03-28 | 泰立克公司 | 作为微管蛋白聚合抑制剂的取代的4-氨基-5-苯甲酰基-2-(苯基氨基)噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-(苯基氨基)噻吩-3-羧酰胺 |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| US8710062B2 (en) * | 2011-03-11 | 2014-04-29 | Taipei Medical University | Piperazinedione compounds |
| MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| EA028343B1 (ru) | 2011-10-10 | 2017-11-30 | Ампио Фармасьютикалз, Инк. | Лечение дегенеративного заболевания сустава |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| JP6311097B2 (ja) * | 2013-07-31 | 2018-04-18 | 学校法人東京薬科大学 | 微小管脱重合剤 |
| RU2736513C2 (ru) | 2014-08-18 | 2020-11-17 | Ампио Фармасьютикалз, Инк. | Лечение патологических состояний суставов |
| CN104356077B (zh) * | 2014-09-11 | 2016-09-14 | 中国科学院南海海洋研究所 | 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用 |
| SG11201707128TA (en) | 2015-03-06 | 2017-09-28 | Beyondspring Pharmaceuticals Inc | Method of treating a brain tumor |
| AU2016229294B2 (en) | 2015-03-06 | 2021-11-04 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
| EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES |
| JP6969848B2 (ja) | 2015-07-13 | 2021-11-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリン組成物 |
| KR20180105685A (ko) | 2016-02-08 | 2018-09-28 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 투카레솔 또는 이의 유사체를 함유하는 조성물 |
| JP7025416B2 (ja) | 2016-06-06 | 2022-02-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | 好中球減少症を低減させるための組成物および方法 |
| WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| CN109580801B (zh) * | 2018-06-26 | 2021-09-07 | 深圳海王医药科技研究院有限公司 | 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法 |
| CN112010930B (zh) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | Rgd修饰的五环哌嗪二酮及其制备和应用 |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
| CN117285516A (zh) * | 2022-06-16 | 2023-12-26 | 大连万众益生大健康有限公司 | 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5973574A (ja) * | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
| GB8609908D0 (en) * | 1986-04-23 | 1986-05-29 | Fujisawa Pharmaceutical Co | Piperazine compound |
| US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| US5708804A (en) * | 1994-07-25 | 1998-01-13 | International Business Machines Corp. | Apparatus and method therefor of intelligently searching for information in a personal communications device |
| JP3795093B2 (ja) * | 1994-11-25 | 2006-07-12 | キッセイ薬品工業株式会社 | １−ヒドロキシインドール誘導体 |
| JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
-
2001
- 2001-05-08 BR BR0110745-3A patent/BR0110745A/pt not_active Application Discontinuation
- 2001-05-08 RU RU2002132897/04A patent/RU2269520C2/ru not_active IP Right Cessation
- 2001-05-08 DE DE60137037T patent/DE60137037D1/de not_active Expired - Lifetime
- 2001-05-08 CN CNB018125212A patent/CN100522949C/zh not_active Expired - Fee Related
- 2001-05-08 EP EP01975152A patent/EP1282609B1/en not_active Expired - Lifetime
- 2001-05-08 KR KR1020027015025A patent/KR100852965B1/ko not_active Expired - Fee Related
- 2001-05-08 US US09/851,077 patent/US6635649B2/en not_active Expired - Fee Related
- 2001-05-08 HU HU0302358A patent/HUP0302358A3/hu unknown
- 2001-05-08 CZ CZ20023693A patent/CZ301743B6/cs not_active IP Right Cessation
- 2001-05-08 AT AT01975152T patent/ATE417614T1/de not_active IP Right Cessation
- 2001-05-08 WO PCT/US2001/014721 patent/WO2001095858A2/en not_active Ceased
- 2001-05-08 JP JP2002510040A patent/JP5101781B2/ja not_active Expired - Fee Related
-
2002
- 2002-11-08 NO NO20025373A patent/NO326341B1/no not_active IP Right Cessation
- 2002-12-06 ZA ZA200209917A patent/ZA200209917B/en unknown
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