RU2269520C2 - Соединения пиперазиндиона - Google Patents

Соединения пиперазиндиона Download PDF

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Publication number
RU2269520C2
RU2269520C2 RU2002132897/04A RU2002132897A RU2269520C2 RU 2269520 C2 RU2269520 C2 RU 2269520C2 RU 2002132897/04 A RU2002132897/04 A RU 2002132897/04A RU 2002132897 A RU2002132897 A RU 2002132897A RU 2269520 C2 RU2269520 C2 RU 2269520C2
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RU
Russia
Prior art keywords
compound
aryl
double bond
alkyl
compound according
Prior art date
Application number
RU2002132897/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2002132897A (ru
Inventor
Чэ-Мин ТЭН (CN)
Чэ-Мин ТЭН
Хуэй-По ВАН (CN)
Хуэй-По ВАН
Эрик И. С. ЛИ (CN)
Эрик И. С. ЛИ
Он ЛЕЕ (CN)
Он ЛЕЕ
Цзих-Хва ГУХ (CN)
Цзих-Хва ГУХ
Хуэй-Тин ЧЭНЬ (CN)
Хуэй-Тин ЧЭНЬ
Янь-Бин ФАНЬ (CN)
Янь-Бин ФАНЬ
Я-Лань ЧЭНЬ (CN)
Я-Лань ЧЭНЬ
Original Assignee
Эдфарма, Инк.
Чэ-Мин ТЭН
Хуэй-По ВАН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эдфарма, Инк., Чэ-Мин ТЭН, Хуэй-По ВАН filed Critical Эдфарма, Инк.
Publication of RU2002132897A publication Critical patent/RU2002132897A/ru
Application granted granted Critical
Publication of RU2269520C2 publication Critical patent/RU2269520C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Saccharide Compounds (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
RU2002132897/04A 2000-05-09 2001-05-08 Соединения пиперазиндиона RU2269520C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30419100P 2000-05-09 2000-05-09
US60/304,191 2000-05-09

Publications (2)

Publication Number Publication Date
RU2002132897A RU2002132897A (ru) 2004-06-27
RU2269520C2 true RU2269520C2 (ru) 2006-02-10

Family

ID=23175471

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002132897/04A RU2269520C2 (ru) 2000-05-09 2001-05-08 Соединения пиперазиндиона

Country Status (14)

Country Link
US (1) US6635649B2 (https=)
EP (1) EP1282609B1 (https=)
JP (1) JP5101781B2 (https=)
KR (1) KR100852965B1 (https=)
CN (1) CN100522949C (https=)
AT (1) ATE417614T1 (https=)
BR (1) BR0110745A (https=)
CZ (1) CZ301743B6 (https=)
DE (1) DE60137037D1 (https=)
HU (1) HUP0302358A3 (https=)
NO (1) NO326341B1 (https=)
RU (1) RU2269520C2 (https=)
WO (1) WO2001095858A2 (https=)
ZA (1) ZA200209917B (https=)

Cited By (1)

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RU2519948C2 (ru) * 2008-08-22 2014-06-20 Бритиш Коламбиа Кэнсер Эйдженси Бранч Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов

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US7288545B2 (en) * 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) * 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
NZ539735A (en) * 2002-10-02 2009-07-31 Dmi Biosciences Inc Diagnosis and monitoring of diseases using markers, such as diketopiperazines
EP1622633B1 (en) 2003-05-15 2016-02-24 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
US20050192348A1 (en) * 2003-09-25 2005-09-01 David Bar-Or Methods and products which utilize N-acyl-L-aspartic acid
EP1711487A1 (en) * 2004-02-04 2006-10-18 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
US8129527B2 (en) * 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc THERAPEUTIC PROCESSES AND COMPOUNDS
JP2012524066A (ja) * 2009-04-16 2012-10-11 テリック，インコーポレイテッド チューブリン重合阻害剤としての置換４−アミノ−５−ベンゾイル−２−（フェニルアミノ）チオフェン−３−カルボニトリルおよび置換４−アミノ−５−ベンゾイル−２−（フェニルアミノ）チオフェン−３−カルボキサミド
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
US8710062B2 (en) * 2011-03-11 2014-04-29 Taipei Medical University Piperazinedione compounds
SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP3721884A1 (en) 2011-10-10 2020-10-14 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
CN103841974A (zh) 2011-10-28 2014-06-04 安皮奥制药股份有限公司 鼻炎的治疗
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
JP6311097B2 (ja) * 2013-07-31 2018-04-18 学校法人東京薬科大学 微小管脱重合剤
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104356077B (zh) * 2014-09-11 2016-09-14 中国科学院南海海洋研究所 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用
HK1249051A1 (zh) 2015-03-06 2018-10-26 BeyondSpring Pharmaceuticals Inc. 治疗脑肿瘤的方法
MX383691B (es) 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
WO2017139231A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CN109580801B (zh) * 2018-06-26 2021-09-07 深圳海王医药科技研究院有限公司 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
CN117285516A (zh) * 2022-06-16 2023-12-26 大连万众益生大健康有限公司 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines
US5902812A (en) * 1994-02-14 1999-05-11 Xenova Limited Pharmaceutical piperazine compounds

Family Cites Families (8)

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JPS5973574A (ja) * 1982-10-21 1984-04-25 Grelan Pharmaceut Co Ltd 環状ジペプチド類
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
GB8609908D0 (en) * 1986-04-23 1986-05-29 Fujisawa Pharmaceutical Co Piperazine compound
DK181687A (da) * 1986-04-23 1987-10-24 Fujisawa Pharmaceutical Co Piperazinderivater og fremgangsmaade til fremstiling deraf
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
US5708804A (en) * 1994-07-25 1998-01-13 International Business Machines Corp. Apparatus and method therefor of intelligently searching for information in a personal communications device
JP3795093B2 (ja) * 1994-11-25 2006-07-12 キッセイ薬品工業株式会社 １−ヒドロキシインドール誘導体
JP3131574B2 (ja) * 1996-09-04 2001-02-05 新日本製鐵株式会社 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines
US5902812A (en) * 1994-02-14 1999-05-11 Xenova Limited Pharmaceutical piperazine compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519948C2 (ru) * 2008-08-22 2014-06-20 Бритиш Коламбиа Кэнсер Эйдженси Бранч Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов

Also Published As

Publication number Publication date
CN1441789A (zh) 2003-09-10
CN100522949C (zh) 2009-08-05
EP1282609A2 (en) 2003-02-12
JP5101781B2 (ja) 2012-12-19
ATE417614T1 (de) 2009-01-15
US20020028819A1 (en) 2002-03-07
BR0110745A (pt) 2003-12-30
WO2001095858A2 (en) 2001-12-20
NO20025373L (no) 2002-12-13
DE60137037D1 (de) 2009-01-29
ZA200209917B (en) 2004-04-28
CZ301743B6 (cs) 2010-06-09
EP1282609A4 (en) 2003-06-04
JP2004510701A (ja) 2004-04-08
US6635649B2 (en) 2003-10-21
NO326341B1 (no) 2008-11-10
HUP0302358A2 (hu) 2003-11-28
WO2001095858A3 (en) 2002-03-21
KR100852965B1 (ko) 2008-08-19
CZ20023693A3 (cs) 2003-05-14
NO20025373D0 (no) 2002-11-08
EP1282609B1 (en) 2008-12-17
KR20030005336A (ko) 2003-01-17
HUP0302358A3 (en) 2007-09-28

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Effective date: 20090622

MM4A The patent is invalid due to non-payment of fees

Effective date: 20110509