CN110997669A - 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 - Google Patents

取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 Download PDF

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CN110997669A
CN110997669A CN201880050247.0A CN201880050247A CN110997669A CN 110997669 A CN110997669 A CN 110997669A CN 201880050247 A CN201880050247 A CN 201880050247A CN 110997669 A CN110997669 A CN 110997669A
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amino
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CN110997669B (zh
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邓贤明
黄伟
孙细欢
张婷
何志祥
刘琰
吴昕瑞
张保锭
李小阳
张婧芳
陈云
李莉
徐庆妍
胡志钰
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Xiamen University
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

一类具有PIKfyve激酶选择性抑制活性的取代五元并六元杂环化合物及其药学上可接受的盐或药学上可接受的溶剂合物，其制备方法、包含该化合物的药物组合物，以及这些化合物在制备用于预防或治疗与生物体内PIKfyve相关疾病的药物中的用途，尤其是在制备用于预防或治疗肿瘤生长与转移的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN201880050247.0A 2017-08-04 2018-08-03 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 Active CN110997669B (zh)

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KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
CN111825674A (zh) * 2019-04-22 2020-10-27 上海仕谱生物科技有限公司 嘧啶并五元杂环类化合物及其作为突变型idh2抑制剂的用途
CA3153096A1 (en) 2019-09-13 2021-03-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder
US11814388B1 (en) 2020-08-28 2023-11-14 Ferris State University Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
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CN114149409B (zh) * 2021-11-16 2024-03-22 中国药科大学 一种具有蛋白激酶抑制活性的（杂）芳基酰胺类化合物
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TW201910329A (zh) 2019-03-16
AU2018309245A1 (en) 2020-03-19
CN115057855B (zh) 2024-04-26
CN110997669B (zh) 2022-12-27
EP3663293A4 (en) 2021-04-21
US11352354B2 (en) 2022-06-07
US20200165246A1 (en) 2020-05-28
WO2019024908A1 (zh) 2019-02-07
CA3071900A1 (en) 2019-02-07
CN115057855A (zh) 2022-09-16
JP2021176847A (ja) 2021-11-11
CN109384782A (zh) 2019-02-26
JP7050093B2 (ja) 2022-04-07
JP2020529968A (ja) 2020-10-15
EP3663293A1 (en) 2020-06-10
AU2018309245B2 (en) 2021-03-04

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