CN115916759A - 取代喹唑啉类化合物、其制备方法、药物组合及应用 - Google Patents

取代喹唑啉类化合物、其制备方法、药物组合及应用 Download PDF

Info

Publication number
CN115916759A
CN115916759A CN202180041037.7A CN202180041037A CN115916759A CN 115916759 A CN115916759 A CN 115916759A CN 202180041037 A CN202180041037 A CN 202180041037A CN 115916759 A CN115916759 A CN 115916759A
Authority
CN
China
Prior art keywords
piperidinyl
methyl
piperazinyl
formyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180041037.7A
Other languages
English (en)
Inventor
邓贤明
黄伟
盛伸
云彩红
张建明
黄鑫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Hongyun Bio Tech Co ltd
Original Assignee
Nanjing Hongyun Bio Tech Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Hongyun Bio Tech Co ltd filed Critical Nanjing Hongyun Bio Tech Co ltd
Publication of CN115916759A publication Critical patent/CN115916759A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一种取代喹唑啉类化合物、其制备方法、药物组合及应用;具体地,涉及一类具有BRK和/或BTK激酶抑制活性的取代喹唑啉类化合物及其药学上可接受的盐或药学上可接受的溶剂合物,其制备方法、包含该化合物的药物组合物,以及这些化合物在制备用于预防或治疗与生物体内BRK、BTK激酶或二者相关疾病的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (10)

  1. PCT国内申请,权利要求书已公开。
CN202180041037.7A 2020-06-19 2021-06-18 取代喹唑啉类化合物、其制备方法、药物组合及应用 Pending CN115916759A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010565460 2020-06-19
CN2020105654604 2020-06-19
CN2021106544786 2021-06-11
CN202110654478 2021-06-11
PCT/CN2021/100775 WO2021254464A1 (zh) 2020-06-19 2021-06-18 取代喹唑啉类化合物、其制备方法、药物组合及应用

Publications (1)

Publication Number Publication Date
CN115916759A true CN115916759A (zh) 2023-04-04

Family

ID=79268489

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180041037.7A Pending CN115916759A (zh) 2020-06-19 2021-06-18 取代喹唑啉类化合物、其制备方法、药物组合及应用

Country Status (2)

Country Link
CN (1) CN115916759A (zh)
WO (1) WO2021254464A1 (zh)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
WO2009046448A1 (en) * 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
AR081960A1 (es) * 2010-06-22 2012-10-31 Fovea Pharmaceuticals Sa Compuestos heterociclicos, su preparacion y su aplicacion terapeutica
CN109305944B (zh) * 2017-07-28 2022-09-02 深圳睿熙生物科技有限公司 布鲁顿酪氨酸激酶的抑制剂
US20210353626A1 (en) * 2018-04-20 2021-11-18 The Regents Of The University Of California Beta-adrenergic receptor allosteric modulators
CN112239459B (zh) * 2019-07-19 2021-11-26 中国科学院上海药物研究所 稠环嘧啶氨基化合物、其制备方法、药物组合物及应用

Also Published As

Publication number Publication date
WO2021254464A1 (zh) 2021-12-23

Similar Documents

Publication Publication Date Title
CA2736097C (en) Carbazole compounds for inhibition of nf-kb activity
CN113717156B (zh) Egfr抑制剂、其制备方法及用途
CN107698603B (zh) 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用
JP6457623B2 (ja) 2,4−二置換7H−ピロロ[2,3−d]ピリミジン誘導体、その製造方法および医薬における使用
CN110997669B (zh) 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途
CN110770234B (zh) 取代芳基醚类化合物、其制备方法、药用组合物及其应用
JP7145873B2 (ja) 5員環および6員環が縮合したアザ環式芳香族系化合物、その製造方法、医薬組成物およびその応用
KR20200115583A (ko) Cdk4 및 cdk6 억제제로서의 2h-인다졸 유도체 및 그의 치료 용도
CN107151250A (zh) 嘧啶类七元环化合物、其制备方法、药用组合物及其应用
CN109575045B (zh) 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用
CN106488918B (zh) 三唑并嘧啶酮或三唑并吡啶酮衍生物及其用途
CN115803325B (zh) 一种egfr抑制剂及其制备方法和应用
CN111875583B (zh) 三氮唑衍生物及其制备方法和用途
CN111295387B (zh) 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用
CN115697996A (zh) 烯基嘧啶类化合物、其制备方法与应用
CN115916759A (zh) 取代喹唑啉类化合物、其制备方法、药物组合及应用
TWI807343B (zh) 取代喹唑啉類化合物、藥物組合物及應用
CN117794923A (zh) 苯并二噁烷类化合物、其制备方法与应用
AU2022321449A1 (en) Pyrimidine-4,6-diamine derivative, a preparation method therefor, and a pharmaceutical application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Country or region after: China

Address after: Room 410, Building 6, No. 2 Jiejiashe Road, Medical High tech Industrial Development Zone, Taizhou City, Jiangsu Province, 225316

Applicant after: Taizhou Hongyun Pharmaceutical Co.,Ltd.

Address before: 211112 Longmian Avenue 568, Jiangning District, Nanjing City, Jiangsu Province

Applicant before: NANJING HONGYUN BIO-TECH Co.,Ltd.

Country or region before: China