JP2004509128A5 - - Google Patents
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- Publication number
- JP2004509128A5 JP2004509128A5 JP2002526877A JP2002526877A JP2004509128A5 JP 2004509128 A5 JP2004509128 A5 JP 2004509128A5 JP 2002526877 A JP2002526877 A JP 2002526877A JP 2002526877 A JP2002526877 A JP 2002526877A JP 2004509128 A5 JP2004509128 A5 JP 2004509128A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen atoms
- quaternary ammonium
- amino acid
- ammonium cation
- proton
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 17
- 229940024606 amino acid Drugs 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 12
- 125000001931 aliphatic group Chemical group 0.000 claims 10
- 150000001412 amines Chemical class 0.000 claims 7
- 229960005527 combretastatin A-4 phosphate Drugs 0.000 claims 7
- WDOGQTQEKVLZIJ-WAYWQWQTSA-N combretastatin a-4 phosphate Chemical compound C1=C(OP(O)(O)=O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 WDOGQTQEKVLZIJ-WAYWQWQTSA-N 0.000 claims 7
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 125000002843 carboxylic acid group Chemical group 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 4
- 229960000281 trometamol Drugs 0.000 claims 4
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 108010021119 Trichosanthin Proteins 0.000 claims 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 3
- 229960001231 choline Drugs 0.000 claims 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 3
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 3
- 229960002885 histidine Drugs 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- XGIHQYAWBCFNPY-AZOCGYLKSA-N hydrabamine Chemical compound C([C@@H]12)CC3=CC(C(C)C)=CC=C3[C@@]2(C)CCC[C@@]1(C)CNCCNC[C@@]1(C)[C@@H]2CCC3=CC(C(C)C)=CC=C3[C@@]2(C)CCC1 XGIHQYAWBCFNPY-AZOCGYLKSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- -1 alkyl ester compound Chemical class 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229960003121 arginine Drugs 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 229960002743 glutamine Drugs 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229960002591 hydroxyproline Drugs 0.000 claims 2
- 229960003646 lysine Drugs 0.000 claims 2
- 229960003104 ornithine Drugs 0.000 claims 2
- 229960002429 proline Drugs 0.000 claims 2
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims 2
- 229960004799 tryptophan Drugs 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 150000003141 primary amines Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23256800P | 2000-09-14 | 2000-09-14 | |
| US25192100P | 2000-12-07 | 2000-12-07 | |
| PCT/US2001/028401 WO2002022626A1 (en) | 2000-09-14 | 2001-09-12 | Combretastatin a-4 phosphate prodrug salts with nitrogen-containing compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008121719A Division JP2008195740A (ja) | 2000-09-14 | 2008-05-07 | コンブレタスタチンａ−４ホスフェートプロドラッグのモノ−およびジ−有機アミン塩、モノ−およびジ−アミノ酸塩、ならびにモノ−およびジ−アミノ酸エステル塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509128A JP2004509128A (ja) | 2004-03-25 |
| JP2004509128A5 true JP2004509128A5 (enExample) | 2005-09-29 |
| JP4149804B2 JP4149804B2 (ja) | 2008-09-17 |
Family
ID=26926130
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526877A Expired - Fee Related JP4149804B2 (ja) | 2000-09-14 | 2001-09-12 | コンブレタスタチンａ−４ホスフェートプロドラッグのモノ−およびジ−有機アミン塩、モノ−およびジ−アミノ酸塩、ならびにモノ−およびジ−アミノ酸エステル塩 |
| JP2008121719A Withdrawn JP2008195740A (ja) | 2000-09-14 | 2008-05-07 | コンブレタスタチンａ−４ホスフェートプロドラッグのモノ−およびジ−有機アミン塩、モノ−およびジ−アミノ酸塩、ならびにモノ−およびジ−アミノ酸エステル塩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008121719A Withdrawn JP2008195740A (ja) | 2000-09-14 | 2008-05-07 | コンブレタスタチンａ−４ホスフェートプロドラッグのモノ−およびジ−有機アミン塩、モノ−およびジ−アミノ酸塩、ならびにモノ−およびジ−アミノ酸エステル塩 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6670344B2 (enExample) |
| EP (1) | EP1320534B1 (enExample) |
| JP (2) | JP4149804B2 (enExample) |
| KR (1) | KR100858464B1 (enExample) |
| CN (1) | CN100338077C (enExample) |
| AR (1) | AR030727A1 (enExample) |
| AT (1) | ATE293630T1 (enExample) |
| AU (2) | AU785183B2 (enExample) |
| BR (1) | BRPI0107210B1 (enExample) |
| CA (1) | CA2422359C (enExample) |
| DE (1) | DE60110249T2 (enExample) |
| EE (1) | EE200200249A (enExample) |
| ES (1) | ES2241872T3 (enExample) |
| HK (1) | HK1052356B (enExample) |
| HU (1) | HU229055B1 (enExample) |
| IL (3) | IL149601A0 (enExample) |
| MX (1) | MXPA03002209A (enExample) |
| NO (1) | NO329973B1 (enExample) |
| NZ (1) | NZ524926A (enExample) |
| PE (1) | PE20020445A1 (enExample) |
| PT (1) | PT1320534E (enExample) |
| RS (1) | RS50309B (enExample) |
| SK (1) | SK287117B6 (enExample) |
| TW (1) | TWI250163B (enExample) |
| UY (1) | UY26935A1 (enExample) |
| WO (1) | WO2002022626A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019944D0 (en) * | 2000-08-15 | 2000-09-27 | Angiogene Pharm Ltd | Compositions with vascular damaging activity |
| US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| US20050153939A1 (en) * | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| WO2002086869A1 (en) * | 2001-04-19 | 2002-10-31 | Sony Corporation | Digital recording/reproducing apparatus |
| EP1406600A4 (en) * | 2001-07-13 | 2007-06-06 | Oxigene Inc | COMPOSITIONS AND METHOD FOR THE ADMINISTRATION OF TUBULIN BINDING AGENTS FOR THE TREATMENT OF EYE DISEASES |
| US20040229960A1 (en) * | 2001-07-13 | 2004-11-18 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| US20090137687A1 (en) * | 2003-02-28 | 2009-05-28 | Oxigene, Inc. | Compositions and Methods With Enhanced Therapeutic Activity |
| CN100365000C (zh) * | 2003-09-18 | 2008-01-30 | 雍智全 | Combretastatin A-4磷酰胆碱类前体药物以及其合成与应用 |
| CN100579532C (zh) | 2003-12-23 | 2010-01-13 | 先灵-普劳有限公司 | 具有改善水溶性的氟苯尼考前药 |
| TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| TWI415635B (zh) | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| ES2551086T3 (es) | 2005-06-14 | 2015-11-16 | Baylor University | Análogos de combretastatina con actividad de unión a tubulina |
| CN1907989B (zh) * | 2005-08-02 | 2011-08-17 | 浙江天皇药业有限公司 | 毛兰素盐及其制备方法和包含其的药物组合物 |
| BRPI0620040A2 (pt) * | 2005-12-19 | 2011-10-25 | Methylgene Inc | inibidores de histona desacetilase para realçar a atividade de agentes antifúngicos |
| HUE040311T2 (hu) | 2006-04-04 | 2019-02-28 | Kg Acquisition Llc | Vérlemezke aggregációt gátló szert és sav inhibitort tartalmazó orális dózisformák |
| WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
| MX2009006542A (es) | 2006-12-19 | 2009-06-30 | Methylgene Inc | Inhibidores de histona desacetilasa y sus profarmacos. |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| US20090012325A1 (en) * | 2007-02-22 | 2009-01-08 | Ajith Manage | Methods for preparing phosphoric acids of combrestastatin and derivatives thereof |
| WO2008109076A1 (en) * | 2007-03-02 | 2008-09-12 | Oxigene, Inc. | Methods for enhancing the efficacy of vascular disrupting agents |
| JP2010530889A (ja) * | 2007-06-22 | 2010-09-16 | ブリストル−マイヤーズ スクイブ カンパニー | アタザナビルを含む錠剤組成物 |
| ES2359770T3 (es) * | 2007-06-22 | 2011-05-26 | Bristol-Myers Squibb Company | Composiciones en comprimidos que contienen atazanavir. |
| SI2170292T1 (sl) * | 2007-06-22 | 2014-05-30 | Bristol-Myers Squibb Holdings Ireland | Tabletirani sestavki, ki vsebujejo atazanavir |
| JP2010530892A (ja) * | 2007-06-22 | 2010-09-16 | ブリストル−マイヤーズ スクイブ カンパニー | アタザナビルを含む錠剤組成物 |
| US20090264382A1 (en) | 2007-11-21 | 2009-10-22 | David Chaplin | Methods for Treating Hematopoietic Neoplasms |
| CN102757338B (zh) * | 2012-02-29 | 2015-02-25 | 郑州泰基鸿诺药物科技有限公司 | 一种非诺贝特酸氨基酸乙酯盐、制备方法及其用途 |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| US11419934B2 (en) | 2015-08-18 | 2022-08-23 | Oncotelic Therapeutics, Inc. | Use of VDAS to enhance immunomodulating therapies against tumors |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US12552763B2 (en) | 2017-02-02 | 2026-02-17 | Bioventures, Llc | Methods of protecting against neurodegeneration |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| WO2025250885A1 (en) * | 2024-05-31 | 2025-12-04 | Oncotelic, Inc. | In situ tumor-infiltrating lymphocyte therapeutics for cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| DE3438386A1 (de) | 1984-09-22 | 1986-04-03 | Basf Ag, 6700 Ludwigshafen | Phosphorsaeurevinylbenzylester, ihre herstellung und verwendung |
| GB9106177D0 (en) | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| DE19506885A1 (de) | 1995-02-17 | 1996-08-22 | Schering Ag | Neue Borneolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| TW334418B (en) | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| WO1999035159A1 (en) * | 1998-01-08 | 1999-07-15 | Brigham & Women's Hospital, Inc. | Lymphoma/leukemia oncogene, oncoprotein and methods of use |
| JP2002500227A (ja) * | 1998-01-09 | 2002-01-08 | アリゾナ ボード オブ リーゼンツ | コンブレタスタチンａ−４プロドラッグとそのトランス異性体 |
| GB9903404D0 (en) | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis |
| GB9903403D0 (en) | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Substituted stilbene compounds with vascular damaging activity |
| GB0019944D0 (en) | 2000-08-15 | 2000-09-27 | Angiogene Pharm Ltd | Compositions with vascular damaging activity |
| US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
-
2001
- 2001-09-11 US US09/950,500 patent/US6670344B2/en not_active Expired - Lifetime
- 2001-09-12 SK SK672-2002A patent/SK287117B6/sk not_active IP Right Cessation
- 2001-09-12 KR KR1020027006168A patent/KR100858464B1/ko not_active Expired - Fee Related
- 2001-09-12 CN CNB018031404A patent/CN100338077C/zh not_active Expired - Fee Related
- 2001-09-12 MX MXPA03002209A patent/MXPA03002209A/es active IP Right Grant
- 2001-09-12 EE EEP200200249A patent/EE200200249A/xx unknown
- 2001-09-12 DE DE60110249T patent/DE60110249T2/de not_active Expired - Lifetime
- 2001-09-12 NZ NZ524926A patent/NZ524926A/en not_active IP Right Cessation
- 2001-09-12 AU AU90771/01A patent/AU785183B2/en not_active Ceased
- 2001-09-12 ES ES01970806T patent/ES2241872T3/es not_active Expired - Lifetime
- 2001-09-12 HK HK03104615.4A patent/HK1052356B/zh not_active IP Right Cessation
- 2001-09-12 HU HU0204423A patent/HU229055B1/hu not_active IP Right Cessation
- 2001-09-12 PT PT01970806T patent/PT1320534E/pt unknown
- 2001-09-12 EP EP01970806A patent/EP1320534B1/en not_active Expired - Lifetime
- 2001-09-12 TW TW090122636A patent/TWI250163B/zh not_active IP Right Cessation
- 2001-09-12 IL IL14960101A patent/IL149601A0/xx active IP Right Grant
- 2001-09-12 BR BRPI0107210-2A patent/BRPI0107210B1/pt not_active IP Right Cessation
- 2001-09-12 JP JP2002526877A patent/JP4149804B2/ja not_active Expired - Fee Related
- 2001-09-12 CA CA002422359A patent/CA2422359C/en not_active Expired - Fee Related
- 2001-09-12 AT AT01970806T patent/ATE293630T1/de active
- 2001-09-12 RS YUP-348/02A patent/RS50309B/sr unknown
- 2001-09-12 WO PCT/US2001/028401 patent/WO2002022626A1/en not_active Ceased
- 2001-09-13 UY UY26935A patent/UY26935A1/es not_active Application Discontinuation
- 2001-09-13 AR ARP010104346A patent/AR030727A1/es unknown
- 2001-09-14 PE PE2001000927A patent/PE20020445A1/es not_active Application Discontinuation
-
2002
- 2002-05-12 IL IL149601A patent/IL149601A/en unknown
- 2002-05-13 NO NO20022270A patent/NO329973B1/no not_active IP Right Cessation
-
2003
- 2003-09-10 US US10/660,439 patent/US6855702B2/en not_active Expired - Lifetime
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2006
- 2006-06-04 IL IL176088A patent/IL176088A0/en unknown
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2007
- 2007-01-19 AU AU2007200218A patent/AU2007200218A1/en not_active Abandoned
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2008
- 2008-05-07 JP JP2008121719A patent/JP2008195740A/ja not_active Withdrawn