JP2017533964A5 - - Google Patents
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- JP2017533964A5 JP2017533964A5 JP2017543338A JP2017543338A JP2017533964A5 JP 2017533964 A5 JP2017533964 A5 JP 2017533964A5 JP 2017543338 A JP2017543338 A JP 2017543338A JP 2017543338 A JP2017543338 A JP 2017543338A JP 2017533964 A5 JP2017533964 A5 JP 2017533964A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- compound
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 9
- 102000004132 Ornithine aminotransferases Human genes 0.000 claims description 6
- 108090000691 Ornithine aminotransferases Proteins 0.000 claims description 6
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 5
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims description 2
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 27
- 0 *C(CC(C1)C(O)=O)C1=C(*)* Chemical compound *C(CC(C1)C(O)=O)C1=C(*)* 0.000 description 7
- 239000006143 cell culture medium Substances 0.000 description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- -1 carboxylate salt Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076980P | 2014-11-07 | 2014-11-07 | |
| US62/076,980 | 2014-11-07 | ||
| PCT/US2015/059738 WO2016073983A2 (en) | 2014-11-07 | 2015-11-09 | Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533964A JP2017533964A (ja) | 2017-11-16 |
| JP2017533964A5 true JP2017533964A5 (enExample) | 2018-12-06 |
| JP6867949B2 JP6867949B2 (ja) | 2021-05-12 |
Family
ID=55910047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543338A Active JP6867949B2 (ja) | 2014-11-07 | 2015-11-09 | 肝細胞癌を治療する為のｇａｂａ類似体を用いたオルニチンアミノ基転移酵素の阻害方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9603820B2 (enExample) |
| EP (1) | EP3215144B1 (enExample) |
| JP (1) | JP6867949B2 (enExample) |
| AU (1) | AU2015342801A1 (enExample) |
| CA (1) | CA2966642C (enExample) |
| ES (1) | ES2882126T3 (enExample) |
| IL (1) | IL252042B (enExample) |
| MX (1) | MX2017006022A (enExample) |
| WO (1) | WO2016073983A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019243586A1 (en) * | 2018-03-29 | 2020-10-15 | Ovid Therapeutics Inc. | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of eye disorders |
| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| JP7475055B2 (ja) | 2018-05-25 | 2024-04-26 | ノースウェスタン ユニバーシティ | （ｓ）－３－アミノ－４－（ジフルオロメチレニル）シクロペンタ－１－エン－１－カルボン酸の合成法 |
| WO2019236938A1 (en) | 2018-06-07 | 2019-12-12 | Ovid Therapeutics Inc. | Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1s,3s)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and vigabatrin in the treatment of developmental disorders |
| US11203596B2 (en) | 2019-02-25 | 2021-12-21 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| US11078153B2 (en) * | 2019-04-03 | 2021-08-03 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| EP4301724A4 (en) * | 2021-03-03 | 2025-05-28 | Northwestern University | (S)-3-AMINO-4,4-DIHALOCYCLOPENT-1-CARBOXYLIC ACID AS SELECTIVE INACTIVATORS OF HUMAN ORNITHINE AMINOTRANSFERASE |
| US12150998B2 (en) * | 2021-04-20 | 2024-11-26 | Bicycletx Limited | Bicyclic peptide ligands specific for P-selectin |
| CN118401255A (zh) * | 2021-08-19 | 2024-07-26 | N1生命股份有限公司 | 紫杉醇缀合化合物、包含所述化合物的药物组合物及它们的使用方法 |
| US20250171397A1 (en) * | 2022-02-27 | 2025-05-29 | Northwestern University | (3s,4r)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic acid and related compounds as selective inactivators of ornithine aminotransferase |
| WO2024196851A1 (en) * | 2023-03-17 | 2024-09-26 | Northwestern University | Bicyclic compounds as inactivators of oat and gaba-at |
| US20260130878A1 (en) * | 2024-11-12 | 2026-05-14 | Ovid Therapeutics Inc. | Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid in the treatment of pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6794413B1 (en) * | 2002-07-19 | 2004-09-21 | Northwestern University | Compounds and related methods for inhibition of γ-aminobutyric acid aminotransferase |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| IL177609A (en) | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
-
2015
- 2015-11-09 AU AU2015342801A patent/AU2015342801A1/en not_active Abandoned
- 2015-11-09 ES ES15856956T patent/ES2882126T3/es active Active
- 2015-11-09 WO PCT/US2015/059738 patent/WO2016073983A2/en not_active Ceased
- 2015-11-09 MX MX2017006022A patent/MX2017006022A/es unknown
- 2015-11-09 EP EP15856956.6A patent/EP3215144B1/en active Active
- 2015-11-09 JP JP2017543338A patent/JP6867949B2/ja active Active
- 2015-11-09 US US14/936,153 patent/US9603820B2/en active Active
- 2015-11-09 CA CA2966642A patent/CA2966642C/en active Active
-
2017
- 2017-04-30 IL IL252042A patent/IL252042B/en active IP Right Grant
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