JP2010526826A5 - - Google Patents
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- Publication number
- JP2010526826A5 JP2010526826A5 JP2010507665A JP2010507665A JP2010526826A5 JP 2010526826 A5 JP2010526826 A5 JP 2010526826A5 JP 2010507665 A JP2010507665 A JP 2010507665A JP 2010507665 A JP2010507665 A JP 2010507665A JP 2010526826 A5 JP2010526826 A5 JP 2010526826A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- composition
- pharmaceutically acceptable
- stereoisomer
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 206010039897 Sedation Diseases 0.000 claims 2
- TVOJVHAUFRZWKB-UHFFFAOYSA-N [2,6-di(butan-2-yl)phenyl] carbamate Chemical compound CCC(C)C1=CC=CC(C(C)CC)=C1OC(N)=O TVOJVHAUFRZWKB-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000002695 general anesthesia Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000036280 sedation Effects 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000002960 lipid emulsion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92842907P | 2007-05-09 | 2007-05-09 | |
| US92829607P | 2007-05-09 | 2007-05-09 | |
| US92832707P | 2007-05-09 | 2007-05-09 | |
| US60/928,296 | 2007-05-09 | ||
| US60/928,327 | 2007-05-09 | ||
| US60/928,429 | 2007-05-09 | ||
| PCT/US2008/063082 WO2008141097A2 (en) | 2007-05-09 | 2008-05-08 | Stereoisomers propofol therapeutic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526826A JP2010526826A (ja) | 2010-08-05 |
| JP2010526826A5 true JP2010526826A5 (enExample) | 2011-06-23 |
| JP5651009B2 JP5651009B2 (ja) | 2015-01-07 |
Family
ID=39798084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507665A Expired - Fee Related JP5651009B2 (ja) | 2007-05-09 | 2008-05-08 | 治療用化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8071818B2 (enExample) |
| EP (4) | EP2292577A1 (enExample) |
| JP (1) | JP5651009B2 (enExample) |
| KR (1) | KR20100017436A (enExample) |
| CN (1) | CN101715437B (enExample) |
| AT (1) | ATE487685T1 (enExample) |
| AU (1) | AU2008251482C1 (enExample) |
| BR (1) | BRPI0811220A2 (enExample) |
| CA (1) | CA2685570A1 (enExample) |
| DE (1) | DE602008003431D1 (enExample) |
| DK (2) | DK2146946T3 (enExample) |
| ES (1) | ES2501592T3 (enExample) |
| HR (1) | HRP20140896T1 (enExample) |
| IL (1) | IL201795A0 (enExample) |
| MX (1) | MX2009012124A (enExample) |
| NZ (1) | NZ580752A (enExample) |
| PL (2) | PL2301908T3 (enExample) |
| PT (1) | PT2146946E (enExample) |
| RU (1) | RU2470908C2 (enExample) |
| SI (1) | SI2301908T1 (enExample) |
| WO (1) | WO2008141097A2 (enExample) |
| ZA (1) | ZA201007603B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2292577A1 (en) | 2007-05-09 | 2011-03-09 | Pharmacofore, Inc. | (+)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof |
| JP5924539B2 (ja) * | 2010-08-03 | 2016-05-25 | 学校法人 久留米大学 | 実験用小動物の脳波測定用装置及び脳波測定方法 |
| CN102731265B (zh) * | 2012-06-12 | 2014-12-10 | 四川百利药业有限责任公司 | 一种高纯度丙泊酚的制备方法 |
| US11331271B2 (en) * | 2016-05-27 | 2022-05-17 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| RU2635532C1 (ru) * | 2016-09-06 | 2017-11-13 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ профилактики ажитационного синдрома у детей с онкологической патологией |
| CN115708819A (zh) * | 2022-11-24 | 2023-02-24 | 中国科学院深圳先进技术研究院 | 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US237213A (en) | 1881-02-01 | William j | ||
| US2747982A (en) * | 1955-05-11 | 1956-05-29 | Dow Chemical Co | Method and composition for the control of the growth of vegetation |
| US4798846A (en) | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| SU1525139A1 (ru) * | 1987-11-10 | 1989-11-30 | Куйбышевский политехнический институт им.В.В.Куйбышева | Способ получени о-втор-бутилфенола |
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5731355A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| US6254853B1 (en) | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| JP2002537243A (ja) | 1999-02-18 | 2002-11-05 | スーパージェン インコーポレイテッド | ホスホコリン結合プロドラッグ誘導体 |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6362234B1 (en) | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| US7144877B2 (en) | 2000-10-06 | 2006-12-05 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| EP1383445A4 (en) * | 2001-03-20 | 2005-04-13 | Cydex Inc | FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN |
| US20050042280A1 (en) | 2001-12-28 | 2005-02-24 | Rogers Tracey L. | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
| WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| BR0308857A (pt) | 2002-04-08 | 2005-01-04 | Guilford Pharm Inc | Composições farmacêuticas contendo promedicamentos de propofol, solúveis em água, e métodos de administrar os mesmos |
| DE60323756D1 (de) | 2002-10-08 | 2008-11-06 | Fresenius Kabi De Gmbh | Pharmazeutisch aktive oligosaccharid-conjugate |
| DE20215415U1 (de) | 2002-10-08 | 2004-02-26 | Biotechnologie Gesellschaft Mittelhessen Mbh | Wasserlösliche Medikamentenvorstufen von Propofol |
| ZA200504940B (en) | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| AU2003901815A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| US7230003B2 (en) | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| US20070043121A1 (en) * | 2003-09-29 | 2007-02-22 | Brown Milton L | Discovery of novel soluble crystalline anesthetics |
| WO2006017351A1 (en) | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| US20080214508A1 (en) | 2004-09-17 | 2008-09-04 | Mgi Gp, Inc. | Methods of Administering Water-Soluble Prodrugs of Propofol |
| JP2008525501A (ja) | 2004-12-23 | 2008-07-17 | ゼノポート，インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
| DE102005033496A1 (de) * | 2005-07-19 | 2007-01-25 | Bayer Healthcare Ag | Desinfektionsmittel |
| JP5537033B2 (ja) * | 2005-12-19 | 2014-07-02 | ザ ユニヴァーシティー オブ リヴァプール | 無痛覚 |
| US7535698B2 (en) | 2006-03-07 | 2009-05-19 | Panasonic Corporation | Case, portable information equipment using the same and manufacturing method of the case |
| US7731356B1 (en) * | 2006-07-24 | 2010-06-08 | Daniel Ayers Gilbert | Hanging eyeglasses |
| EP2292577A1 (en) | 2007-05-09 | 2011-03-09 | Pharmacofore, Inc. | (+)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof |
| AU2008251484A1 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
-
2008
- 2008-05-08 EP EP10009233A patent/EP2292577A1/en not_active Withdrawn
- 2008-05-08 DE DE602008003431T patent/DE602008003431D1/de active Active
- 2008-05-08 KR KR1020097024780A patent/KR20100017436A/ko not_active Ceased
- 2008-05-08 PT PT08769338T patent/PT2146946E/pt unknown
- 2008-05-08 EP EP08769338A patent/EP2146946B1/en active Active
- 2008-05-08 PL PL10014318T patent/PL2301908T3/pl unknown
- 2008-05-08 ES ES10014318.9T patent/ES2501592T3/es active Active
- 2008-05-08 CA CA002685570A patent/CA2685570A1/en not_active Abandoned
- 2008-05-08 SI SI200831288T patent/SI2301908T1/sl unknown
- 2008-05-08 BR BRPI0811220-7A2A patent/BRPI0811220A2/pt not_active IP Right Cessation
- 2008-05-08 MX MX2009012124A patent/MX2009012124A/es active IP Right Grant
- 2008-05-08 NZ NZ580752A patent/NZ580752A/en not_active IP Right Cessation
- 2008-05-08 PL PL08769338T patent/PL2146946T3/pl unknown
- 2008-05-08 AU AU2008251482A patent/AU2008251482C1/en not_active Ceased
- 2008-05-08 DK DK08769338.8T patent/DK2146946T3/da active
- 2008-05-08 AT AT08769338T patent/ATE487685T1/de active
- 2008-05-08 US US12/596,800 patent/US8071818B2/en not_active Expired - Fee Related
- 2008-05-08 EP EP14173149.7A patent/EP2810927A1/en not_active Withdrawn
- 2008-05-08 CN CN2008800153921A patent/CN101715437B/zh not_active Expired - Fee Related
- 2008-05-08 WO PCT/US2008/063082 patent/WO2008141097A2/en not_active Ceased
- 2008-05-08 DK DK10014318.9T patent/DK2301908T3/da active
- 2008-05-08 RU RU2009145537/04A patent/RU2470908C2/ru not_active IP Right Cessation
- 2008-05-08 JP JP2010507665A patent/JP5651009B2/ja not_active Expired - Fee Related
- 2008-05-08 EP EP10014318.9A patent/EP2301908B8/en active Active
-
2009
- 2009-10-28 IL IL201795A patent/IL201795A0/en not_active IP Right Cessation
-
2010
- 2010-10-25 ZA ZA2010/07603A patent/ZA201007603B/en unknown
-
2011
- 2011-10-14 US US13/274,172 patent/US8242315B2/en not_active Expired - Fee Related
-
2012
- 2012-07-13 US US13/548,991 patent/US8575400B2/en not_active Expired - Fee Related
-
2013
- 2013-09-23 US US14/034,305 patent/US8871815B2/en not_active Expired - Fee Related
-
2014
- 2014-09-18 HR HRP20140896AT patent/HRP20140896T1/hr unknown
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