ATE487685T1 - (-)-stereoisomer von 2,6-di-sec-butylphenol und analoga davon - Google Patents

(-)-stereoisomer von 2,6-di-sec-butylphenol und analoga davon

Info

Publication number
ATE487685T1
ATE487685T1 AT08769338T AT08769338T ATE487685T1 AT E487685 T1 ATE487685 T1 AT E487685T1 AT 08769338 T AT08769338 T AT 08769338T AT 08769338 T AT08769338 T AT 08769338T AT E487685 T1 ATE487685 T1 AT E487685T1
Authority
AT
Austria
Prior art keywords
stereoisomer
butylphenol
analogs
sec
anesthetic
Prior art date
Application number
AT08769338T
Other languages
German (de)
English (en)
Inventor
Thomas E Jenkins
Original Assignee
Pharmacofore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacofore Inc filed Critical Pharmacofore Inc
Application granted granted Critical
Publication of ATE487685T1 publication Critical patent/ATE487685T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT08769338T 2007-05-09 2008-05-08 (-)-stereoisomer von 2,6-di-sec-butylphenol und analoga davon ATE487685T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92829607P 2007-05-09 2007-05-09
US92842907P 2007-05-09 2007-05-09
US92832707P 2007-05-09 2007-05-09
PCT/US2008/063082 WO2008141097A2 (en) 2007-05-09 2008-05-08 Stereoisomers propofol therapeutic compounds

Publications (1)

Publication Number Publication Date
ATE487685T1 true ATE487685T1 (de) 2010-11-15

Family

ID=39798084

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08769338T ATE487685T1 (de) 2007-05-09 2008-05-08 (-)-stereoisomer von 2,6-di-sec-butylphenol und analoga davon

Country Status (22)

Country Link
US (4) US8071818B2 (enExample)
EP (4) EP2301908B8 (enExample)
JP (1) JP5651009B2 (enExample)
KR (1) KR20100017436A (enExample)
CN (1) CN101715437B (enExample)
AT (1) ATE487685T1 (enExample)
AU (1) AU2008251482C1 (enExample)
BR (1) BRPI0811220A2 (enExample)
CA (1) CA2685570A1 (enExample)
DE (1) DE602008003431D1 (enExample)
DK (2) DK2146946T3 (enExample)
ES (1) ES2501592T3 (enExample)
HR (1) HRP20140896T1 (enExample)
IL (1) IL201795A0 (enExample)
MX (1) MX2009012124A (enExample)
NZ (1) NZ580752A (enExample)
PL (2) PL2301908T3 (enExample)
PT (1) PT2146946E (enExample)
RU (1) RU2470908C2 (enExample)
SI (1) SI2301908T1 (enExample)
WO (1) WO2008141097A2 (enExample)
ZA (1) ZA201007603B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2470908C2 (ru) 2007-05-09 2012-12-27 Сигничер Терапьютикс, Инк. Терапевтические соединения
JP5924539B2 (ja) * 2010-08-03 2016-05-25 学校法人 久留米大学 実験用小動物の脳波測定用装置及び脳波測定方法
CN102731265B (zh) * 2012-06-12 2014-12-10 四川百利药业有限责任公司 一种高纯度丙泊酚的制备方法
US11331271B2 (en) * 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
RU2635532C1 (ru) * 2016-09-06 2017-11-13 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики ажитационного синдрома у детей с онкологической патологией
CN115708819A (zh) * 2022-11-24 2023-02-24 中国科学院深圳先进技术研究院 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂

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US4798846A (en) 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
SU1525139A1 (ru) * 1987-11-10 1989-11-30 Куйбышевский политехнический институт им.В.В.Куйбышева Способ получени о-втор-бутилфенола
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5731355A (en) 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
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US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6140374A (en) 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
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US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
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WO2002044324A2 (en) 2000-10-06 2002-06-06 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
US20030055023A1 (en) * 2001-03-20 2003-03-20 Rajewski Roger A. Formulations containing etomidate and a sulfoalkyl ether cyclodextrin
CA2470500C (en) 2001-12-28 2012-05-15 Guilford Pharmaceuticals, Inc. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
BR0308857A (pt) 2002-04-08 2005-01-04 Guilford Pharm Inc Composições farmacêuticas contendo promedicamentos de propofol, solúveis em água, e métodos de administrar os mesmos
WO2004032971A1 (en) 2002-10-08 2004-04-22 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
DE20215415U1 (de) 2002-10-08 2004-02-26 Biotechnologie Gesellschaft Mittelhessen Mbh Wasserlösliche Medikamentenvorstufen von Propofol
ZA200504940B (en) 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
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Also Published As

Publication number Publication date
CA2685570A1 (en) 2008-11-20
EP2301908A1 (en) 2011-03-30
HRP20140896T1 (hr) 2015-01-02
MX2009012124A (es) 2010-02-18
RU2470908C2 (ru) 2012-12-27
JP2010526826A (ja) 2010-08-05
US20120035271A1 (en) 2012-02-09
SI2301908T1 (sl) 2014-10-30
WO2008141097A3 (en) 2008-12-31
DK2146946T3 (da) 2011-02-14
KR20100017436A (ko) 2010-02-16
EP2146946B1 (en) 2010-11-10
ES2501592T3 (es) 2014-10-02
NZ580752A (en) 2012-03-30
BRPI0811220A2 (pt) 2014-10-29
US20130059919A1 (en) 2013-03-07
AU2008251482A1 (en) 2008-11-20
PL2301908T3 (pl) 2015-02-27
EP2810927A1 (en) 2014-12-10
JP5651009B2 (ja) 2015-01-07
WO2008141097A2 (en) 2008-11-20
US8242315B2 (en) 2012-08-14
EP2146946A2 (en) 2010-01-27
AU2008251482B2 (en) 2013-09-26
US8575400B2 (en) 2013-11-05
PL2146946T3 (pl) 2011-04-29
EP2301908B1 (en) 2014-06-25
US20140206773A1 (en) 2014-07-24
ZA201007603B (en) 2012-08-29
HK1138829A1 (en) 2010-09-03
EP2292577A1 (en) 2011-03-09
RU2009145537A (ru) 2011-06-20
DE602008003431D1 (de) 2010-12-23
WO2008141097A9 (en) 2009-04-02
CN101715437A (zh) 2010-05-26
US8871815B2 (en) 2014-10-28
EP2301908B8 (en) 2014-09-03
IL201795A0 (en) 2010-06-16
US20100292346A1 (en) 2010-11-18
AU2008251482C1 (en) 2014-04-03
US8071818B2 (en) 2011-12-06
DK2301908T3 (da) 2014-09-15
HK1156019A1 (en) 2012-06-01
PT2146946E (pt) 2011-02-14
CN101715437B (zh) 2013-06-12

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