IL201795A0 - Stereoisomers propofol therapeutic compounds - Google Patents
Stereoisomers propofol therapeutic compoundsInfo
- Publication number
- IL201795A0 IL201795A0 IL201795A IL20179509A IL201795A0 IL 201795 A0 IL201795 A0 IL 201795A0 IL 201795 A IL201795 A IL 201795A IL 20179509 A IL20179509 A IL 20179509A IL 201795 A0 IL201795 A0 IL 201795A0
- Authority
- IL
- Israel
- Prior art keywords
- propofol
- stereoisomers
- therapeutic compounds
- anesthetic
- stereoisomer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title 1
- 229960004134 propofol Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/06—Alkylated phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
- C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92842907P | 2007-05-09 | 2007-05-09 | |
| US92829607P | 2007-05-09 | 2007-05-09 | |
| US92832707P | 2007-05-09 | 2007-05-09 | |
| PCT/US2008/063082 WO2008141097A2 (en) | 2007-05-09 | 2008-05-08 | Stereoisomers propofol therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL201795A0 true IL201795A0 (en) | 2010-06-16 |
Family
ID=39798084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL201795A IL201795A0 (en) | 2007-05-09 | 2009-10-28 | Stereoisomers propofol therapeutic compounds |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8071818B2 (enExample) |
| EP (4) | EP2292577A1 (enExample) |
| JP (1) | JP5651009B2 (enExample) |
| KR (1) | KR20100017436A (enExample) |
| CN (1) | CN101715437B (enExample) |
| AT (1) | ATE487685T1 (enExample) |
| AU (1) | AU2008251482C1 (enExample) |
| BR (1) | BRPI0811220A2 (enExample) |
| CA (1) | CA2685570A1 (enExample) |
| DE (1) | DE602008003431D1 (enExample) |
| DK (2) | DK2146946T3 (enExample) |
| ES (1) | ES2501592T3 (enExample) |
| HR (1) | HRP20140896T1 (enExample) |
| IL (1) | IL201795A0 (enExample) |
| MX (1) | MX2009012124A (enExample) |
| NZ (1) | NZ580752A (enExample) |
| PL (2) | PL2301908T3 (enExample) |
| PT (1) | PT2146946E (enExample) |
| RU (1) | RU2470908C2 (enExample) |
| SI (1) | SI2301908T1 (enExample) |
| WO (1) | WO2008141097A2 (enExample) |
| ZA (1) | ZA201007603B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2292577A1 (en) | 2007-05-09 | 2011-03-09 | Pharmacofore, Inc. | (+)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof |
| JP5924539B2 (ja) * | 2010-08-03 | 2016-05-25 | 学校法人 久留米大学 | 実験用小動物の脳波測定用装置及び脳波測定方法 |
| CN102731265B (zh) * | 2012-06-12 | 2014-12-10 | 四川百利药业有限责任公司 | 一种高纯度丙泊酚的制备方法 |
| US11331271B2 (en) * | 2016-05-27 | 2022-05-17 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| RU2635532C1 (ru) * | 2016-09-06 | 2017-11-13 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ профилактики ажитационного синдрома у детей с онкологической патологией |
| CN115708819A (zh) * | 2022-11-24 | 2023-02-24 | 中国科学院深圳先进技术研究院 | 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US237213A (en) | 1881-02-01 | William j | ||
| US2747982A (en) * | 1955-05-11 | 1956-05-29 | Dow Chemical Co | Method and composition for the control of the growth of vegetation |
| US4798846A (en) | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| SU1525139A1 (ru) * | 1987-11-10 | 1989-11-30 | Куйбышевский политехнический институт им.В.В.Куйбышева | Способ получени о-втор-бутилфенола |
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5731355A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| US6254853B1 (en) | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| JP2002537243A (ja) | 1999-02-18 | 2002-11-05 | スーパージェン インコーポレイテッド | ホスホコリン結合プロドラッグ誘導体 |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6362234B1 (en) | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| US7144877B2 (en) | 2000-10-06 | 2006-12-05 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| EP1383445A4 (en) * | 2001-03-20 | 2005-04-13 | Cydex Inc | FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN |
| US20050042280A1 (en) | 2001-12-28 | 2005-02-24 | Rogers Tracey L. | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
| WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| BR0308857A (pt) | 2002-04-08 | 2005-01-04 | Guilford Pharm Inc | Composições farmacêuticas contendo promedicamentos de propofol, solúveis em água, e métodos de administrar os mesmos |
| DE60323756D1 (de) | 2002-10-08 | 2008-11-06 | Fresenius Kabi De Gmbh | Pharmazeutisch aktive oligosaccharid-conjugate |
| DE20215415U1 (de) | 2002-10-08 | 2004-02-26 | Biotechnologie Gesellschaft Mittelhessen Mbh | Wasserlösliche Medikamentenvorstufen von Propofol |
| ZA200504940B (en) | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| AU2003901815A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| US7230003B2 (en) | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| US20070043121A1 (en) * | 2003-09-29 | 2007-02-22 | Brown Milton L | Discovery of novel soluble crystalline anesthetics |
| WO2006017351A1 (en) | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| US20080214508A1 (en) | 2004-09-17 | 2008-09-04 | Mgi Gp, Inc. | Methods of Administering Water-Soluble Prodrugs of Propofol |
| JP2008525501A (ja) | 2004-12-23 | 2008-07-17 | ゼノポート，インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
| DE102005033496A1 (de) * | 2005-07-19 | 2007-01-25 | Bayer Healthcare Ag | Desinfektionsmittel |
| JP5537033B2 (ja) * | 2005-12-19 | 2014-07-02 | ザ ユニヴァーシティー オブ リヴァプール | 無痛覚 |
| US7535698B2 (en) | 2006-03-07 | 2009-05-19 | Panasonic Corporation | Case, portable information equipment using the same and manufacturing method of the case |
| US7731356B1 (en) * | 2006-07-24 | 2010-06-08 | Daniel Ayers Gilbert | Hanging eyeglasses |
| EP2292577A1 (en) | 2007-05-09 | 2011-03-09 | Pharmacofore, Inc. | (+)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof |
| AU2008251484A1 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
-
2008
- 2008-05-08 EP EP10009233A patent/EP2292577A1/en not_active Withdrawn
- 2008-05-08 DE DE602008003431T patent/DE602008003431D1/de active Active
- 2008-05-08 KR KR1020097024780A patent/KR20100017436A/ko not_active Ceased
- 2008-05-08 PT PT08769338T patent/PT2146946E/pt unknown
- 2008-05-08 EP EP08769338A patent/EP2146946B1/en active Active
- 2008-05-08 PL PL10014318T patent/PL2301908T3/pl unknown
- 2008-05-08 ES ES10014318.9T patent/ES2501592T3/es active Active
- 2008-05-08 CA CA002685570A patent/CA2685570A1/en not_active Abandoned
- 2008-05-08 SI SI200831288T patent/SI2301908T1/sl unknown
- 2008-05-08 BR BRPI0811220-7A2A patent/BRPI0811220A2/pt not_active IP Right Cessation
- 2008-05-08 MX MX2009012124A patent/MX2009012124A/es active IP Right Grant
- 2008-05-08 NZ NZ580752A patent/NZ580752A/en not_active IP Right Cessation
- 2008-05-08 PL PL08769338T patent/PL2146946T3/pl unknown
- 2008-05-08 AU AU2008251482A patent/AU2008251482C1/en not_active Ceased
- 2008-05-08 DK DK08769338.8T patent/DK2146946T3/da active
- 2008-05-08 AT AT08769338T patent/ATE487685T1/de active
- 2008-05-08 US US12/596,800 patent/US8071818B2/en not_active Expired - Fee Related
- 2008-05-08 EP EP14173149.7A patent/EP2810927A1/en not_active Withdrawn
- 2008-05-08 CN CN2008800153921A patent/CN101715437B/zh not_active Expired - Fee Related
- 2008-05-08 WO PCT/US2008/063082 patent/WO2008141097A2/en not_active Ceased
- 2008-05-08 DK DK10014318.9T patent/DK2301908T3/da active
- 2008-05-08 RU RU2009145537/04A patent/RU2470908C2/ru not_active IP Right Cessation
- 2008-05-08 JP JP2010507665A patent/JP5651009B2/ja not_active Expired - Fee Related
- 2008-05-08 EP EP10014318.9A patent/EP2301908B8/en active Active
-
2009
- 2009-10-28 IL IL201795A patent/IL201795A0/en not_active IP Right Cessation
-
2010
- 2010-10-25 ZA ZA2010/07603A patent/ZA201007603B/en unknown
-
2011
- 2011-10-14 US US13/274,172 patent/US8242315B2/en not_active Expired - Fee Related
-
2012
- 2012-07-13 US US13/548,991 patent/US8575400B2/en not_active Expired - Fee Related
-
2013
- 2013-09-23 US US14/034,305 patent/US8871815B2/en not_active Expired - Fee Related
-
2014
- 2014-09-18 HR HRP20140896AT patent/HRP20140896T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |