HRP20140896T1 - (-)-stereoizomer 2,6-di-sec-butilfenola i njegovi analozi za poticanje antiemetskog uäśinka, lijeäśenje muäśnine i povraä†anja, te lijeäśenje migrene - Google Patents

(-)-stereoizomer 2,6-di-sec-butilfenola i njegovi analozi za poticanje antiemetskog uäśinka, lijeäśenje muäśnine i povraä†anja, te lijeäśenje migrene Download PDF

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Publication number
HRP20140896T1
HRP20140896T1 HRP20140896AT HRP20140896T HRP20140896T1 HR P20140896 T1 HRP20140896 T1 HR P20140896T1 HR P20140896A T HRP20140896A T HR P20140896AT HR P20140896 T HRP20140896 T HR P20140896T HR P20140896 T1 HRP20140896 T1 HR P20140896T1
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HR
Croatia
Prior art keywords
treatment
stereoisomer
migraine
nausea
vomiting
Prior art date
Application number
HRP20140896AT
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English (en)
Croatian (hr)
Inventor
Thomas E. Jenkins
Original Assignee
Sowood Healthcare Llc
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Publication date
Application filed by Sowood Healthcare Llc filed Critical Sowood Healthcare Llc
Publication of HRP20140896T1 publication Critical patent/HRP20140896T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRP20140896AT 2007-05-09 2014-09-18 (-)-stereoizomer 2,6-di-sec-butilfenola i njegovi analozi za poticanje antiemetskog uäśinka, lijeäśenje muäśnine i povraä†anja, te lijeäśenje migrene HRP20140896T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92832707P 2007-05-09 2007-05-09
US92829607P 2007-05-09 2007-05-09
US92842907P 2007-05-09 2007-05-09

Publications (1)

Publication Number Publication Date
HRP20140896T1 true HRP20140896T1 (hr) 2015-01-02

Family

ID=39798084

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20140896AT HRP20140896T1 (hr) 2007-05-09 2014-09-18 (-)-stereoizomer 2,6-di-sec-butilfenola i njegovi analozi za poticanje antiemetskog uäśinka, lijeäśenje muäśnine i povraä†anja, te lijeäśenje migrene

Country Status (22)

Country Link
US (4) US8071818B2 (enExample)
EP (4) EP2146946B1 (enExample)
JP (1) JP5651009B2 (enExample)
KR (1) KR20100017436A (enExample)
CN (1) CN101715437B (enExample)
AT (1) ATE487685T1 (enExample)
AU (1) AU2008251482C1 (enExample)
BR (1) BRPI0811220A2 (enExample)
CA (1) CA2685570A1 (enExample)
DE (1) DE602008003431D1 (enExample)
DK (2) DK2146946T3 (enExample)
ES (1) ES2501592T3 (enExample)
HR (1) HRP20140896T1 (enExample)
IL (1) IL201795A0 (enExample)
MX (1) MX2009012124A (enExample)
NZ (1) NZ580752A (enExample)
PL (2) PL2146946T3 (enExample)
PT (1) PT2146946E (enExample)
RU (1) RU2470908C2 (enExample)
SI (1) SI2301908T1 (enExample)
WO (1) WO2008141097A2 (enExample)
ZA (1) ZA201007603B (enExample)

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* Cited by examiner, † Cited by third party
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PL2146946T3 (pl) 2007-05-09 2011-04-29 Pharmacofore Inc (-)-Stereoizomer 2,6-di-sec-butylofenolu i jego analogi
JP5924539B2 (ja) * 2010-08-03 2016-05-25 学校法人 久留米大学 実験用小動物の脳波測定用装置及び脳波測定方法
CN102731265B (zh) * 2012-06-12 2014-12-10 四川百利药业有限责任公司 一种高纯度丙泊酚的制备方法
US11331271B2 (en) * 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
RU2635532C1 (ru) * 2016-09-06 2017-11-13 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики ажитационного синдрома у детей с онкологической патологией
CN115708819A (zh) * 2022-11-24 2023-02-24 中国科学院深圳先进技术研究院 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂

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ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
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Also Published As

Publication number Publication date
DK2146946T3 (da) 2011-02-14
US20120035271A1 (en) 2012-02-09
US8071818B2 (en) 2011-12-06
NZ580752A (en) 2012-03-30
AU2008251482C1 (en) 2014-04-03
EP2301908A1 (en) 2011-03-30
JP2010526826A (ja) 2010-08-05
WO2008141097A2 (en) 2008-11-20
EP2301908B8 (en) 2014-09-03
US8575400B2 (en) 2013-11-05
AU2008251482A1 (en) 2008-11-20
US20130059919A1 (en) 2013-03-07
EP2146946A2 (en) 2010-01-27
IL201795A0 (en) 2010-06-16
CN101715437B (zh) 2013-06-12
RU2009145537A (ru) 2011-06-20
CA2685570A1 (en) 2008-11-20
EP2146946B1 (en) 2010-11-10
AU2008251482B2 (en) 2013-09-26
PL2301908T3 (pl) 2015-02-27
BRPI0811220A2 (pt) 2014-10-29
US20140206773A1 (en) 2014-07-24
EP2810927A1 (en) 2014-12-10
EP2301908B1 (en) 2014-06-25
US8242315B2 (en) 2012-08-14
PT2146946E (pt) 2011-02-14
WO2008141097A3 (en) 2008-12-31
SI2301908T1 (sl) 2014-10-30
CN101715437A (zh) 2010-05-26
DK2301908T3 (da) 2014-09-15
ATE487685T1 (de) 2010-11-15
WO2008141097A9 (en) 2009-04-02
EP2292577A1 (en) 2011-03-09
HK1156019A1 (en) 2012-06-01
US8871815B2 (en) 2014-10-28
DE602008003431D1 (de) 2010-12-23
MX2009012124A (es) 2010-02-18
RU2470908C2 (ru) 2012-12-27
KR20100017436A (ko) 2010-02-16
ZA201007603B (en) 2012-08-29
PL2146946T3 (pl) 2011-04-29
ES2501592T3 (es) 2014-10-02
US20100292346A1 (en) 2010-11-18
HK1138829A1 (en) 2010-09-03
JP5651009B2 (ja) 2015-01-07

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