JP6867949B2 - 肝細胞癌を治療する為のｇａｂａ類似体を用いたオルニチンアミノ基転移酵素の阻害方法 - Google Patents

肝細胞癌を治療する為のｇａｂａ類似体を用いたオルニチンアミノ基転移酵素の阻害方法 Download PDF

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JP6867949B2
JP6867949B2 JP2017543338A JP2017543338A JP6867949B2 JP 6867949 B2 JP6867949 B2 JP 6867949B2 JP 2017543338 A JP2017543338 A JP 2017543338A JP 2017543338 A JP2017543338 A JP 2017543338A JP 6867949 B2 JP6867949 B2 JP 6867949B2
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pharmaceutical composition
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JP2017533964A5 (enExample
JP2017533964A (ja
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リチャード ビー． シルバーマン
リチャード ビー． シルバーマン
ヤーロン イラン
ヤーロン イラン
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Northwestern University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
JP2017543338A 2014-11-07 2015-11-09 肝細胞癌を治療する為のｇａｂａ類似体を用いたオルニチンアミノ基転移酵素の阻害方法 Active JP6867949B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462076980P 2014-11-07 2014-11-07
US62/076,980 2014-11-07
PCT/US2015/059738 WO2016073983A2 (en) 2014-11-07 2015-11-09 Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma

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JP2017533964A JP2017533964A (ja) 2017-11-16
JP2017533964A5 JP2017533964A5 (enExample) 2018-12-06
JP6867949B2 true JP6867949B2 (ja) 2021-05-12

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US (1) US9603820B2 (enExample)
EP (1) EP3215144B1 (enExample)
JP (1) JP6867949B2 (enExample)
AU (1) AU2015342801A1 (enExample)
CA (1) CA2966642C (enExample)
ES (1) ES2882126T3 (enExample)
IL (1) IL252042B (enExample)
MX (1) MX2017006022A (enExample)
WO (1) WO2016073983A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019243586A1 (en) * 2018-03-29 2020-10-15 Ovid Therapeutics Inc. Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of eye disorders
US10822301B2 (en) 2018-04-12 2020-11-03 Northwestern University 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase
JP7475055B2 (ja) 2018-05-25 2024-04-26 ノースウェスタン ユニバーシティ （ｓ）－３－アミノ－４－（ジフルオロメチレニル）シクロペンタ－１－エン－１－カルボン酸の合成法
WO2019236938A1 (en) 2018-06-07 2019-12-12 Ovid Therapeutics Inc. Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1s,3s)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and vigabatrin in the treatment of developmental disorders
US11203596B2 (en) 2019-02-25 2021-12-21 Northwestern University Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity
US11078153B2 (en) * 2019-04-03 2021-08-03 Northwestern University 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase
US11993569B2 (en) 2020-01-23 2024-05-28 Northwestern University 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases
EP4301724A4 (en) * 2021-03-03 2025-05-28 Northwestern University (S)-3-AMINO-4,4-DIHALOCYCLOPENT-1-CARBOXYLIC ACID AS SELECTIVE INACTIVATORS OF HUMAN ORNITHINE AMINOTRANSFERASE
US12150998B2 (en) * 2021-04-20 2024-11-26 Bicycletx Limited Bicyclic peptide ligands specific for P-selectin
CN118401255A (zh) * 2021-08-19 2024-07-26 N1生命股份有限公司 紫杉醇缀合化合物、包含所述化合物的药物组合物及它们的使用方法
US20250171397A1 (en) * 2022-02-27 2025-05-29 Northwestern University (3s,4r)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic acid and related compounds as selective inactivators of ornithine aminotransferase
WO2024196851A1 (en) * 2023-03-17 2024-09-26 Northwestern University Bicyclic compounds as inactivators of oat and gaba-at
US20260130878A1 (en) * 2024-11-12 2026-05-14 Ovid Therapeutics Inc. Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid in the treatment of pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794413B1 (en) * 2002-07-19 2004-09-21 Northwestern University Compounds and related methods for inhibition of γ-aminobutyric acid aminotransferase
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
IL177609A (en) 2006-08-21 2015-11-30 Yaron Ilan Use of gobacoline or its analogue to produce a drug to treat liver carcinoma

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US20160128958A1 (en) 2016-05-12
ES2882126T3 (es) 2021-12-01
EP3215144B1 (en) 2021-04-28
AU2015342801A1 (en) 2017-05-18
EP3215144A2 (en) 2017-09-13
IL252042B (en) 2020-05-31
EP3215144A4 (en) 2018-06-20
US9603820B2 (en) 2017-03-28
MX2017006022A (es) 2017-11-17
CA2966642C (en) 2023-03-28
WO2016073983A3 (en) 2016-08-11
WO2016073983A2 (en) 2016-05-12
IL252042A0 (en) 2017-06-29
CA2966642A1 (en) 2016-05-12
JP2017533964A (ja) 2017-11-16

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