CA2966642C - Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma - Google Patents
Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma Download PDFInfo
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- CA2966642C CA2966642C CA2966642A CA2966642A CA2966642C CA 2966642 C CA2966642 C CA 2966642C CA 2966642 A CA2966642 A CA 2966642A CA 2966642 A CA2966642 A CA 2966642A CA 2966642 C CA2966642 C CA 2966642C
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| PCT/US2015/059738 WO2016073983A2 (en) | 2014-11-07 | 2015-11-09 | Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma |
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| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| KR20250051780A (ko) | 2018-05-25 | 2025-04-17 | 노오쓰웨스턴 유니버시티 | (s)-3-아미노-4-(디플루오로메틸레닐)사이클로펜트-1-엔-1-카르복실산의합성을 위한 공정 |
| PL3813816T3 (pl) | 2018-06-07 | 2023-07-31 | Ovid Therapeutics Inc. | Zastosowanie kwasu (s)-3-amino-4-(difluorometylenylo)cyklopentano-1-eno-1-karboksylowego i związków pokrewnych, kwasu (1s,3s)-3-amino-4-(difluorometylideno)cyklopentano-1-karboksylowego w leczeniu zespołu łamliwego chromosomu x lub zespołu drżenia/ataksji związanego z zespołem łamliwego chromosomu x |
| US11203596B2 (en) | 2019-02-25 | 2021-12-21 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| WO2020206234A1 (en) * | 2019-04-03 | 2020-10-08 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| JP2024510422A (ja) * | 2021-03-03 | 2024-03-07 | ノースウェスタン ユニバーシティ | ヒトオルニチンアミノトランスフェラーゼの選択的不活化剤としての３－アミノ－４，４－ジハロシクロペンタ－１－エンカルボン酸 |
| EP4326743A1 (en) * | 2021-04-20 | 2024-02-28 | BicycleTX Limited | Bicyclic peptide ligands specific for p-selectin |
| CN118401255A (zh) * | 2021-08-19 | 2024-07-26 | N1生命股份有限公司 | 紫杉醇缀合化合物、包含所述化合物的药物组合物及它们的使用方法 |
| WO2024196851A1 (en) * | 2023-03-17 | 2024-09-26 | Northwestern University | Bicyclic compounds as inactivators of oat and gaba-at |
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| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| IL177609A (en) | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
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| ES2882126T3 (es) | 2021-12-01 |
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| MX2017006022A (es) | 2017-11-17 |
| WO2016073983A2 (en) | 2016-05-12 |
| JP2017533964A (ja) | 2017-11-16 |
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