CA2966642C - Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma - Google Patents
Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma Download PDFInfo
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- CA2966642C CA2966642C CA2966642A CA2966642A CA2966642C CA 2966642 C CA2966642 C CA 2966642C CA 2966642 A CA2966642 A CA 2966642A CA 2966642 A CA2966642 A CA 2966642A CA 2966642 C CA2966642 C CA 2966642C
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| PCT/US2015/059738 WO2016073983A2 (en) | 2014-11-07 | 2015-11-09 | Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma |
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| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| US10836708B2 (en) * | 2018-05-25 | 2020-11-17 | Northwestern University | Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid |
| JP7387179B2 (ja) | 2018-06-07 | 2023-11-28 | オービッド・セラピューティクス・インコーポレイテッド | 発達障害の処置における（ｓ）－３－アミノ－４－（ジフルオロメチレニル）シクロペンタ－１－エン－１－カルボン酸および関連化合物、（１ｓ，３ｓ）－３－アミノ－４－（ジフルオロメチリデン）シクロペンタン－１－カルボン酸ならびにビガバトリンの使用 |
| WO2020176511A1 (en) * | 2019-02-25 | 2020-09-03 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene) cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| WO2020206234A1 (en) * | 2019-04-03 | 2020-10-08 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| CN117321025A (zh) * | 2021-03-03 | 2023-12-29 | 西北大学 | 作为人鸟氨酸氨基转移酶的选择性灭活剂的(s)-3-氨基-4,4-二卤代环戊-1-烯甲酸 |
| JP2024515306A (ja) * | 2021-04-20 | 2024-04-08 | バイスクルテクス・リミテッド | Ｐ－セレクチンに特異的な二環式ペプチドリガンド |
| AU2022331568A1 (en) * | 2021-08-19 | 2024-03-14 | N1 Life, Inc. | Taxol conjugate compounds, pharmaceutical compositions comprising the same, and methods for their use |
| WO2024196851A1 (en) * | 2023-03-17 | 2024-09-26 | Northwestern University | Bicyclic compounds as inactivators of oat and gaba-at |
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| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| IL177609A (en) | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
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| US9603820B2 (en) | 2017-03-28 |
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| JP6867949B2 (ja) | 2021-05-12 |
| EP3215144B1 (en) | 2021-04-28 |
| JP2017533964A (ja) | 2017-11-16 |
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| EP3215144A4 (en) | 2018-06-20 |
| ES2882126T3 (es) | 2021-12-01 |
| WO2016073983A3 (en) | 2016-08-11 |
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