JP2005511725A5 - - Google Patents
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- Publication number
- JP2005511725A5 JP2005511725A5 JP2003550823A JP2003550823A JP2005511725A5 JP 2005511725 A5 JP2005511725 A5 JP 2005511725A5 JP 2003550823 A JP2003550823 A JP 2003550823A JP 2003550823 A JP2003550823 A JP 2003550823A JP 2005511725 A5 JP2005511725 A5 JP 2005511725A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chohch
- phosphate ester
- coox
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 6
- -1 phosphate ester Chemical class 0.000 claims 12
- 230000000699 topical effect Effects 0.000 claims 10
- 239000008139 complexing agent Substances 0.000 claims 8
- 229910019142 PO4 Inorganic materials 0.000 claims 5
- 150000002440 hydroxy compounds Chemical class 0.000 claims 5
- 239000010452 phosphate Substances 0.000 claims 5
- JUIUXBHZFNHITF-IEOSBIPESA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate Chemical compound OP(=O)(O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C JUIUXBHZFNHITF-IEOSBIPESA-N 0.000 claims 4
- 229940011871 estrogen Drugs 0.000 claims 4
- 239000000262 estrogen Substances 0.000 claims 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- 229930003347 Atropine Natural products 0.000 claims 3
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 229960000396 atropine Drugs 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- AFINAILKDBCXMX-PBHICJAKSA-N (2s,3r)-2-amino-3-hydroxy-n-(4-octylphenyl)butanamide Chemical compound CCCCCCCCC1=CC=C(NC(=O)[C@@H](N)[C@@H](C)O)C=C1 AFINAILKDBCXMX-PBHICJAKSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002280 amphoteric surfactant Substances 0.000 claims 2
- 239000003093 cationic surfactant Substances 0.000 claims 2
- 239000008367 deionised water Substances 0.000 claims 2
- 229910021641 deionized water Inorganic materials 0.000 claims 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- SWKDMSRRIBZZAY-UHFFFAOYSA-N n-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline;hydrochloride Chemical compound Cl.N=1CCNC=1CN(C=1C=CC=CC=1)CC1=CC=CC=C1 SWKDMSRRIBZZAY-UHFFFAOYSA-N 0.000 claims 2
- 125000004355 nitrogen functional group Chemical group 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 235000021357 Behenic acid Nutrition 0.000 claims 1
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- SZAMSYKZCSDVBH-CLFAGFIQSA-N [(z)-octadec-9-enyl] (z)-docos-13-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCCCCCCCC\C=C/CCCCCCCC SZAMSYKZCSDVBH-CLFAGFIQSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 1
- 229940116226 behenic acid Drugs 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 229940073669 ceteareth 20 Drugs 0.000 claims 1
- 229940081733 cetearyl alcohol Drugs 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940075529 glyceryl stearate Drugs 0.000 claims 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 1
- 229940120511 oleyl erucate Drugs 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR9463A AUPR946301A0 (en) | 2001-12-13 | 2001-12-13 | Transdermal therapy |
| AU2002950711A AU2002950711A0 (en) | 2002-08-09 | 2002-08-09 | Transdermal transport of compounds |
| PCT/AU2002/001686 WO2003049774A1 (en) | 2001-12-13 | 2002-12-13 | Transdermal transport of compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511725A JP2005511725A (ja) | 2005-04-28 |
| JP2005511725A5 true JP2005511725A5 (enExample) | 2010-07-22 |
| JP4624673B2 JP4624673B2 (ja) | 2011-02-02 |
Family
ID=25646859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003550823A Expired - Fee Related JP4624673B2 (ja) | 2001-12-13 | 2002-12-13 | 化合物の経皮輸送 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050089495A1 (enExample) |
| EP (1) | EP1460995B1 (enExample) |
| JP (1) | JP4624673B2 (enExample) |
| CN (1) | CN1604772A (enExample) |
| AT (1) | ATE487456T1 (enExample) |
| AU (1) | AU2002350272B1 (enExample) |
| BR (1) | BR0215102A (enExample) |
| CA (1) | CA2466536C (enExample) |
| DE (1) | DE60238276D1 (enExample) |
| MX (1) | MXPA04005361A (enExample) |
| WO (1) | WO2003049774A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
| US20040097472A1 (en) * | 2000-11-14 | 2004-05-20 | West Simon Michael | Complexes of phosphate derivatives |
| US20020141970A1 (en) * | 2001-03-05 | 2002-10-03 | Pettit Dean K. | Stable aqueous solutions of granulocyte macrophage colony-stimulating factor |
| JP4745608B2 (ja) | 2001-07-27 | 2011-08-10 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 電子伝達剤のリン酸誘導体を用いた皮膚治療 |
| ATE487456T1 (de) * | 2001-12-13 | 2010-11-15 | Vital Health Sciences Pty Ltd | Transdermaler transport von verbindungen |
| AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| MXPA05007278A (es) * | 2003-01-17 | 2005-09-30 | Vital Health Sciences Pty Ltd | Compuestos que tienen propiedades anti-proliferativas. |
| AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| AU2003901813A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Pharmaceutical derivatives |
| EP1720551B9 (en) | 2004-03-03 | 2011-09-21 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
| DE602005025883D1 (de) * | 2004-08-03 | 2011-02-24 | Vital Health Sciences Pty Ltd | Träger für die enterale verabreichung |
| JP2008531602A (ja) * | 2005-03-03 | 2008-08-14 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 抗癌特性を有する化合物 |
| WO2006133506A1 (en) | 2005-06-17 | 2006-12-21 | Vital Health Sciences Pty Ltd | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| BRPI0621081A2 (pt) * | 2005-12-23 | 2011-11-29 | Vital Health Sciences Pty Ltd | método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos |
| JP2007308403A (ja) * | 2006-05-17 | 2007-11-29 | Kenji Yoshida | 皮膚外用剤 |
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| ES2643643T3 (es) * | 2009-12-23 | 2017-11-23 | Phosphagenics Limited | Composición portadora para suministro de un compuesto biológicamente activo |
| ES2999020T3 (en) | 2010-02-05 | 2025-02-24 | Phosphagenics Ltd | Carrier comprising non-neutralised tocopheryl phosphate |
| RU2553350C2 (ru) | 2010-03-30 | 2015-06-10 | Фосфейдженикс Лимитед | Трансдермальные пластыри |
| WO2011120070A1 (en) * | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
| US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
| KR20160001419A (ko) * | 2014-06-27 | 2016-01-06 | 포항공과대학교 산학협력단 | 양이온성 분자 수송체 및 음이온성 생리활성 물질을 포함하는 피부 투과용 조성물 |
| CN114712308A (zh) | 2015-12-09 | 2022-07-08 | 磷肌酸有限公司 | 药物制剂 |
| US20190330260A1 (en) | 2016-12-21 | 2019-10-31 | Avecho Biotechnology Limited | Process |
| CN109589331B (zh) * | 2019-02-19 | 2021-02-19 | 刘晓双 | 一种抑制术后静脉血栓形成的外用药物及其用途 |
| WO2022155656A1 (en) | 2021-01-13 | 2022-07-21 | Rodan & Fields, Llc | Cosmetic compositions |
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-
2002
- 2002-12-13 AT AT02784914T patent/ATE487456T1/de not_active IP Right Cessation
- 2002-12-13 CN CNA028249674A patent/CN1604772A/zh active Pending
- 2002-12-13 DE DE60238276T patent/DE60238276D1/de not_active Expired - Lifetime
- 2002-12-13 US US10/498,684 patent/US20050089495A1/en not_active Abandoned
- 2002-12-13 EP EP02784914A patent/EP1460995B1/en not_active Expired - Lifetime
- 2002-12-13 CA CA2466536A patent/CA2466536C/en not_active Expired - Fee Related
- 2002-12-13 JP JP2003550823A patent/JP4624673B2/ja not_active Expired - Fee Related
- 2002-12-13 MX MXPA04005361A patent/MXPA04005361A/es active IP Right Grant
- 2002-12-13 WO PCT/AU2002/001686 patent/WO2003049774A1/en not_active Ceased
- 2002-12-13 BR BR0215102-2A patent/BR0215102A/pt not_active IP Right Cessation
- 2002-12-13 AU AU2002350272A patent/AU2002350272B1/en not_active Ceased
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