HU229055B1 - Kombretasztatin A-4-foszfát prodrug nitrogént tartalmazó vegyületekkel alkotott sói - Google Patents

Kombretasztatin A-4-foszfát prodrug nitrogént tartalmazó vegyületekkel alkotott sói Download PDF

Info

Publication number
HU229055B1
HU229055B1 HU0204423A HUP0204423A HU229055B1 HU 229055 B1 HU229055 B1 HU 229055B1 HU 0204423 A HU0204423 A HU 0204423A HU P0204423 A HUP0204423 A HU P0204423A HU 229055 B1 HU229055 B1 HU 229055B1
Authority
HU
Hungary
Prior art keywords
formula
compound
amino acid
acid
salt
Prior art date
Application number
HU0204423A
Other languages
English (en)
Hungarian (hu)
Inventor
John J Venit
Mandar V Dali
Manisha M Dali
Yande Huang
Charles E Dahlheim
Ravindra W Tejwani
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HUP0204423A2 publication Critical patent/HUP0204423A2/hu
Publication of HUP0204423A3 publication Critical patent/HUP0204423A3/hu
Publication of HU229055B1 publication Critical patent/HU229055B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/12—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0204423A 2000-09-14 2001-09-12 Kombretasztatin A-4-foszfát prodrug nitrogént tartalmazó vegyületekkel alkotott sói HU229055B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23256800P 2000-09-14 2000-09-14
US25192100P 2000-12-07 2000-12-07
PCT/US2001/028401 WO2002022626A1 (en) 2000-09-14 2001-09-12 Combretastatin a-4 phosphate prodrug salts with nitrogen-containing compounds

Publications (3)

Publication Number Publication Date
HUP0204423A2 HUP0204423A2 (en) 2003-05-28
HUP0204423A3 HUP0204423A3 (en) 2005-02-28
HU229055B1 true HU229055B1 (hu) 2013-07-29

Family

ID=26926130

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204423A HU229055B1 (hu) 2000-09-14 2001-09-12 Kombretasztatin A-4-foszfát prodrug nitrogént tartalmazó vegyületekkel alkotott sói

Country Status (26)

Country Link
US (2) US6670344B2 (enExample)
EP (1) EP1320534B1 (enExample)
JP (2) JP4149804B2 (enExample)
KR (1) KR100858464B1 (enExample)
CN (1) CN100338077C (enExample)
AR (1) AR030727A1 (enExample)
AT (1) ATE293630T1 (enExample)
AU (2) AU785183B2 (enExample)
BR (1) BRPI0107210B1 (enExample)
CA (1) CA2422359C (enExample)
DE (1) DE60110249T2 (enExample)
EE (1) EE200200249A (enExample)
ES (1) ES2241872T3 (enExample)
HK (1) HK1052356B (enExample)
HU (1) HU229055B1 (enExample)
IL (3) IL149601A0 (enExample)
MX (1) MXPA03002209A (enExample)
NO (1) NO329973B1 (enExample)
NZ (1) NZ524926A (enExample)
PE (1) PE20020445A1 (enExample)
PT (1) PT1320534E (enExample)
RS (1) RS50309B (enExample)
SK (1) SK287117B6 (enExample)
TW (1) TWI250163B (enExample)
UY (1) UY26935A1 (enExample)
WO (1) WO2002022626A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019944D0 (en) * 2000-08-15 2000-09-27 Angiogene Pharm Ltd Compositions with vascular damaging activity
US6670344B2 (en) * 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
US20050153939A1 (en) * 2003-09-10 2005-07-14 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
WO2002086869A1 (en) * 2001-04-19 2002-10-31 Sony Corporation Digital recording/reproducing apparatus
EP1406600A4 (en) * 2001-07-13 2007-06-06 Oxigene Inc COMPOSITIONS AND METHOD FOR THE ADMINISTRATION OF TUBULIN BINDING AGENTS FOR THE TREATMENT OF EYE DISEASES
US20040229960A1 (en) * 2001-07-13 2004-11-18 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
US20090137687A1 (en) * 2003-02-28 2009-05-28 Oxigene, Inc. Compositions and Methods With Enhanced Therapeutic Activity
CN100365000C (zh) * 2003-09-18 2008-01-30 雍智全 Combretastatin A-4磷酰胆碱类前体药物以及其合成与应用
CN100579532C (zh) 2003-12-23 2010-01-13 先灵-普劳有限公司 具有改善水溶性的氟苯尼考前药
TW200534879A (en) * 2004-03-25 2005-11-01 Bristol Myers Squibb Co Coated tablet formulation and method
US7829720B2 (en) 2004-05-04 2010-11-09 Bristol-Myers Squibb Company Process for preparing atazanavir bisulfate and novel forms
US20050256314A1 (en) * 2004-05-04 2005-11-17 Soojin Kim Process employing controlled crystallization in forming crystals of a pharmaceutical
TWI415635B (zh) 2004-05-28 2013-11-21 必治妥施貴寶公司 加衣錠片調製物及製備彼之方法
ES2551086T3 (es) 2005-06-14 2015-11-16 Baylor University Análogos de combretastatina con actividad de unión a tubulina
CN1907989B (zh) * 2005-08-02 2011-08-17 浙江天皇药业有限公司 毛兰素盐及其制备方法和包含其的药物组合物
BRPI0620040A2 (pt) * 2005-12-19 2011-10-25 Methylgene Inc inibidores de histona desacetilase para realçar a atividade de agentes antifúngicos
HUE040311T2 (hu) 2006-04-04 2019-02-28 Kg Acquisition Llc Vérlemezke aggregációt gátló szert és sav inhibitort tartalmazó orális dózisformák
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
MX2009006542A (es) 2006-12-19 2009-06-30 Methylgene Inc Inhibidores de histona desacetilasa y sus profarmacos.
US8796330B2 (en) * 2006-12-19 2014-08-05 Methylgene Inc. Inhibitors of histone deacetylase and prodrugs thereof
US20090012325A1 (en) * 2007-02-22 2009-01-08 Ajith Manage Methods for preparing phosphoric acids of combrestastatin and derivatives thereof
WO2008109076A1 (en) * 2007-03-02 2008-09-12 Oxigene, Inc. Methods for enhancing the efficacy of vascular disrupting agents
JP2010530889A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
ES2359770T3 (es) * 2007-06-22 2011-05-26 Bristol-Myers Squibb Company Composiciones en comprimidos que contienen atazanavir.
SI2170292T1 (sl) * 2007-06-22 2014-05-30 Bristol-Myers Squibb Holdings Ireland Tabletirani sestavki, ki vsebujejo atazanavir
JP2010530892A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
US20090264382A1 (en) 2007-11-21 2009-10-22 David Chaplin Methods for Treating Hematopoietic Neoplasms
CN102757338B (zh) * 2012-02-29 2015-02-25 郑州泰基鸿诺药物科技有限公司 一种非诺贝特酸氨基酸乙酯盐、制备方法及其用途
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
AU2014228822A1 (en) 2013-03-15 2015-10-01 Memorial Sloan-Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
US11419934B2 (en) 2015-08-18 2022-08-23 Oncotelic Therapeutics, Inc. Use of VDAS to enhance immunomodulating therapies against tumors
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US12552763B2 (en) 2017-02-02 2026-02-17 Bioventures, Llc Methods of protecting against neurodegeneration
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
WO2025250885A1 (en) * 2024-05-31 2025-12-04 Oncotelic, Inc. In situ tumor-infiltrating lymphocyte therapeutics for cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231112A (en) 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
DE3438386A1 (de) 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Phosphorsaeurevinylbenzylester, ihre herstellung und verwendung
GB9106177D0 (en) 1991-03-22 1991-05-08 Aston Molecules Ltd Substituted diphenylethylenes and analogues or derivatives thereof
US5561122A (en) * 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
DE19506885A1 (de) 1995-02-17 1996-08-22 Schering Ag Neue Borneolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
TW334418B (en) 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
WO1999035159A1 (en) * 1998-01-08 1999-07-15 Brigham & Women's Hospital, Inc. Lymphoma/leukemia oncogene, oncoprotein and methods of use
JP2002500227A (ja) * 1998-01-09 2002-01-08 アリゾナ ボード オブ リーゼンツ コンブレタスタチンａ−４プロドラッグとそのトランス異性体
GB9903404D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis
GB9903403D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Substituted stilbene compounds with vascular damaging activity
GB0019944D0 (en) 2000-08-15 2000-09-27 Angiogene Pharm Ltd Compositions with vascular damaging activity
US6670344B2 (en) * 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts

Also Published As

Publication number Publication date
EP1320534A1 (en) 2003-06-25
AR030727A1 (es) 2003-09-03
CA2422359A1 (en) 2002-03-21
IL149601A0 (en) 2002-11-10
NO20022270D0 (no) 2002-05-13
JP2008195740A (ja) 2008-08-28
NZ524926A (en) 2004-10-29
WO2002022626A8 (en) 2002-04-18
CN100338077C (zh) 2007-09-19
RS50309B (sr) 2009-09-08
ES2241872T3 (es) 2005-11-01
UY26935A1 (es) 2002-04-26
SK287117B6 (sk) 2009-12-07
US20040054212A1 (en) 2004-03-18
HK1052356B (zh) 2008-06-27
DE60110249T2 (de) 2006-03-02
IL176088A0 (en) 2006-10-05
AU9077101A (en) 2002-03-26
YU34802A (sh) 2005-07-19
US6670344B2 (en) 2003-12-30
JP4149804B2 (ja) 2008-09-17
TWI250163B (en) 2006-03-01
NO20022270L (no) 2002-07-01
US6855702B2 (en) 2005-02-15
ATE293630T1 (de) 2005-05-15
NO329973B1 (no) 2011-01-31
EP1320534B1 (en) 2005-04-20
DE60110249D1 (de) 2005-05-25
BR0107210A (pt) 2003-02-25
EE200200249A (et) 2003-06-16
AU785183B2 (en) 2006-10-19
US20020072507A1 (en) 2002-06-13
CN1392876A (zh) 2003-01-22
PT1320534E (pt) 2005-08-31
MXPA03002209A (es) 2004-03-02
WO2002022626A1 (en) 2002-03-21
CA2422359C (en) 2008-12-23
BRPI0107210B1 (pt) 2017-09-26
KR100858464B1 (ko) 2008-09-16
JP2004509128A (ja) 2004-03-25
PE20020445A1 (es) 2002-05-18
IL149601A (en) 2007-06-17
HUP0204423A3 (en) 2005-02-28
AU2007200218A1 (en) 2007-02-08
SK6722002A3 (en) 2002-11-06
KR20020063187A (ko) 2002-08-01
HUP0204423A2 (en) 2003-05-28
HK1052356A1 (en) 2003-09-11

Similar Documents

Publication Publication Date Title
TWI250163B (en) Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
TWI237022B (en) Novel acyl-dipeptide-like compounds bearing an accessory functional side chain spacer, a method for preparing the same and pharmaceutical compositions containing such products
HUE027549T2 (hu) Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére
ES2907708T3 (es) Compuestos heterocíclicos para obtención de imágenes y tratamiento del cáncer y métodos para su uso
JP2019508371A (ja) 薬剤の細胞内送達のための化合物および組成物
HUE025013T2 (hu) Szulfonamid-származékok
HUE035408T2 (en) Amino-substituted imidazo [1,2-a] pyridinecarboxamides and their use
CN112778155B (zh) 妥卡雷琐衍生物及其用途
US20230265070A1 (en) Novel usp7 inhibitors for treating multiple myeloma
EA028457B1 (ru) Пирролобензодиазепины
SA516370842B1 (ar) مثبطات مصنفة لمُستضد غشاء معين للبروتستاتا (psma)، استخدامها كعوامل تصوير وكعوامل صيدلانية لعلاج سرطان البروستاتا
CN109415353A (zh) 聚乙二醇化卡非佐米化合物
TW201043623A (en) Crystalline tripeptide epoxy ketone protease inhibitors
CN101573351A (zh) 2－[6－(3－氨基－哌啶－1－基)－3－甲基－2，4－二氧代－3，4－二氢－2h－嘧啶－1－基甲基]－4－氟－苄腈的琥珀酸盐的多晶型物及其使用方法
CZ100693A3 (en) Non-peptidic antagonists of bembesin
CN108026144A (zh) 18f-标记的前列腺特异性膜抗原(psma)的抑制剂以及它们作为前列腺癌的成像剂的应用
HU229317B1 (en) 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine derivatives, and enantiomers of the same az cortikotropine releasing factor (cfr) ligands
CN102099035A (zh) Iap抑制剂的免疫调节
CN116981486A (zh) 双模式放射性示踪剂和治疗剂
CN110312522A (zh) 赖氨酸特异性组蛋白脱甲基化酶-1抑制剂及其用途
TW202416974A (zh) 標靶細胞外HSP90(eHSP90)之放射性藥物及其用途
BRPI0710538A2 (pt) processo para a sìntese de um estereoisÈmero substancialmente puro, compostos, composição farmacêutica que compreende um composto, processo para a sìntese de um composto e uso do mesmo.
WO2025260849A1 (zh) 一种pd-l1小分子抑制剂及其制备方法和应用
CN115916340A (zh) 免疫调节剂
JPWO1992004028A1 (ja) 抗腫瘍効果増強剤及び抗腫瘍剤

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees