JP2004508398A5 - - Google Patents
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- JP2004508398A5 JP2004508398A5 JP2002526362A JP2002526362A JP2004508398A5 JP 2004508398 A5 JP2004508398 A5 JP 2004508398A5 JP 2002526362 A JP2002526362 A JP 2002526362A JP 2002526362 A JP2002526362 A JP 2002526362A JP 2004508398 A5 JP2004508398 A5 JP 2004508398A5
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- JP
- Japan
- Prior art keywords
- dosing
- period
- phase
- pharmaceutical composition
- last
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000000034 method Methods 0.000 description 25
- 239000008194 pharmaceutical composition Substances 0.000 description 24
- 230000003054 hormonal effect Effects 0.000 description 20
- 239000003433 contraceptive agent Substances 0.000 description 6
- 230000002254 contraceptive effect Effects 0.000 description 6
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 4
- 229940011871 estrogen Drugs 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- 229960004400 levonorgestrel Drugs 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 2
- YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 description 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 2
- 229960001616 chlormadinone acetate Drugs 0.000 description 2
- 229960000978 cyproterone acetate Drugs 0.000 description 2
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 2
- 229960004976 desogestrel Drugs 0.000 description 2
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229960002568 ethinylestradiol Drugs 0.000 description 2
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 description 2
- 229960005352 gestodene Drugs 0.000 description 2
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 2
- 229960001910 lynestrenol Drugs 0.000 description 2
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 2
- 229960001390 mestranol Drugs 0.000 description 2
- 229940053934 norethindrone Drugs 0.000 description 2
- 229960001652 norethindrone acetate Drugs 0.000 description 2
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 2
- 229960000417 norgestimate Drugs 0.000 description 2
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229960003309 dienogest Drugs 0.000 description 1
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10045380A DE10045380A1 (de) | 2000-09-14 | 2000-09-14 | Verfahren zur Kontrazeption und dessen Darreichungsform |
| PCT/EP2001/010207 WO2002022110A2 (en) | 2000-09-14 | 2001-09-05 | Contraception process and administration form for the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198547A Division JP2013006866A (ja) | 2000-09-14 | 2012-09-10 | 避妊方法及び同方法の投与形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508398A JP2004508398A (ja) | 2004-03-18 |
| JP2004508398A5 true JP2004508398A5 (enExample) | 2008-10-23 |
Family
ID=7656125
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526362A Withdrawn JP2004508398A (ja) | 2000-09-14 | 2001-09-05 | 避妊方法及び同方法の投与形態 |
| JP2012198547A Withdrawn JP2013006866A (ja) | 2000-09-14 | 2012-09-10 | 避妊方法及び同方法の投与形態 |
| JP2013166891A Pending JP2013241456A (ja) | 2000-09-14 | 2013-08-09 | 避妊方法及び同方法の投与形態 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198547A Withdrawn JP2013006866A (ja) | 2000-09-14 | 2012-09-10 | 避妊方法及び同方法の投与形態 |
| JP2013166891A Pending JP2013241456A (ja) | 2000-09-14 | 2013-08-09 | 避妊方法及び同方法の投与形態 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8076317B2 (enExample) |
| EP (2) | EP1317286B1 (enExample) |
| JP (3) | JP2004508398A (enExample) |
| KR (3) | KR20030031185A (enExample) |
| CN (1) | CN100560132C (enExample) |
| AR (1) | AR030737A1 (enExample) |
| AT (1) | ATE447972T1 (enExample) |
| AU (2) | AU2001284052B2 (enExample) |
| BG (2) | BG107625A (enExample) |
| BR (1) | BR0113902A (enExample) |
| CA (1) | CA2420292C (enExample) |
| CZ (1) | CZ2003723A3 (enExample) |
| DE (2) | DE10045380A1 (enExample) |
| EA (1) | EA006875B1 (enExample) |
| EE (1) | EE200300103A (enExample) |
| HR (1) | HRP20030294A2 (enExample) |
| HU (1) | HUP0301042A3 (enExample) |
| IL (2) | IL154521A0 (enExample) |
| ME (1) | ME00291B (enExample) |
| MX (1) | MXPA03002070A (enExample) |
| NO (1) | NO20031152L (enExample) |
| NZ (1) | NZ524448A (enExample) |
| PE (1) | PE20020425A1 (enExample) |
| PL (1) | PL361161A1 (enExample) |
| SK (1) | SK3102003A3 (enExample) |
| TW (1) | TWI297271B (enExample) |
| UA (1) | UA93650C2 (enExample) |
| UY (1) | UY26932A1 (enExample) |
| WO (1) | WO2002022110A2 (enExample) |
| YU (1) | YU19003A (enExample) |
| ZA (1) | ZA200301359B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004019743B4 (de) | 2004-04-20 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens |
| MY151322A (en) * | 2004-04-30 | 2014-05-15 | Bayer Ip Gmbh | Management of breakthrough bleeding in extended hormonal contraceptive regimens |
| AU2011226911B2 (en) * | 2004-04-30 | 2014-06-19 | Bayer Intellectual Property Gmbh | Management of breakthrough bleeding in extended hormonal contraceptive regimens |
| DE102004026671A1 (de) | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Darreichungsform zur hormonalen Kontrazeption |
| DE102004026679A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat |
| DE102004026670A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat |
| DE102004026669A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels |
| EP1655031A1 (de) | 2004-10-08 | 2006-05-10 | Schering AG | Dienogest enthaltendes Langzeit-Verfahren zur Empfängnisverhütung |
| TW200744610A (en) * | 2005-06-21 | 2007-12-16 | Organon Nv | New regimens for controlled drug delivery devices for contraception |
| TW200727920A (en) * | 2005-06-21 | 2007-08-01 | Organon Nv | New regimens for oral monophasic contraceptives |
| US8153616B2 (en) | 2005-10-17 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same |
| DE102006003509A1 (de) * | 2006-01-24 | 2007-07-26 | Grünenthal GmbH | Kontrazeptivum |
| EP1930010A1 (de) | 2006-10-20 | 2008-06-11 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido |
| GB0623813D0 (en) * | 2006-11-29 | 2007-01-10 | Stephenson Group Ltd | Foam reduction |
| DE102007011486A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Arzneimittel umfassend wenigstens ein Gestagen |
| EP2140860A1 (en) * | 2008-07-03 | 2010-01-06 | Bayer Schering Pharma Oy | An improved method of contraception |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2365103C3 (de) * | 1973-12-21 | 1980-08-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | V erwendung von Hormonen zur Kontrazeption |
| NL9301562A (nl) * | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| DE4344462C2 (de) * | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
| ATE264106T1 (de) * | 1994-11-22 | 2004-04-15 | Balance Pharmaceuticals Inc | Verfahren zur empfängnisverhütung |
| DE19525017A1 (de) * | 1995-06-28 | 1997-01-02 | Schering Ag | Pharmazeutisches Kombinatonspräparat, Kit und Methode zur hormonalen Kontrazeption |
| US5922349A (en) * | 1995-09-28 | 1999-07-13 | Schering Aktiengesellschaft | Hormone replacement therapy method and hormone dispenser |
| DE69729956T2 (de) | 1996-07-26 | 2004-12-16 | Wyeth | Orale einstufige empfängnisverhütungsmethode und kombinationspräparat das gestagen und estrogen enthält |
| US5898032A (en) * | 1997-06-23 | 1999-04-27 | Medical College Of Hampton Roads | Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy |
-
2000
- 2000-09-14 DE DE10045380A patent/DE10045380A1/de not_active Withdrawn
-
2001
- 2001-09-05 UA UA2003043067A patent/UA93650C2/ru unknown
- 2001-09-05 KR KR10-2003-7003667A patent/KR20030031185A/ko not_active Ceased
- 2001-09-05 US US10/380,405 patent/US8076317B2/en not_active Expired - Fee Related
- 2001-09-05 JP JP2002526362A patent/JP2004508398A/ja not_active Withdrawn
- 2001-09-05 EP EP01962996A patent/EP1317286B1/en not_active Expired - Lifetime
- 2001-09-05 AU AU2001284052A patent/AU2001284052B2/en not_active Ceased
- 2001-09-05 BR BR0113902-9A patent/BR0113902A/pt active Search and Examination
- 2001-09-05 PL PL36116101A patent/PL361161A1/xx not_active Application Discontinuation
- 2001-09-05 SK SK310-2003A patent/SK3102003A3/sk not_active Application Discontinuation
- 2001-09-05 KR KR1020107010166A patent/KR101240232B1/ko not_active Expired - Fee Related
- 2001-09-05 KR KR1020097005863A patent/KR20090033502A/ko not_active Withdrawn
- 2001-09-05 EA EA200300338A patent/EA006875B1/ru not_active IP Right Cessation
- 2001-09-05 CN CNB018155707A patent/CN100560132C/zh not_active Expired - Fee Related
- 2001-09-05 IL IL15452101A patent/IL154521A0/xx unknown
- 2001-09-05 HR HR20030294A patent/HRP20030294A2/hr not_active Application Discontinuation
- 2001-09-05 MX MXPA03002070A patent/MXPA03002070A/es active IP Right Grant
- 2001-09-05 AU AU8405201A patent/AU8405201A/xx active Pending
- 2001-09-05 WO PCT/EP2001/010207 patent/WO2002022110A2/en not_active Ceased
- 2001-09-05 CZ CZ2003723A patent/CZ2003723A3/cs unknown
- 2001-09-05 YU YU19003A patent/YU19003A/sh unknown
- 2001-09-05 ME MEP-2008-376A patent/ME00291B/me unknown
- 2001-09-05 CA CA2420292A patent/CA2420292C/en not_active Expired - Fee Related
- 2001-09-05 EP EP09014071A patent/EP2153849A3/en not_active Ceased
- 2001-09-05 NZ NZ524448A patent/NZ524448A/en not_active IP Right Cessation
- 2001-09-05 AT AT01962996T patent/ATE447972T1/de not_active IP Right Cessation
- 2001-09-05 EE EEP200300103A patent/EE200300103A/xx unknown
- 2001-09-05 HU HU0301042A patent/HUP0301042A3/hu unknown
- 2001-09-05 DE DE60140462T patent/DE60140462D1/de not_active Expired - Lifetime
- 2001-09-10 PE PE2001000903A patent/PE20020425A1/es not_active Application Discontinuation
- 2001-09-11 UY UY26932A patent/UY26932A1/es not_active Application Discontinuation
- 2001-09-12 TW TW090122607A patent/TWI297271B/zh not_active IP Right Cessation
- 2001-09-14 AR ARP010104361A patent/AR030737A1/es not_active Application Discontinuation
-
2003
- 2003-02-18 IL IL154521A patent/IL154521A/en not_active IP Right Cessation
- 2003-02-19 ZA ZA200301359A patent/ZA200301359B/en unknown
- 2003-03-11 BG BG107625A patent/BG107625A/bg unknown
- 2003-03-13 NO NO20031152A patent/NO20031152L/no not_active Application Discontinuation
-
2011
- 2011-11-18 BG BG10111090A patent/BG111090A/bg unknown
- 2011-12-12 US US13/316,887 patent/US8536156B2/en not_active Expired - Fee Related
-
2012
- 2012-09-10 JP JP2012198547A patent/JP2013006866A/ja not_active Withdrawn
-
2013
- 2013-08-09 JP JP2013166891A patent/JP2013241456A/ja active Pending
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