JP2004507500A5 - - Google Patents
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- Publication number
- JP2004507500A5 JP2004507500A5 JP2002522887A JP2002522887A JP2004507500A5 JP 2004507500 A5 JP2004507500 A5 JP 2004507500A5 JP 2002522887 A JP2002522887 A JP 2002522887A JP 2002522887 A JP2002522887 A JP 2002522887A JP 2004507500 A5 JP2004507500 A5 JP 2004507500A5
- Authority
- JP
- Japan
- Prior art keywords
- carbons
- inclusive
- alkyl
- aryl
- carboxyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 description 48
- 150000001875 compounds Chemical class 0.000 description 26
- 125000003118 aryl group Chemical group 0.000 description 23
- 238000000034 method Methods 0.000 description 22
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 21
- 150000001413 amino acids Chemical class 0.000 description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 208000035475 disorder Diseases 0.000 description 14
- 230000002265 prevention Effects 0.000 description 12
- 206010028980 Neoplasm Diseases 0.000 description 9
- 208000033808 peripheral neuropathy Diseases 0.000 description 9
- 230000033115 angiogenesis Effects 0.000 description 6
- 208000032839 leukemia Diseases 0.000 description 6
- 230000001575 pathological effect Effects 0.000 description 6
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 208000030507 AIDS Diseases 0.000 description 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 3
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 description 3
- 201000009273 Endometriosis Diseases 0.000 description 3
- 208000023105 Huntington disease Diseases 0.000 description 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 3
- 208000034578 Multiple myelomas Diseases 0.000 description 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 description 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 201000004681 Psoriasis Diseases 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 3
- 206010015037 epilepsy Diseases 0.000 description 3
- 201000002222 hemangioblastoma Diseases 0.000 description 3
- 208000028867 ischemia Diseases 0.000 description 3
- 208000002780 macular degeneration Diseases 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 206010028537 myelofibrosis Diseases 0.000 description 3
- 230000009826 neoplastic cell growth Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- 208000017497 prostate disease Diseases 0.000 description 3
- 208000005069 pulmonary fibrosis Diseases 0.000 description 3
- 208000037803 restenosis Diseases 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 208000029028 brain injury Diseases 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000020431 spinal cord injury Diseases 0.000 description 2
- 229910003850 O-nPr Inorganic materials 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22780300P | 2000-08-25 | 2000-08-25 | |
| US60/227,803 | 2000-08-25 | ||
| US27845501P | 2001-03-23 | 2001-03-23 | |
| US60/278,455 | 2001-03-23 | ||
| US09/935,285 US6630500B2 (en) | 2000-08-25 | 2001-08-22 | Selected fused pyrrolocarbazoles |
| US09/935,285 | 2001-08-22 | ||
| PCT/US2001/026266 WO2002017914A2 (en) | 2000-08-25 | 2001-08-23 | Fused pyrrolocarbazoles against inflammation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507500A JP2004507500A (ja) | 2004-03-11 |
| JP2004507500A5 true JP2004507500A5 (enExample) | 2008-10-09 |
| JP5399598B2 JP5399598B2 (ja) | 2014-01-29 |
Family
ID=27397767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522887A Expired - Fee Related JP5399598B2 (ja) | 2000-08-25 | 2001-08-23 | 炎症に対する縮合ピロロカルバゾール |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6630500B2 (enExample) |
| EP (1) | EP1311263B1 (enExample) |
| JP (1) | JP5399598B2 (enExample) |
| KR (1) | KR100810190B1 (enExample) |
| CN (1) | CN1298323C (enExample) |
| AR (1) | AR034143A1 (enExample) |
| AT (1) | ATE306920T1 (enExample) |
| AU (1) | AU8520501A (enExample) |
| BG (1) | BG66103B1 (enExample) |
| BR (1) | BR0113776A (enExample) |
| CA (1) | CA2420592C (enExample) |
| CZ (1) | CZ303707B6 (enExample) |
| DE (1) | DE60114215T2 (enExample) |
| DK (1) | DK1311263T3 (enExample) |
| EA (1) | EA006371B1 (enExample) |
| ES (1) | ES2250463T3 (enExample) |
| HU (1) | HU230128B1 (enExample) |
| IL (2) | IL154590A0 (enExample) |
| MX (1) | MXPA03001562A (enExample) |
| NO (1) | NO325689B1 (enExample) |
| NZ (1) | NZ524288A (enExample) |
| PL (1) | PL212956B1 (enExample) |
| SK (1) | SK287498B6 (enExample) |
| TW (1) | TWI299731B (enExample) |
| WO (1) | WO2002017914A2 (enExample) |
Families Citing this family (106)
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|---|---|---|---|---|
| US6811992B1 (en) * | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
| WO2005000194A2 (en) | 2002-10-08 | 2005-01-06 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| DK2270048T3 (en) | 2002-12-24 | 2016-01-18 | Rinat Neuroscience Corp | Anti-NGF antibodies and methods for their use |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| BRPI0407375A (pt) | 2003-02-19 | 2006-02-07 | Rinat Neuroscience Corp | Métodos para tratar dor por meio da administração de um antagonista do fator de crescimento neural e u nsaid e composições contendo os mesmos |
| TWI476206B (zh) | 2003-07-18 | 2015-03-11 | Amgen Inc | 對肝細胞生長因子具專一性之結合劑 |
| US7241779B2 (en) * | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US7169802B2 (en) * | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| EP3372614B1 (en) | 2004-04-07 | 2022-06-08 | Rinat Neuroscience Corp. | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
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| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
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-
2001
- 2001-08-22 US US09/935,285 patent/US6630500B2/en not_active Expired - Lifetime
- 2001-08-23 DK DK01964340T patent/DK1311263T3/da active
- 2001-08-23 TW TW090120678A patent/TWI299731B/zh not_active IP Right Cessation
- 2001-08-23 NZ NZ524288A patent/NZ524288A/en unknown
- 2001-08-23 MX MXPA03001562A patent/MXPA03001562A/es active IP Right Grant
- 2001-08-23 AU AU8520501A patent/AU8520501A/xx active Pending
- 2001-08-23 EP EP01964340A patent/EP1311263B1/en not_active Expired - Lifetime
- 2001-08-23 AT AT01964340T patent/ATE306920T1/de active
- 2001-08-23 ES ES01964340T patent/ES2250463T3/es not_active Expired - Lifetime
- 2001-08-23 DE DE60114215T patent/DE60114215T2/de not_active Expired - Lifetime
- 2001-08-23 EA EA200300293A patent/EA006371B1/ru not_active IP Right Cessation
- 2001-08-23 HU HU0303103A patent/HU230128B1/hu not_active IP Right Cessation
- 2001-08-23 CN CNB018146333A patent/CN1298323C/zh not_active Expired - Fee Related
- 2001-08-23 JP JP2002522887A patent/JP5399598B2/ja not_active Expired - Fee Related
- 2001-08-23 CZ CZ20030539A patent/CZ303707B6/cs not_active IP Right Cessation
- 2001-08-23 SK SK219-2003A patent/SK287498B6/sk not_active IP Right Cessation
- 2001-08-23 PL PL365683A patent/PL212956B1/pl unknown
- 2001-08-23 AR ARP010104016A patent/AR034143A1/es not_active Application Discontinuation
- 2001-08-23 WO PCT/US2001/026266 patent/WO2002017914A2/en not_active Ceased
- 2001-08-23 IL IL15459001A patent/IL154590A0/xx unknown
- 2001-08-23 BR BR0113776-0A patent/BR0113776A/pt not_active Application Discontinuation
- 2001-08-23 CA CA2420592A patent/CA2420592C/en not_active Expired - Fee Related
- 2001-08-23 KR KR1020037002676A patent/KR100810190B1/ko not_active Expired - Fee Related
-
2003
- 2003-02-24 NO NO20030845A patent/NO325689B1/no not_active IP Right Cessation
- 2003-03-21 BG BG107659A patent/BG66103B1/bg unknown
- 2003-03-26 US US10/400,136 patent/US7115613B2/en not_active Expired - Fee Related
-
2006
- 2006-02-08 US US11/350,170 patent/US7230026B2/en not_active Expired - Fee Related
-
2008
- 2008-04-27 IL IL191104A patent/IL191104A0/en unknown
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