JP2004505931A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004505931A5 JP2004505931A5 JP2002517102A JP2002517102A JP2004505931A5 JP 2004505931 A5 JP2004505931 A5 JP 2004505931A5 JP 2002517102 A JP2002517102 A JP 2002517102A JP 2002517102 A JP2002517102 A JP 2002517102A JP 2004505931 A5 JP2004505931 A5 JP 2004505931A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- weight
- component
- range
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
- 229920002125 Sokalan® Polymers 0.000 claims 8
- MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 8
- -1 diethylene glycol monoalkyl ether Chemical class 0.000 claims 8
- 239000003349 gelling agent Substances 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 150000002191 fatty alcohols Chemical class 0.000 claims 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 229920000896 Ethulose Polymers 0.000 claims 4
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 229940072056 alginate Drugs 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920003052 natural elastomer Polymers 0.000 claims 4
- 229920001194 natural rubber Polymers 0.000 claims 4
- 239000001814 pectin Substances 0.000 claims 4
- 229920001277 pectin Polymers 0.000 claims 4
- 235000010987 pectin Nutrition 0.000 claims 4
- 239000003961 penetration enhancing agent Substances 0.000 claims 4
- 239000004584 polyacrylic acid Substances 0.000 claims 4
- 229920001451 polypropylene glycol Polymers 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 150000004671 saturated fatty acids Chemical class 0.000 claims 4
- 150000005846 sugar alcohols Polymers 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical class C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 230000000949 anxiolytic effect Effects 0.000 claims 1
- 229940005530 anxiolytics Drugs 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 230000001624 sedative effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0007533 | 2000-08-03 | ||
| PCT/EP2001/009007 WO2002011768A1 (en) | 2000-08-03 | 2001-08-03 | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505931A JP2004505931A (ja) | 2004-02-26 |
| JP2004505931A5 true JP2004505931A5 (enExample) | 2005-03-17 |
Family
ID=8164048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517102A Pending JP2004505931A (ja) | 2000-08-03 | 2001-08-03 | 適切な治療水準を保証する活性化合物の経皮投与及び／又は経粘膜投与のための新規組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7214381B2 (enExample) |
| EP (4) | EP1323431B1 (enExample) |
| JP (1) | JP2004505931A (enExample) |
| KR (1) | KR100856523B1 (enExample) |
| AR (1) | AR030312A1 (enExample) |
| AT (3) | ATE356636T1 (enExample) |
| AU (2) | AU2001282064B2 (enExample) |
| CA (1) | CA2418135C (enExample) |
| DE (3) | DE60127134T2 (enExample) |
| ES (2) | ES2283425T3 (enExample) |
| NZ (1) | NZ524423A (enExample) |
| WO (1) | WO2002011768A1 (enExample) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| ATE356636T1 (de) | 2000-08-03 | 2007-04-15 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert |
| US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| SK7932003A3 (en) * | 2000-12-22 | 2003-11-04 | August Wolff Gmbh & Co Dr | Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| FR2851470B1 (fr) | 2003-02-20 | 2007-11-16 | Besins Int Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
| US7858607B2 (en) | 2003-03-14 | 2010-12-28 | Mamchur Stephen A | System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer |
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| US8883769B2 (en) * | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| ES2237298B1 (es) * | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| ITMI20031640A1 (it) * | 2003-08-08 | 2005-02-09 | Mipharm S P A | Base per gel bioadesivi. |
| US7387788B1 (en) | 2003-10-10 | 2008-06-17 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
| MXPA06003316A (es) * | 2003-10-10 | 2006-06-08 | Antares Pharma Ipl Ag | Formulacion farmaceutica transdermica para minimizar los residuos en la piel. |
| US7425340B2 (en) | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
| ES2265239B1 (es) * | 2004-09-23 | 2008-02-01 | Laboratorio Reig Jofre, S.A. | Composicion farmaceutica para administracion transdermica. |
| WO2006039659A1 (en) * | 2004-10-02 | 2006-04-13 | Sri International | Bioadhesive delivery system for transmucosal delivery of beneficial agents |
| FI20041425A0 (fi) | 2004-11-05 | 2004-11-05 | Orion Corp | Transmukosaalinen veterinäärinen koostumus |
| WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
| WO2006133349A2 (en) * | 2005-06-08 | 2006-12-14 | Alpharma, Inc. | Orally disintegrable sleep aid formulations |
| US20060292223A1 (en) * | 2005-06-16 | 2006-12-28 | Warner Chilcott Company Inc, | Gel compositions for topical administration |
| WO2006138686A1 (en) * | 2005-06-16 | 2006-12-28 | Warner Chilcott Company, Inc. | Estrogen compositions for vaginal administration |
| CN101237889A (zh) * | 2005-06-16 | 2008-08-06 | 沃纳奇尔科特公司 | 用于阴道给药的雌激素组合物 |
| GB0517840D0 (en) * | 2005-09-02 | 2005-10-12 | Henderson Morley Plc | Topical anti viral formulations |
| DE102005050431A1 (de) * | 2005-10-21 | 2007-04-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreicherung lipophiler und/oder wenig hautpermeabler Wirkstoffe |
| NZ571460A (en) | 2006-04-21 | 2010-10-29 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
| FR2900575B1 (fr) * | 2006-05-05 | 2008-10-17 | Anteis Sa | Gel biocompatible a liberation controlee, son procede de preparation et son utilisation |
| WO2008012071A2 (en) * | 2006-07-24 | 2008-01-31 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
| TW200824693A (en) | 2006-08-28 | 2008-06-16 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of clonazepam and methods of use thereof |
| WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
| ES2310968B1 (es) | 2007-06-25 | 2010-02-08 | Italfarmaco, S.A. | Uso de estriol en bajas dosis. |
| AR068408A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Pulverizacion de hormonas transdermicas |
| AR068409A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Composiciones farmaceuticas, transdermicas sin alcohol |
| CL2008003507A1 (es) * | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| US8927537B2 (en) * | 2007-12-21 | 2015-01-06 | Nuvo Research Inc. | Patches, formulations, and associated methods for transdermal delivery of alprazolam and other drugs |
| ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| CN102176818A (zh) * | 2008-08-12 | 2011-09-07 | 诺华贝制药公司 | 抗微生物凝胶制剂 |
| ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
| DE102009013469B4 (de) | 2009-03-19 | 2014-04-17 | Bubbles And Beyond Gmbh | Zubereitung zur äußerlichen Anwendung |
| GB0906868D0 (en) * | 2009-04-21 | 2009-06-03 | Rabin Bennie | Amlodipine salt compositions |
| US8470304B2 (en) | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
| US10080760B2 (en) | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
| GB0921686D0 (en) | 2009-12-11 | 2010-01-27 | Reckitt Benckiser Healthcare I | Topical formulation |
| US20130053448A1 (en) | 2010-05-12 | 2013-02-28 | Louis O'Dea | Therapeutic Regimens |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| CA2818491A1 (en) | 2010-11-18 | 2012-05-24 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
| US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2014083432A2 (en) * | 2012-11-14 | 2014-06-05 | Trimel Biopharma Srl | Female intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US20140303128A1 (en) * | 2013-03-14 | 2014-10-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| US8785426B1 (en) * | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
| CA2943611A1 (en) | 2014-03-28 | 2015-10-01 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| MX360738B (es) * | 2014-06-25 | 2018-10-31 | Univ Mexico Nac Autonoma | Parche transdérmico con quitosán y poloxámero. |
| WO2016018993A1 (en) | 2014-07-29 | 2016-02-04 | Therapeuticsmd, Inc. | Transdermal cream |
| US10149828B2 (en) | 2015-01-09 | 2018-12-11 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
| CN113750091B (zh) | 2015-04-29 | 2025-03-11 | 雷迪厄斯制药公司 | 用于治疗癌症的方法 |
| JP2018515552A (ja) | 2015-05-18 | 2018-06-14 | アジル・セラピューティクス・インコーポレイテッドＡｇｉｌｅ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 避妊用組成物ならびに有効性改善および副作用調節方法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017053594A1 (en) * | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Compositions and methods of using the same for decontamination of skin |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| MX389702B (es) | 2016-06-22 | 2025-03-20 | Ellipses Pharma Ltd | Compuestos para usarse en el tratamiento de cancer de mama que expresa el receptor de androgenos (ar+). |
| US10385008B2 (en) | 2017-01-05 | 2019-08-20 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD1901-2HCL |
| US9987207B1 (en) | 2017-06-29 | 2018-06-05 | L'oreal | Foaming warming cleanser |
| KR102845228B1 (ko) * | 2017-09-27 | 2025-08-14 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 투과를 가지는 약물학적 조성물 |
| US11523994B2 (en) | 2018-01-10 | 2022-12-13 | Celista Pharmaceuticals Llc | Testosterone transdermal spray with film |
| KR102792490B1 (ko) | 2018-07-04 | 2025-04-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| AU2019299538B2 (en) | 2018-07-05 | 2025-05-08 | Celista Pharmaceuticals Llc | Testosterone and estradiol transdermal spray |
| JP2022500362A (ja) * | 2018-08-29 | 2022-01-04 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規組成物および方法 |
| CN113348163B (zh) | 2019-02-12 | 2024-10-08 | 雷迪厄斯制药公司 | 方法和化合物 |
Family Cites Families (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990332A (en) * | 1958-04-02 | 1961-06-27 | Wallace & Tiernan Inc | Pharmaceutical preparations comprising cation exchange resin adsorption compounds and treatment therewith |
| US3143465A (en) * | 1961-06-19 | 1964-08-04 | Wallace & Tiernan Inc | Pharmaceutical preparations comprising phosphorus containing cation exchange resins having a basic drug adsorbed thereon; and treatment therewith |
| US5736577A (en) * | 1995-01-31 | 1998-04-07 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
| DE2350315C2 (de) | 1973-10-06 | 1984-01-12 | Johnson & Johnson GmbH, 4000 Düsseldorf | Pharmazeutische und kosmetische Präparate zur äußerlichen Anwendung |
| US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4316893A (en) * | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
| US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
| US4082881A (en) | 1976-12-23 | 1978-04-04 | E. R. Squibb & Sons, Inc. | Topical and other type pharmaceutical formulations containing isosorbide carrier |
| US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
| US4315925A (en) | 1980-05-30 | 1982-02-16 | University Of Kentucky Research Foundation | Method of administering natural female sex hormones |
| US4383993A (en) | 1980-05-30 | 1983-05-17 | University Of Kentucky Research Foundation | Nasal dosage forms containing natural female sex hormones |
| FR2518879A1 (fr) | 1981-12-30 | 1983-07-01 | Besins Jean | Medicament a base d'oestradiol pour le traitement de la pathologie menopausique |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| DE3333240A1 (de) | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen |
| CA1249968A (en) * | 1984-04-05 | 1989-02-14 | Kazuo Kigasawa | Ointment base |
| US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
| US4597961A (en) * | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US5783207A (en) * | 1985-05-01 | 1998-07-21 | University Of Utah Research Foundation | Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine |
| DE3522550A1 (de) * | 1985-06-24 | 1987-01-02 | Klinge Co Chem Pharm Fab | Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung |
| US5731303A (en) | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
| US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
| US4801586A (en) | 1986-04-23 | 1989-01-31 | Nelson Research & Development Co. | Penetration enhancers for transdermal delivery of systemic agents |
| CA1272922A (en) | 1986-06-03 | 1990-08-21 | Peter William Berry | Drug delivery device, its preparation and use |
| EP0249397B1 (en) * | 1986-06-13 | 1992-08-12 | The Procter & Gamble Company | Improved penetrating topical pharmaceutical compositions |
| US5041439A (en) * | 1986-06-13 | 1991-08-20 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| US4908389A (en) | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
| MY102980A (en) | 1986-10-31 | 1993-03-31 | Pfizer | Transdermal flux enhancing compositions |
| EP0267617B1 (en) | 1986-11-14 | 1992-06-24 | Theratech, Inc. | Penetration enhancement with binary system of cell envelope disordering compounds and lower alcohols |
| US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
| US4788062A (en) | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
| US4783450A (en) * | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
| US4808411A (en) * | 1987-06-05 | 1989-02-28 | Abbott Laboratories | Antibiotic-polymer compositions |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5225189A (en) * | 1988-02-18 | 1993-07-06 | The Upjohn Company | Minoxidil gel |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5004610A (en) * | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| US4942158A (en) | 1988-10-13 | 1990-07-17 | Eastman Kodak | Transdermal steroid penetrant compositions and methods utilizing isopropanol and isobutanol |
| US4883660A (en) * | 1988-10-17 | 1989-11-28 | Thames Pharmacal Co., Inc. | Gel bases for pharmaceutical compositions |
| DE69003632T2 (de) | 1989-02-28 | 1994-02-17 | Teijin Ltd | Pflaster sowie dessen herstellung. |
| US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
| US5053227A (en) * | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5059426A (en) * | 1989-03-22 | 1991-10-22 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US4956171A (en) * | 1989-07-21 | 1990-09-11 | Paco Pharmaceutical Services, Inc. | Transdermal drug delivery using a dual permeation enhancer and method of performing the same |
| DE69007886T2 (de) | 1989-07-21 | 1994-11-17 | Izhak Blank | Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung. |
| US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| JP3273430B2 (ja) | 1989-12-28 | 2002-04-08 | 日東電工株式会社 | エストロゲン含有ゲル製剤 |
| US5188825A (en) * | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5371005A (en) | 1990-04-10 | 1994-12-06 | Kyowa Hakko Kogyo Co., Ltd. | Cholesterol oxidase |
| US5602017A (en) | 1990-04-10 | 1997-02-11 | Kyowa Hakko Kogyo Co., Ltd. | Cholesterol oxidase |
| US5149719A (en) | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
| ES2084174T3 (es) * | 1990-07-20 | 1996-05-01 | Tillotts Pharma Ag | Productos y procesos para el tratamiento del conducto alimentario. |
| GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| FR2668945B1 (fr) | 1990-11-12 | 1993-02-19 | Theramex | Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus. |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| US5238933A (en) | 1991-10-28 | 1993-08-24 | Sri International | Skin permeation enhancer compositions |
| US5178879A (en) | 1992-04-17 | 1993-01-12 | Michael Adekunle | Capsaicin gel |
| US5453279A (en) * | 1992-04-21 | 1995-09-26 | Tbs Laboratories, Inc. | Enhancing transdermal absorption compositions; transdermal dosage form; and process |
| US5900250A (en) * | 1992-05-13 | 1999-05-04 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutnin |
| US5458884A (en) | 1992-09-10 | 1995-10-17 | Britton; Peter | Bioerodible device for administering active ingredients |
| FR2695826B1 (fr) | 1992-09-21 | 1995-01-06 | Theramex | Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention. |
| AU684483B2 (en) * | 1992-11-23 | 1997-12-18 | Estee Lauder Inc. | Self-tanning cosmetic compositions and methods of using the same |
| US5503844A (en) | 1993-05-18 | 1996-04-02 | Mli Acquisition Corp. Ii | Foam laminate transdermal patch |
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| JPH09505028A (ja) * | 1993-07-09 | 1997-05-20 | シグナス，インコーポレイテッド | 経皮的／経頬的にニコチン置換治療を提供する方法およびデバイス |
| JP3223404B2 (ja) | 1993-10-30 | 2001-10-29 | 日本ソシア株式会社 | 育毛・養毛剤 |
| CN1106259A (zh) * | 1994-02-05 | 1995-08-09 | 日东制药株式会社 | 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂 |
| DE4405898A1 (de) | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
| US5503843A (en) * | 1994-04-22 | 1996-04-02 | Flora Inc. | Transdermal delivery of alpha adrenoceptor blocking agents |
| US5580574A (en) * | 1994-04-28 | 1996-12-03 | Hoffmann-La Roche Inc. | Pharmaceutical composition for transdermal delivery |
| AU2345695A (en) | 1994-04-28 | 1995-11-29 | F. Hoffmann-La Roche Ag | Pharmaceutical composition for transdermal delivery |
| US5540934A (en) | 1994-06-22 | 1996-07-30 | Touitou; Elka | Compositions for applying active substances to or through the skin |
| JP3032682B2 (ja) * | 1994-07-01 | 2000-04-17 | キヤノン株式会社 | 印刷装置及びその制御方法 |
| FR2722102B1 (fr) | 1994-07-11 | 1996-08-23 | Cird Galderma | Utilisation de particules creuses deformables dans une composition cosmetique et/ou dermatologique, contenant des matieres grasses |
| US5831035A (en) | 1994-10-25 | 1998-11-03 | Curators Of The University Of Missouri | Antibody against human endometrial stromal cell glycoprotein |
| US6309843B1 (en) | 1994-10-25 | 2001-10-30 | The Curators Of The University Of Missouri | Glycoprotein for use in determining endometrial receptivity |
| US5686100A (en) | 1994-11-22 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Prophylactic and therapeutic treatment of skin sensitization and irritation |
| US5532278A (en) * | 1995-01-31 | 1996-07-02 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
| US5677346A (en) * | 1995-01-31 | 1997-10-14 | Sepracor, Inc. | Treating urinary incontinence using (S)-desethyloxybutynin |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| AT408067B (de) | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
| US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| US6124355A (en) * | 1995-05-22 | 2000-09-26 | Guittard; George V. | Oxybutynin therapy |
| US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
| ES2098193B1 (es) | 1995-07-21 | 1997-12-01 | Gomez Jesus Calderon | Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea. |
| US5897539A (en) * | 1995-09-28 | 1999-04-27 | Schering Aktiengesellschaft | Hormone replacement therapy method and hormone dispenser |
| FR2739558B1 (fr) | 1995-10-05 | 1997-11-28 | Innothera Lab Sa | Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale |
| JP4036496B2 (ja) | 1995-10-24 | 2008-01-23 | リンテック株式会社 | ゲル製剤の製造方法 |
| US5817527A (en) | 1995-11-06 | 1998-10-06 | Chiron Diagnostics Corporation | Conjugation of ligand to immobilized protein in organic solvent |
| DE19548332A1 (de) | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| EP0785212A1 (en) | 1996-01-22 | 1997-07-23 | Laboratoire Theramex | New 19-nor-pregnene derivatives |
| EP0785211A1 (en) | 1996-01-22 | 1997-07-23 | Laboratoire Theramex | New substituted 19-nor-pregnane derivatives |
| US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| US6929801B2 (en) * | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| AU2036297A (en) | 1996-03-20 | 1997-10-10 | Glaxo Group Limited | Topical formulations of aciclovir |
| GB9607955D0 (en) | 1996-04-17 | 1996-06-19 | Tillotts Pharma Ag | Hydrophobic carbomer salt compositions |
| US5814659A (en) * | 1996-04-23 | 1998-09-29 | Dtr Dermal Therapy (Barbados) Inc. | Topical analgesic composition |
| DE19619045C1 (de) * | 1996-05-02 | 1997-11-13 | Jenapharm Gmbh | Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen |
| GB9610862D0 (en) * | 1996-05-23 | 1996-07-31 | Evans Brian K | Pharmaceutical products |
| IT1283102B1 (it) * | 1996-06-06 | 1998-04-07 | Permatec Nv | Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| US6123961A (en) * | 1996-09-25 | 2000-09-26 | Bridge Pharma, Inc. | Treating urinary incontinence with (R)-desethyloxybutynin and (R)-oxybutynin |
| US5760096A (en) | 1996-10-18 | 1998-06-02 | Thornfeldt; Carl R. | Potent penetration enhancers |
| US5855920A (en) | 1996-12-13 | 1999-01-05 | Chein; Edmund Y. M. | Total hormone replacement therapy |
| US5945405A (en) * | 1997-01-17 | 1999-08-31 | Abbott Laboratories | Crystal form O of clarithromycin |
| US20010023261A1 (en) | 1997-01-27 | 2001-09-20 | Lg Chemical Limited. | Novel composition for the transdermal administration of drugs |
| IT1289973B1 (it) | 1997-02-25 | 1998-10-19 | Helsinn Healthcare Sa | Sistemi gelificati di nimesulide per uso topico |
| CZ301382B6 (cs) | 1997-03-12 | 2010-02-10 | Abbott Laboratories Chad377/Ap6D-2 | Hydrofilní binární systémy pro podávání cyklosporinu |
| US6426078B1 (en) * | 1997-03-17 | 2002-07-30 | Roche Vitamins Inc. | Oil in water microemulsion |
| US6133248A (en) * | 1997-06-13 | 2000-10-17 | Cydex, Inc. | Polar drug of prodrug compositions with extended shelf-life storage and a method of making thereof |
| US6034079A (en) * | 1997-08-11 | 2000-03-07 | University Of South Florida | Nicotine antagonists for nicotine-responsive neuropsychiatric disorders |
| GB9720470D0 (en) * | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
| US20030095926A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| US5968919A (en) | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
| IL136042A (en) | 1997-11-10 | 2005-12-18 | Cellegy Pharma Inc | Alcohol-containing composition for topical application |
| FR2776191B1 (fr) | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
| US20010038855A1 (en) * | 1998-06-05 | 2001-11-08 | Desjardin Michael A. | Dosage form for administering prescribed dose |
| DE19827732A1 (de) | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| MXPA00012844A (es) | 1998-07-07 | 2004-05-21 | Transdermal Technologies Inc | Composiciones para la liberacion transdermica rapida y sin irritacion de agentes farmaceuticamente activos y metodos para formular tales composiciones y liberar los mismos. |
| US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| US6096733A (en) | 1998-12-10 | 2000-08-01 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| DE19913732A1 (de) * | 1999-03-26 | 2000-09-28 | Lohmann Therapie Syst Lts | Nikotin-TTS mit einem Zusatz von Monoterpenketonen |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| AU781084B2 (en) * | 1999-07-28 | 2005-05-05 | Board Of Trustees Of The Leland Stanford Junior University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2798065B1 (fr) * | 1999-09-02 | 2003-09-05 | Assist Publ Hopitaux De Paris | Utilisation de la nicotine ou de ses derives dans un medicament pour le traitement des maladies neurologiques, notamment la maladie de parkinson |
| US6562368B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| US6562370B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
| US6586000B2 (en) | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| US6432446B2 (en) * | 2000-02-03 | 2002-08-13 | Bridge Pharma, Inc. | Non-arrhythmogenic metabolite of oxybutynin |
| US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
| DK1280486T3 (da) * | 2000-04-26 | 2011-02-14 | Watson Pharmaceuticals Inc | Minimering af bivirkning forbundet med oxybutinin-terapi |
| ATE356636T1 (de) | 2000-08-03 | 2007-04-15 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert |
| US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| BR0113649A (pt) | 2000-08-30 | 2004-07-20 | Unimed Pharmaceuticals Inc | Processo para aumentar a testosterona e as relacionadas concentrações de esteróide em mulheres |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040002482A1 (en) | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6545046B2 (en) * | 2000-08-30 | 2003-04-08 | Theramax Inc. | Method for enhanced delivery of oxybutynin and compositions thereof |
| US20040092494A9 (en) | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| FR2814074B1 (fr) | 2000-09-15 | 2003-03-07 | Theramex | Nouvelles compositions estro-progestatives topiques a effet systemique |
| US6596740B2 (en) * | 2000-10-24 | 2003-07-22 | Richard L. Jones | Nicotine mucosal spray |
| US6479076B2 (en) * | 2001-01-12 | 2002-11-12 | Izhak Blank | Nicotine delivery compositions |
| WO2002058634A2 (en) | 2001-01-25 | 2002-08-01 | Yale University | ESTRADIOL-16α-CARBOXYLIC ACID ESTERS AS LOCALLY ACTIVE ESTROGENS |
| EP1231158A1 (de) * | 2001-02-12 | 2002-08-14 | Hellermann Tyton GmbH | Magazinstreifen von Bandschlössern und Werkzeug für dessen Verarbeitung |
| US20030175329A1 (en) * | 2001-10-04 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
| WO2003053292A1 (en) * | 2001-12-20 | 2003-07-03 | Femmepharma, Inc. | Vaginal delivery of drugs |
| US6951846B2 (en) * | 2002-03-07 | 2005-10-04 | The United States Of America As Represented By The Secretary Of The Army | Artemisinins with improved stability and bioavailability for therapeutic drug development and application |
| US6586449B1 (en) * | 2002-05-28 | 2003-07-01 | Cambrex Charles City, Inc. | Nicotine-containing, controlled release composition and method |
| US6889875B2 (en) * | 2002-06-04 | 2005-05-10 | Cellegy Pharmaceuticals, Inc. | Taper well meter dose pump |
| DE10253216A1 (de) * | 2002-11-15 | 2004-05-27 | Cognis Deutschland Gmbh & Co. Kg | Verwendung von niedermolekularen Proteinhydrolysaten in Wasch- und Reinigungsmitteln |
| US6995265B2 (en) * | 2003-08-26 | 2006-02-07 | North Carolina State University | Synthesis of nicotine derivatives from nicotine |
| MXPA06003316A (es) * | 2003-10-10 | 2006-06-08 | Antares Pharma Ipl Ag | Formulacion farmaceutica transdermica para minimizar los residuos en la piel. |
| US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
-
2001
- 2001-08-03 AT AT03003313T patent/ATE356636T1/de not_active IP Right Cessation
- 2001-08-03 EP EP03003316A patent/EP1323431B1/en not_active Expired - Lifetime
- 2001-08-03 EP EP03003317A patent/EP1325752A3/en not_active Withdrawn
- 2001-08-03 AT AT01960619T patent/ATE355854T1/de not_active IP Right Cessation
- 2001-08-03 WO PCT/EP2001/009007 patent/WO2002011768A1/en not_active Ceased
- 2001-08-03 CA CA2418135A patent/CA2418135C/en not_active Expired - Fee Related
- 2001-08-03 ES ES01960619T patent/ES2283425T3/es not_active Expired - Lifetime
- 2001-08-03 DE DE60127134T patent/DE60127134T2/de not_active Expired - Lifetime
- 2001-08-03 NZ NZ524423A patent/NZ524423A/en not_active IP Right Cessation
- 2001-08-03 EP EP01960619A patent/EP1307232B1/en not_active Expired - Lifetime
- 2001-08-03 EP EP03003313A patent/EP1323430B1/en not_active Expired - Lifetime
- 2001-08-03 ES ES03003313T patent/ES2283665T3/es not_active Expired - Lifetime
- 2001-08-03 AR ARP010103720A patent/AR030312A1/es not_active Application Discontinuation
- 2001-08-03 KR KR1020037001526A patent/KR100856523B1/ko not_active Expired - Fee Related
- 2001-08-03 AU AU2001282064A patent/AU2001282064B2/en not_active Ceased
- 2001-08-03 US US10/343,570 patent/US7214381B2/en not_active Expired - Fee Related
- 2001-08-03 DE DE60143360T patent/DE60143360D1/de not_active Expired - Lifetime
- 2001-08-03 AU AU8206401A patent/AU8206401A/xx active Pending
- 2001-08-03 DE DE60127277T patent/DE60127277T2/de not_active Expired - Lifetime
- 2001-08-03 AT AT03003316T patent/ATE485837T1/de not_active IP Right Cessation
- 2001-08-03 JP JP2002517102A patent/JP2004505931A/ja active Pending
-
2006
- 2006-12-04 US US11/634,005 patent/US7404965B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004505931A5 (enExample) | ||
| AU725283B2 (en) | Bioadhesive pharmaceutical composition for the controlled release of active principles | |
| CA2418135A1 (en) | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels | |
| RU2004114225A (ru) | Перорально вводимые жидкие композиции, включающие гвайфенезин и блок-сополимеры полиоксиалкилена | |
| AU669856B2 (en) | Compositions and methods for the sublingual or buccal administration of therapeutic agents | |
| EP2387394B1 (en) | Transdermal administration of tamsulosin | |
| RU2004118487A (ru) | Тонкоизмельченный пленкообразующий порошок, содержащие его композиции, способы его получения и применения | |
| CA2012875A1 (en) | Skin permeation enhancer compositions | |
| US5716609A (en) | Therapeutic anti-inflammatory and analgesic composition containing nimesulide for use transdermally and a process for the manufacture thereof | |
| JPH10182450A5 (enExample) | ||
| JP2010515761A5 (enExample) | ||
| JPH07508975A (ja) | 生体接着性水性鉱油エマルション軟膏基剤，それからなる局所医薬組成物及び創傷治癒におけるその使用 | |
| JP2002516832A5 (enExample) | ||
| JP2012521351A5 (enExample) | ||
| JPS63174924A (ja) | 軟膏基剤および軟膏剤 | |
| JP2002532535A5 (enExample) | ||
| CA2186919C (en) | Therapeutic anti-inflammatory and analgesic pharmaceutical composition containing nimesulide 4-nitro, 2 phenoxyphenyl methane sulphonamide for use transdermally and a process for the manufacture thereof | |
| ATE249224T1 (de) | Oxytetracyclin enthaltendes arzneimittel mit verzögerter wirksoffabgabe | |
| CA2535123A1 (en) | Bioadhesive gel based on hydroxyethylcellulose | |
| CA2380128A1 (en) | Plasters containing 4-biphenylacetic acid | |
| JPS5750914A (en) | Betamethasone external pharmaceutical | |
| JP3503425B2 (ja) | 練歯磨組成物 | |
| TR201909422T4 (tr) | Flurbiprofen ve dekspantenolün oral topikal sulu farmasötik bileşimleri. | |
| AU610963B2 (en) | New dithranol formulation | |
| WO2002004012A1 (en) | Anhydrous pharmaceutical composition of vancomycin for topical use |