JP2004504052A5 - - Google Patents

Download PDF

Info

Publication number
JP2004504052A5
JP2004504052A5 JP2002513417A JP2002513417A JP2004504052A5 JP 2004504052 A5 JP2004504052 A5 JP 2004504052A5 JP 2002513417 A JP2002513417 A JP 2002513417A JP 2002513417 A JP2002513417 A JP 2002513417A JP 2004504052 A5 JP2004504052 A5 JP 2004504052A5
Authority
JP
Japan
Prior art keywords
culture
cell
mineral source
pulp
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002513417A
Other languages
English (en)
Other versions
JP2004504052A (ja
JP5645338B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/023053 external-priority patent/WO2002007679A2/en
Publication of JP2004504052A publication Critical patent/JP2004504052A/ja
Publication of JP2004504052A5 publication Critical patent/JP2004504052A5/ja
Application granted granted Critical
Publication of JP5645338B2 publication Critical patent/JP5645338B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Description

【特許請求の範囲】
【請求項１】 単離した成人歯髄幹細胞の培養物。
【請求項２】 幹細胞が象牙芽細胞に分化し得る請求項１記載の培養物。
【請求項３】 幹細胞がイン・ビボ（in vivo)において象牙質／歯髄構造を再生し得る請求項１記載の培養物。
【請求項４】 幹細胞が脂肪細胞分化性（adipogenic）でない請求項１記載の培養物。
【請求項５】 細胞が骨シアロタンパク質を産生しない請求項１記載の培養物。
【請求項６】 請求項１記載の培養物を鉱物供給源と接触させることにより得られた細胞であって、哺乳動物に移植することによりヒト象牙質／歯髄組織を再生するための細胞。
【請求項７】 鉱物供給源がヒドロキシアパタイト／リン酸三カルシウムである請求項６記載の細胞。
【請求項８】 請求項１記載の培養物を鉱物供給源と接触させることにより得られた細胞であって、哺乳動物に移植することによりヒト象牙質／歯髄組織を作り出すための細胞。
【請求項９】 鉱物供給源がヒドロキシアパタイト／リン酸三カルシウムである請求項８記載の細胞。
JP2002513417A 2000-07-21 2001-07-23 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞 Expired - Lifetime JP5645338B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21998900P 2000-07-21 2000-07-21
US60/219,989 2000-07-21
PCT/US2001/023053 WO2002007679A2 (en) 2000-07-21 2001-07-23 Adult human dental pulp stem cells in vitro and in vivo

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012103397A Division JP5635556B2 (ja) 2000-07-21 2012-04-27 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2014183191A Division JP5976740B2 (ja) 2000-07-21 2014-09-09 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞

Publications (3)

Publication Number Publication Date
JP2004504052A JP2004504052A (ja) 2004-02-12
JP2004504052A5 true JP2004504052A5 (ja) 2008-09-04
JP5645338B2 JP5645338B2 (ja) 2014-12-24

Family

ID=22821575

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002513417A Expired - Lifetime JP5645338B2 (ja) 2000-07-21 2001-07-23 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2012103397A Expired - Lifetime JP5635556B2 (ja) 2000-07-21 2012-04-27 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2014183191A Expired - Lifetime JP5976740B2 (ja) 2000-07-21 2014-09-09 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012103397A Expired - Lifetime JP5635556B2 (ja) 2000-07-21 2012-04-27 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞
JP2014183191A Expired - Lifetime JP5976740B2 (ja) 2000-07-21 2014-09-09 イン・ビトロおよびイン・ビボにおける成人歯髄幹細胞

Country Status (7)

Country Link
US (1) US7052907B2 (ja)
EP (1) EP1305400B1 (ja)
JP (3) JP5645338B2 (ja)
AU (2) AU2001277078B2 (ja)
CA (1) CA2416801C (ja)
ES (1) ES2423898T3 (ja)
WO (1) WO2002007679A2 (ja)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100203481A1 (en) * 1996-03-21 2010-08-12 Nova Southeastern University Method and kit for delivering endodontic regenerative treatment
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
NZ534540A (en) 2002-02-06 2005-07-29 Stiftung Caesar Described is the development of a stem cell bank for teeth or teeth derived tissues, as well as the development of membrane-like meso/endodermal matrices which can be used in regenerative medicine
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
JP4489761B2 (ja) * 2003-03-14 2010-06-23 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法
AU2003231015B2 (en) * 2003-04-19 2009-10-08 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Postnatal stem cells and uses thereof
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
BRPI0402659A (pt) * 2004-06-23 2006-01-31 Univ Fed Sao Paulo Unifesp Uso de células tronco, método de engenharia tecidual, usos de tecidos dentais e substituto biológico do dente
JP4831687B2 (ja) * 2004-07-23 2011-12-07 株式会社カネカ 間葉系幹細胞から象牙芽細胞への分化誘導方法
ITNA20040043A1 (it) * 2004-07-28 2004-10-28 Francesco Carinci Tecnica di ingegneria tissutale ottenibile mediante isolamento di una nuova sottopopolazione di cellule staminali mbp-shed ed mbp-dpsc, isolate da polpa di denti decidui e permanenti in grado di produrre in vitro tessuto osseo umano.
TW200609355A (en) * 2004-09-01 2006-03-16 Tzu Chi Buddhist General Hospital Nurr1-positive neuron stem cells, pharmaceutical composition thereof and methods for their isolation, culture and preservation
KR20160028498A (ko) 2004-09-24 2016-03-11 메소블라스트, 아이엔씨. 간엽 전구세포의 증식 및/또는 생존성 증강 방법
JP4884678B2 (ja) * 2005-02-03 2012-02-29 国立大学法人名古屋大学 ヒト歯髄細胞からの象牙質再生方法
US20070258957A1 (en) * 2006-05-04 2007-11-08 Russell Bowermaster Method for obtaining and storing multipotent stem cells
ATE419334T1 (de) * 2005-07-29 2009-01-15 Stiftung Caesar Verfahren zur isolierung von stammzellen aus ein kissenformiges gewebe der zähne
JP4781037B2 (ja) * 2005-08-01 2011-09-28 株式会社カネカ ヒト歯髄細胞の判別及び選択方法
KR100759388B1 (ko) 2005-08-02 2007-09-19 유형근 치조골 골수 유래 성체 줄기세포의 골아세포 분화 방법
CA2626206A1 (en) * 2005-10-19 2007-04-26 Osaka University Therapeutic agent for dentin-dental pulp complex regeneration
US7448871B2 (en) * 2005-12-09 2008-11-11 Krasner Paul R Apparatus and method for storing and transporting teeth
BRPI0711896A2 (pt) 2006-05-22 2012-07-17 Univ Columbia sistemas e métodos de troca sem membrana microfluida usando filtração da extração de correntes de saìda de fluido.
WO2008067488A2 (en) * 2006-11-29 2008-06-05 University Of Southern California Mesenchymal stem cell-mediated functional tooth regeneration
CN101668848B (zh) 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
EP2155860B1 (en) * 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US20100098670A1 (en) * 2007-11-21 2010-04-22 Cerapedics Inc. Autologous dental pulp stem cell-based bone graft substitute
US20110002895A1 (en) * 2007-12-05 2011-01-06 Minoru Ueda Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition
KR20100103821A (ko) * 2007-12-14 2010-09-28 노바 사우쓰이스턴 유니버시티 재생 근관치료의 전달을 위한 방법 및 키트
US8323944B2 (en) 2007-12-19 2012-12-04 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
JP2011514182A (ja) 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 流体分離装置、システム、及び方法
WO2009124213A2 (en) * 2008-04-02 2009-10-08 The Trustees Of Columbia University In The City Of New York Dental stem cell differentiation
US7771983B2 (en) 2008-12-04 2010-08-10 Novozymos, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EP2379712B1 (en) 2008-12-19 2017-02-22 Novozymes Inc. Methods for increasing hydrolysis of cellulosic material in the presence of cellobiose dehydrogenase
EP2379732A2 (en) 2008-12-19 2011-10-26 Novozymes Inc. Methods for increasing enzymatic hydrolysis of cellulosic material in the presence of a peroxidase
US8338121B2 (en) 2008-12-19 2012-12-25 Novozymes, Inc. Methods for determining cellulolytic enhancing activity of a polypeptide
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
CN102388134A (zh) 2009-01-28 2012-03-21 诺维信股份有限公司 具有β-葡糖苷酶活性的多肽和编码该多肽的多核苷酸
CN104480088A (zh) 2009-06-02 2015-04-01 诺维信股份有限公司 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
WO2011030552A1 (ja) * 2009-09-11 2011-03-17 独立行政法人国立長寿医療研究センター 非抜歯根管充填材及び非抜歯による歯組織再生方法
EP2478096B1 (en) 2009-09-17 2017-05-24 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
BR112012006982B1 (pt) 2009-09-29 2021-12-21 Novozymes, Inc. Célula hospedeira microbiana transgênica, métodos para produzir um polipeptídeo, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, para fermentar um material celulósico, construções de ácido nucleico, vetor de expressão, polipeptídeo isolado tendo atividade intensificadora celulolítica, polinucleotídeo isolado que codifica o mesmo, e, composição detergente
CN107338233A (zh) 2009-09-29 2017-11-10 诺维信股份有限公司 具有木聚糖酶活性的多肽和编码该多肽的多核苷酸
CN108165542A (zh) 2009-09-30 2018-06-15 诺维信股份有限公司 具有纤维素分解增强活性的多肽和编码该多肽的多核苷酸
KR101194821B1 (ko) 2009-10-08 2012-10-25 경북대학교 산학협력단 킬레이팅제 용해성 치아 단백질 및 이의 용도
US20120260371A1 (en) 2009-10-29 2012-10-11 Novozymes A/S Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
DK2496692T3 (en) 2009-11-06 2016-06-27 Novozymes Inc POLYPEPTIDES WITH xylanase AND POLYNUCLEOTIDES ENCODING THEM
CA2780176A1 (en) 2009-11-06 2011-05-12 Novozymes, Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
US9081008B2 (en) 2009-12-04 2015-07-14 James Sherley Detecting and counting tissue—specific stem cells and uses thereof
US8759098B2 (en) 2009-12-04 2014-06-24 Boston Biomedical Research Institute, Inc. Method for cloning pluripotent stem cells
CA2794963A1 (en) 2010-03-31 2011-10-06 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8581042B2 (en) 2010-06-30 2013-11-12 Novozymes A/S Polypeptides having beta-glucosidase activity and polynucleotides encoding same
DK2670853T3 (en) 2011-01-31 2017-08-28 Novozymes North America Inc Process for enzymatic refining of pretreated cellulosic material for sugars
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
RU2466680C1 (ru) 2011-10-03 2012-11-20 Общество С Ограниченной Ответственностью "Витацел" Способ диагностики состояния кожи пациента (варианты)
EP2633870B1 (en) * 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom
WO2013146992A1 (ja) 2012-03-29 2013-10-03 日本ケミカルリサーチ株式会社 歯髄由来の多能性幹細胞の製造方法
US9790468B2 (en) 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
SG11202012227PA (en) 2018-07-31 2021-01-28 Jcr Pharmaceuticals Co Ltd Method for producing dental pulp-derived cells
CA3146004A1 (en) * 2019-07-29 2021-02-04 Relevance Total Health Compositions and methods of using multipotent stem cells to reduce disease and enhance wellness
JPWO2021153719A1 (ja) 2020-01-30 2021-08-05
WO2023227972A1 (en) 2022-05-24 2023-11-30 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3214797A (en) * 1996-05-28 1998-01-05 Regents Of The University Of Michigan, The Engineering oral tissues
US6328765B1 (en) * 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6899915B2 (en) * 2000-11-29 2005-05-31 President And Fellows Of Harvard College Methods and compositions for culturing a biological tooth
US6767740B2 (en) * 2001-10-09 2004-07-27 Roger Anton Sramek Stem cell and dental pulp harvesting method and apparatus
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
NZ534540A (en) * 2002-02-06 2005-07-29 Stiftung Caesar Described is the development of a stem cell bank for teeth or teeth derived tissues, as well as the development of membrane-like meso/endodermal matrices which can be used in regenerative medicine
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds

Similar Documents

Publication Publication Date Title
JP2004504052A5 (ja)
CA2416801A1 (en) Adult human dental pulp stem cells in vitro and in vivo
Tatullo et al. Dental pulp stem cells and human periapical cyst mesenchymal stem cells in bone tissue regeneration: Comparison of basal and osteogenic differentiated gene expression of a newly discovered mesenchymal stem cell lineage
Hynes et al. Clinical utility of stem cells for periodontal regeneration
Zhang et al. Composite cell sheet for periodontal regeneration: crosstalk between different types of MSCs in cell sheet facilitates complex periodontal-like tissue regeneration
EP1491093A3 (en) Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
BR0214217A (pt) Aumento de função de órgão
IL210618A0 (en) Population of multipotent adult stem cells expressing telomerase and being cd45- and glycophorin a-, methods for their preparation and uses
JPWO2005103233A1 (ja) 培養歯根膜細胞シート、製造方法及びその利用方法
FR2833271B1 (fr) Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles
WO2003046161A3 (de) Verfahren zur ex vivo-expansion und -differenzierung von multipotenten stammzellen
JP2009502146A (ja) 幹細胞および歯のパッド様組織由来の幹細胞を単離するための方法
Zhao et al. Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering
WO2003018077A1 (fr) Procede de regeneration osseuse
JP2004201612A (ja) 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
CN101906401A (zh) 一种在非接触条件下培养诱导成体骨髓间充质干细胞转变为汗腺细胞的方法
EP0276836A3 (en) Implant material and method of producing the same
US20020001623A1 (en) Organism-compatible materials with combined extra-cellular matrices, extracellular-matrix preparations, and production methods
JPWO2003101503A1 (ja) 歯胚の再生方法および再生歯胚
Bao Ha et al. Study on culture of human dental pulp stem cells to apply in tissue engineering
JP2007020682A (ja) 細胞の播種方法
JP4921767B2 (ja) 細胞の分化誘導方法
RU2006116152A (ru) Способ восстановления кости альвеолярного гребня челюсти и тканей пародонта с редуцированным регенераторным потенциалом
Ramazanoglu et al. Potential use of dental stem cells for craniofacial tissue regeneration
WO2004050102A8 (en) Methods for preparing a solid-fibrin web