JP2004502409A5 - - Google Patents
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- JP2004502409A5 JP2004502409A5 JP2001580185A JP2001580185A JP2004502409A5 JP 2004502409 A5 JP2004502409 A5 JP 2004502409A5 JP 2001580185 A JP2001580185 A JP 2001580185A JP 2001580185 A JP2001580185 A JP 2001580185A JP 2004502409 A5 JP2004502409 A5 JP 2004502409A5
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- Prior art keywords
- variable region
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- amino acid
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- acid residues
- Prior art date
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- 125000000539 amino acid group Chemical group 0.000 claims 38
- 239000002773 nucleotide Substances 0.000 claims 32
- 125000003729 nucleotide group Chemical group 0.000 claims 32
- 108060003951 Immunoglobulin Proteins 0.000 claims 24
- 102000018358 immunoglobulin Human genes 0.000 claims 24
- 241000588724 Escherichia coli Species 0.000 claims 22
- 241000620209 Escherichia coli DH5[alpha] Species 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 15
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 3
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims 2
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims 2
- 102000012960 Immunoglobulin kappa-Chains Human genes 0.000 claims 2
- 108010090227 Immunoglobulin kappa-Chains Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 101100495352 Candida albicans CDR4 gene Proteins 0.000 claims 1
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20134400P | 2000-05-02 | 2000-05-02 | |
| PCT/US2001/014151 WO2001083560A1 (en) | 2000-05-02 | 2001-05-02 | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005113535A Division JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Division JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502409A JP2004502409A (ja) | 2004-01-29 |
| JP2004502409A5 true JP2004502409A5 (OSRAM) | 2007-02-01 |
| JP4156238B2 JP4156238B2 (ja) | 2008-09-24 |
Family
ID=22745456
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001580185A Expired - Lifetime JP4156238B2 (ja) | 2000-05-02 | 2001-05-02 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターについて選択的な抗体、およびそれらの使用 |
| JP2005113535A Expired - Lifetime JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Pending JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2008194948A Expired - Lifetime JP4575975B2 (ja) | 2000-05-02 | 2008-07-29 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005113535A Expired - Lifetime JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Pending JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2008194948A Expired - Lifetime JP4575975B2 (ja) | 2000-05-02 | 2008-07-29 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US7244429B2 (OSRAM) |
| EP (4) | EP2065401B1 (OSRAM) |
| JP (4) | JP4156238B2 (OSRAM) |
| KR (2) | KR100817967B1 (OSRAM) |
| CN (2) | CN100497388C (OSRAM) |
| AT (1) | ATE426615T1 (OSRAM) |
| AU (2) | AU2001259366B2 (OSRAM) |
| BG (3) | BG109275A (OSRAM) |
| BR (1) | BR0110547A (OSRAM) |
| CA (1) | CA2407965C (OSRAM) |
| CY (1) | CY1109179T1 (OSRAM) |
| CZ (2) | CZ306996B6 (OSRAM) |
| DE (1) | DE60138097D1 (OSRAM) |
| DK (1) | DK1287035T3 (OSRAM) |
| EE (1) | EE05548B1 (OSRAM) |
| ES (1) | ES2323448T3 (OSRAM) |
| HU (2) | HU229417B1 (OSRAM) |
| IL (1) | IL152605A0 (OSRAM) |
| MX (1) | MXPA02010823A (OSRAM) |
| NO (2) | NO329843B1 (OSRAM) |
| NZ (1) | NZ522881A (OSRAM) |
| PL (1) | PL211733B1 (OSRAM) |
| PT (1) | PT1287035E (OSRAM) |
| RU (1) | RU2298013C2 (OSRAM) |
| TW (1) | TWI318983B (OSRAM) |
| WO (1) | WO2001083560A1 (OSRAM) |
| ZA (1) | ZA200209230B (OSRAM) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| ATE352618T1 (de) | 1997-03-17 | 2007-02-15 | Human Genome Sciences Inc | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
| CA2369371A1 (en) * | 1999-05-04 | 2000-11-09 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| TWI318983B (en) * | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| WO2002094880A1 (fr) * | 2001-05-18 | 2002-11-28 | Kirin Beer Kabushiki Kaisha | Anticorps anti-trail-r |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
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| NZ532348A (en) | 2001-10-19 | 2006-06-30 | Vascular Biogenics Ltd | Polynucleotide constructs comprising ligand binding domains, effector domains of apoptosis signaling molecules and a promoter or enhancer and their use in gene therapy |
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| RU2313368C2 (ru) * | 2001-11-01 | 2007-12-27 | Ю Эй Би Рисерч Фаундейшн | Комбинации антител, обладающих селективностью по отношению к рецептору лиганда, индуцирующему апоптоз, ассоциированный с фактором некроза опухоли, и других терапевтических средств |
| CN1610696A (zh) * | 2001-12-20 | 2005-04-27 | 人体基因组科学有限公司 | 免疫特异性结合trail受体的抗体 |
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| DE10210427A1 (de) * | 2002-03-09 | 2003-10-09 | Hans Konrad Mueller-Hermelink | Humaner monoklonaler Antikörper |
| US7772372B2 (en) | 2002-07-04 | 2010-08-10 | Patrys Limited | Neoplasm specific antibodies and uses thereof |
| AU2008201431B2 (en) * | 2002-11-27 | 2011-11-24 | Irm, Llc | Methods and compositions for inducing Apoptosis in cancer cells |
| MXPA05005726A (es) | 2002-11-27 | 2005-08-16 | Irm Llc | Metodos y composiciones para inducir apoptosis en celulas de cancer. |
| DE10311248A1 (de) | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
| EP1531162A1 (en) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
| DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
| KR20060132006A (ko) | 2004-03-23 | 2006-12-20 | 비오겐 아이덱 엠에이 아이엔씨. | 수용체 커플링제 및 이의 치료적 용도 |
| CN100427505C (zh) * | 2004-08-19 | 2008-10-22 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体(ad5-10)及其制法与用途 |
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| CN101495646A (zh) | 2005-02-02 | 2009-07-29 | Uab研究基金会 | 与降低对细胞凋亡诱导性死亡受体激动剂的抗性有关的试剂和方法 |
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| JP5004154B2 (ja) * | 2005-04-06 | 2012-08-22 | 一般財団法人化学及血清療法研究所 | 組換え抗ボツリヌス神経毒素抗体 |
| JP5372500B2 (ja) | 2005-06-17 | 2013-12-18 | トレラクス リクイデーティング トラスト | Ilt3結合分子およびその使用 |
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