JP2004501189A5 - - Google Patents
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- Publication number
- JP2004501189A5 JP2004501189A5 JP2002504991A JP2002504991A JP2004501189A5 JP 2004501189 A5 JP2004501189 A5 JP 2004501189A5 JP 2002504991 A JP2002504991 A JP 2002504991A JP 2002504991 A JP2002504991 A JP 2002504991A JP 2004501189 A5 JP2004501189 A5 JP 2004501189A5
- Authority
- JP
- Japan
- Prior art keywords
- aminomethyl
- sleep
- insomnia
- methyl
- cyclopentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 description 5
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- IUVMAUQEZFTTFB-YUMQZZPRSA-N Atagabalin Chemical compound C[C@H]1CC(CN)(CC(O)=O)C[C@@H]1C IUVMAUQEZFTTFB-YUMQZZPRSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- KKXFMWXZXDUYBF-BDAKNGLRSA-N (3s,5r)-3-(aminomethyl)-5-methyloctanoic acid Chemical compound CCC[C@@H](C)C[C@H](CN)CC(O)=O KKXFMWXZXDUYBF-BDAKNGLRSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000000147 hypnotic effect Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21417100P | 2000-06-26 | 2000-06-26 | |
| PCT/US2001/016343 WO2002000209A2 (en) | 2000-06-26 | 2001-05-18 | Gabapentin analogues for sleep disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004501189A JP2004501189A (ja) | 2004-01-15 |
| JP2004501189A5 true JP2004501189A5 (https=) | 2006-06-22 |
| JP3909842B2 JP3909842B2 (ja) | 2007-04-25 |
Family
ID=22798045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504991A Expired - Fee Related JP3909842B2 (ja) | 2000-06-26 | 2001-05-18 | 睡眠障害のためのガバペンチン類似物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7141606B2 (https=) |
| EP (1) | EP1296671B1 (https=) |
| JP (1) | JP3909842B2 (https=) |
| KR (1) | KR100785182B1 (https=) |
| CN (1) | CN1279900C (https=) |
| AT (1) | ATE390133T1 (https=) |
| AU (2) | AU6473601A (https=) |
| BR (1) | BR0111913A (https=) |
| CA (1) | CA2414008C (https=) |
| CZ (1) | CZ20024110A3 (https=) |
| DE (1) | DE60133389T2 (https=) |
| DK (1) | DK1296671T3 (https=) |
| ES (1) | ES2300332T3 (https=) |
| HU (1) | HUP0300833A3 (https=) |
| IL (2) | IL152770A0 (https=) |
| MX (1) | MXPA02010668A (https=) |
| NZ (1) | NZ522480A (https=) |
| PL (1) | PL359872A1 (https=) |
| PT (1) | PT1296671E (https=) |
| SK (1) | SK17922002A3 (https=) |
| TW (1) | TWI298020B (https=) |
| WO (1) | WO2002000209A2 (https=) |
| ZA (1) | ZA200209418B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK12822003A3 (sk) | 2001-04-19 | 2004-04-06 | Warner - Lambert Company Llc | Fúzne bicyklické alebo tricyklické aminokyseliny |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| ATE540678T1 (de) | 2001-06-11 | 2012-01-15 | Xenoport Inc | Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen |
| US7420002B2 (en) | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| WO2003099338A2 (en) | 2002-05-17 | 2003-12-04 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| WO2004052360A1 (en) | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| PL377286A1 (pl) * | 2002-12-13 | 2006-01-23 | Warner-Lambert Company Llc | Analogi gabapentyny do włókniako-mięśniakowych i innych pokrewnych zaburzeń |
| EP1622603A4 (en) * | 2003-03-25 | 2010-03-24 | Kiel Lab Inc | GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE |
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| AU2004274002B2 (en) | 2003-09-17 | 2011-04-28 | Arbor Pharmaceuticals, Llc | Treating or preventing restless legs syndrome using prodrugs of GABA analogs |
| PT1677767E (pt) | 2003-10-14 | 2011-10-13 | Xenoport Inc | Forma cristalina de análogo de ácido gama-aminobutírico |
| JP4613031B2 (ja) * | 2004-05-06 | 2011-01-12 | エスエス製薬株式会社 | 催眠剤組成物 |
| JP2005325070A (ja) * | 2004-05-14 | 2005-11-24 | Ss Pharmaceut Co Ltd | 睡眠改善剤 |
| CA2584338C (en) | 2004-11-04 | 2013-08-06 | Xenoport, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| US7837982B2 (en) | 2005-06-23 | 2010-11-23 | Emory University | Imaging agents |
| KR20070070307A (ko) * | 2005-08-24 | 2007-07-04 | 에스에스 세야쿠 가부시키 가이샤 | 수면 개선 의약 조성물 |
| CN101420947A (zh) * | 2006-03-06 | 2009-04-29 | 辉瑞产品公司 | 用于非恢复性睡眠的α-2-δ配体 |
| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| CA2706575C (en) | 2008-01-25 | 2015-07-14 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
| CN105330603A (zh) | 2008-10-08 | 2016-02-17 | 凯飞药业公司 | Gaba偶联物及其使用方法 |
| EP2509596B1 (en) | 2009-12-08 | 2019-08-28 | Case Western Reserve University | Gamma aminoacids for treating ocular disorders |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
| KR20240155382A (ko) * | 2016-05-26 | 2024-10-28 | 가부시키가이샤 아미노 압 | 수면 개선제 |
| CN112424158A (zh) | 2018-05-14 | 2021-02-26 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
| CN117776950B (zh) * | 2022-09-20 | 2025-12-23 | 中科中山药物创新研究院 | 一种γ-氨基丁酸衍生物、药物组合物和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5084479A (en) | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US5510381A (en) | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
| DE19525598C2 (de) * | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| WO1997033859A1 (en) * | 1996-03-14 | 1997-09-18 | Warner-Lambert Company | Novel bridged cyclic amino acids as pharmaceutical agents |
| US6372792B1 (en) * | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
| ATE323067T1 (de) * | 1997-10-27 | 2006-04-15 | Warner Lambert Co | Zyklische aminosäuren und deren derivate als arzneimittel |
| WO2000002546A2 (en) | 1998-07-09 | 2000-01-20 | Warner-Lambert Company | Use of caba-analogues for treating insomnia |
| PT1187832E (pt) * | 1999-06-02 | 2003-03-31 | Warner Lambert Co | Amino heterociclos uteis como agentes farmaceuticos |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| CN1607201A (zh) * | 1999-12-08 | 2005-04-20 | 沃尼尔·朗伯公司 | 立体选择性地合成环状氨基酸的方法 |
| GB9930083D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
-
2001
- 2001-05-18 IL IL15277001A patent/IL152770A0/xx unknown
- 2001-05-18 AT AT01939192T patent/ATE390133T1/de not_active IP Right Cessation
- 2001-05-18 AU AU6473601A patent/AU6473601A/xx active Pending
- 2001-05-18 DK DK01939192T patent/DK1296671T3/da active
- 2001-05-18 DE DE60133389T patent/DE60133389T2/de not_active Expired - Lifetime
- 2001-05-18 WO PCT/US2001/016343 patent/WO2002000209A2/en not_active Ceased
- 2001-05-18 PT PT01939192T patent/PT1296671E/pt unknown
- 2001-05-18 KR KR1020027017609A patent/KR100785182B1/ko not_active Expired - Fee Related
- 2001-05-18 EP EP01939192A patent/EP1296671B1/en not_active Expired - Lifetime
- 2001-05-18 JP JP2002504991A patent/JP3909842B2/ja not_active Expired - Fee Related
- 2001-05-18 SK SK1792-2002A patent/SK17922002A3/sk not_active Application Discontinuation
- 2001-05-18 US US10/297,827 patent/US7141606B2/en not_active Expired - Fee Related
- 2001-05-18 CZ CZ20024110A patent/CZ20024110A3/cs unknown
- 2001-05-18 BR BR0111913-3A patent/BR0111913A/pt not_active Application Discontinuation
- 2001-05-18 NZ NZ522480A patent/NZ522480A/en unknown
- 2001-05-18 AU AU2001264736A patent/AU2001264736B2/en not_active Ceased
- 2001-05-18 PL PL35987201A patent/PL359872A1/xx not_active Application Discontinuation
- 2001-05-18 CA CA2414008A patent/CA2414008C/en not_active Expired - Fee Related
- 2001-05-18 ES ES01939192T patent/ES2300332T3/es not_active Expired - Lifetime
- 2001-05-18 CN CNB018110487A patent/CN1279900C/zh not_active Expired - Fee Related
- 2001-05-18 MX MXPA02010668A patent/MXPA02010668A/es active IP Right Grant
- 2001-05-18 HU HU0300833A patent/HUP0300833A3/hu unknown
- 2001-06-19 TW TW090114841A patent/TWI298020B/zh not_active IP Right Cessation
-
2002
- 2002-11-11 IL IL152770A patent/IL152770A/en not_active IP Right Cessation
- 2002-11-19 ZA ZA200209418A patent/ZA200209418B/en unknown
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