JP2004043453A5 - - Google Patents
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- Publication number
- JP2004043453A5 JP2004043453A5 JP2003137413A JP2003137413A JP2004043453A5 JP 2004043453 A5 JP2004043453 A5 JP 2004043453A5 JP 2003137413 A JP2003137413 A JP 2003137413A JP 2003137413 A JP2003137413 A JP 2003137413A JP 2004043453 A5 JP2004043453 A5 JP 2004043453A5
- Authority
- JP
- Japan
- Prior art keywords
- following formula
- tetrahydrofurylcarbonyl
- piperidinylmethyl
- amino
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MMAHZLJRNLZQCI-NRFANRHFSA-N 4-amino-5-chloro-2-methoxy-n-[1-[[1-[(2s)-oxolane-2-carbonyl]piperidin-4-yl]methyl]piperidin-4-yl]benzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1CCN(CC2CCN(CC2)C(=O)[C@H]2OCCC2)CC1 MMAHZLJRNLZQCI-NRFANRHFSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- UJJLJRQIPMGXEZ-BYPYZUCNSA-N (2s)-oxolane-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCO1 UJJLJRQIPMGXEZ-BYPYZUCNSA-N 0.000 claims 1
- FZHHVJNKANNVMK-HNNXBMFYSA-N [4-[(4-aminopiperidin-1-yl)methyl]piperidin-1-yl]-[(2s)-oxolan-2-yl]methanone Chemical compound C1CC(N)CCN1CC1CCN(C(=O)[C@H]2OCCC2)CC1 FZHHVJNKANNVMK-HNNXBMFYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003137413A JP3643107B2 (ja) | 2002-05-16 | 2003-05-15 | （ｓ）−４−アミノ−５−クロロ−２−メトキシ−ｎ−［１−［１−（２−テトラヒドロフリルカルボニル）−４−ピペリジニルメチル］−４−ピペリジニル］ベンズアミド、その製造方法、それを含有する医薬組成物及び該化合物の中間体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002141262 | 2002-05-16 | ||
| JP2003137413A JP3643107B2 (ja) | 2002-05-16 | 2003-05-15 | （ｓ）−４−アミノ−５−クロロ−２−メトキシ−ｎ−［１−［１−（２−テトラヒドロフリルカルボニル）−４−ピペリジニルメチル］−４−ピペリジニル］ベンズアミド、その製造方法、それを含有する医薬組成物及び該化合物の中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004043453A JP2004043453A (ja) | 2004-02-12 |
| JP3643107B2 JP3643107B2 (ja) | 2005-04-27 |
| JP2004043453A5 true JP2004043453A5 (enExample) | 2005-06-16 |
Family
ID=29267809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003137413A Expired - Fee Related JP3643107B2 (ja) | 2002-05-16 | 2003-05-15 | （ｓ）−４−アミノ−５−クロロ−２−メトキシ−ｎ−［１−［１−（２−テトラヒドロフリルカルボニル）−４−ピペリジニルメチル］−４−ピペリジニル］ベンズアミド、その製造方法、それを含有する医薬組成物及び該化合物の中間体 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6696468B2 (enExample) |
| EP (1) | EP1362857B1 (enExample) |
| JP (1) | JP3643107B2 (enExample) |
| KR (1) | KR20040107520A (enExample) |
| CN (1) | CN1653063A (enExample) |
| AR (1) | AR040021A1 (enExample) |
| AT (1) | ATE273304T1 (enExample) |
| AU (1) | AU2003230245A1 (enExample) |
| BR (1) | BR0309933A (enExample) |
| CA (1) | CA2483368A1 (enExample) |
| CZ (1) | CZ20041084A3 (enExample) |
| DE (1) | DE60300021T2 (enExample) |
| DK (1) | DK1362857T3 (enExample) |
| ES (1) | ES2227500T3 (enExample) |
| HU (1) | HUP0501016A2 (enExample) |
| IL (1) | IL165012A0 (enExample) |
| MX (1) | MXPA04011332A (enExample) |
| NO (1) | NO20045469L (enExample) |
| PL (1) | PL372724A1 (enExample) |
| PT (1) | PT1362857E (enExample) |
| RU (1) | RU2004136853A (enExample) |
| SK (1) | SK50192004A3 (enExample) |
| TR (1) | TR200403020T2 (enExample) |
| TW (1) | TW200400186A (enExample) |
| WO (1) | WO2003097638A1 (enExample) |
| ZA (1) | ZA200409053B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904377D0 (sv) * | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| DE602005016446D1 (de) * | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| ES2327142T3 (es) * | 2004-11-05 | 2009-10-26 | Theravance, Inc. | Compuestos de quinolinona-carboxamida. |
| ES2347265T3 (es) * | 2004-12-22 | 2010-10-27 | Theravance, Inc. | Compuestos de indazol-carboxamida. |
| EP1871772B1 (en) * | 2005-03-02 | 2014-09-10 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| US7256294B2 (en) * | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
| MY147756A (en) | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| TW200722419A (en) * | 2005-05-27 | 2007-06-16 | Astrazeneca Ab | Chemical compounds |
| US20080200505A1 (en) * | 2005-05-27 | 2008-08-21 | Astrazeneca Ab | Piperidines for the Treatment of Chemokine Mediated Diseases |
| JP2009501793A (ja) | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規ピペリジン誘導体 |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| EA201491990A1 (ru) | 2012-05-03 | 2015-02-27 | Новартис Аг | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH111472A (ja) | 1996-04-30 | 1999-01-06 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びそれを含有する医薬組成物 |
| DE69922186T2 (de) * | 1998-04-28 | 2005-05-04 | Dainippon Pharmaceutical Co., Ltd. | 1-(1-subst.-4-piperidinyl)methyl]-4-piperidin-derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung |
| JP2000080081A (ja) | 1998-06-24 | 2000-03-21 | Dainippon Pharmaceut Co Ltd | １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物 |
| JP2001122784A (ja) | 1999-10-27 | 2001-05-08 | Dainippon Pharmaceut Co Ltd | １−［（１−置換−４−ピペリジニル）メチル］−４−ピペリジン誘導体からなる医薬 |
-
2002
- 2002-12-18 US US10/321,615 patent/US6696468B2/en not_active Expired - Fee Related
-
2003
- 2003-01-03 DE DE60300021T patent/DE60300021T2/de not_active Expired - Fee Related
- 2003-01-03 PT PT03250050T patent/PT1362857E/pt unknown
- 2003-01-03 ES ES03250050T patent/ES2227500T3/es not_active Expired - Lifetime
- 2003-01-03 DK DK03250050T patent/DK1362857T3/da active
- 2003-01-03 EP EP03250050A patent/EP1362857B1/en not_active Expired - Lifetime
- 2003-01-03 AT AT03250050T patent/ATE273304T1/de not_active IP Right Cessation
- 2003-05-08 TW TW092112525A patent/TW200400186A/zh unknown
- 2003-05-15 BR BR0309933-4A patent/BR0309933A/pt not_active Application Discontinuation
- 2003-05-15 CA CA002483368A patent/CA2483368A1/en not_active Abandoned
- 2003-05-15 JP JP2003137413A patent/JP3643107B2/ja not_active Expired - Fee Related
- 2003-05-15 AU AU2003230245A patent/AU2003230245A1/en not_active Abandoned
- 2003-05-15 HU HU0501016A patent/HUP0501016A2/hu unknown
- 2003-05-15 IL IL16501203A patent/IL165012A0/xx unknown
- 2003-05-15 RU RU2004136853/04A patent/RU2004136853A/ru not_active Application Discontinuation
- 2003-05-15 KR KR10-2004-7018158A patent/KR20040107520A/ko not_active Withdrawn
- 2003-05-15 MX MXPA04011332A patent/MXPA04011332A/es unknown
- 2003-05-15 AR ARP030101702A patent/AR040021A1/es unknown
- 2003-05-15 CN CNA03811089XA patent/CN1653063A/zh active Pending
- 2003-05-15 SK SK5019-2004A patent/SK50192004A3/sk unknown
- 2003-05-15 CZ CZ20041084A patent/CZ20041084A3/cs unknown
- 2003-05-15 PL PL03372724A patent/PL372724A1/xx not_active Application Discontinuation
- 2003-05-15 TR TR2004/03020T patent/TR200403020T2/xx unknown
- 2003-05-15 WO PCT/JP2003/006051 patent/WO2003097638A1/en not_active Ceased
-
2004
- 2004-11-09 ZA ZA200409035A patent/ZA200409053B/en unknown
- 2004-12-15 NO NO20045469A patent/NO20045469L/no unknown
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