JP2003528628A5 - - Google Patents
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- JP2003528628A5 JP2003528628A5 JP2001570845A JP2001570845A JP2003528628A5 JP 2003528628 A5 JP2003528628 A5 JP 2003528628A5 JP 2001570845 A JP2001570845 A JP 2001570845A JP 2001570845 A JP2001570845 A JP 2001570845A JP 2003528628 A5 JP2003528628 A5 JP 2003528628A5
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- JP
- Japan
- Prior art keywords
- sample
- gcc
- gastric
- esophageal cancer
- translation product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 description 44
- 239000000523 sample Substances 0.000 description 39
- 108090000623 proteins and genes Proteins 0.000 description 26
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 16
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 16
- 201000004101 esophageal cancer Diseases 0.000 description 16
- 238000013519 translation Methods 0.000 description 15
- 230000002496 gastric effect Effects 0.000 description 12
- 238000013518 transcription Methods 0.000 description 11
- 230000035897 transcription Effects 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 208000005718 Stomach Neoplasms Diseases 0.000 description 9
- 206010017758 gastric cancer Diseases 0.000 description 9
- 201000011549 stomach cancer Diseases 0.000 description 9
- 210000004881 tumor cell Anatomy 0.000 description 9
- 206010063916 Metastatic gastric cancer Diseases 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 238000003752 polymerase chain reaction Methods 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 108010066676 Abrin Proteins 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 206010061968 Gastric neoplasm Diseases 0.000 description 2
- 238000002944 PCR assay Methods 0.000 description 2
- 108010039491 Ricin Proteins 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000013584 assay control Substances 0.000 description 2
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- 210000002751 lymph Anatomy 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 210000003563 lymphoid tissue Anatomy 0.000 description 2
- 208000025402 neoplasm of esophagus Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 150000004057 1,4-benzoquinones Chemical class 0.000 description 1
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 235000013395 American pokeweed Nutrition 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101900238431 Clostridium perfringens Phospholipase C Proteins 0.000 description 1
- 101710172562 Cobra venom factor Proteins 0.000 description 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
- 240000007643 Phytolacca americana Species 0.000 description 1
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
- 108010084592 Saporins Proteins 0.000 description 1
- -1 biscumin Proteins 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
- 229960004630 chlorambucil Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 108700030388 macromomycin Proteins 0.000 description 1
- HXKWEZFTHHFQMB-UHFFFAOYSA-N macromomycin b Chemical compound O1C(=C)C(=O)NC2=C1C=C(OC)C=C2C(=O)OC HXKWEZFTHHFQMB-UHFFFAOYSA-N 0.000 description 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
- 229960001924 melphalan Drugs 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- OBBCSXFCDPPXOL-UHFFFAOYSA-N misonidazole Chemical compound COCC(O)CN1C=CN=C1[N+]([O-])=O OBBCSXFCDPPXOL-UHFFFAOYSA-N 0.000 description 1
- 229950010514 misonidazole Drugs 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 108010010621 modeccin Proteins 0.000 description 1
- 108700028325 pokeweed antiviral Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108010026134 purothionin Proteins 0.000 description 1
- PXSOHRWMIRDKMP-UHFFFAOYSA-N triaziquone Chemical compound O=C1C(N2CC2)=C(N2CC2)C(=O)C=C1N1CC1 PXSOHRWMIRDKMP-UHFFFAOYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 108010043904 volkensin Proteins 0.000 description 1
- KQNNSYZQMSOOQH-GLDAUDTLSA-N volkensin Chemical compound C=1([C@@H]2C[C@@H]3O[C@@H](O)C[C@@H]4[C@]5(C)[C@H]6[C@H]([C@H]([C@@]4(C)C3=C2C)O)OC[C@]6(C)[C@H](OC(C)=O)C[C@@H]5OC(=O)C(/C)=C/C)C=COC=1 KQNNSYZQMSOOQH-GLDAUDTLSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19222900P | 2000-03-27 | 2000-03-27 | |
| US60/192,229 | 2000-03-27 | ||
| PCT/US2001/009790 WO2001073132A1 (en) | 2000-03-27 | 2001-03-27 | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003528628A JP2003528628A (ja) | 2003-09-30 |
| JP2003528628A5 true JP2003528628A5 (enExample) | 2008-05-22 |
Family
ID=22708782
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570846A Expired - Fee Related JP5122713B2 (ja) | 2000-03-27 | 2001-03-27 | 癌細胞を同定およびターゲティングするための組成物および方法 |
| JP2001570845A Ceased JP2003528628A (ja) | 2000-03-27 | 2001-03-27 | 消化管由来の癌細胞を同定およびターゲティングするための組成物および方法 |
| JP2001570844A Pending JP2003535580A (ja) | 2000-03-27 | 2001-03-27 | 高特異性マーカー検出 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570846A Expired - Fee Related JP5122713B2 (ja) | 2000-03-27 | 2001-03-27 | 癌細胞を同定およびターゲティングするための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570844A Pending JP2003535580A (ja) | 2000-03-27 | 2001-03-27 | 高特異性マーカー検出 |
Country Status (10)
| Country | Link |
|---|---|
| US (20) | US20010036635A1 (enExample) |
| EP (6) | EP1268854A4 (enExample) |
| JP (3) | JP5122713B2 (enExample) |
| AT (2) | ATE452989T1 (enExample) |
| AU (3) | AU2001249548A1 (enExample) |
| CA (3) | CA2404431C (enExample) |
| DE (2) | DE60142228D1 (enExample) |
| ES (2) | ES2346637T3 (enExample) |
| PT (1) | PT1272665E (enExample) |
| WO (3) | WO2001073132A1 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
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| US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
| CA2404431C (en) * | 2000-03-27 | 2011-06-07 | Thomas Jefferson University | Guanylyl cyclase c in the detection of stomach and esophageal cancers |
| US7829276B2 (en) * | 2000-09-18 | 2010-11-09 | Thomas Jefferson University | Methods of using CRCA-1 as a stomach and esophageal cancer marker |
| AU2002306768A1 (en) * | 2001-03-20 | 2002-10-03 | Ortho-Clinical Diagnostics, Inc. | Expression profiles and methods of use |
| EP2359689B1 (en) * | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| EP1578940A4 (en) * | 2002-11-13 | 2007-12-12 | Genentech Inc | METHOD AND COMPOSITIONS FOR DYSPLASED DIAGNOSIS |
| DE10259703A1 (de) * | 2002-12-19 | 2004-07-08 | Ivonex Gmbh | Trennungsverfahren |
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| CA2571642A1 (en) * | 2004-07-09 | 2006-02-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N | Identification of markers in lung and breast cancer |
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| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US8535914B2 (en) * | 2005-01-21 | 2013-09-17 | Canon Kabushiki Kaisha | Probe, probe set and information acquisition method using the same |
| US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
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-
2010
- 2010-06-28 US US12/824,897 patent/US20110250228A1/en not_active Abandoned
- 2010-08-20 US US12/860,835 patent/US20110086064A1/en not_active Abandoned
- 2010-12-06 US US12/961,373 patent/US8067007B2/en not_active Expired - Fee Related
-
2011
- 2011-10-20 US US13/277,612 patent/US8946168B2/en not_active Expired - Fee Related
-
2014
- 2014-10-22 US US14/520,962 patent/US9429576B2/en not_active Expired - Fee Related
-
2016
- 2016-08-26 US US15/249,291 patent/US20170049869A1/en not_active Abandoned
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