JP2003525081A5 - - Google Patents
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- Publication number
- JP2003525081A5 JP2003525081A5 JP2001563080A JP2001563080A JP2003525081A5 JP 2003525081 A5 JP2003525081 A5 JP 2003525081A5 JP 2001563080 A JP2001563080 A JP 2001563080A JP 2001563080 A JP2001563080 A JP 2001563080A JP 2003525081 A5 JP2003525081 A5 JP 2003525081A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- single dose
- multiparticulate
- particles
- mouthpiece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 description 47
- 229940079593 drug Drugs 0.000 description 47
- 239000002245 particle Substances 0.000 description 24
- 239000013583 drug formulation Substances 0.000 description 17
- 210000000214 mouth Anatomy 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 230000008021 deposition Effects 0.000 description 8
- 238000012377 drug delivery Methods 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000002496 gastric effect Effects 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0004701.9 | 2000-02-28 | ||
| GB0004701A GB0004701D0 (en) | 2000-02-28 | 2000-02-28 | Improvements in or relating to the delivery of powdered oral drugs |
| GB0009023.3 | 2000-04-12 | ||
| GB0009023A GB0009023D0 (en) | 2000-02-28 | 2000-04-12 | Improvements in or relating to the delivery of oral drugs |
| PCT/IB2001/000251 WO2001064182A2 (en) | 2000-02-28 | 2001-02-26 | Improvements in or relating to the delivery of oral drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003525081A JP2003525081A (ja) | 2003-08-26 |
| JP2003525081A5 true JP2003525081A5 (enExample) | 2008-05-01 |
Family
ID=26243754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001563080A Pending JP2003525081A (ja) | 2000-02-28 | 2001-02-26 | 経口薬物の送達における改良、またはそれに関する改良 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7089934B2 (enExample) |
| EP (2) | EP1261316B1 (enExample) |
| JP (1) | JP2003525081A (enExample) |
| CN (1) | CN100341483C (enExample) |
| AT (1) | ATE392885T1 (enExample) |
| AU (2) | AU2001234005B2 (enExample) |
| BR (1) | BR0108730A (enExample) |
| CA (1) | CA2401288A1 (enExample) |
| DE (1) | DE60133723T2 (enExample) |
| ES (1) | ES2305057T3 (enExample) |
| HU (1) | HUP0300491A2 (enExample) |
| MX (1) | MXPA02008403A (enExample) |
| NO (1) | NO20024072L (enExample) |
| NZ (1) | NZ521034A (enExample) |
| PL (1) | PL204106B1 (enExample) |
| WO (1) | WO2001064182A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8499966B2 (en) | 2006-01-06 | 2013-08-06 | Acelrx Pharmaceuticals, Inc. | Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms |
| US8574189B2 (en) | 2009-03-18 | 2013-11-05 | Acelrx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8905964B2 (en) | 2006-01-06 | 2014-12-09 | Acelrx Pharmaceuticals, Inc. | Drug storage and dispensing devices and systems comprising the same |
Families Citing this family (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US20070122353A1 (en) * | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| CA2447519C (en) * | 2001-05-24 | 2008-09-16 | Alexza Molecular Delivery Corporation | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US6737042B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US7498019B2 (en) | 2001-05-24 | 2009-03-03 | Alexza Pharmaceuticals, Inc. | Delivery of compounds for the treatment of headache through an inhalation route |
| US6759029B2 (en) * | 2001-05-24 | 2004-07-06 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan and zolmitriptan through an inhalation route |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| WO2003020241A2 (en) * | 2001-09-05 | 2003-03-13 | Vectura Limited | Functional powders for oral delivery |
| WO2003041693A1 (en) * | 2001-11-09 | 2003-05-22 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| WO2003057188A1 (en) | 2001-11-21 | 2003-07-17 | Alexza Molecular Delivery Corporation | Delivery of caffeine through an inhalation route |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
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| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US8288372B2 (en) | 2002-11-26 | 2012-10-16 | Alexza Pharmaceuticals, Inc. | Method for treating headache with loxapine |
| US7550133B2 (en) | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| DE10300032B3 (de) * | 2003-01-03 | 2004-05-27 | E. Braun Gmbh | Pulverinhalator |
| US20040255936A1 (en) * | 2003-04-30 | 2004-12-23 | David Urbanus | Disposable metered dose inhaler with integrated electronic counter |
| US20050079166A1 (en) | 2003-05-21 | 2005-04-14 | Alexza Molecular Delivery Corporation | Self-contained heating unit and drug-supply unit employing same |
| CA2553392A1 (en) * | 2004-01-16 | 2005-08-11 | Biodel Inc | Sublingual drug delivery device |
| US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| PL2319500T3 (pl) * | 2004-03-12 | 2013-05-31 | Biodel Inc | Szybko działające kompozycje do dostarczania leku |
| US20080248999A1 (en) * | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| CA2576961A1 (en) | 2004-08-12 | 2006-03-02 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| CN101010305B (zh) | 2004-08-20 | 2010-08-11 | 曼金德公司 | 二酮哌嗪合成的催化反应 |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| HRP20130246T1 (hr) | 2004-11-19 | 2013-04-30 | Glaxosmithkline Llc | Postupak personaliziranog izdavanja kombinacije lijekova u promjenjivoj koncentraciji iz proizvoda namijenjenih za individualiziranje terapije |
| FR2881119B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| EP1890732B1 (en) * | 2005-06-17 | 2018-03-28 | Wisconsin Alumni Research Foundation | Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy |
| KR101384456B1 (ko) | 2005-09-14 | 2014-04-10 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
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| DE102006009637A1 (de) * | 2005-10-28 | 2007-05-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion |
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| US9289583B2 (en) * | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
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| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
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-
2001
- 2001-02-26 CA CA002401288A patent/CA2401288A1/en not_active Abandoned
- 2001-02-26 AU AU2001234005A patent/AU2001234005B2/en not_active Ceased
- 2001-02-26 US US09/793,304 patent/US7089934B2/en not_active Expired - Fee Related
- 2001-02-26 EP EP01906043A patent/EP1261316B1/en not_active Expired - Lifetime
- 2001-02-26 NZ NZ521034A patent/NZ521034A/xx unknown
- 2001-02-26 PL PL365076A patent/PL204106B1/pl not_active IP Right Cessation
- 2001-02-26 JP JP2001563080A patent/JP2003525081A/ja active Pending
- 2001-02-26 ES ES01906043T patent/ES2305057T3/es not_active Expired - Lifetime
- 2001-02-26 MX MXPA02008403A patent/MXPA02008403A/es active IP Right Grant
- 2001-02-26 AU AU3400501A patent/AU3400501A/xx active Pending
- 2001-02-26 EP EP08153350A patent/EP1941868A3/en not_active Withdrawn
- 2001-02-26 DE DE60133723T patent/DE60133723T2/de not_active Expired - Fee Related
- 2001-02-26 AT AT01906043T patent/ATE392885T1/de not_active IP Right Cessation
- 2001-02-26 CN CNB018087590A patent/CN100341483C/zh not_active Expired - Fee Related
- 2001-02-26 WO PCT/IB2001/000251 patent/WO2001064182A2/en not_active Ceased
- 2001-02-26 BR BR0108730-4A patent/BR0108730A/pt not_active Application Discontinuation
- 2001-02-26 HU HU0300491A patent/HUP0300491A2/hu unknown
-
2002
- 2002-08-27 NO NO20024072A patent/NO20024072L/no not_active Application Discontinuation
-
2005
- 2005-01-06 US US11/030,259 patent/US20050158394A1/en not_active Abandoned
-
2008
- 2008-06-17 US US12/214,097 patent/US20090011031A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8499966B2 (en) | 2006-01-06 | 2013-08-06 | Acelrx Pharmaceuticals, Inc. | Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8905964B2 (en) | 2006-01-06 | 2014-12-09 | Acelrx Pharmaceuticals, Inc. | Drug storage and dispensing devices and systems comprising the same |
| US8574189B2 (en) | 2009-03-18 | 2013-11-05 | Acelrx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
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