JP2003523946A5 - - Google Patents
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- Publication number
- JP2003523946A5 JP2003523946A5 JP2001522249A JP2001522249A JP2003523946A5 JP 2003523946 A5 JP2003523946 A5 JP 2003523946A5 JP 2001522249 A JP2001522249 A JP 2001522249A JP 2001522249 A JP2001522249 A JP 2001522249A JP 2003523946 A5 JP2003523946 A5 JP 2003523946A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- hydroxy
- estradien
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 45
- 150000003839 salts Chemical class 0.000 claims 22
- -1 hydroxymethylene Chemical group 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 150000004795 grignard reagents Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 238000007259 addition reaction Methods 0.000 claims 12
- 239000007818 Grignard reagent Substances 0.000 claims 10
- 238000006460 hydrolysis reaction Methods 0.000 claims 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000000583 progesterone congener Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010000210 abortion Diseases 0.000 claims 3
- 231100000176 abortion Toxicity 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000035558 fertility Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
- XRFPEHHQCQWRSS-UHFFFAOYSA-N 4-bromo-n-cyclohexyl-n-methylaniline Chemical compound C=1C=C(Br)C=CC=1N(C)C1CCCCC1 XRFPEHHQCQWRSS-UHFFFAOYSA-N 0.000 claims 2
- FQGLYWZKVCFREG-UHFFFAOYSA-N 4-bromo-n-cyclohexylaniline Chemical compound C1=CC(Br)=CC=C1NC1CCCCC1 FQGLYWZKVCFREG-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000006170 formylation reaction Methods 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000005051 trimethylchlorosilane Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116829.1 | 1999-09-02 | ||
| CN99116829A CN1117759C (zh) | 1999-09-02 | 1999-09-02 | 甾体化合物,其制备方法和其药物组合物及其应用 |
| PCT/CN2000/000255 WO2001018026A1 (en) | 1999-09-02 | 2000-08-31 | Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006263647A Division JP2007210994A (ja) | 1999-09-02 | 2006-09-27 | ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003523946A JP2003523946A (ja) | 2003-08-12 |
| JP2003523946A5 true JP2003523946A5 (enExample) | 2005-06-09 |
| JP4002438B2 JP4002438B2 (ja) | 2007-10-31 |
Family
ID=5279500
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522249A Expired - Lifetime JP4002438B2 (ja) | 1999-09-02 | 2000-08-31 | ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用 |
| JP2006263647A Pending JP2007210994A (ja) | 1999-09-02 | 2006-09-27 | ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006263647A Pending JP2007210994A (ja) | 1999-09-02 | 2006-09-27 | ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6514956B1 (enExample) |
| EP (1) | EP1219632B1 (enExample) |
| JP (2) | JP4002438B2 (enExample) |
| CN (1) | CN1117759C (enExample) |
| AT (1) | ATE343585T1 (enExample) |
| AU (1) | AU774234B2 (enExample) |
| CA (1) | CA2382106C (enExample) |
| CY (1) | CY1105798T1 (enExample) |
| DE (1) | DE60031557T2 (enExample) |
| DK (1) | DK1219632T3 (enExample) |
| ES (1) | ES2273724T3 (enExample) |
| GB (1) | GB2358398B8 (enExample) |
| IL (2) | IL147927A0 (enExample) |
| PT (1) | PT1219632E (enExample) |
| WO (1) | WO2001018026A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6064445A (en) * | 1996-11-28 | 2000-05-16 | Samsung Electronics Co., Ltd. | Automatic picture size control method for semiwide-screen television receiver |
| CN100588393C (zh) * | 2004-12-15 | 2010-02-10 | 上海三合生物技术有限公司 | 赛米司酮类用于治疗抑郁症的用途 |
| CN1899289A (zh) | 2005-07-22 | 2007-01-24 | 上海三合生物技术有限公司 | 赛米司酮类化合物用于治疗艾滋病的用途 |
| CN102106805B (zh) * | 2009-12-29 | 2013-06-12 | 上海中西制药有限公司 | 赛米司酮固体制剂及其制备方法 |
| CN103083324B (zh) * | 2011-11-01 | 2016-03-02 | 贾力 | 干预循环肿瘤细胞粘附和浸润到外周组织的药物和新方法 |
| CN111040013A (zh) * | 2019-12-21 | 2020-04-21 | 长沙霍滋生物科技有限公司 | 一种类固醇衍生物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| DE3625315A1 (de) * | 1986-07-25 | 1988-01-28 | Schering Ag | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
| US5272140A (en) * | 1987-01-23 | 1993-12-21 | Akzo N.V. | 11-aryl steroid derivatives |
| DE3866410D1 (de) * | 1987-04-24 | 1992-01-09 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
-
1999
- 1999-09-02 CN CN99116829A patent/CN1117759C/zh not_active Expired - Lifetime
-
2000
- 2000-08-31 EP EP00956034A patent/EP1219632B1/en not_active Expired - Lifetime
- 2000-08-31 JP JP2001522249A patent/JP4002438B2/ja not_active Expired - Lifetime
- 2000-08-31 GB GB0110793A patent/GB2358398B8/en not_active Expired - Lifetime
- 2000-08-31 DE DE60031557T patent/DE60031557T2/de not_active Expired - Lifetime
- 2000-08-31 WO PCT/CN2000/000255 patent/WO2001018026A1/zh not_active Ceased
- 2000-08-31 AT AT00956034T patent/ATE343585T1/de active
- 2000-08-31 PT PT00956034T patent/PT1219632E/pt unknown
- 2000-08-31 AU AU68167/00A patent/AU774234B2/en not_active Expired
- 2000-08-31 US US09/830,935 patent/US6514956B1/en not_active Expired - Lifetime
- 2000-08-31 ES ES00956034T patent/ES2273724T3/es not_active Expired - Lifetime
- 2000-08-31 DK DK00956034T patent/DK1219632T3/da active
- 2000-08-31 CA CA002382106A patent/CA2382106C/en not_active Expired - Lifetime
- 2000-08-31 IL IL14792700A patent/IL147927A0/xx active IP Right Grant
-
2002
- 2002-01-31 IL IL147927A patent/IL147927A/en unknown
-
2006
- 2006-09-27 JP JP2006263647A patent/JP2007210994A/ja active Pending
- 2006-11-20 CY CY20061101685T patent/CY1105798T1/el unknown
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