CN1117759C - 甾体化合物,其制备方法和其药物组合物及其应用 - Google Patents

甾体化合物,其制备方法和其药物组合物及其应用 Download PDF

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Publication number
CN1117759C
CN1117759C CN99116829A CN99116829A CN1117759C CN 1117759 C CN1117759 C CN 1117759C CN 99116829 A CN99116829 A CN 99116829A CN 99116829 A CN99116829 A CN 99116829A CN 1117759 C CN1117759 C CN 1117759C
Authority
CN
China
Prior art keywords
compound
formula
pharmaceutically acceptable
phenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN99116829A
Other languages
English (en)
Chinese (zh)
Other versions
CN1287123A (zh
Inventor
陈连植
左林
王明伟
叶正宇
陈文亮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Zhongxi Pharmaceutical Co Ltd
Zhejiang Xianju Pharmaceutical Co Ltd
Shanghai Zhongxi Sunve Pharmaceutical Co Ltd
Original Assignee
SHANGHAI CHINESE AND WESTERN MEDICINE INDUSTRIAL Co Ltd
Shanghai Zhongxi Pharmaceutical Co Ltd
Zhejiang Xianju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN99116829A priority Critical patent/CN1117759C/zh
Application filed by SHANGHAI CHINESE AND WESTERN MEDICINE INDUSTRIAL Co Ltd, Shanghai Zhongxi Pharmaceutical Co Ltd, Zhejiang Xianju Pharmaceutical Co Ltd filed Critical SHANGHAI CHINESE AND WESTERN MEDICINE INDUSTRIAL Co Ltd
Priority to GB0110793A priority patent/GB2358398B8/en
Priority to US09/830,935 priority patent/US6514956B1/en
Priority to SI200030919T priority patent/SI1219632T1/sl
Priority to CA002382106A priority patent/CA2382106C/en
Priority to DE60031557T priority patent/DE60031557T2/de
Priority to JP2001522249A priority patent/JP4002438B2/ja
Priority to PT00956034T priority patent/PT1219632E/pt
Priority to IL14792700A priority patent/IL147927A0/xx
Priority to PCT/CN2000/000255 priority patent/WO2001018026A1/zh
Priority to AU68167/00A priority patent/AU774234B2/en
Priority to DK00956034T priority patent/DK1219632T3/da
Priority to ES00956034T priority patent/ES2273724T3/es
Priority to EP00956034A priority patent/EP1219632B1/en
Priority to AT00956034T priority patent/ATE343585T1/de
Publication of CN1287123A publication Critical patent/CN1287123A/zh
Priority to IL147927A priority patent/IL147927A/en
Application granted granted Critical
Publication of CN1117759C publication Critical patent/CN1117759C/zh
Priority to JP2006263647A priority patent/JP2007210994A/ja
Priority to CY20061101685T priority patent/CY1105798T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN99116829A 1999-09-02 1999-09-02 甾体化合物,其制备方法和其药物组合物及其应用 Expired - Lifetime CN1117759C (zh)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CN99116829A CN1117759C (zh) 1999-09-02 1999-09-02 甾体化合物,其制备方法和其药物组合物及其应用
DK00956034T DK1219632T3 (da) 1999-09-02 2000-08-31 Steroider, deres fremstilling, farmaceutiske præparater deraf og anvendelser af forbindelserne
SI200030919T SI1219632T1 (sl) 1999-09-02 2000-08-31 Steroidi, njihova priprava, farmacevtski sestavki, ki jih vsebujejo, in uporabe spojin
CA002382106A CA2382106C (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
DE60031557T DE60031557T2 (de) 1999-09-02 2000-08-31 Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen
JP2001522249A JP4002438B2 (ja) 1999-09-02 2000-08-31 ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用
PT00956034T PT1219632E (pt) 1999-09-02 2000-08-31 Esteróides, sua preparação, suas composições farmacológicas e uso dos composto
IL14792700A IL147927A0 (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
PCT/CN2000/000255 WO2001018026A1 (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
EP00956034A EP1219632B1 (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
GB0110793A GB2358398B8 (en) 1999-09-02 2000-08-31 Steroid compounds, a method for preparation thereof, pharmaceutical compositions containing the same and use thereof
US09/830,935 US6514956B1 (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
AU68167/00A AU774234B2 (en) 1999-09-02 2000-08-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
AT00956034T ATE343585T1 (de) 1999-09-02 2000-08-31 Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen
ES00956034T ES2273724T3 (es) 1999-09-02 2000-08-31 Esteroides, su preparacion, composiciones farmaceuticas que los contienen, y sus utilizaciones.
IL147927A IL147927A (en) 1999-09-02 2002-01-31 Steroids, their preparation, pharmaceutical compositions thereof and uses of the compounds
JP2006263647A JP2007210994A (ja) 1999-09-02 2006-09-27 ステロイド類、それらの調製、それらの薬学的組成物およびこの化合物の使用
CY20061101685T CY1105798T1 (el) 1999-09-02 2006-11-20 Στepοειδη, η παρασκευη τους, φαρμακευτικες συνθεσεις απο αυτα και χρησεις των ενωσεων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN99116829A CN1117759C (zh) 1999-09-02 1999-09-02 甾体化合物,其制备方法和其药物组合物及其应用

Publications (2)

Publication Number Publication Date
CN1287123A CN1287123A (zh) 2001-03-14
CN1117759C true CN1117759C (zh) 2003-08-13

Family

ID=5279500

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99116829A Expired - Lifetime CN1117759C (zh) 1999-09-02 1999-09-02 甾体化合物,其制备方法和其药物组合物及其应用

Country Status (15)

Country Link
US (1) US6514956B1 (enExample)
EP (1) EP1219632B1 (enExample)
JP (2) JP4002438B2 (enExample)
CN (1) CN1117759C (enExample)
AT (1) ATE343585T1 (enExample)
AU (1) AU774234B2 (enExample)
CA (1) CA2382106C (enExample)
CY (1) CY1105798T1 (enExample)
DE (1) DE60031557T2 (enExample)
DK (1) DK1219632T3 (enExample)
ES (1) ES2273724T3 (enExample)
GB (1) GB2358398B8 (enExample)
IL (2) IL147927A0 (enExample)
PT (1) PT1219632E (enExample)
WO (1) WO2001018026A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6064445A (en) * 1996-11-28 2000-05-16 Samsung Electronics Co., Ltd. Automatic picture size control method for semiwide-screen television receiver
CN100588393C (zh) * 2004-12-15 2010-02-10 上海三合生物技术有限公司 赛米司酮类用于治疗抑郁症的用途
CN1899289A (zh) 2005-07-22 2007-01-24 上海三合生物技术有限公司 赛米司酮类化合物用于治疗艾滋病的用途
CN102106805B (zh) * 2009-12-29 2013-06-12 上海中西制药有限公司 赛米司酮固体制剂及其制备方法
CN103083324B (zh) * 2011-11-01 2016-03-02 贾力 干预循环肿瘤细胞粘附和浸润到外周组织的药物和新方法
CN111040013A (zh) * 2019-12-21 2020-04-21 长沙霍滋生物科技有限公司 一种类固醇衍生物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386085A (en) * 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
CN88102416A (zh) * 1987-04-24 1988-12-14 阿克佐公司 新的11-芳基雌烷和11-芳基·孕烷衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625315A1 (de) * 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
US5272140A (en) * 1987-01-23 1993-12-21 Akzo N.V. 11-aryl steroid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386085A (en) * 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
CN88102416A (zh) * 1987-04-24 1988-12-14 阿克佐公司 新的11-芳基雌烷和11-芳基·孕烷衍生物

Also Published As

Publication number Publication date
EP1219632B1 (en) 2006-10-25
WO2001018026A1 (en) 2001-03-15
EP1219632A4 (en) 2003-01-02
ATE343585T1 (de) 2006-11-15
DK1219632T3 (da) 2006-12-04
IL147927A (en) 2006-08-01
CA2382106C (en) 2007-10-30
JP2007210994A (ja) 2007-08-23
EP1219632A1 (en) 2002-07-03
GB2358398B (en) 2004-12-15
AU6816700A (en) 2001-04-10
GB2358398A (en) 2001-07-25
DE60031557D1 (de) 2006-12-07
GB2358398B8 (en) 2005-11-11
GB0110793D0 (en) 2001-06-27
CY1105798T1 (el) 2011-02-02
JP4002438B2 (ja) 2007-10-31
JP2003523946A (ja) 2003-08-12
PT1219632E (pt) 2006-12-29
US6514956B1 (en) 2003-02-04
CA2382106A1 (en) 2001-03-15
IL147927A0 (en) 2002-08-14
DE60031557T2 (de) 2007-08-30
AU774234B2 (en) 2004-06-17
ES2273724T3 (es) 2007-05-16
CN1287123A (zh) 2001-03-14

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
PP01 Preservation of patent right

Effective date of registration: 20030822

Pledge (preservation): Preservation

PD01 Discharge of preservation of patent

Effective date of registration: 20040729

Pledge (preservation): Preservation

ASS Succession or assignment of patent right

Owner name: SHANGHAI ZHONGXI SUNVE PHARMACEUTICAL CO., LTD.

Free format text: FORMER OWNER: SHANGHAI CHINESE AND WESTERN MEDICINE INDUSTRIAL CO. LTD.

Effective date: 20110916

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: 200065 PUTUO, SHANGHAI TO: 200331 PUTUO, SHANGHAI

TR01 Transfer of patent right

Effective date of registration: 20110916

Address after: 200331 No. 50, Yongdeng Road, Shanghai

Co-patentee after: Zhejiang Xianju Pharmaceutical Co., Ltd.

Patentee after: Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

Co-patentee after: Shanghai Zhongxi Pharmaceutical Co Ltd

Address before: 200065 No. 1515 traffic road, Shanghai

Co-patentee before: Zhejiang Xianju Pharmaceutical Co., Ltd.

Patentee before: Shanghai Chinese and Western Medicine Industrial Co., Ltd.

Co-patentee before: Shanghai Zhongxi Pharmaceutical Co Ltd

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20030813