JP2003520207A5 - - Google Patents
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- Publication number
- JP2003520207A5 JP2003520207A5 JP2001543129A JP2001543129A JP2003520207A5 JP 2003520207 A5 JP2003520207 A5 JP 2003520207A5 JP 2001543129 A JP2001543129 A JP 2001543129A JP 2001543129 A JP2001543129 A JP 2001543129A JP 2003520207 A5 JP2003520207 A5 JP 2003520207A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- composition according
- composition
- feed
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 36
- 102000004190 Enzymes Human genes 0.000 description 21
- 108090000790 Enzymes Proteins 0.000 description 21
- 229940088598 enzyme Drugs 0.000 description 21
- 239000003814 drug Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 239000004599 antimicrobial Substances 0.000 description 5
- 229960005475 antiinfective agent Drugs 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 3
- 108010064785 Phospholipases Proteins 0.000 description 3
- 102000015439 Phospholipases Human genes 0.000 description 3
- 108010089934 carbohydrase Proteins 0.000 description 3
- 244000079416 protozoan pathogen Species 0.000 description 3
- 241000193755 Bacillus cereus Species 0.000 description 2
- 102100032487 Beta-mannosidase Human genes 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 108010055059 beta-Mannosidase Proteins 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 229940059442 hemicellulase Drugs 0.000 description 2
- 108010002430 hemicellulase Proteins 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000003905 phosphatidylinositols Chemical class 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- 241000193422 Bacillus lentus Species 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000223935 Cryptosporidium Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- 241000223924 Eimeria Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 102000006486 Phosphoinositide Phospholipase C Human genes 0.000 description 1
- 108010044302 Phosphoinositide phospholipase C Proteins 0.000 description 1
- 102000011420 Phospholipase D Human genes 0.000 description 1
- 108090000553 Phospholipase D Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 description 1
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 102000014384 Type C Phospholipases Human genes 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N Xylose Natural products O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 108010050200 endo-1,4-beta-D-mannanase Proteins 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 1
- 244000000190 yeast pathogen Species 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16993599P | 1999-12-10 | 1999-12-10 | |
| US60/169,935 | 1999-12-10 | ||
| PCT/US2000/033466 WO2001041785A2 (en) | 1999-12-10 | 2000-12-08 | Enzyme treatment for infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520207A JP2003520207A (ja) | 2003-07-02 |
| JP2003520207A5 true JP2003520207A5 (enExample) | 2008-01-24 |
| JP4871473B2 JP4871473B2 (ja) | 2012-02-08 |
Family
ID=22617824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543129A Expired - Lifetime JP4871473B2 (ja) | 1999-12-10 | 2000-12-08 | 酵素による感染治療 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6780628B2 (enExample) |
| EP (1) | EP1239872B1 (enExample) |
| JP (1) | JP4871473B2 (enExample) |
| KR (1) | KR100639746B1 (enExample) |
| CN (3) | CN1433319A (enExample) |
| AR (2) | AR026764A1 (enExample) |
| AT (1) | ATE481981T1 (enExample) |
| AU (1) | AU782831B2 (enExample) |
| BR (1) | BRPI0016231B8 (enExample) |
| CA (1) | CA2394856C (enExample) |
| CL (1) | CL2008000057A1 (enExample) |
| CO (1) | CO5280226A1 (enExample) |
| CR (1) | CR6674A (enExample) |
| CZ (1) | CZ304925B6 (enExample) |
| DE (1) | DE60045010D1 (enExample) |
| DK (1) | DK1239872T3 (enExample) |
| ES (1) | ES2353371T3 (enExample) |
| HU (1) | HU230301B1 (enExample) |
| IL (2) | IL150048A0 (enExample) |
| IN (1) | IN247731B (enExample) |
| MX (1) | MX264033B (enExample) |
| MY (1) | MY124714A (enExample) |
| NZ (1) | NZ519404A (enExample) |
| PH (1) | PH12000003381B1 (enExample) |
| PL (1) | PL203054B1 (enExample) |
| PT (1) | PT1239872E (enExample) |
| RU (1) | RU2272419C2 (enExample) |
| SK (1) | SK287956B6 (enExample) |
| TW (1) | TWI255189B (enExample) |
| UA (1) | UA78486C2 (enExample) |
| WO (1) | WO2001041785A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA78486C2 (uk) | 1999-12-10 | 2007-04-10 | Хемджен Корпорейшн | Композиція для перорального введення птахам та тваринам для лікування або зниження ризику інфекції травного тракту (варіанти), її застосування (варіанти) та спосіб лікування або зниження ризику інфекцій травного тракту (варіанти) |
| US7247299B2 (en) * | 2002-11-27 | 2007-07-24 | Kemin Industries, Inc. | Antimicrobial compounds from Bacillus subtilis for use against animal and human pathogens |
| US7566447B2 (en) * | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| US8394379B2 (en) * | 2003-05-15 | 2013-03-12 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| US8703134B2 (en) | 2003-05-15 | 2014-04-22 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| US20050014932A1 (en) * | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8710012B2 (en) | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| AU2005332655A1 (en) * | 2004-10-20 | 2006-12-14 | Iogenetics, Llc | Biocides |
| US8916151B2 (en) | 2005-04-25 | 2014-12-23 | Cls Therapeutics Limited | Method for treating a reduction of fertility |
| BRPI0620155B1 (pt) * | 2005-12-15 | 2015-07-21 | Lilly Co Eli | Composição adequada para administração oral a um animal compreendendo uma enzima redutora de estresse imunológico em um veículo aceitável por via oral |
| WO2007087517A2 (en) * | 2006-01-23 | 2007-08-02 | Hill's Pet Nutrition, Inc. | Methods for reducing food intake and controlling the weight of animals |
| RU2319481C1 (ru) * | 2006-10-20 | 2008-03-20 | Илья Николаевич Медведев | Способ коррекции уровня оксида азота в крови поросят с острым катаральным энтеритом |
| JP5372769B2 (ja) | 2006-11-28 | 2013-12-18 | シーエルエス セラピューティック リミティド | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
| US8263088B2 (en) * | 2007-06-08 | 2012-09-11 | Australian Poultry Crc Pty Ltd. | Clostridial toxin NetB |
| RU2440369C2 (ru) * | 2007-08-03 | 2012-01-20 | Бёрингер Ингельхайм Ветмедика Гмбх | ГЕНЫ И БЕЛКИ Brachyspira hyodysenteriae И ИХ ПРИМЕНЕНИЕ |
| MX2010006743A (es) * | 2007-12-20 | 2010-08-16 | Danisco Us Inc | Prevencion enzimatica y control de la biopelicula. |
| US20090202516A1 (en) | 2008-02-08 | 2009-08-13 | Prothera, Inc. | Inhibition and treatment of gastrointestinal biofilms |
| RU2380901C1 (ru) * | 2008-08-13 | 2010-02-10 | Государственное научное учреждение Ставропольский научно-исследовательский институт животноводства и кормопроизводства Российской академии сельскохозяйственных наук | Способ повышения однородности стада, живой массы, конверсии корма при выращивании цыплят |
| CA2864887C (en) | 2012-02-16 | 2017-04-25 | Eli Lilly And Company | Methods and compositions for reducing the environmental impact of animal waste |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| TWI656872B (zh) | 2014-11-13 | 2019-04-21 | 美商益農美國公司 | 甲基鹽黴素於豬飼料中之抗病毒效果 |
| US11701410B2 (en) | 2015-05-22 | 2023-07-18 | Cls Therapeutics Limited | Extracellular DNA as a therapeutic target in neurodegeneration |
| CN106119221A (zh) * | 2016-06-28 | 2016-11-16 | 浙江省农业科学院 | 磷脂酰肌醇特异性磷脂酶c基因、载体、工程菌及应用 |
| CN106318925B (zh) * | 2016-08-19 | 2021-04-02 | 浙江省农业科学院 | 利用枯草芽孢杆菌高效表达pi-plc基因的方法 |
| CN106615691B (zh) * | 2016-10-11 | 2019-07-02 | 上海国龙生物技术集团有限公司 | 一种抗感染酶复合剂及其在饲料中的应用 |
| US10501730B2 (en) * | 2017-05-30 | 2019-12-10 | Ab Enzymes Oy | Mannanase variants |
| AU2019209770B2 (en) | 2018-01-16 | 2025-07-31 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity |
| KR20200128413A (ko) * | 2018-03-02 | 2020-11-12 | 에보니크 오퍼레이션즈 게엠베하 | 오보트랜스페린을 결정함으로써 동물에서의 장 장벽 기능상실을 검출하기 위한 시험관내 방법 |
| MX2021006917A (es) | 2018-12-14 | 2021-07-07 | Evonik Operations Gmbh | Procedimiento in vitro para la deteccion de disbiosis intestinal aviar. |
| RU2720471C1 (ru) * | 2019-03-21 | 2020-04-30 | Федеральное Государственное бюджетное научное учреждение "Федеральный научный центр биологических систем и агротехнологий российской академии наук" | Кормовая добавка для цыплят-бройлеров |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1509866A (en) | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| JPS5534039A (en) | 1978-08-30 | 1980-03-10 | Hiroo Ikezawa | Preparation of phsophatidylinositol phospholipase c from bacillus thuringiensis |
| WO1987000196A1 (en) | 1985-07-09 | 1987-01-15 | Quadrant Bioresources Limited | Protection of proteins and the like |
| US4877738A (en) | 1986-07-25 | 1989-10-31 | Wisconsin Alumni Research Foundation | Biological control of damping off and root rot and inoculum preparation therefor |
| US5049379A (en) | 1987-07-27 | 1991-09-17 | Wisconsin Alumni Research Foundation | Fungicidal toxin and method and inoculum for controlling root rot and damping off |
| JPH0338530A (ja) * | 1989-07-03 | 1991-02-19 | Ajinomoto Co Inc | 抗真菌剤 |
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| EP0531437B1 (en) | 1990-05-29 | 1997-12-29 | Chemgen Corporation | Hemicellulase supplement to improve the energy efficiency of hemicellulose-containing food and animal feed |
| EP0477739A3 (en) * | 1990-09-27 | 1992-12-09 | F. Hoffmann-La Roche Ag | Glycosyl-phosphatidylinositol-specific phospholipase d |
| EP0596962A4 (en) * | 1991-07-24 | 1997-01-15 | Enzacor Pty Ltd | Therapeutic compositions and methods. |
| JPH07184642A (ja) * | 1993-12-27 | 1995-07-25 | Toagosei Co Ltd | ホスホリパーゼｃの生産方法 |
| MY134684A (en) | 1995-05-15 | 2007-12-31 | Gist Brocades Bv | Application of phospholipases in animal feed |
| EP0743017B1 (en) * | 1995-05-15 | 2004-09-29 | DSM IP Assets B.V. | Application of phospholipases in animal feed |
| JPH08332032A (ja) * | 1995-06-12 | 1996-12-17 | Showa Denko Kk | 動物経口物用酵素剤及びその用途 |
| JP3914585B2 (ja) * | 1995-10-19 | 2007-05-16 | イーエヌ大塚製薬株式会社 | マクロファージ一酸化窒素産生亢進剤 |
| US6162473A (en) * | 1996-05-03 | 2000-12-19 | Chemgen Corporation | Hemicellulase use in feeds with low caloric content |
| CN1092495C (zh) * | 1996-05-03 | 2002-10-16 | 开姆根有限公司 | 半纤维素酶在低热焓饲料中的应用 |
| JPH1045581A (ja) * | 1996-07-29 | 1998-02-17 | Hideyo Yamaguchi | 好中球機能低下抑制剤又は感染防御剤 |
| JP2001504327A (ja) * | 1996-10-31 | 2001-04-03 | ノボ ノルディスク アクティーゼルスカブ | 新規ホスホリパーゼ、その生産及び使用 |
| WO2000021381A1 (en) * | 1998-10-15 | 2000-04-20 | Dsm N.V. | Antimicrobial enzymes in animal feed |
| UA78486C2 (uk) | 1999-12-10 | 2007-04-10 | Хемджен Корпорейшн | Композиція для перорального введення птахам та тваринам для лікування або зниження ризику інфекції травного тракту (варіанти), її застосування (варіанти) та спосіб лікування або зниження ризику інфекцій травного тракту (варіанти) |
| US20020116028A1 (en) * | 2001-02-20 | 2002-08-22 | Wilson Greatbatch | MRI-compatible pacemaker with pulse carrying photonic catheter providing VOO functionality |
-
2000
- 2000-08-12 UA UA2002075677A patent/UA78486C2/uk unknown
- 2000-12-07 AR ARP000106541A patent/AR026764A1/es not_active Application Discontinuation
- 2000-12-07 CO CO00093684A patent/CO5280226A1/es not_active Application Discontinuation
- 2000-12-08 WO PCT/US2000/033466 patent/WO2001041785A2/en not_active Ceased
- 2000-12-08 CZ CZ2002-2007A patent/CZ304925B6/cs not_active IP Right Cessation
- 2000-12-08 JP JP2001543129A patent/JP4871473B2/ja not_active Expired - Lifetime
- 2000-12-08 PL PL356175A patent/PL203054B1/pl unknown
- 2000-12-08 MY MYPI20005779A patent/MY124714A/en unknown
- 2000-12-08 AU AU25776/01A patent/AU782831B2/en not_active Expired
- 2000-12-08 US US09/731,971 patent/US6780628B2/en not_active Expired - Lifetime
- 2000-12-08 KR KR1020027007363A patent/KR100639746B1/ko not_active Expired - Lifetime
- 2000-12-08 CN CN00818851A patent/CN1433319A/zh active Pending
- 2000-12-08 DE DE60045010T patent/DE60045010D1/de not_active Expired - Lifetime
- 2000-12-08 PT PT00989240T patent/PT1239872E/pt unknown
- 2000-12-08 EP EP00989240A patent/EP1239872B1/en not_active Expired - Lifetime
- 2000-12-08 MX MXPA02005735 patent/MX264033B/es active IP Right Grant
- 2000-12-08 NZ NZ519404A patent/NZ519404A/en not_active IP Right Cessation
- 2000-12-08 ES ES00989240T patent/ES2353371T3/es not_active Expired - Lifetime
- 2000-12-08 PH PH12000003381A patent/PH12000003381B1/en unknown
- 2000-12-08 BR BRPI0016231A patent/BRPI0016231B8/pt not_active IP Right Cessation
- 2000-12-08 RU RU2002118694/13A patent/RU2272419C2/ru active
- 2000-12-08 IL IL15004800A patent/IL150048A0/xx unknown
- 2000-12-08 HU HU0203402A patent/HU230301B1/hu unknown
- 2000-12-08 AT AT00989240T patent/ATE481981T1/de active
- 2000-12-08 SK SK826-2002A patent/SK287956B6/sk not_active IP Right Cessation
- 2000-12-08 CN CN201110076924.6A patent/CN102172262B/zh not_active Expired - Lifetime
- 2000-12-08 CN CNA2008101259037A patent/CN101327320A/zh active Pending
- 2000-12-08 DK DK00989240.7T patent/DK1239872T3/da active
- 2000-12-08 CA CA2394856A patent/CA2394856C/en not_active Expired - Lifetime
-
2001
- 2001-03-07 TW TW089126252A patent/TWI255189B/zh not_active IP Right Cessation
-
2002
- 2002-06-05 IL IL150048A patent/IL150048A/en active IP Right Grant
- 2002-06-06 IN IN585DE2002 patent/IN247731B/en unknown
- 2002-06-07 CR CR6674A patent/CR6674A/es unknown
-
2004
- 2004-05-28 US US10/855,416 patent/US7723091B2/en not_active Expired - Lifetime
-
2008
- 2008-01-09 CL CL200800057A patent/CL2008000057A1/es unknown
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2013
- 2013-01-24 AR ARP130100218A patent/AR089799A2/es not_active Application Discontinuation
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