JP2003517041A5 - - Google Patents
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- Publication number
- JP2003517041A5 JP2003517041A5 JP2001545542A JP2001545542A JP2003517041A5 JP 2003517041 A5 JP2003517041 A5 JP 2003517041A5 JP 2001545542 A JP2001545542 A JP 2001545542A JP 2001545542 A JP2001545542 A JP 2001545542A JP 2003517041 A5 JP2003517041 A5 JP 2003517041A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide sequence
- seq
- phosphodiester nucleotide
- synthetic phosphodiester
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 description 12
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003667 hormone antagonist Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17032599P | 1999-12-13 | 1999-12-13 | |
| US60/170,325 | 1999-12-13 | ||
| US22892500P | 2000-08-29 | 2000-08-29 | |
| US60/228,925 | 2000-08-29 | ||
| PCT/CA2000/001467 WO2001044465A2 (en) | 1999-12-13 | 2000-12-12 | Therapeutically useful synthetic oligonucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517041A JP2003517041A (ja) | 2003-05-20 |
| JP2003517041A5 true JP2003517041A5 (enExample) | 2008-02-07 |
| JP4772245B2 JP4772245B2 (ja) | 2011-09-14 |
Family
ID=26865979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001545542A Expired - Fee Related JP4772245B2 (ja) | 1999-12-13 | 2000-12-12 | 治療上有用な合成オリゴヌクレオチド |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7157436B2 (enExample) |
| EP (2) | EP1238070B1 (enExample) |
| JP (1) | JP4772245B2 (enExample) |
| KR (1) | KR100829646B1 (enExample) |
| CN (2) | CN100445380C (enExample) |
| AT (2) | ATE455851T1 (enExample) |
| AU (1) | AU785212B2 (enExample) |
| CA (1) | CA2393808A1 (enExample) |
| CZ (1) | CZ20022372A3 (enExample) |
| DE (2) | DE60036019T2 (enExample) |
| DK (2) | DK1867718T3 (enExample) |
| ES (2) | ES2288883T3 (enExample) |
| HU (1) | HUP0300627A3 (enExample) |
| IL (2) | IL150196A0 (enExample) |
| MX (1) | MXPA02005842A (enExample) |
| NO (1) | NO330508B1 (enExample) |
| PT (1) | PT1238070E (enExample) |
| WO (1) | WO2001044465A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032610A1 (en) | 1996-06-03 | 2003-02-13 | Gilchrest Barbara A. | Method to inhibit cell growth using oligonucleotides |
| US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| JP2002541264A (ja) | 1999-04-08 | 2002-12-03 | ユーエイビー・リサーチ・ファウンデーション | 冨gオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法 |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| ATE455851T1 (de) * | 1999-12-13 | 2010-02-15 | Bioniche Life Sciences Inc | Therapeutisch nützliche synthetische oligonukleotide |
| AU6886301A (en) | 2000-08-29 | 2002-03-13 | Bioniche Life Sciences Inc | Modulation of fas and fasl expression |
| DE60134421D1 (de) * | 2000-12-08 | 2008-07-24 | Coley Pharmaceuticals Gmbh | Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung |
| US7087586B2 (en) * | 2001-04-24 | 2006-08-08 | Bioniche Life Sciences, Inc. | Oligonucleotide compositions and their use to induce differentiation of cells |
| CA2457783A1 (en) * | 2001-08-17 | 2003-02-27 | Bioniche Life Sciences Inc. | Oligonucleotide compositions and their use to induce apoptosis |
| KR100971571B1 (ko) * | 2001-10-03 | 2010-07-20 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 치료적으로 유용한 트리에틸렌글리콜 콜레스테릴올리고뉴클레오타이드 |
| KR101092043B1 (ko) * | 2002-04-22 | 2011-12-12 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도 |
| AU2004226605A1 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
| EP1628531A4 (en) * | 2003-05-16 | 2010-06-30 | Idera Pharmaceuticals Inc | SYNERGISTIC TREATMENT OF CANCER BY COMMON USE OF IMMUNOMER AND CHEMOTHERAPEUTICS |
| AU2006216493A1 (en) * | 2005-02-24 | 2006-08-31 | Coley Pharmaceutical Gmbh | Immunostimulatory oligonucleotides |
| JP2008532520A (ja) * | 2005-03-09 | 2008-08-21 | ベイラー カレッジ オブ メディスン | Toll様受容体8のシグナル伝達によるcd4+調節性t細胞の抑制機能の直接的な反転 |
| WO2007028985A2 (en) * | 2005-09-07 | 2007-03-15 | The Secretary Of State For Defence | Adjuvanted vaccine |
| CN102439149B (zh) * | 2009-02-12 | 2018-01-02 | 库尔纳公司 | 通过抑制针对胶质细胞衍生神经营养因子(gdnf)的天然反义转录物来治疗gdnf相关的疾病 |
| GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
| KR100998365B1 (ko) | 2009-06-29 | 2010-12-06 | 압타바이오 주식회사 | 치료 효능이 있는 변형핵산 및 구아노신을 함유하는 올리고뉴클레오티드 변형체 |
| EP2490767A4 (en) * | 2009-07-15 | 2013-02-13 | Santaris Pharma As | GLI2 TARGETING TARGET ANTAGONIST FOR THE TREATMENT OF LEUKEMIA |
| CN104520439A (zh) * | 2012-02-28 | 2015-04-15 | 国立大学法人东京农工大学 | Tdp-43细胞内存在量关联疾患的认定方法 |
| EP4000597A1 (en) * | 2020-11-17 | 2022-05-25 | The Boots Company plc | Tetrapeptide and compositions comprising tetrapeptides |
| AU2022421244A1 (en) * | 2021-12-22 | 2024-07-11 | Camp4 Therapeutics Corporation | Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172815A (en) * | 1962-04-24 | 1965-03-09 | Warner Lambert Pharmaceutical | Method for preparing reticulo-endo-thelial system stimulant and stimulant thereof |
| FR2160326B1 (enExample) * | 1971-11-19 | 1975-02-07 | Anvar | |
| US4152423A (en) * | 1971-11-19 | 1979-05-01 | Agence Nationale De Valorisation De La Recherche (Anvar) | Immunological agents |
| US4010257A (en) * | 1973-02-23 | 1977-03-01 | Burroughs Wellcome Co. | Biological extracts |
| US3976544A (en) * | 1973-06-19 | 1976-08-24 | The Agence Nationale De Valorisation De Le Recherche | Water-soluble immunological adjuvants, in particular for vaccines, obtained from mycobacteria and related microorganisms and process for their extraction |
| FR2374042A1 (fr) * | 1976-06-04 | 1978-07-13 | Merieux Inst | Nouveau medicament immunostimulant et son procede de preparation |
| JPS54140710A (en) * | 1978-03-10 | 1979-11-01 | Mitsui Toatsu Chem Inc | Anti-tumor substance and its preparation |
| DE3011461C2 (de) * | 1980-03-25 | 1986-10-30 | Dr. Madaus & Co, 5000 Köln | Verwendung von Propionibakterien |
| US4520019A (en) * | 1982-04-29 | 1985-05-28 | Ribi Immunochem Research, Inc. | Stable composition and preparation thereof |
| US4579941A (en) * | 1982-08-13 | 1986-04-01 | Mitsuitoatsu Chemicals, Inc. | Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent |
| US4663306A (en) * | 1983-09-23 | 1987-05-05 | Ribi Immunochem Research, Inc. | Pyridine-soluble extract-refined detoxified endotoxin composition and use |
| GB8404280D0 (en) * | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
| DE3423234A1 (de) * | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| US4877611A (en) * | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| DE3723075A1 (de) * | 1987-07-11 | 1989-01-19 | Boehringer Mannheim Gmbh | Eukaryotische expressionsvektoren mit multimeren enhancer-subelementen, verfahren zu ihrer herstellung und verwendung |
| US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| WO1992007095A1 (en) * | 1990-10-15 | 1992-04-30 | Stratagene | Arbitrarily primed polymerase chain reaction method for fingerprinting genomes |
| AU1456092A (en) * | 1991-02-21 | 1992-09-15 | Gilead Sciences, Inc. | Aptamers specific for thrombin and methods of use |
| WO1998017320A1 (en) * | 1991-07-03 | 1998-04-30 | Hyal Pharmaceutical Corporation | Use of hyaluronan in gene therapy |
| US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5523389A (en) * | 1992-09-29 | 1996-06-04 | Isis Pharmaceuticals, Inc. | Inhibitors of human immunodeficiency virus |
| ATE179333T1 (de) * | 1993-01-29 | 1999-05-15 | Vetrepharm Inc | Immunotherapeutische zubereitung |
| US5567604A (en) * | 1993-04-23 | 1996-10-22 | Aronex Pharmaceuticals, Inc. | Anti-viral guanosine-rich oligonucleotides |
| CN1154702A (zh) * | 1994-05-25 | 1997-07-16 | 海布里登公司 | 具有抗巨细胞病毒活性的寡核苷酸 |
| CN1164869A (zh) * | 1994-08-30 | 1997-11-12 | 联邦科学和工业研究组织 | 来源于环病毒的植物转录调节物 |
| US5643890A (en) | 1995-01-31 | 1997-07-01 | The Board Of Regents Of The University Of Nebraska | Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases |
| IN181358B (enExample) * | 1995-02-14 | 1998-05-30 | Bioniche Inc | |
| ZA964446B (en) * | 1995-06-06 | 1996-12-06 | Hoffmann La Roche | Oligonucleotides specific for hepatitis c virus |
| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
| EP0879241A4 (en) * | 1995-11-21 | 2000-04-19 | Icn Pharmaceuticals | INHIBITION OF TUMOR GROWTH BY ANTISENSE OLIGONUCLEOTIDES FOR IL-8 AND THE IL-8 RECEPTOR |
| IT1277025B1 (it) * | 1995-12-04 | 1997-11-04 | Cooperativa Centro Ricerche Po | Classe di oligonucleotidi fosfodiesterici ad attivita' citotossica composizioni farmaceutiche che li contengono e loro uso |
| US6015710A (en) * | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
| AU737926B2 (en) * | 1996-05-20 | 2001-09-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Oligonucleotides which specifically bind retroviral nucleocapsid proteins |
| CA2299548C (en) * | 1997-08-05 | 2009-12-29 | Bioniche Inc. | Composition and method for regulating cell proliferation and cell death |
| US6255473B1 (en) * | 1997-08-29 | 2001-07-03 | Duke University | Presenilin-1 gene promoter |
| PL354997A1 (en) * | 1999-09-25 | 2004-03-22 | University Of Iowa Research Foundation | Immunostimulatory nucleic acids |
| ATE455851T1 (de) * | 1999-12-13 | 2010-02-15 | Bioniche Life Sciences Inc | Therapeutisch nützliche synthetische oligonukleotide |
| US20020091095A1 (en) * | 1999-12-13 | 2002-07-11 | Phillips Nigel C. | Modulation of Fas and FasL expression |
| DK1250152T3 (da) * | 1999-12-28 | 2013-08-26 | Bioniche Urology Ip Inc | Synergistisk sammensætning indeholdende hyaluronsyre til behandling af cancer |
| KR100971571B1 (ko) * | 2001-10-03 | 2010-07-20 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 치료적으로 유용한 트리에틸렌글리콜 콜레스테릴올리고뉴클레오타이드 |
| KR101092043B1 (ko) * | 2002-04-22 | 2011-12-12 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도 |
-
2000
- 2000-12-12 AT AT07015976T patent/ATE455851T1/de not_active IP Right Cessation
- 2000-12-12 CA CA002393808A patent/CA2393808A1/en not_active Abandoned
- 2000-12-12 CN CNB008188580A patent/CN100445380C/zh not_active Expired - Fee Related
- 2000-12-12 KR KR1020027007557A patent/KR100829646B1/ko not_active Expired - Fee Related
- 2000-12-12 DE DE60036019T patent/DE60036019T2/de not_active Expired - Lifetime
- 2000-12-12 EP EP00981117A patent/EP1238070B1/en not_active Expired - Lifetime
- 2000-12-12 DK DK07015976.9T patent/DK1867718T3/da active
- 2000-12-12 IL IL15019600A patent/IL150196A0/xx unknown
- 2000-12-12 US US09/735,363 patent/US7157436B2/en not_active Expired - Fee Related
- 2000-12-12 AU AU18479/01A patent/AU785212B2/en not_active Ceased
- 2000-12-12 EP EP07015976A patent/EP1867718B1/en not_active Expired - Lifetime
- 2000-12-12 AT AT00981117T patent/ATE370231T1/de active
- 2000-12-12 CN CN2008101740188A patent/CN101491536B/zh not_active Expired - Fee Related
- 2000-12-12 WO PCT/CA2000/001467 patent/WO2001044465A2/en not_active Ceased
- 2000-12-12 PT PT00981117T patent/PT1238070E/pt unknown
- 2000-12-12 MX MXPA02005842A patent/MXPA02005842A/es active IP Right Grant
- 2000-12-12 ES ES00981117T patent/ES2288883T3/es not_active Expired - Lifetime
- 2000-12-12 ES ES07015976T patent/ES2340807T3/es not_active Expired - Lifetime
- 2000-12-12 JP JP2001545542A patent/JP4772245B2/ja not_active Expired - Fee Related
- 2000-12-12 DE DE60043759T patent/DE60043759D1/de not_active Expired - Lifetime
- 2000-12-12 CZ CZ20022372A patent/CZ20022372A3/cs unknown
- 2000-12-12 DK DK00981117T patent/DK1238070T3/da active
- 2000-12-12 HU HU0300627A patent/HUP0300627A3/hu unknown
-
2002
- 2002-06-12 IL IL150196A patent/IL150196A/en not_active IP Right Cessation
- 2002-06-13 NO NO20022820A patent/NO330508B1/no not_active IP Right Cessation
-
2006
- 2006-12-18 US US11/641,542 patent/US20070213291A1/en not_active Abandoned
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