JP2003506377A5 - - Google Patents
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- Publication number
- JP2003506377A5 JP2003506377A5 JP2001514341A JP2001514341A JP2003506377A5 JP 2003506377 A5 JP2003506377 A5 JP 2003506377A5 JP 2001514341 A JP2001514341 A JP 2001514341A JP 2001514341 A JP2001514341 A JP 2001514341A JP 2003506377 A5 JP2003506377 A5 JP 2003506377A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- aromatic
- aliphatic group
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001931 aliphatic group Chemical group 0.000 description 204
- 125000003118 aryl group Chemical group 0.000 description 137
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 52
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 38
- 150000001875 compounds Chemical class 0.000 description 38
- 239000003814 drug Substances 0.000 description 28
- 229940124597 therapeutic agent Drugs 0.000 description 26
- 125000002252 acyl group Chemical group 0.000 description 22
- 229910052799 carbon Inorganic materials 0.000 description 20
- 125000004432 carbon atom Chemical group C* 0.000 description 20
- 229910052757 nitrogen Inorganic materials 0.000 description 20
- 125000004433 nitrogen atom Chemical group N* 0.000 description 20
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000000623 heterocyclic group Chemical group 0.000 description 11
- 125000004103 aminoalkyl group Chemical group 0.000 description 10
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 9
- 230000002159 abnormal effect Effects 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 125000006575 electron-withdrawing group Chemical group 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- 230000007115 recruitment Effects 0.000 description 6
- 125000006413 ring segment Chemical group 0.000 description 6
- 230000004913 activation Effects 0.000 description 5
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- VGYLMOJQAHXYCK-UHFFFAOYSA-N CN1CNCC1 Chemical compound CN1CNCC1 VGYLMOJQAHXYCK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/362,837 | 1999-07-28 | ||
| US09/362,837 US6509346B2 (en) | 1998-01-21 | 1999-07-28 | Chemokine receptor antagonists and methods of use therefor |
| PCT/US2000/020732 WO2001009138A2 (en) | 1999-07-28 | 2000-07-28 | Chemokine receptor antagonists and methods of use therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003506377A JP2003506377A (ja) | 2003-02-18 |
| JP2003506377A5 true JP2003506377A5 (https=) | 2007-10-04 |
| JP4903333B2 JP4903333B2 (ja) | 2012-03-28 |
Family
ID=23427735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001514341A Expired - Fee Related JP4903333B2 (ja) | 1999-07-28 | 2000-07-28 | ケモカイン受容体アンタゴニストおよびその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6509346B2 (https=) |
| EP (1) | EP1204665B1 (https=) |
| JP (1) | JP4903333B2 (https=) |
| KR (1) | KR20020016926A (https=) |
| CN (1) | CN1471536A (https=) |
| AT (1) | ATE420090T1 (https=) |
| AU (1) | AU6391400A (https=) |
| BR (1) | BR0013065A (https=) |
| CA (1) | CA2391267A1 (https=) |
| DE (1) | DE60041336D1 (https=) |
| EA (1) | EA200200194A1 (https=) |
| ES (1) | ES2321798T3 (https=) |
| HK (1) | HK1044333A1 (https=) |
| HU (1) | HUP0202202A3 (https=) |
| IL (1) | IL147852A0 (https=) |
| MX (1) | MXPA02000978A (https=) |
| WO (1) | WO2001009138A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| MXPA04004826A (es) * | 1998-09-04 | 2004-08-11 | Millenium Pharmaceuticals Inc | Antagonista del receptor de quimioquinas y metodos para su uso. |
| US6919313B2 (en) * | 2001-03-30 | 2005-07-19 | President & Fellows Of Harvard College | Protein waving a PDZ and a RGS domain |
| US7541365B2 (en) * | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| NZ596484A (en) * | 2001-11-21 | 2013-05-31 | Millennium Pharm Inc | Chemokine receptor antagonists and methods of use thereof |
| US20060019977A1 (en) * | 2002-10-18 | 2006-01-26 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compound as the active ingredient |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| CA2520660C (en) * | 2003-03-28 | 2013-08-20 | Sigmoid Biotechnologies Limited | Solid oral dosage form containing seamless microcapsules |
| CN100526301C (zh) * | 2003-12-26 | 2009-08-12 | 卫材R&D管理有限公司 | 1,2-二(环式基)取代苯化合物 |
| MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| US20060276465A1 (en) * | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
| US7410971B2 (en) * | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| DE102004004719A1 (de) * | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
| EP2444071A1 (en) * | 2004-09-27 | 2012-04-25 | Sigmoid Pharma Limited | Minicapsule formulations |
| ATE553761T1 (de) | 2004-12-17 | 2012-05-15 | Millennium Pharm Inc | Solide formen eines chemokin-rezeptorantagonisten und anwendungsverfahren dafür |
| EP1832580A4 (en) | 2004-12-20 | 2009-03-11 | Eisai R&D Man Co Ltd | 1-CYCLOPROPYLMETHYL-4-Ý2- (3,3,5,5) -TETRAMETHYLCYCLOHEXYL) PHENYL PIPERAZINE CRYSTAL AND SALT |
| MY144974A (en) * | 2005-06-14 | 2011-11-30 | Eisai R&D Man Co Ltd | 1,2-di(cyclic) substituted benzene derivatives |
| EP2079456B1 (en) | 2007-04-04 | 2012-12-05 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
| EP2586428B1 (en) * | 2007-04-26 | 2023-11-08 | Sublimity Therapeutics Limited | Manufacture of multiple minicapsules |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| US20090286823A1 (en) * | 2007-12-17 | 2009-11-19 | Millennium Pharmaceuticals Inc. | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders |
| ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| CN107582526A (zh) | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| US8859777B2 (en) | 2010-04-30 | 2014-10-14 | Kinentia Biosciences Llc | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| KR101102335B1 (ko) * | 2011-09-06 | 2012-01-03 | (주)칠칠공사 | 수영 연습용 가변형 풀 |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| EP3881829A1 (en) | 2014-11-07 | 2021-09-22 | Sublimity Therapeutics Limited | Compositions comprising cyclosporin |
| CN115389659B (zh) * | 2022-08-23 | 2024-07-16 | 浙江中医药大学 | 一种细胞膜键合磁性碳球复合材料及其制备方法和应用 |
Family Cites Families (70)
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| DE80449C (https=) | ||||
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| NL132137C (https=) * | 1963-04-24 | |||
| BE664609A (https=) | 1964-06-01 | |||
| CH421138A (de) | 1965-11-04 | 1966-09-30 | Wander Ag Dr A | Verfahren zur Herstellung von Thioxanthenderivaten |
| US3409621A (en) | 1966-04-01 | 1968-11-05 | Schering Corp | Piperazino-aza-dibenzo-[a, d]-cycloheptenes |
| US3625974A (en) | 1967-04-28 | 1971-12-07 | Fujisawa Pharmaceutical Co | Dibenzothiazepine derivatives |
| NL6905642A (https=) | 1968-04-12 | 1969-10-14 | ||
| GB1330966A (en) | 1970-12-22 | 1973-09-19 | Yoshitomi Pharmaceutical | N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them |
| US3770729A (en) | 1970-12-22 | 1973-11-06 | Yoshitomi Pharmaceutical | N substituted piperidine compounds |
| CA1010870A (en) | 1972-12-08 | 1977-05-24 | Niels Lassen | Thiaxanthene derivative and method |
| US4250176A (en) | 1976-12-21 | 1981-02-10 | Janssen Pharmaceutica N.V. | Piperazine derivatives |
| US4335122A (en) | 1981-03-18 | 1982-06-15 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use |
| DE3326641A1 (de) | 1982-07-27 | 1984-02-02 | Basf Ag, 6700 Ludwigshafen | 5,6-dihydro-11-h-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel |
| CA1237428A (en) | 1983-06-24 | 1988-05-31 | Hiroshi Tanaka | ¬1| benzepino¬3,4-b|pyridine derivative |
| DE3402060A1 (de) | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPH0665664B2 (ja) | 1985-01-18 | 1994-08-24 | 大塚製薬株式会社 | モルフアントリジン誘導体 |
| SE8500273D0 (sv) | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| WO1988000049A1 (fr) * | 1986-06-26 | 1988-01-14 | Kyowa Hakko Kogyo Co., Ltd. | Agent antiarythmique |
| US5089496A (en) | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| IT8721978A0 (it) | 1987-09-21 | 1987-09-21 | Angeli Inst Spa | Nuovi derivati ammidinici triciclici. |
| US4882351A (en) | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| AU612437B2 (en) | 1987-12-14 | 1991-07-11 | Kyowa Hakko Kogyo Co. Ltd. | Tricyclic compounds |
| EP0411048A1 (en) | 1988-04-28 | 1991-02-06 | Schering Corporation | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
| CA1338625C (en) | 1988-06-09 | 1996-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5242931A (en) | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| DE3838912A1 (de) | 1988-11-17 | 1990-05-23 | Thomae Gmbh Dr K | Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen |
| JPH0694464B2 (ja) | 1991-01-23 | 1994-11-24 | 協和醗酵工業株式会社 | 三環式化合物およびその中間体 |
| EP0511477B1 (en) | 1991-03-11 | 1996-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
| WO1992016226A1 (en) | 1991-03-19 | 1992-10-01 | Smithkline Beecham Corporation | Il-1 inhibitors |
| WO1992020681A1 (en) | 1991-05-23 | 1992-11-26 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
| WO1993002081A1 (en) | 1991-07-23 | 1993-02-04 | Schering Corporation | Novel benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use |
| US5378701A (en) | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
| US5679703A (en) | 1992-09-16 | 1997-10-21 | Kyowa Hakko Kogyo, Co., Ltd. | Tricyclic compounds having ACAT inhibiting activity |
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| UA54385C2 (uk) | 1995-04-07 | 2003-03-17 | Ново Нордіск А/С | N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування |
| AU5270796A (en) | 1995-04-07 | 1996-10-23 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and esters th ereof |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| JPH0940662A (ja) | 1995-05-24 | 1997-02-10 | Kyowa Hakko Kogyo Co Ltd | 三環式化合物 |
| US6150355A (en) | 1995-09-13 | 2000-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Phenylpiperidine derivative |
| AU1208397A (en) | 1995-12-28 | 1997-07-28 | Takeda Chemical Industries Ltd. | Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists |
| DE69709647T2 (de) | 1996-05-20 | 2002-11-07 | Dupont Pharmaceuticals Research Laboratories, Inc. | Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren |
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| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
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| CA2264666A1 (en) | 1996-09-13 | 1998-03-19 | Schering Corporation | Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase |
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| CZ84199A3 (cs) | 1996-09-13 | 1999-11-17 | Schering Corporation | Nové, tricyklické piperidinylové sloučeniny použitelné jako inhibitory farnesylprotein transferasy |
| NZ334437A (en) | 1996-09-13 | 2000-09-29 | Schering Corp | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase |
| IL128949A0 (en) | 1996-09-13 | 2000-02-17 | Schering Corp | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| CA2267500A1 (en) | 1996-10-04 | 1998-04-16 | Novo Nordisk A/S | N-substituted azaheterocyclic compounds |
| AU5604998A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| WO1998025605A1 (en) | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
| AU5812498A (en) | 1996-12-20 | 1998-07-17 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| AU6517398A (en) | 1997-03-27 | 1998-10-22 | Kyowa Hakko Kogyo Co. Ltd. | Therapeutic agent for autoimmune diseases |
| ES2273413T3 (es) | 1997-04-15 | 2007-05-01 | Kyowa Hakko Kogyo Co., Ltd. | Compuestos triciclicos. |
| US5877177A (en) | 1997-06-17 | 1999-03-02 | Schering Corporation | Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US6040318A (en) | 1997-06-25 | 2000-03-21 | Novo Nordisk A/S | Tricycle substituted with azaheterocyclic carboxylic acids |
| US6048856A (en) | 1997-12-17 | 2000-04-11 | Novo Nordisk A/S | Heterocyclic compounds |
| BR9910144A (pt) | 1998-01-21 | 2002-04-02 | Millennium Pharm Inc | Antagonistas de receptores de quimiocinas e seu uso |
| US6613905B1 (en) * | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CA2343536A1 (en) | 1998-09-04 | 2000-03-16 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
-
1999
- 1999-07-28 US US09/362,837 patent/US6509346B2/en not_active Expired - Lifetime
-
2000
- 2000-07-28 JP JP2001514341A patent/JP4903333B2/ja not_active Expired - Fee Related
- 2000-07-28 CA CA002391267A patent/CA2391267A1/en not_active Abandoned
- 2000-07-28 DE DE60041336T patent/DE60041336D1/de not_active Expired - Lifetime
- 2000-07-28 AU AU63914/00A patent/AU6391400A/en not_active Abandoned
- 2000-07-28 WO PCT/US2000/020732 patent/WO2001009138A2/en not_active Ceased
- 2000-07-28 CN CNA008131481A patent/CN1471536A/zh active Pending
- 2000-07-28 KR KR1020027001177A patent/KR20020016926A/ko not_active Withdrawn
- 2000-07-28 EP EP00950880A patent/EP1204665B1/en not_active Expired - Lifetime
- 2000-07-28 IL IL14785200A patent/IL147852A0/xx unknown
- 2000-07-28 AT AT00950880T patent/ATE420090T1/de not_active IP Right Cessation
- 2000-07-28 HK HK02104294.3A patent/HK1044333A1/zh unknown
- 2000-07-28 HU HU0202202A patent/HUP0202202A3/hu unknown
- 2000-07-28 ES ES00950880T patent/ES2321798T3/es not_active Expired - Lifetime
- 2000-07-28 BR BR0013065-6A patent/BR0013065A/pt not_active Application Discontinuation
- 2000-07-28 EA EA200200194A patent/EA200200194A1/ru unknown
- 2000-07-28 MX MXPA02000978A patent/MXPA02000978A/es unknown
-
2002
- 2002-08-13 US US10/217,865 patent/US20030045516A1/en not_active Abandoned
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