JP2003506377A5 - - Google Patents
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- Publication number
- JP2003506377A5 JP2003506377A5 JP2001514341A JP2001514341A JP2003506377A5 JP 2003506377 A5 JP2003506377 A5 JP 2003506377A5 JP 2001514341 A JP2001514341 A JP 2001514341A JP 2001514341 A JP2001514341 A JP 2001514341A JP 2003506377 A5 JP2003506377 A5 JP 2003506377A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- aromatic
- aliphatic group
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001931 aliphatic group Chemical group 0.000 description 204
- 125000003118 aryl group Chemical group 0.000 description 137
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 52
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 38
- 150000001875 compounds Chemical class 0.000 description 38
- 239000003814 drug Substances 0.000 description 28
- 229940124597 therapeutic agent Drugs 0.000 description 26
- 125000002252 acyl group Chemical group 0.000 description 22
- 229910052799 carbon Inorganic materials 0.000 description 20
- 125000004432 carbon atom Chemical group C* 0.000 description 20
- 229910052757 nitrogen Inorganic materials 0.000 description 20
- 125000004433 nitrogen atom Chemical group N* 0.000 description 20
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000000623 heterocyclic group Chemical group 0.000 description 11
- 125000004103 aminoalkyl group Chemical group 0.000 description 10
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 9
- 230000002159 abnormal effect Effects 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 125000006575 electron-withdrawing group Chemical group 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- 230000007115 recruitment Effects 0.000 description 6
- 125000006413 ring segment Chemical group 0.000 description 6
- 230000004913 activation Effects 0.000 description 5
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- VGYLMOJQAHXYCK-UHFFFAOYSA-N CN1CNCC1 Chemical compound CN1CNCC1 VGYLMOJQAHXYCK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/362,837 | 1999-07-28 | ||
| US09/362,837 US6509346B2 (en) | 1998-01-21 | 1999-07-28 | Chemokine receptor antagonists and methods of use therefor |
| PCT/US2000/020732 WO2001009138A2 (en) | 1999-07-28 | 2000-07-28 | Chemokine receptor antagonists and methods of use therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003506377A JP2003506377A (ja) | 2003-02-18 |
| JP2003506377A5 true JP2003506377A5 (https=) | 2007-10-04 |
| JP4903333B2 JP4903333B2 (ja) | 2012-03-28 |
Family
ID=23427735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001514341A Expired - Fee Related JP4903333B2 (ja) | 1999-07-28 | 2000-07-28 | ケモカイン受容体アンタゴニストおよびその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6509346B2 (https=) |
| EP (1) | EP1204665B1 (https=) |
| JP (1) | JP4903333B2 (https=) |
| KR (1) | KR20020016926A (https=) |
| CN (1) | CN1471536A (https=) |
| AT (1) | ATE420090T1 (https=) |
| AU (1) | AU6391400A (https=) |
| BR (1) | BR0013065A (https=) |
| CA (1) | CA2391267A1 (https=) |
| DE (1) | DE60041336D1 (https=) |
| EA (1) | EA200200194A1 (https=) |
| ES (1) | ES2321798T3 (https=) |
| HK (1) | HK1044333A1 (https=) |
| HU (1) | HUP0202202A3 (https=) |
| IL (1) | IL147852A0 (https=) |
| MX (1) | MXPA02000978A (https=) |
| WO (1) | WO2001009138A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| HU228314B1 (hu) * | 1998-09-04 | 2013-03-28 | Millennium Pharmaceuticals | Kemokin receptor antagonisták, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| US6919313B2 (en) * | 2001-03-30 | 2005-07-19 | President & Fellows Of Harvard College | Protein waving a PDZ and a RGS domain |
| CN1911930A (zh) * | 2001-11-21 | 2007-02-14 | 千禧药品公司 | 趋化因子受体拮抗剂及其方法和用途 |
| US7541365B2 (en) * | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| EP1553098A1 (en) * | 2002-10-18 | 2005-07-13 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| ES2665464T3 (es) * | 2003-03-28 | 2018-04-25 | Sigmoid Pharma Limited | Forma de dosificación oral sólida que contiene microcápsulas sin costuras |
| MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| CN100526301C (zh) * | 2003-12-26 | 2009-08-12 | 卫材R&D管理有限公司 | 1,2-二(环式基)取代苯化合物 |
| US7410971B2 (en) * | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| US20060276465A1 (en) * | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
| DE102004004719A1 (de) * | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
| EP1802287A2 (en) * | 2004-09-27 | 2007-07-04 | Sigmoid Biotechnologies Limited | Minicapsule formulations |
| US7960549B2 (en) * | 2004-12-17 | 2011-06-14 | Carole Neves | Solid forms of a chemokine receptor antagonist and methods of use thereof |
| CN101068798B (zh) | 2004-12-20 | 2010-05-12 | 卫材R&D管理有限公司 | 1-环丙基甲基-4-[2-(3,3,5,5-四甲基环己基)苯基]哌嗪的盐及结晶 |
| MY144974A (en) * | 2005-06-14 | 2011-11-30 | Eisai R&D Man Co Ltd | 1,2-di(cyclic) substituted benzene derivatives |
| ES2393814T3 (es) | 2007-04-04 | 2012-12-28 | Sigmoid Pharma Limited | Una composición farmacéutica oral |
| CA2685118C (en) * | 2007-04-26 | 2016-11-01 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
| WO2008132712A2 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Combination pharmaceutical compositions |
| US20090286823A1 (en) * | 2007-12-17 | 2009-11-19 | Millennium Pharmaceuticals Inc. | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| CN102573802A (zh) | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| WO2011137331A2 (en) * | 2010-04-30 | 2011-11-03 | Kinentia Biosciences Llc | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| KR101102335B1 (ko) * | 2011-09-06 | 2012-01-03 | (주)칠칠공사 | 수영 연습용 가변형 풀 |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| JP6716582B2 (ja) | 2014-11-07 | 2020-07-01 | サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | シクロスポリンを含む組成物 |
| CN115389659B (zh) * | 2022-08-23 | 2024-07-16 | 浙江中医药大学 | 一种细胞膜键合磁性碳球复合材料及其制备方法和应用 |
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| FR145F (https=) | 1964-06-01 | |||
| CH421138A (de) | 1965-11-04 | 1966-09-30 | Wander Ag Dr A | Verfahren zur Herstellung von Thioxanthenderivaten |
| US3409621A (en) | 1966-04-01 | 1968-11-05 | Schering Corp | Piperazino-aza-dibenzo-[a, d]-cycloheptenes |
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| NL6905642A (https=) | 1968-04-12 | 1969-10-14 | ||
| DE2163657A1 (de) | 1970-12-22 | 1972-07-13 | Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) | N-substituierte Piperidinverbindungen |
| GB1330966A (en) | 1970-12-22 | 1973-09-19 | Yoshitomi Pharmaceutical | N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them |
| CA1010870A (en) | 1972-12-08 | 1977-05-24 | Niels Lassen | Thiaxanthene derivative and method |
| US4250176A (en) | 1976-12-21 | 1981-02-10 | Janssen Pharmaceutica N.V. | Piperazine derivatives |
| US4335122A (en) | 1981-03-18 | 1982-06-15 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use |
| DE3326641A1 (de) | 1982-07-27 | 1984-02-02 | Basf Ag, 6700 Ludwigshafen | 5,6-dihydro-11-h-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel |
| US4547496A (en) | 1983-06-24 | 1985-10-15 | Kyowa Hakko Kogyo Co., Ltd. | Antiulcer [1] benzepino[3,4-b]pyridine and compositions |
| DE3402060A1 (de) | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPH0665664B2 (ja) | 1985-01-18 | 1994-08-24 | 大塚製薬株式会社 | モルフアントリジン誘導体 |
| SE8500273D0 (sv) | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
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| WO1989010369A1 (en) | 1988-04-28 | 1989-11-02 | Schering Corporation | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
| US5242931A (en) | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| US4999363A (en) | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| DE3838912A1 (de) | 1988-11-17 | 1990-05-23 | Thomae Gmbh Dr K | Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen |
| JPH0694464B2 (ja) | 1991-01-23 | 1994-11-24 | 協和醗酵工業株式会社 | 三環式化合物およびその中間体 |
| EP0511477B1 (en) | 1991-03-11 | 1996-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
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| WO1998043638A1 (en) | 1997-03-27 | 1998-10-08 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for autoimmune diseases |
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| CA2318088A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
| AU2331999A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) * | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| WO2000014089A1 (en) | 1998-09-04 | 2000-03-16 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
-
1999
- 1999-07-28 US US09/362,837 patent/US6509346B2/en not_active Expired - Lifetime
-
2000
- 2000-07-28 IL IL14785200A patent/IL147852A0/xx unknown
- 2000-07-28 WO PCT/US2000/020732 patent/WO2001009138A2/en not_active Ceased
- 2000-07-28 CA CA002391267A patent/CA2391267A1/en not_active Abandoned
- 2000-07-28 ES ES00950880T patent/ES2321798T3/es not_active Expired - Lifetime
- 2000-07-28 CN CNA008131481A patent/CN1471536A/zh active Pending
- 2000-07-28 HK HK02104294.3A patent/HK1044333A1/zh unknown
- 2000-07-28 AT AT00950880T patent/ATE420090T1/de not_active IP Right Cessation
- 2000-07-28 JP JP2001514341A patent/JP4903333B2/ja not_active Expired - Fee Related
- 2000-07-28 MX MXPA02000978A patent/MXPA02000978A/es unknown
- 2000-07-28 KR KR1020027001177A patent/KR20020016926A/ko not_active Withdrawn
- 2000-07-28 DE DE60041336T patent/DE60041336D1/de not_active Expired - Lifetime
- 2000-07-28 AU AU63914/00A patent/AU6391400A/en not_active Abandoned
- 2000-07-28 BR BR0013065-6A patent/BR0013065A/pt not_active Application Discontinuation
- 2000-07-28 EP EP00950880A patent/EP1204665B1/en not_active Expired - Lifetime
- 2000-07-28 EA EA200200194A patent/EA200200194A1/ru unknown
- 2000-07-28 HU HU0202202A patent/HUP0202202A3/hu unknown
-
2002
- 2002-08-13 US US10/217,865 patent/US20030045516A1/en not_active Abandoned
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