JP2009501234A5 - - Google Patents
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- Publication number
- JP2009501234A5 JP2009501234A5 JP2008521582A JP2008521582A JP2009501234A5 JP 2009501234 A5 JP2009501234 A5 JP 2009501234A5 JP 2008521582 A JP2008521582 A JP 2008521582A JP 2008521582 A JP2008521582 A JP 2008521582A JP 2009501234 A5 JP2009501234 A5 JP 2009501234A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aralkyl
- heteroaralkyl
- heterocycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)=C(C(*)=CC(*)C(**)C(*)C(C(*)(*1)C1C(*)C(*)(*)C(*)CC(*)Cc1c(c(O)c2)[N+](C)(*)[O-])OC(N(*)*)=O)N(*)c2c1O Chemical compound CC(*)=C(C(*)=CC(*)C(**)C(*)C(C(*)(*1)C1C(*)C(*)(*)C(*)CC(*)Cc1c(c(O)c2)[N+](C)(*)[O-])OC(N(*)*)=O)N(*)c2c1O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/180,314 US20060019941A1 (en) | 2003-12-23 | 2005-07-13 | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| PCT/US2006/027113 WO2007009007A2 (en) | 2005-07-13 | 2006-07-13 | Methods of treatment using hydroquinone ansamycins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009501234A JP2009501234A (ja) | 2009-01-15 |
| JP2009501234A5 true JP2009501234A5 (https=) | 2009-08-27 |
Family
ID=37637939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008521582A Pending JP2009501234A (ja) | 2005-07-13 | 2006-07-13 | ヒドロキノンアンサマイシンを用いた治療方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060019941A1 (https=) |
| EP (1) | EP1904057B1 (https=) |
| JP (1) | JP2009501234A (https=) |
| KR (1) | KR20080030093A (https=) |
| CN (1) | CN101267816A (https=) |
| AT (1) | ATE451919T1 (https=) |
| AU (1) | AU2006268196A1 (https=) |
| BR (1) | BRPI0612870A2 (https=) |
| CA (1) | CA2612506A1 (https=) |
| DE (1) | DE602006011161D1 (https=) |
| ES (1) | ES2337397T3 (https=) |
| IL (1) | IL188355A0 (https=) |
| MX (1) | MX2007016469A (https=) |
| NO (1) | NO20080304L (https=) |
| WO (1) | WO2007009007A2 (https=) |
| ZA (1) | ZA200800906B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004309395C1 (en) | 2003-12-23 | 2012-10-04 | Infinity Discovery, Inc. | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
| WO2006098761A2 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| US20100279994A1 (en) * | 2005-06-21 | 2010-11-04 | Inifinity Discovery, Inc. | Ansamycin Formulations and Methods of Use Thereof |
| FR2907453B1 (fr) * | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| PE20081506A1 (es) * | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| WO2008128063A1 (en) * | 2007-04-12 | 2008-10-23 | Infinity Discovery, Inc. | Hydroquinone ansamycin formulations |
| WO2009026548A1 (en) | 2007-08-23 | 2009-02-26 | The Regents Of The University Of Colorado | Hsp90 inhibitors with modified toxicity |
| US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
| AU2009283157B2 (en) * | 2008-08-21 | 2015-02-26 | Alvine Pharmaceuticals, Inc. | Formulation for oral administration of proteins |
| KR20110090925A (ko) * | 2008-10-15 | 2011-08-10 | 인피니티 파마슈티컬스, 인코포레이티드 | 안사마이신 하이드로퀴논 조성물 |
| WO2010135426A1 (en) * | 2009-05-19 | 2010-11-25 | Infinity Pharmaceuticals, Inc. | Methods of treating liposarcoma |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
| US9603829B2 (en) | 2011-11-14 | 2017-03-28 | The Regents Of The University Of Colorado, A Body Corporate | HSP90 inhibitors with modified toxicity |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| EA036496B1 (ru) | 2014-05-01 | 2020-11-17 | Ионис Фармасьютикалз, Инк. | Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b |
| JP6948708B2 (ja) * | 2015-06-19 | 2021-10-13 | センチュリオン バイオファーマ コーポレイション | 薬物制御放出のための送達系 |
| CN114259564B (zh) * | 2021-11-30 | 2023-03-14 | 清华大学 | Hsp90抑制剂阻碍stat3线粒体转运和治疗哮喘的新应用 |
| CN115227692A (zh) * | 2022-09-05 | 2022-10-25 | 中国医学科学院基础医学研究所 | Reblastatin在制备治疗慢性惊厥的药物中的用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| GB2106111B (en) * | 1981-09-17 | 1985-11-06 | Takeda Chemical Industries Ltd | Macbecin derivatives and their production |
| US4762857A (en) * | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| CA2127457A1 (en) * | 1992-01-06 | 1993-07-22 | Walter P. Cullen | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| US5387584A (en) * | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| JP2794342B2 (ja) * | 1993-06-29 | 1998-09-03 | ファイザー・インク． | 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体 |
| US5932566A (en) * | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| DK1373215T3 (da) * | 2001-03-30 | 2006-11-13 | Us Health | Gelanamycinderivater egnet til behandling af cancer |
| US6872715B2 (en) * | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| AU2002330998A1 (en) * | 2001-08-06 | 2003-02-24 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003066005A2 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| AU2004309395C1 (en) * | 2003-12-23 | 2012-10-04 | Infinity Discovery, Inc. | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
| WO2006098761A2 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
-
2005
- 2005-07-13 US US11/180,314 patent/US20060019941A1/en not_active Abandoned
-
2006
- 2006-07-13 ES ES06787067T patent/ES2337397T3/es active Active
- 2006-07-13 ZA ZA200800906A patent/ZA200800906B/xx unknown
- 2006-07-13 BR BRPI0612870-0A patent/BRPI0612870A2/pt not_active IP Right Cessation
- 2006-07-13 DE DE602006011161T patent/DE602006011161D1/de active Active
- 2006-07-13 WO PCT/US2006/027113 patent/WO2007009007A2/en not_active Ceased
- 2006-07-13 CA CA002612506A patent/CA2612506A1/en not_active Abandoned
- 2006-07-13 AT AT06787067T patent/ATE451919T1/de not_active IP Right Cessation
- 2006-07-13 KR KR1020087003410A patent/KR20080030093A/ko not_active Withdrawn
- 2006-07-13 MX MX2007016469A patent/MX2007016469A/es not_active Application Discontinuation
- 2006-07-13 CN CNA2006800335526A patent/CN101267816A/zh active Pending
- 2006-07-13 EP EP06787067A patent/EP1904057B1/en active Active
- 2006-07-13 JP JP2008521582A patent/JP2009501234A/ja active Pending
- 2006-07-13 AU AU2006268196A patent/AU2006268196A1/en not_active Abandoned
-
2007
- 2007-12-24 IL IL188355A patent/IL188355A0/en unknown
-
2008
- 2008-01-16 NO NO20080304A patent/NO20080304L/no not_active Application Discontinuation
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