JP2003501361A5 - - Google Patents
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- JP2003501361A5 JP2003501361A5 JP2001500655A JP2001500655A JP2003501361A5 JP 2003501361 A5 JP2003501361 A5 JP 2003501361A5 JP 2001500655 A JP2001500655 A JP 2001500655A JP 2001500655 A JP2001500655 A JP 2001500655A JP 2003501361 A5 JP2003501361 A5 JP 2003501361A5
- Authority
- JP
- Japan
- Prior art keywords
- exendin
- pharmaceutical composition
- agonist
- exendin agonist
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 18
- 239000000556 agonist Substances 0.000 description 17
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exendin-4 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 11
- 101700024131 EXE4 Proteins 0.000 description 8
- 229960001519 exenatide Drugs 0.000 description 8
- 150000001408 amides Chemical class 0.000 description 3
- 208000004104 Gestational Diabetes Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 108010015174 exendin 3 Proteins 0.000 description 2
- LMHMJYMCGJNXRS-IOPUOMRJSA-N exendin-3 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@H](C)O)[C@H](C)O)C(C)C)C1=CC=CC=C1 LMHMJYMCGJNXRS-IOPUOMRJSA-N 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000004369 Blood Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000036849 Islet amyloid polypeptide Human genes 0.000 description 1
- 108010041872 Islet amyloid polypeptide Proteins 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- -1 exendin-4 amide Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Description
【特許請求の範囲】
【請求項1】 治療上有効量のエキセンジンまたはエキセンジンアゴニストを含むことを特徴とする対象における妊娠糖尿病を治療するための医薬組成物。
【請求項2】 連続投与されることを特徴とする請求項1記載の医薬組成物。
【請求項3】 注射によって投与されることを特徴とする請求項1記載の医薬組成物。
【請求項4】 該注射が皮下注射であることを特徴とする請求項3記載の医薬組成物。
【請求項5】 一日当たり約1μg〜30μgないし1mgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項6】 一日当たり約1μg〜30μgないし500mgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項7】 一日当たり約1μg〜30μgないし100μgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項8】 一日当たり約3μgないし約50μgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項9】 該対象がヒトであることを特徴とする請求項1記載の医薬組成物。
【請求項10】 治療上有効量のエキセンジンまたはエキセンジンアゴニストを含むことを特徴とする妊娠糖尿病に罹っている対象の血中グルコースレベルを低減するための医薬組成物。
【請求項11】 該エキセンジンがエキセンジン−3である請求項1〜10いずれか1記載の医薬組成物。
【請求項12】 該エキセンジンがエキセンジン−4である請求項1〜10いずれか1記載の医薬組成物。
【請求項13】 該エキセンジンアゴニストが、エキセンジン−4酸、エキセンジン−4(1〜30)、エキセンジン−4(1〜30)アミド、エキセンジン−4(1〜28)アミド、14Leu,25Pheエキセンジン−4アミド、および14Leu,25Pheエキセンジン−4(1〜28)アミドよりなる群から選択される請求項1〜10いずれか1記載の医薬組成物。
【請求項14】 該医薬組成物の投与の後に、治療上有効量の、インスリンおよびアミリンアゴニストよりなる群から選択される1以上の化合物が投与されることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
【請求項15】 該エキセンジンアゴニストが式Iで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1に記載の医薬組成物。
【請求項16】 該エキセンジンアゴニストが式IIで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
【請求項17】 該エキセンジンアゴニストが式IIIで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
【請求項1】 治療上有効量のエキセンジンまたはエキセンジンアゴニストを含むことを特徴とする対象における妊娠糖尿病を治療するための医薬組成物。
【請求項2】 連続投与されることを特徴とする請求項1記載の医薬組成物。
【請求項3】 注射によって投与されることを特徴とする請求項1記載の医薬組成物。
【請求項4】 該注射が皮下注射であることを特徴とする請求項3記載の医薬組成物。
【請求項5】 一日当たり約1μg〜30μgないし1mgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項6】 一日当たり約1μg〜30μgないし500mgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項7】 一日当たり約1μg〜30μgないし100μgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項8】 一日当たり約3μgないし約50μgのエキセンジンまたはエキセンジンアゴニストが投与されることを特徴とする請求項1記載の医薬組成物。
【請求項9】 該対象がヒトであることを特徴とする請求項1記載の医薬組成物。
【請求項10】 治療上有効量のエキセンジンまたはエキセンジンアゴニストを含むことを特徴とする妊娠糖尿病に罹っている対象の血中グルコースレベルを低減するための医薬組成物。
【請求項11】 該エキセンジンがエキセンジン−3である請求項1〜10いずれか1記載の医薬組成物。
【請求項12】 該エキセンジンがエキセンジン−4である請求項1〜10いずれか1記載の医薬組成物。
【請求項13】 該エキセンジンアゴニストが、エキセンジン−4酸、エキセンジン−4(1〜30)、エキセンジン−4(1〜30)アミド、エキセンジン−4(1〜28)アミド、14Leu,25Pheエキセンジン−4アミド、および14Leu,25Pheエキセンジン−4(1〜28)アミドよりなる群から選択される請求項1〜10いずれか1記載の医薬組成物。
【請求項14】 該医薬組成物の投与の後に、治療上有効量の、インスリンおよびアミリンアゴニストよりなる群から選択される1以上の化合物が投与されることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
【請求項15】 該エキセンジンアゴニストが式Iで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1に記載の医薬組成物。
【請求項16】 該エキセンジンアゴニストが式IIで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
【請求項17】 該エキセンジンアゴニストが式IIIで表されるエキセンジンアゴニストであることを特徴とする請求項1〜10いずれか1記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/323,867 | 1999-06-01 | ||
US09/323,867 US6506724B1 (en) | 1999-06-01 | 1999-06-01 | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
PCT/US2000/014231 WO2000073331A2 (en) | 1999-06-01 | 2000-05-23 | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2003501361A JP2003501361A (ja) | 2003-01-14 |
JP2003501361A5 true JP2003501361A5 (ja) | 2007-02-01 |
Family
ID=23261070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001500655A Pending JP2003501361A (ja) | 1999-06-01 | 2000-05-23 | 妊娠糖尿病の治療のためのエキセンジンおよびそのアゴニストの使用 |
Country Status (13)
Country | Link |
---|---|
US (4) | US6506724B1 (ja) |
EP (1) | EP1181043B1 (ja) |
JP (1) | JP2003501361A (ja) |
AT (1) | ATE367169T1 (ja) |
AU (2) | AU778002C (ja) |
CA (1) | CA2373266C (ja) |
CY (1) | CY1107752T1 (ja) |
DE (1) | DE60035584T2 (ja) |
DK (1) | DK1181043T3 (ja) |
ES (1) | ES2290039T3 (ja) |
HK (1) | HK1044280B (ja) |
PT (1) | PT1181043E (ja) |
WO (1) | WO2000073331A2 (ja) |
Families Citing this family (112)
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- 2000-05-23 JP JP2001500655A patent/JP2003501361A/ja active Pending
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- 2000-05-23 AU AU52846/00A patent/AU778002C/en not_active Ceased
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- 2000-05-23 AT AT00937710T patent/ATE367169T1/de active
- 2000-05-23 DK DK00937710T patent/DK1181043T3/da active
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