JP2002543202A5 - - Google Patents

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JP2002543202A5
JP2002543202A5 JP2000615617A JP2000615617A JP2002543202A5 JP 2002543202 A5 JP2002543202 A5 JP 2002543202A5 JP 2000615617 A JP2000615617 A JP 2000615617A JP 2000615617 A JP2000615617 A JP 2000615617A JP 2002543202 A5 JP2002543202 A5 JP 2002543202A5
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group
alkyl
cycloalkyl
independently
alkenyl
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JP2000615617A
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JP4743673B2 (ja
JP2002543202A (ja
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Priority claimed from PCT/US2000/011591 external-priority patent/WO2000066587A2/en
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Publication of JP4743673B2 publication Critical patent/JP4743673B2/ja
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JP2000615617A 1999-04-30 2000-04-27 ポリアミンおよび治療におけるそれらの使用 Expired - Fee Related JP4743673B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13177999P 1999-04-30 1999-04-30
US60/131,779 1999-04-30
PCT/US2000/011591 WO2000066587A2 (en) 1999-04-30 2000-04-27 Polyamines and their use in therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011017302A Division JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

Publications (3)

Publication Number Publication Date
JP2002543202A JP2002543202A (ja) 2002-12-17
JP2002543202A5 true JP2002543202A5 (https=) 2007-06-07
JP4743673B2 JP4743673B2 (ja) 2011-08-10

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JP2000615617A Expired - Fee Related JP4743673B2 (ja) 1999-04-30 2000-04-27 ポリアミンおよび治療におけるそれらの使用
JP2011017302A Pending JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

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JP2011017302A Pending JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

Country Status (14)

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US (3) US6794545B1 (https=)
EP (2) EP1177197B1 (https=)
JP (2) JP4743673B2 (https=)
AT (1) ATE335719T1 (https=)
AU (3) AU4679900A (https=)
BR (1) BR0010701A (https=)
CA (1) CA2371625C (https=)
DE (1) DE60029944T2 (https=)
ES (1) ES2269138T3 (https=)
HK (1) HK1040993B (https=)
IL (2) IL146127A0 (https=)
MX (1) MXPA01011000A (https=)
NZ (1) NZ515140A (https=)
WO (1) WO2000066587A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4743673B2 (ja) * 1999-04-30 2011-08-10 プロゲン ファーマシューティカルズ, インコーポレイテッド ポリアミンおよび治療におけるそれらの使用
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
AU4678300A (en) 1999-04-30 2000-11-17 Slil Biomedical Corporation Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
WO2001097794A2 (en) * 2000-06-21 2001-12-27 Georgetown University Inhibitors of matriptase for the treatment of cancer
AU2001297817A1 (en) 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
WO2003013245A1 (en) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
US7030126B2 (en) 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
EP1448183A2 (en) * 2001-11-16 2004-08-25 ALS Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
MXPA04005509A (es) 2001-12-07 2004-12-06 Slil Biomedical Corp Poliaminas sustituidas con cicloalquilo para terapia de cancer y metodos de sintesis de las mismas.
US20050027016A1 (en) 2002-02-07 2005-02-03 Fahl Kathleen L Polyamine compounds and compositions for use in conjection with cancer therapy
WO2004002991A1 (en) * 2002-06-26 2004-01-08 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
WO2005014524A2 (en) 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
JP2007537158A (ja) * 2004-02-13 2007-12-20 メディクエスト セラピューティックス インク アンチザイムフレームシフトを活性化するポリアミン類似体
FR2867189A1 (fr) * 2004-03-08 2005-09-09 Ludovic Bourre Nouveaux composes medicamenteux destines au traitement des pathologies dependantes de l'activite proteine kinase
MX2007004030A (es) * 2004-10-04 2008-01-14 Cellgate Inc Analogos de poliamina como agentes terapeuticos para enfermedades oculares.
WO2006052854A2 (en) * 2004-11-04 2006-05-18 Raul Andino Syntheses of polyamine conjugates of small interfering rnas (si-rnas) and conjugates formed thereby
WO2006086773A2 (en) * 2005-02-11 2006-08-17 Cellgate, Inc. Polyamine analogs as modulators of cell migration and cell motility
CA2619005A1 (en) 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
WO2007111993A2 (en) * 2006-03-22 2007-10-04 Cellgate, Inc. Polyamine analogs as therapeutic agents for skin diseases
US8258186B2 (en) 2009-07-16 2012-09-04 Pathologica, Llc Pharmaceutical for oral delivery comprising MGBG
WO2013134047A2 (en) 2012-03-07 2013-09-12 The Mclean Hospital Corporation Aminoquinoline derivatives and uses thereof
JP6338065B2 (ja) 2012-12-20 2018-06-06 ヘンケル アイピー アンド ホールディング ゲゼルシャフト ミット ベシュレンクテル ハフツング 容器用シーリング材組成物
DK2943189T3 (da) 2013-01-08 2021-04-06 Pathologica Llc Mitoguazon til behandling af progressiv multipel sklerose
EP3613426A1 (en) 2014-05-21 2020-02-26 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
EP3746105A4 (en) 2018-01-29 2022-05-18 Ohio State Innovation Foundation CYCLIC PEPTIDYLIN HIBITORS OF THE CAL-PDZ-BINDING DOMAIN
EP3749365A4 (en) 2018-01-29 2022-01-12 Ohio State Innovation Foundation PEPTIDY INHIBITORS OF THE CALCINEURIN-NFAT INTERACTION
AU2019213664B2 (en) * 2018-01-30 2023-03-16 Panbela Therapeutics, Inc. Methods for producing (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol
TW201945014A (zh) 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法
WO2021108632A1 (en) 2019-11-25 2021-06-03 The General Hospital Corporation Methods and compositions for enzymatic polymerization of n3' -> p5' phosphoramidate dna

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2440724A (en) * 1944-10-27 1948-05-04 Commercial Solvents Corp Nu-substituted, 2-butene-1, 4-diamines, and process for preparing
US3008993A (en) * 1957-02-14 1961-11-14 Monsanto Chemicals Alkenyl polyamines
CH413364A (de) * 1959-04-22 1966-05-15 Geigy Ag J R Verfahren zur Herstellung von oxydationsbeständigen Polyamiden
US3397223A (en) * 1966-05-19 1968-08-13 Shell Oil Co Preparation of cyclopropane derivatives
US3773833A (en) * 1970-07-14 1973-11-20 Monsanto Co Unsaturated polyamines
US4035174A (en) * 1975-10-09 1977-07-12 Merck & Co., Inc. Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines and methods for their preparation
SE417569B (sv) 1975-10-22 1981-03-30 Kemanobel Ab Vissa angivna blandningar av guaniderade alifatiska polyaminer, eller deras syraadditionssalter till anvendning som pesticid och antimikrobiellt medel
US4153567A (en) * 1977-11-10 1979-05-08 Milliken Research Corporation Additives for lubricants and fuels
US4443604A (en) * 1979-07-31 1984-04-17 Standard Oil Company (Indiana) 1,4,Bis-N,N'-dipolyalkylquinonyl aminopropyl piperazine
US4491651A (en) 1982-05-17 1985-01-01 Petrolite Corporation Antistats containing acrylonitrile copolymers and polyamines
US4537601A (en) 1982-05-17 1985-08-27 Petrolite Corporation Antistats containing acrylonitrile copolymers and polyamines
US4661509A (en) * 1982-09-28 1987-04-28 Gordon Arnold Z Methods for treating leukopenia
JPS60126291A (ja) * 1983-03-14 1985-07-05 Koichi Shiyudo ポルフイリン誘導体
US4590288A (en) 1983-06-29 1986-05-20 Exxon Research And Engineering Co. Bi- or polymetallic coordination complex
US4551550A (en) 1983-12-06 1985-11-05 Merrell Dow Pharmaceuticals Inc. N-2,3-Butadienyl-1,4-butanediamine derivatives
DE3401675A1 (de) 1984-01-19 1985-07-25 Bayer Ag, 5090 Leverkusen Neue polyamine und ein verfahren zu ihrer herstellung
CA1315780C (en) * 1986-01-17 1993-04-06 Yozo Fukuda Porphyrin derivatives
JPH0720963B2 (ja) * 1986-01-17 1995-03-08 浜理薬品工業株式会社 ポルフイリン誘導体
US4698446A (en) 1986-07-01 1987-10-06 The Bf Goodrich Company Synthesis of polyamines and mixture formed thereby, of diprimary polyalkylene polyamines with disubstituted N-adjacent terminal carbon atom(s)
US4784736A (en) 1986-07-07 1988-11-15 Bend Research, Inc. Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US6184232B1 (en) 1986-12-02 2001-02-06 University Of Florida Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
US5677351A (en) * 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
WO1989002269A1 (en) 1987-09-08 1989-03-23 The Rockefeller University Use of metalloporphyrins to reverse the toxic effect of tumor therapy
US5654484A (en) * 1987-10-08 1997-08-05 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US4868219A (en) * 1988-04-07 1989-09-19 Thornfeldt Carl R Treatment of skin diseases with aliphatic amines
JPH01246286A (ja) * 1988-03-28 1989-10-02 Hamari Yakuhin Kogyo Kk ポルフィリン誘導体
US4935449A (en) 1988-08-04 1990-06-19 Merrell Dow Pharmaceuticals Inc. N-2,3-butadienyl tri- and tetraaminoalkane derivatives
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5374658A (en) 1988-10-26 1994-12-20 Ortho Phamaceutical Corporation Use of oxidized polyamines, especially NN'-bis-(3-propionaldehyde)-1-4-diaminobutane (spermine dialdehye) in graft treatment
US5719193A (en) * 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
US5021571A (en) 1989-06-29 1991-06-04 Associated Universities, Inc. Cyclohexyl EDTA monoanhydride
US5283367A (en) * 1989-08-30 1994-02-01 Ciba-Geigy Corporation Substituted 1,4-diamino-2-butene stabilizers
US5021409A (en) 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
JP3007391B2 (ja) * 1990-08-13 2000-02-07 花王株式会社 新規第4級アンモニウム化合物
US5561136A (en) 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
US5354782A (en) 1991-01-17 1994-10-11 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5217964A (en) 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
GB9111794D0 (en) * 1991-05-31 1991-07-24 Robins David J Antifungal compounds
JPH0532902A (ja) * 1991-07-31 1993-02-09 Idemitsu Petrochem Co Ltd 熱可塑性樹脂組成物
JP2684473B2 (ja) 1991-09-02 1997-12-03 富士写真フイルム株式会社 マイクロカプセルの連続的製造方法
US5242684A (en) * 1991-10-25 1993-09-07 Isp Investments Inc. Antimicrobial, low toxicity, non-irritating composition comprising a blend of bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer
US5512597A (en) * 1991-11-08 1996-04-30 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
US6051611A (en) * 1991-11-08 2000-04-18 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias
CA2094341A1 (en) 1992-04-28 1993-10-29 Carl W. Porter Methods for the use of spermidine/spermine n1-acetyltransferase as a prognostic indicator and/or tumor response marker
DE4232925A1 (de) 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
GB9220921D0 (en) 1992-10-05 1992-11-18 Merrell Dow Pharma Polyamine derivatives as anticytomegaloviral agents
US5274090A (en) * 1992-11-09 1993-12-28 The Board Of Trustees Of The Leland Stanford Junior University Tetraphenylporphyrin compounds and method
ES2119203T3 (es) 1993-05-26 1998-10-01 Merrell Pharma Inc Derivados de poliamina n-alquiltio utilizados como agentes radioprotectores.
US5451347A (en) * 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
CA2126889C (en) 1993-09-02 2005-06-14 Paul R. Hart Method of breaking reverse emulsions in a crude oil desalting system
US5541230A (en) 1993-11-05 1996-07-30 Us Health Therapeutic polyamines
DK0686143T3 (da) * 1993-12-27 1999-05-17 Novartis Ag Umættede aminoforbindelser som middel mod cancer og mod protozoer
US5413719A (en) 1994-01-18 1995-05-09 Nalco Chemical Company Fluorescent tracer in a water treatment process
JPH07277964A (ja) * 1994-04-08 1995-10-24 Nippon Kayaku Co Ltd 抗腫瘍剤
DE4413402A1 (de) * 1994-04-18 1995-10-19 Hoechst Ag Verfahren zur Herstellung von Zwischenprodukten für die Synthese von Glucose-6-Phosphatase-Inhibitoren sowie neue Zwischenprodukte
US5516807A (en) 1994-10-25 1996-05-14 Warner-Lambert Company Method for treating vascular proliferative disorders following balloon angioplasty
CA2203883A1 (en) 1994-10-31 1996-05-09 Gerald Guerro Methods of coagulating and decolorizing waste streams
WO1996022962A1 (en) * 1995-01-23 1996-08-01 The Trustees Of Columbia University In The City Of New York Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
FR2729852A1 (fr) 1995-01-30 1996-08-02 Oreal Composition reductrice comprenant un acide amine basique et un polymere cationique
USH1633H (en) 1995-03-08 1997-02-04 The Lubrizol Corporation Deodorizing polysulfide materials
US5912341A (en) * 1995-03-14 1999-06-15 Hoffman/Barrett, L.L.C. Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom
US5612478A (en) 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5677349A (en) 1995-04-27 1997-10-14 Gilad; Gad M. Agmatine for the treatment of neurotrauma and neurodegenerative diseases
US5606053A (en) 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5677350A (en) 1995-06-07 1997-10-14 Wisconsin Alumni Research Foundation Inhibition of cancer cell growth, proliferation, and metastasis using N,N'-dα,ω-diaminoalkanes
US5646188A (en) 1995-07-05 1997-07-08 Teva Pharmaceutical Industries, Ltd. Polyamine derivatives of 1-aminoindan
US5608061A (en) 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
GB9516929D0 (en) 1995-08-18 1995-10-18 Ciba Geigy Ag Pigment compositions
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
US5886051A (en) * 1995-11-08 1999-03-23 University Of Florida Research Foundation, Inc. Methods and compositions for the treatment of neurodegeneration
US6126964A (en) * 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US5744453A (en) 1996-01-05 1998-04-28 Mintz; Clifford S. Polyamine conjugates for treatment of infection
US5962533A (en) * 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines
CN1105496C (zh) * 1996-02-07 2003-04-16 巴科曼实验室国际公司 含一种紫罗烯聚合物及十二烷胺盐的协同抗微生物组合物及其使用方法
AU2193797A (en) 1996-03-01 1997-09-16 Chiron Corporation Delivery of therapeutic agents to the prostate
US6034129A (en) * 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
US5958397A (en) * 1996-07-22 1999-09-28 Schering-Plough Healthcare Products, Inc. Method and composition for protecting against jellyfish stings
US5906996A (en) * 1996-08-21 1999-05-25 Murphy; Michael A. Tetramine treatment of neurological disorders
DE69733207T2 (de) * 1996-09-13 2006-02-02 University of Florida Research Foundation, Inc., Gainesville Verfahren zur hemmung von elf5a-biosynthese
ES2171911T3 (es) * 1996-10-18 2002-09-16 Wisconsin Alumni Res Found Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos.
US5763388A (en) 1996-12-18 1998-06-09 Dsm Copolymer, Inc. Process for producing improved silica-reinforced masterbatch of polymers prepared in latex form
JPH10204040A (ja) 1997-01-24 1998-08-04 Daicel Chem Ind Ltd 脂環式ポリアミン類およびその製造方法
US5843959A (en) 1997-03-19 1998-12-01 University Of Florida Research Foundation, Inc. Methods and bicyclic polyamine compositions for the treatment of inflammation
US6235794B1 (en) * 1997-04-03 2001-05-22 University Of Florida Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment
US20030013772A1 (en) 2000-02-23 2003-01-16 Murphy Michael A. Composition, synthesis and therapeutic applications of polyamines
US6307102B1 (en) * 1997-10-15 2001-10-23 Tosoh Corporation Amine catalyst for producing polyurethane and polyisocyanurate
US5889061A (en) * 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
CA2304557C (en) 1998-04-21 2008-12-30 Universite Laval Polyamine transport inhibitors
US20020155999A1 (en) 1998-04-30 2002-10-24 Han In Suk Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer
EP1082138B1 (en) * 1998-06-05 2004-08-25 The Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
DE19831217A1 (de) * 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
AU5241499A (en) * 1998-07-31 2000-02-21 Health Research, Inc., The Method of treating cancer in patients having a deficiency in p53 tumor suppressor gene
AU1180300A (en) * 1998-11-16 2000-06-05 Rohto Pharmaceutical Co., Ltd. Liquid ophthalmic preparations
JP3747355B2 (ja) 1998-12-21 2006-02-22 独立行政法人理化学研究所 鎖状ポリアミン系化合物及びポリアミン系抗ガン剤
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
AU4678300A (en) 1999-04-30 2000-11-17 Slil Biomedical Corporation Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
JP4743673B2 (ja) 1999-04-30 2011-08-10 プロゲン ファーマシューティカルズ, インコーポレイテッド ポリアミンおよび治療におけるそれらの使用
CA2372611A1 (en) 1999-04-30 2000-11-09 Andrei V. Blokhin Quinones for treatment of diseases
US6673890B1 (en) * 1999-07-16 2004-01-06 Basf Aktiengesellschaft Zwitterionic polyamines and process for their production
GB9920107D0 (en) 1999-08-26 1999-10-27 Avecia Ltd Fluidising agents
FR2802817B1 (fr) * 1999-12-23 2002-10-11 Centre Nat Rech Scient Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete
DE60128407T2 (de) * 2000-01-10 2008-01-10 Zetetic Research, Inc., Coconut Creek Verwendung einer pharmazeutischen zusammensetzung enthaltend zwei quaternäre ammoniumverbindungen und eine organometal-verbindung zur behandlung von viralen und fungalen infekten und krankheiten
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US7351807B2 (en) * 2000-01-18 2008-04-01 Mallinckrodt Inc. Cyanine-sulfenates for dual phototherapy
US7235685B2 (en) 2001-07-03 2007-06-26 Mallinckrodt, Inc. Aromatic sulfenates for type I phototherapy
AU7814301A (en) 2000-08-02 2002-02-13 Slil Biomedical Corp Cyclic polyamine compounds for cancer therapy
US6444707B1 (en) * 2000-08-22 2002-09-03 West Agro Topically applied hoof treatment composition and concentrate
EP1318801B1 (en) * 2000-09-19 2009-03-11 Dermal Therapy (Barbados) Inc. Topical analgesic compositions containing aliphatic polyamines and methods of using same
US6545181B1 (en) * 2000-10-24 2003-04-08 Pilot Chemical Holdings, Inc. Demulsifying compound and a method of breaking or inhibiting emulsions
CA2429982C (en) * 2000-12-01 2010-07-13 Ning Li Copper chelators for treating ocular inflammation
US7754765B2 (en) 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
US6399662B1 (en) * 2000-12-13 2002-06-04 University Of Florida Method and composition for the treatment of diarrhea and gastrointestinal spasms
WO2002062341A1 (en) 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth
US6635679B2 (en) * 2001-05-14 2003-10-21 Akzo Nobel N.V. Methods and compositions for inactivating viruses
CA2448570A1 (en) * 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US6713653B2 (en) * 2001-08-24 2004-03-30 E. I. Du Pont De Nemours And Company Polyamines and polymers made therewith
IL161428A0 (en) 2001-10-16 2004-09-27 Slil Biomedical Corp Oligoamine derivatives, methods for the production thereof and pharmaceutical compositions containing the same
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
US7030126B2 (en) * 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
MXPA04005509A (es) 2001-12-07 2004-12-06 Slil Biomedical Corp Poliaminas sustituidas con cicloalquilo para terapia de cancer y metodos de sintesis de las mismas.
US20050027016A1 (en) 2002-02-07 2005-02-03 Fahl Kathleen L Polyamine compounds and compositions for use in conjection with cancer therapy
US6881732B2 (en) * 2002-06-13 2005-04-19 Chelator Llc Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements
WO2004002991A1 (en) 2002-06-26 2004-01-08 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
US20040019043A1 (en) * 2002-07-23 2004-01-29 Dimitri Coucouvanis Thiomolybdate analogues and uses thereof
US7189865B2 (en) * 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
US20040192665A1 (en) * 2002-08-02 2004-09-30 Slil Biomedical Corporation Conjugates of porphyrin compounds with chemotherapeutic agents

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