JP2002543202A5 - - Google Patents

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JP2002543202A5
JP2002543202A5 JP2000615617A JP2000615617A JP2002543202A5 JP 2002543202 A5 JP2002543202 A5 JP 2002543202A5 JP 2000615617 A JP2000615617 A JP 2000615617A JP 2000615617 A JP2000615617 A JP 2000615617A JP 2002543202 A5 JP2002543202 A5 JP 2002543202A5
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alkyl
cycloalkyl
independently
alkenyl
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JP2000615617A
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JP2002543202A (ja
JP4743673B2 (ja
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Priority claimed from PCT/US2000/011591 external-priority patent/WO2000066587A2/en
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Publication of JP2002543202A5 publication Critical patent/JP2002543202A5/ja
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Publication of JP4743673B2 publication Critical patent/JP4743673B2/ja
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JP2000615617A 1999-04-30 2000-04-27 ポリアミンおよび治療におけるそれらの使用 Expired - Fee Related JP4743673B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13177999P 1999-04-30 1999-04-30
US60/131,779 1999-04-30
PCT/US2000/011591 WO2000066587A2 (en) 1999-04-30 2000-04-27 Polyamines and their use in therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011017302A Division JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

Publications (3)

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JP2002543202A JP2002543202A (ja) 2002-12-17
JP2002543202A5 true JP2002543202A5 (https=) 2007-06-07
JP4743673B2 JP4743673B2 (ja) 2011-08-10

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JP2000615617A Expired - Fee Related JP4743673B2 (ja) 1999-04-30 2000-04-27 ポリアミンおよび治療におけるそれらの使用
JP2011017302A Pending JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

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JP2011017302A Pending JP2011084586A (ja) 1999-04-30 2011-01-28 ポリアミンおよび治療におけるそれらの使用

Country Status (14)

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US (3) US6794545B1 (https=)
EP (2) EP1698629A3 (https=)
JP (2) JP4743673B2 (https=)
AT (1) ATE335719T1 (https=)
AU (3) AU4679900A (https=)
BR (1) BR0010701A (https=)
CA (1) CA2371625C (https=)
DE (1) DE60029944T2 (https=)
ES (1) ES2269138T3 (https=)
HK (1) HK1040993B (https=)
IL (2) IL146127A0 (https=)
MX (1) MXPA01011000A (https=)
NZ (1) NZ515140A (https=)
WO (1) WO2000066587A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
DE60029944T2 (de) 1999-04-30 2007-04-05 Cellgate, Inc., Redwood City Polyamine und ihre therapeutische verwendung
IL146126A0 (en) * 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
WO2001097794A2 (en) * 2000-06-21 2001-12-27 Georgetown University Inhibitors of matriptase for the treatment of cancer
WO2003013245A1 (en) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
EP1448183A2 (en) * 2001-11-16 2004-08-25 ALS Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
JP2005510524A (ja) 2001-11-16 2005-04-21 アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド ポリアミン経路の調節による神経変性障害の治療
CA2469354A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003066572A1 (en) 2002-02-07 2003-08-14 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
EP1515973A1 (en) 2002-06-26 2005-03-23 Cellgate Inc. Porphyrin-polyamine conjugates for cancer therapy
US7314959B2 (en) 2003-08-07 2008-01-01 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
JP2007537158A (ja) * 2004-02-13 2007-12-20 メディクエスト セラピューティックス インク アンチザイムフレームシフトを活性化するポリアミン類似体
FR2867189A1 (fr) * 2004-03-08 2005-09-09 Ludovic Bourre Nouveaux composes medicamenteux destines au traitement des pathologies dependantes de l'activite proteine kinase
BRPI0517551A (pt) * 2004-10-04 2008-10-14 Cellgate Inc análogos de poliamina como agentes terapêuticos para doenças oculares
WO2006052854A2 (en) * 2004-11-04 2006-05-18 Raul Andino Syntheses of polyamine conjugates of small interfering rnas (si-rnas) and conjugates formed thereby
WO2006086773A2 (en) * 2005-02-11 2006-08-17 Cellgate, Inc. Polyamine analogs as modulators of cell migration and cell motility
WO2007021839A2 (en) 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
US20070232677A1 (en) * 2006-03-14 2007-10-04 Marton Laurence J Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
WO2007111993A2 (en) * 2006-03-22 2007-10-04 Cellgate, Inc. Polyamine analogs as therapeutic agents for skin diseases
JP6112449B2 (ja) 2009-07-16 2017-04-12 パソロジカ エルエルシー Mgbgを含む経口送達用の医薬品および疾患を処置する方法
PT2822936T (pt) 2012-03-07 2021-12-02 Univ Of Delhi Derivados da aminoquinolina e suas utilizações
US11421097B2 (en) 2012-12-20 2022-08-23 Henkel Ag & Co. Kgaa Container sealant composition
CN109432073A (zh) 2013-01-08 2019-03-08 帕萨罗杰卡有限公司 Mgbg在制备治疗或预防进行性ms及其进展的药物中的用途
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
JP6807831B2 (ja) 2014-05-21 2021-01-06 エントラーダ セラピューティクス,インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
WO2016033368A1 (en) 2014-08-27 2016-03-03 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
CA3078504A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
WO2019148195A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of cal-pdz binding domain
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
EP4257581A1 (en) * 2018-01-30 2023-10-11 Panbela Therapeutics, Inc. Methods for producing (6s,15s)-3,8,13,18-tetraazaicosane-6,15-diol
WO2019165183A1 (en) 2018-02-22 2019-08-29 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US12428658B2 (en) 2019-11-25 2025-09-30 The General Hospital Corporation Methods and compositions for enzymatic polymerization of N3′→P5′ phosphoramidate DNA

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2440724A (en) 1944-10-27 1948-05-04 Commercial Solvents Corp Nu-substituted, 2-butene-1, 4-diamines, and process for preparing
US3008993A (en) * 1957-02-14 1961-11-14 Monsanto Chemicals Alkenyl polyamines
CH413364A (de) 1959-04-22 1966-05-15 Geigy Ag J R Verfahren zur Herstellung von oxydationsbeständigen Polyamiden
US3397223A (en) 1966-05-19 1968-08-13 Shell Oil Co Preparation of cyclopropane derivatives
US3773833A (en) * 1970-07-14 1973-11-20 Monsanto Co Unsaturated polyamines
US4035174A (en) * 1975-10-09 1977-07-12 Merck & Co., Inc. Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines and methods for their preparation
SE417569B (sv) 1975-10-22 1981-03-30 Kemanobel Ab Vissa angivna blandningar av guaniderade alifatiska polyaminer, eller deras syraadditionssalter till anvendning som pesticid och antimikrobiellt medel
US4153567A (en) 1977-11-10 1979-05-08 Milliken Research Corporation Additives for lubricants and fuels
US4443604A (en) 1979-07-31 1984-04-17 Standard Oil Company (Indiana) 1,4,Bis-N,N'-dipolyalkylquinonyl aminopropyl piperazine
US4537601A (en) 1982-05-17 1985-08-27 Petrolite Corporation Antistats containing acrylonitrile copolymers and polyamines
US4491651A (en) 1982-05-17 1985-01-01 Petrolite Corporation Antistats containing acrylonitrile copolymers and polyamines
US4661509A (en) 1982-09-28 1987-04-28 Gordon Arnold Z Methods for treating leukopenia
JPS60126291A (ja) * 1983-03-14 1985-07-05 Koichi Shiyudo ポルフイリン誘導体
US4590288A (en) * 1983-06-29 1986-05-20 Exxon Research And Engineering Co. Bi- or polymetallic coordination complex
US4551550A (en) 1983-12-06 1985-11-05 Merrell Dow Pharmaceuticals Inc. N-2,3-Butadienyl-1,4-butanediamine derivatives
DE3401675A1 (de) 1984-01-19 1985-07-25 Bayer Ag, 5090 Leverkusen Neue polyamine und ein verfahren zu ihrer herstellung
CA1315780C (en) * 1986-01-17 1993-04-06 Yozo Fukuda Porphyrin derivatives
JPH0720963B2 (ja) * 1986-01-17 1995-03-08 浜理薬品工業株式会社 ポルフイリン誘導体
US4698446A (en) 1986-07-01 1987-10-06 The Bf Goodrich Company Synthesis of polyamines and mixture formed thereby, of diprimary polyalkylene polyamines with disubstituted N-adjacent terminal carbon atom(s)
US4784736A (en) 1986-07-07 1988-11-15 Bend Research, Inc. Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers
US6184232B1 (en) 1986-12-02 2001-02-06 University Of Florida Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5677351A (en) 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5342945A (en) 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
WO1989002269A1 (en) 1987-09-08 1989-03-23 The Rockefeller University Use of metalloporphyrins to reverse the toxic effect of tumor therapy
US5654484A (en) 1987-10-08 1997-08-05 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US4868219A (en) 1988-04-07 1989-09-19 Thornfeldt Carl R Treatment of skin diseases with aliphatic amines
JPH01246286A (ja) * 1988-03-28 1989-10-02 Hamari Yakuhin Kogyo Kk ポルフィリン誘導体
US4935449A (en) 1988-08-04 1990-06-19 Merrell Dow Pharmaceuticals Inc. N-2,3-butadienyl tri- and tetraaminoalkane derivatives
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5374658A (en) 1988-10-26 1994-12-20 Ortho Phamaceutical Corporation Use of oxidized polyamines, especially NN'-bis-(3-propionaldehyde)-1-4-diaminobutane (spermine dialdehye) in graft treatment
US5719193A (en) 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
US5021571A (en) * 1989-06-29 1991-06-04 Associated Universities, Inc. Cyclohexyl EDTA monoanhydride
US5283367A (en) 1989-08-30 1994-02-01 Ciba-Geigy Corporation Substituted 1,4-diamino-2-butene stabilizers
US5021409A (en) 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
JP3007391B2 (ja) 1990-08-13 2000-02-07 花王株式会社 新規第4級アンモニウム化合物
US5561136A (en) 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
US5354782A (en) 1991-01-17 1994-10-11 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5217964A (en) 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
GB9111794D0 (en) 1991-05-31 1991-07-24 Robins David J Antifungal compounds
JPH0532902A (ja) 1991-07-31 1993-02-09 Idemitsu Petrochem Co Ltd 熱可塑性樹脂組成物
JP2684473B2 (ja) 1991-09-02 1997-12-03 富士写真フイルム株式会社 マイクロカプセルの連続的製造方法
US5242684A (en) 1991-10-25 1993-09-07 Isp Investments Inc. Antimicrobial, low toxicity, non-irritating composition comprising a blend of bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer
US6051611A (en) 1991-11-08 2000-04-18 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias
US5512597A (en) 1991-11-08 1996-04-30 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
CA2094341A1 (en) 1992-04-28 1993-10-29 Carl W. Porter Methods for the use of spermidine/spermine n1-acetyltransferase as a prognostic indicator and/or tumor response marker
DE4232925A1 (de) 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
GB9220921D0 (en) 1992-10-05 1992-11-18 Merrell Dow Pharma Polyamine derivatives as anticytomegaloviral agents
US5274090A (en) * 1992-11-09 1993-12-28 The Board Of Trustees Of The Leland Stanford Junior University Tetraphenylporphyrin compounds and method
FI955643A7 (fi) 1993-05-26 1995-11-23 Merrell Pharma Inc N-alkyylitiopolyaminnijohdannaiset säteilyltä suojaavina aineina
US5451347A (en) 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
CA2126889C (en) 1993-09-02 2005-06-14 Paul R. Hart Method of breaking reverse emulsions in a crude oil desalting system
US5541230A (en) 1993-11-05 1996-07-30 Us Health Therapeutic polyamines
ES2119371T3 (es) * 1993-12-27 1998-10-01 Novartis Ag Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.
US5413719A (en) 1994-01-18 1995-05-09 Nalco Chemical Company Fluorescent tracer in a water treatment process
JPH07277964A (ja) * 1994-04-08 1995-10-24 Nippon Kayaku Co Ltd 抗腫瘍剤
DE4413402A1 (de) 1994-04-18 1995-10-19 Hoechst Ag Verfahren zur Herstellung von Zwischenprodukten für die Synthese von Glucose-6-Phosphatase-Inhibitoren sowie neue Zwischenprodukte
US5516807A (en) 1994-10-25 1996-05-14 Warner-Lambert Company Method for treating vascular proliferative disorders following balloon angioplasty
EP0789673B1 (en) 1994-10-31 1998-12-16 Cytec Technology Corp. Methods of coagulating and decolorizing waste streams
WO1996022962A1 (en) * 1995-01-23 1996-08-01 The Trustees Of Columbia University In The City Of New York Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
FR2729852A1 (fr) 1995-01-30 1996-08-02 Oreal Composition reductrice comprenant un acide amine basique et un polymere cationique
USH1633H (en) 1995-03-08 1997-02-04 The Lubrizol Corporation Deodorizing polysulfide materials
US5912341A (en) 1995-03-14 1999-06-15 Hoffman/Barrett, L.L.C. Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom
US5612478A (en) 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5677349A (en) 1995-04-27 1997-10-14 Gilad; Gad M. Agmatine for the treatment of neurotrauma and neurodegenerative diseases
US5606053A (en) 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5677350A (en) 1995-06-07 1997-10-14 Wisconsin Alumni Research Foundation Inhibition of cancer cell growth, proliferation, and metastasis using N,N'-dα,ω-diaminoalkanes
US5646188A (en) 1995-07-05 1997-07-08 Teva Pharmaceutical Industries, Ltd. Polyamine derivatives of 1-aminoindan
US5608061A (en) 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
GB9516929D0 (en) 1995-08-18 1995-10-18 Ciba Geigy Ag Pigment compositions
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
US5886051A (en) 1995-11-08 1999-03-23 University Of Florida Research Foundation, Inc. Methods and compositions for the treatment of neurodegeneration
US6126964A (en) 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US5744453A (en) 1996-01-05 1998-04-28 Mintz; Clifford S. Polyamine conjugates for treatment of infection
US5962533A (en) 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines
AU724312B2 (en) 1996-02-07 2000-09-14 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a salt of dodecylamine and methods of using the same
EP0886524A2 (en) 1996-03-01 1998-12-30 Chiron Corporation Delivery of therapeutic agents to the prostate
US6034129A (en) 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
US5958397A (en) 1996-07-22 1999-09-28 Schering-Plough Healthcare Products, Inc. Method and composition for protecting against jellyfish stings
US5906996A (en) 1996-08-21 1999-05-25 Murphy; Michael A. Tetramine treatment of neurological disorders
CA2264745C (en) 1996-09-13 2003-11-11 University Of Florida Research Foundation, Inc. Method of inhibiting biosynthesis of eif5a
EP0934249B1 (en) * 1996-10-18 2002-03-27 Wisconsin Alumni Research Foundation Conformationally restricted polyamines and their use as antineoplastic agents
US5763388A (en) 1996-12-18 1998-06-09 Dsm Copolymer, Inc. Process for producing improved silica-reinforced masterbatch of polymers prepared in latex form
JPH10204040A (ja) 1997-01-24 1998-08-04 Daicel Chem Ind Ltd 脂環式ポリアミン類およびその製造方法
US5843959A (en) 1997-03-19 1998-12-01 University Of Florida Research Foundation, Inc. Methods and bicyclic polyamine compositions for the treatment of inflammation
US6235794B1 (en) 1997-04-03 2001-05-22 University Of Florida Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment
US20030013772A1 (en) 2000-02-23 2003-01-16 Murphy Michael A. Composition, synthesis and therapeutic applications of polyamines
US6307102B1 (en) 1997-10-15 2001-10-23 Tosoh Corporation Amine catalyst for producing polyurethane and polyisocyanurate
US5889061A (en) 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
AU7131698A (en) 1998-04-21 1999-11-08 Ilex Oncology, Inc. Polyamine transport inhibitors
US20020155999A1 (en) 1998-04-30 2002-10-24 Han In Suk Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer
WO1999062551A1 (en) 1998-06-05 1999-12-09 Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
DE19831217A1 (de) 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
WO2000006136A2 (en) 1998-07-31 2000-02-10 The Health Research, Inc. Therapeutic combination of polyamine with an anticancer agent
WO2000028998A1 (en) 1998-11-16 2000-05-25 Rohto Pharmaceutical Co., Ltd. Liquid ophthalmic preparations
JP3747355B2 (ja) 1998-12-21 2006-02-22 独立行政法人理化学研究所 鎖状ポリアミン系化合物及びポリアミン系抗ガン剤
DE60029944T2 (de) 1999-04-30 2007-04-05 Cellgate, Inc., Redwood City Polyamine und ihre therapeutische verwendung
EP1185493B1 (en) 1999-04-30 2005-07-20 SLIL Biomedical Corporation Quinones for treatment of diseases
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
IL146126A0 (en) 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6673890B1 (en) 1999-07-16 2004-01-06 Basf Aktiengesellschaft Zwitterionic polyamines and process for their production
GB9920107D0 (en) 1999-08-26 1999-10-27 Avecia Ltd Fluidising agents
FR2802817B1 (fr) 1999-12-23 2002-10-11 Centre Nat Rech Scient Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete
WO2001051603A2 (en) 2000-01-10 2001-07-19 Zetetic Research, Inc. Pharmaceutical composition and method of using the same
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US7351807B2 (en) 2000-01-18 2008-04-01 Mallinckrodt Inc. Cyanine-sulfenates for dual phototherapy
US7235685B2 (en) 2001-07-03 2007-06-26 Mallinckrodt, Inc. Aromatic sulfenates for type I phototherapy
MXPA03000905A (es) 2000-08-02 2003-06-24 Slil Biomedical Corp Compuestos de poliamina ciclicos como tratamiento contra el cancer.
US6444707B1 (en) 2000-08-22 2002-09-03 West Agro Topically applied hoof treatment composition and concentrate
ATE424817T1 (de) 2000-09-19 2009-03-15 Dermal Therapy Barbados Inc Topische analgetische zusammensetzungen enthaltend aliphatische polyamine und methoden für ihre verwendung
US6545181B1 (en) 2000-10-24 2003-04-08 Pilot Chemical Holdings, Inc. Demulsifying compound and a method of breaking or inhibiting emulsions
US7754765B2 (en) 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
CA2429982C (en) 2000-12-01 2010-07-13 Ning Li Copper chelators for treating ocular inflammation
US6399662B1 (en) 2000-12-13 2002-06-04 University Of Florida Method and composition for the treatment of diarrhea and gastrointestinal spasms
WO2002062341A1 (en) 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth
US6635679B2 (en) 2001-05-14 2003-10-21 Akzo Nobel N.V. Methods and compositions for inactivating viruses
CA2448570A1 (en) 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US6713653B2 (en) 2001-08-24 2004-03-30 E. I. Du Pont De Nemours And Company Polyamines and polymers made therewith
US20030130356A1 (en) 2001-10-16 2003-07-10 Slil Biomedical Corporation Oligoamine compounds and derivatives thereof for cancer therapy
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
JP2005510524A (ja) 2001-11-16 2005-04-21 アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド ポリアミン経路の調節による神経変性障害の治療
CA2469354A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003066572A1 (en) 2002-02-07 2003-08-14 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
US6881732B2 (en) 2002-06-13 2005-04-19 Chelator Llc Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements
EP1515973A1 (en) 2002-06-26 2005-03-23 Cellgate Inc. Porphyrin-polyamine conjugates for cancer therapy
US7189865B2 (en) 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
US20040019043A1 (en) 2002-07-23 2004-01-29 Dimitri Coucouvanis Thiomolybdate analogues and uses thereof
US20040192665A1 (en) 2002-08-02 2004-09-30 Slil Biomedical Corporation Conjugates of porphyrin compounds with chemotherapeutic agents

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