JP2002540204A5 - - Google Patents
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- Publication number
- JP2002540204A5 JP2002540204A5 JP2000608007A JP2000608007A JP2002540204A5 JP 2002540204 A5 JP2002540204 A5 JP 2002540204A5 JP 2000608007 A JP2000608007 A JP 2000608007A JP 2000608007 A JP2000608007 A JP 2000608007A JP 2002540204 A5 JP2002540204 A5 JP 2002540204A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- ethyl
- dichlorophenoxy
- amino
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 cyano, hydroxyl Chemical group 0.000 description 72
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 50
- 150000001875 compounds Chemical class 0.000 description 22
- 150000003839 salts Chemical class 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 9
- 239000012453 solvate Substances 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000005843 halogen group Chemical group 0.000 description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 3
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 description 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- BPPZIPHINXIUFJ-UHFFFAOYSA-N [1-[2-[(5-chloro-1,3-dimethylpyrazol-4-yl)methylamino]ethyl]piperidin-4-yl]-(4-chlorophenyl)methanone Chemical compound CC1=NN(C)C(Cl)=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 BPPZIPHINXIUFJ-UHFFFAOYSA-N 0.000 description 2
- 125000004450 alkenylene group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- MHIFSXJQGYPPDB-UHFFFAOYSA-N n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NCCN1CCC(OC=2C=C(Cl)C(Cl)=CC=2)CC1 MHIFSXJQGYPPDB-UHFFFAOYSA-N 0.000 description 2
- FTAFETTVRQXSRZ-UHFFFAOYSA-N n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-4-methoxybenzamide Chemical compound C1=CC(OC)=CC=C1C(=O)NCCN1CCC(OC=2C=C(Cl)C(Cl)=CC=2)CC1 FTAFETTVRQXSRZ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 239000001301 oxygen Chemical group 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 125000005030 pyridylthio group Chemical group N1=C(C=CC=C1)S* 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- 229910052717 sulfur Chemical group 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- CCEKWQBFPXXKBN-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-(2-methylpropylamino)ethyl]piperidin-4-yl]methanone Chemical compound C1CN(CCNCC(C)C)CCC1C(=O)C1=CC=C(Cl)C=C1 CCEKWQBFPXXKBN-UHFFFAOYSA-N 0.000 description 1
- QWDIDFWRSBMBFV-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-(3-methylsulfanylbutylamino)ethyl]piperidin-4-yl]methanone Chemical compound C1CN(CCNCCC(C)SC)CCC1C(=O)C1=CC=C(Cl)C=C1 QWDIDFWRSBMBFV-UHFFFAOYSA-N 0.000 description 1
- CBFALSMXAFBKBY-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-(pyridin-2-ylmethylamino)ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2N=CC=CC=2)CC1 CBFALSMXAFBKBY-UHFFFAOYSA-N 0.000 description 1
- HIRXHSWOYNEDIE-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-(pyridin-4-ylmethylamino)ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C=CN=CC=2)CC1 HIRXHSWOYNEDIE-UHFFFAOYSA-N 0.000 description 1
- DPZYXLJALIJPHJ-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-(quinolin-3-ylmethylamino)ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C=C3C=CC=CC3=NC=2)CC1 DPZYXLJALIJPHJ-UHFFFAOYSA-N 0.000 description 1
- CAMLOMWWSRNMDR-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(1-methylbenzimidazol-2-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound N=1C2=CC=CC=C2N(C)C=1CNCCN(CC1)CCC1C(=O)C1=CC=C(Cl)C=C1 CAMLOMWWSRNMDR-UHFFFAOYSA-N 0.000 description 1
- RMTAXKXHFKSHPJ-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2,4-dimethoxypyrimidin-5-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound COC1=NC(OC)=NC=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 RMTAXKXHFKSHPJ-UHFFFAOYSA-N 0.000 description 1
- BZZQZDAWAXXDRW-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2,5-difluorophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound FC1=CC=C(F)C(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1 BZZQZDAWAXXDRW-UHFFFAOYSA-N 0.000 description 1
- QNHDEZAQQYUODX-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2,6-dichlorophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C(=CC=CC=2Cl)Cl)CC1 QNHDEZAQQYUODX-UHFFFAOYSA-N 0.000 description 1
- PLIWJSGXSUYJCZ-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2,6-dichloropyridin-4-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C=C(Cl)N=C(Cl)C=2)CC1 PLIWJSGXSUYJCZ-UHFFFAOYSA-N 0.000 description 1
- FIHOVKRJUWICRZ-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2-chloroquinolin-3-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C(=NC3=CC=CC=C3C=2)Cl)CC1 FIHOVKRJUWICRZ-UHFFFAOYSA-N 0.000 description 1
- CCKAMSOSAWJYBF-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2-fluoro-4,5-dimethoxyphenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=C(OC)C(OC)=CC(F)=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 CCKAMSOSAWJYBF-UHFFFAOYSA-N 0.000 description 1
- FBZOJNNRWXMQGT-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2-phenyl-1h-imidazol-5-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2N=C(NC=2)C=2C=CC=CC=2)CC1 FBZOJNNRWXMQGT-UHFFFAOYSA-N 0.000 description 1
- CRHYLKKTXOMRKU-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(2-phenylpyrazol-3-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2N(N=CC=2)C=2C=CC=CC=2)CC1 CRHYLKKTXOMRKU-UHFFFAOYSA-N 0.000 description 1
- NIRSYNGGTPBPRP-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3,4,5-trimethoxyphenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound COC1=C(OC)C(OC)=CC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1 NIRSYNGGTPBPRP-UHFFFAOYSA-N 0.000 description 1
- BQSJOJBQVLBVLW-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3,5-difluorophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound FC1=CC(F)=CC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1 BQSJOJBQVLBVLW-UHFFFAOYSA-N 0.000 description 1
- GQWDJTMFSZHGMX-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3-hydroxy-4-methoxyphenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=C(O)C(OC)=CC=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 GQWDJTMFSZHGMX-UHFFFAOYSA-N 0.000 description 1
- NTICZMKTSNVWMT-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3-hydroxy-4-nitrophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=C([N+]([O-])=O)C(O)=CC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1 NTICZMKTSNVWMT-UHFFFAOYSA-N 0.000 description 1
- LRKHJDIAAFTZID-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3-methylthiophen-2-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CSC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1C LRKHJDIAAFTZID-UHFFFAOYSA-N 0.000 description 1
- IRHNODZMYZXIQC-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3-nitro-4-pyridin-2-ylsulfanylphenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C=1C=C(SC=2N=CC=CC=2)C([N+](=O)[O-])=CC=1CNCCN(CC1)CCC1C(=O)C1=CC=C(Cl)C=C1 IRHNODZMYZXIQC-UHFFFAOYSA-N 0.000 description 1
- ZGEADYISVFOZKM-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(3-nitrophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=C1 ZGEADYISVFOZKM-UHFFFAOYSA-N 0.000 description 1
- SNSLWGMYHQXIKB-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(4-nitrophenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 SNSLWGMYHQXIKB-UHFFFAOYSA-N 0.000 description 1
- LALDGZAOEXVHEY-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(4-phenylpiperidin-4-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC2(CCNCC2)C=2C=CC=CC=2)CC1 LALDGZAOEXVHEY-UHFFFAOYSA-N 0.000 description 1
- QQZVTJZQPKPZAV-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(5-ethylthiophen-2-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound S1C(CC)=CC=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 QQZVTJZQPKPZAV-UHFFFAOYSA-N 0.000 description 1
- OVNYNSHJGJUENX-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(5-nitro-2-pyridin-2-ylsulfanylphenyl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound C1CC(C(=O)C=2C=CC(Cl)=CC=2)CCN1CCNCC1=CC([N+](=O)[O-])=CC=C1SC1=CC=CC=N1 OVNYNSHJGJUENX-UHFFFAOYSA-N 0.000 description 1
- PSTVENQTOPIJHX-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(6-methylpyridin-2-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound CC1=CC=CC(CNCCN2CCC(CC2)C(=O)C=2C=CC(Cl)=CC=2)=N1 PSTVENQTOPIJHX-UHFFFAOYSA-N 0.000 description 1
- LQNLIYRHRPZSPL-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(6-nitro-1,3-benzodioxol-5-yl)methylamino]ethyl]piperidin-4-yl]methanone Chemical compound [O-][N+](=O)C1=CC=2OCOC=2C=C1CNCCN(CC1)CCC1C(=O)C1=CC=C(Cl)C=C1 LQNLIYRHRPZSPL-UHFFFAOYSA-N 0.000 description 1
- PFYFSSBSMWQHOT-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[(7-hydroxy-3,7-dimethyloctyl)amino]ethyl]piperidin-4-yl]methanone Chemical compound C1CN(CCNCCC(CCCC(C)(C)O)C)CCC1C(=O)C1=CC=C(Cl)C=C1 PFYFSSBSMWQHOT-UHFFFAOYSA-N 0.000 description 1
- USCYTAXQSSZRJK-OWOJBTEDSA-N (4-chlorophenyl)-[1-[2-[[(e)-3-(4-nitrophenyl)prop-2-enyl]amino]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1\C=C\CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 USCYTAXQSSZRJK-OWOJBTEDSA-N 0.000 description 1
- NTMOXDJIDPKQKQ-UHFFFAOYSA-N (4-chlorophenyl)-[1-[2-[[5-(3-nitrophenyl)furan-2-yl]methylamino]ethyl]piperidin-4-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC(C=2OC(CNCCN3CCC(CC3)C(=O)C=3C=CC(Cl)=CC=3)=CC=2)=C1 NTMOXDJIDPKQKQ-UHFFFAOYSA-N 0.000 description 1
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 description 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 1
- ZWXDDWDWMCESKH-RMKNXTFCSA-N (e)-n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-3-phenylprop-2-enamide Chemical compound C1=C(Cl)C(Cl)=CC=C1OC1CCN(CCNC(=O)\C=C\C=2C=CC=CC=2)CC1 ZWXDDWDWMCESKH-RMKNXTFCSA-N 0.000 description 1
- GNTLPZAHICFRRC-XCVCLJGOSA-N (e)-n-[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethyl]-3-(4-nitrophenyl)prop-2-enamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1\C=C\C(=O)NCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 GNTLPZAHICFRRC-XCVCLJGOSA-N 0.000 description 1
- ZOPXEBJEWRETPJ-IZZDOVSWSA-N (e)-n-[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethyl]-3-phenylprop-2-enamide Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNC(=O)\C=C\C=2C=CC=CC=2)CC1 ZOPXEBJEWRETPJ-IZZDOVSWSA-N 0.000 description 1
- HKNFOAKZDXBKRA-UHFFFAOYSA-N 2,6-dimethyl-1H-pyrimidine-2,4-diamine Chemical compound CC1(NC(=CC(=N1)N)C)N HKNFOAKZDXBKRA-UHFFFAOYSA-N 0.000 description 1
- BMHUXUQPWBADAL-UHFFFAOYSA-N 2-[2-[[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethylamino]methyl]-4-nitrophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C([N+]([O-])=O)C=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 BMHUXUQPWBADAL-UHFFFAOYSA-N 0.000 description 1
- GUXFOLSWRZODOX-UHFFFAOYSA-N 2-[3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2,4-dioxoquinazolin-1-yl]-n,n-dimethylacetamide;hydrochloride Chemical compound Cl.O=C1N(CC(=O)N(C)C)C2=CC=CC=C2C(=O)N1CCN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 GUXFOLSWRZODOX-UHFFFAOYSA-N 0.000 description 1
- NSFBBZNOSVHEES-UHFFFAOYSA-N 2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-n-[(3-methoxyphenyl)methyl]ethanamine;dihydrochloride Chemical compound Cl.Cl.COC1=CC=CC(CNCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=C1 NSFBBZNOSVHEES-UHFFFAOYSA-N 0.000 description 1
- XNGVLISOMZWKAQ-UHFFFAOYSA-N 2-[[2-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propylamino]pyrimidin-4-yl]-methylamino]ethanol Chemical compound OCCN(C)C1=CC=NC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 XNGVLISOMZWKAQ-UHFFFAOYSA-N 0.000 description 1
- OLFUWQFGAVROEA-UHFFFAOYSA-N 2-[[2-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propylamino]pyrimidin-4-yl]amino]ethanol Chemical compound OCCNC1=CC=NC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 OLFUWQFGAVROEA-UHFFFAOYSA-N 0.000 description 1
- PVPXVESRTMPRRZ-UHFFFAOYSA-N 2-[[4-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethylamino]pyrimidin-2-yl]-methylamino]ethanol Chemical compound OCCN(C)C1=NC=CC(NCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 PVPXVESRTMPRRZ-UHFFFAOYSA-N 0.000 description 1
- ZNLBTLXZEMUXOG-UHFFFAOYSA-N 2-[[4-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethylamino]pyrimidin-2-yl]amino]ethanol Chemical compound OCCNC1=NC=CC(NCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 ZNLBTLXZEMUXOG-UHFFFAOYSA-N 0.000 description 1
- SSDVFNNGIZCJGU-UHFFFAOYSA-N 2-[[4-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propylamino]pyrimidin-2-yl]-methylamino]ethanol Chemical compound OCCN(C)C1=NC=CC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 SSDVFNNGIZCJGU-UHFFFAOYSA-N 0.000 description 1
- VVWOJGLYFQOSHE-UHFFFAOYSA-N 2-[[4-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propylamino]pyrimidin-2-yl]amino]ethanol Chemical compound OCCNC1=NC=CC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 VVWOJGLYFQOSHE-UHFFFAOYSA-N 0.000 description 1
- QPIPEHZSHGDUEL-UHFFFAOYSA-N 2-acetamido-n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-1,3-thiazole-4-carboxamide Chemical compound S1C(NC(=O)C)=NC(C(=O)NCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=C1 QPIPEHZSHGDUEL-UHFFFAOYSA-N 0.000 description 1
- PFODAJFKGNHIKF-UHFFFAOYSA-N 2-amino-n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-1,3-thiazole-4-carboxamide Chemical compound S1C(N)=NC(C(=O)NCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=C1 PFODAJFKGNHIKF-UHFFFAOYSA-N 0.000 description 1
- WFTYOJFJHQSUGC-UHFFFAOYSA-N 2-bromo-n-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-5-methoxybenzamide Chemical compound COC1=CC=C(Br)C(C(=O)NCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=C1 WFTYOJFJHQSUGC-UHFFFAOYSA-N 0.000 description 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 1
- ZJWLHFWEFOMZAL-UHFFFAOYSA-N 3-[2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]ethyl]-6-methoxy-1h-quinazoline-2,4-dione Chemical compound O=C1C2=CC(OC)=CC=C2NC(=O)N1CCN(CC1)CCC1OC1=CC=C(Cl)C(Cl)=C1 ZJWLHFWEFOMZAL-UHFFFAOYSA-N 0.000 description 1
- QWSWUJUPZKKMCB-UHFFFAOYSA-N 3-[[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethylamino]methyl]-6,7-dimethylchromen-4-one Chemical compound O=C1C=2C=C(C)C(C)=CC=2OC=C1CNCCN(CC1)CCC1C(=O)C1=CC=C(Cl)C=C1 QWSWUJUPZKKMCB-UHFFFAOYSA-N 0.000 description 1
- KFFDPUVRJFFJRV-UHFFFAOYSA-N 3-[[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethylamino]methyl]chromen-4-one Chemical compound C1=CC(Cl)=CC=C1C(=O)C1CCN(CCNCC=2C(C3=CC=CC=C3OC=2)=O)CC1 KFFDPUVRJFFJRV-UHFFFAOYSA-N 0.000 description 1
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- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 description 1
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- OGGFUYHLQSDNBL-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-5-methoxy-2-methylpyrimidin-4-amine Chemical compound COC1=CN=C(C)N=C1NCCCN1CCC(OC=2C=C(Cl)C(Cl)=CC=2)CC1 OGGFUYHLQSDNBL-UHFFFAOYSA-N 0.000 description 1
- KYRIOZQSGUKCBI-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-5-methoxy-2-methylsulfanylpyrimidin-4-amine Chemical compound COC1=CN=C(SC)N=C1NCCCN1CCC(OC=2C=C(Cl)C(Cl)=CC=2)CC1 KYRIOZQSGUKCBI-UHFFFAOYSA-N 0.000 description 1
- QKBVECZBMTUOCW-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-5-methylthieno[2,3-d]pyrimidin-4-amine Chemical compound C=12C(C)=CSC2=NC=NC=1NCCCN(CC1)CCC1OC1=CC=C(Cl)C(Cl)=C1 QKBVECZBMTUOCW-UHFFFAOYSA-N 0.000 description 1
- CENUZHTZTUCONP-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-6-methyl-2-methylsulfanylpyrimidin-4-amine Chemical compound CSC1=NC(C)=CC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 CENUZHTZTUCONP-UHFFFAOYSA-N 0.000 description 1
- NTTHUHDBOMNZQH-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-6-methylpyridin-2-amine Chemical compound CC1=CC=CC(NCCCN2CCC(CC2)OC=2C=C(Cl)C(Cl)=CC=2)=N1 NTTHUHDBOMNZQH-UHFFFAOYSA-N 0.000 description 1
- MPDOZIITBQYNNJ-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-7-methylthieno[3,2-d]pyrimidin-4-amine Chemical compound N1=CN=C2C(C)=CSC2=C1NCCCN(CC1)CCC1OC1=CC=C(Cl)C(Cl)=C1 MPDOZIITBQYNNJ-UHFFFAOYSA-N 0.000 description 1
- YBPQRVURRORWIE-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-7h-purin-6-amine Chemical compound C1=C(Cl)C(Cl)=CC=C1OC1CCN(CCCNC2=C3N=CN=C3N=CN2)CC1 YBPQRVURRORWIE-UHFFFAOYSA-N 0.000 description 1
- NCDKWNZTPAKVCQ-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]-9-methylpurin-6-amine Chemical compound N1=CN=C2N(C)C=NC2=C1NCCCN(CC1)CCC1OC1=CC=C(Cl)C(Cl)=C1 NCDKWNZTPAKVCQ-UHFFFAOYSA-N 0.000 description 1
- VODYKEUGXCHTEC-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]pyridin-2-amine Chemical compound C1=C(Cl)C(Cl)=CC=C1OC1CCN(CCCNC=2N=CC=CC=2)CC1 VODYKEUGXCHTEC-UHFFFAOYSA-N 0.000 description 1
- AXGODTPMEJUMJX-UHFFFAOYSA-N n-[3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propyl]pyrimidin-2-amine Chemical compound C1=C(Cl)C(Cl)=CC=C1OC1CCN(CCCNC=2N=CC=CN=2)CC1 AXGODTPMEJUMJX-UHFFFAOYSA-N 0.000 description 1
- RUHMSOCBISJCEB-UHFFFAOYSA-N n-[4-[[2-[4-(4-chlorobenzoyl)piperidin-1-yl]ethylamino]methyl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1CNCCN1CCC(C(=O)C=2C=CC(Cl)=CC=2)CC1 RUHMSOCBISJCEB-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (5)
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| SE9901117-3 | 1999-03-26 | ||
| SE9901117A SE9901117D0 (sv) | 1999-03-26 | 1999-03-26 | Novel compounds |
| SE9902194-1 | 1999-06-10 | ||
| SE9902194A SE9902194D0 (sv) | 1999-06-10 | 1999-06-10 | Novel compounds |
| PCT/SE2000/000563 WO2000058305A1 (en) | 1999-03-26 | 2000-03-22 | Novel compounds |
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| KR (1) | KR20010108394A (https=) |
| CN (1) | CN1344266A (https=) |
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| BR (1) | BR0009338A (https=) |
| CA (1) | CA2361366A1 (https=) |
| CZ (1) | CZ20013451A3 (https=) |
| EE (1) | EE200100502A (https=) |
| HU (1) | HUP0202017A3 (https=) |
| IL (1) | IL144353A0 (https=) |
| IS (1) | IS6024A (https=) |
| NO (1) | NO20014518D0 (https=) |
| PL (1) | PL350904A1 (https=) |
| SK (1) | SK11822001A3 (https=) |
| TR (1) | TR200102800T2 (https=) |
| WO (1) | WO2000058305A1 (https=) |
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| US6518286B1 (en) | 1999-03-26 | 2003-02-11 | Astrazeneca Ab | Compounds |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| DE19952147A1 (de) * | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004152D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004151D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| CO5300399A1 (es) * | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| US7005439B2 (en) | 2000-06-20 | 2006-02-28 | Astrazeneca Ab | Compounds |
| AR028948A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| TWI227231B (en) * | 2000-07-12 | 2005-02-01 | Novartis Ag | 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3 |
| GB0021670D0 (en) * | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| EP1330436B1 (en) | 2000-10-09 | 2010-06-30 | Novartis AG | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr3-3 receptor antagonists |
| WO2002030899A1 (en) * | 2000-10-09 | 2002-04-18 | Novartis Ag | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr3 receptor antagonists |
| UY27003A1 (es) | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| AR035230A1 (es) | 2001-03-19 | 2004-05-05 | Astrazeneca Ab | Compuestos de bencimidazol, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion farmaceutica, y usos de estos compuestos para la elaboracion de medicamentos |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
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| GB0114699D0 (en) | 2001-06-15 | 2001-08-08 | Novartis Ag | Organic compounds |
| GB0117387D0 (en) * | 2001-07-17 | 2001-09-05 | Novartis Ag | Organic compounds |
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| KR101297924B1 (ko) * | 2002-07-29 | 2013-08-20 | 리겔 파마슈티칼스, 인크. | 2,4-피리미딘디아민 화합물을 이용한 자가면역질환의 치료및 예방 방법 |
| EP2316459B1 (en) * | 2002-07-29 | 2013-11-06 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in methods of treating or preventing autoimmune diseases |
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| JP6322200B2 (ja) * | 2012-11-16 | 2018-05-09 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ヒトホスファチジルイノシトール３−キナーゼデルタのプリン阻害剤 |
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| US10702525B1 (en) * | 2019-09-04 | 2020-07-07 | United Arab Emirates University | Pyrimidine derivatives as anti-diabetic agents |
| US20230167109A1 (en) * | 2020-04-24 | 2023-06-01 | Emory University | Aminopiperidine Amides, Derivatives, Compositions, and Uses Related to CXCR4 Modulation |
| CN116057049A (zh) * | 2020-05-29 | 2023-05-02 | 大邱庆北尖端医疗产业振兴财团 | 甲酰胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物 |
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| US6518286B1 (en) | 1999-03-26 | 2003-02-11 | Astrazeneca Ab | Compounds |
-
2000
- 2000-03-22 US US09/555,565 patent/US6518286B1/en not_active Expired - Fee Related
- 2000-03-22 WO PCT/SE2000/000563 patent/WO2000058305A1/en not_active Ceased
- 2000-03-22 CA CA002361366A patent/CA2361366A1/en not_active Abandoned
- 2000-03-22 IL IL14435300A patent/IL144353A0/xx unknown
- 2000-03-22 CN CN00805451A patent/CN1344266A/zh active Pending
- 2000-03-22 EE EEP200100502A patent/EE200100502A/xx unknown
- 2000-03-22 HU HU0202017A patent/HUP0202017A3/hu unknown
- 2000-03-22 BR BR0009338-6A patent/BR0009338A/pt not_active IP Right Cessation
- 2000-03-22 JP JP2000608007A patent/JP2002540204A/ja active Pending
- 2000-03-22 SK SK1182-2001A patent/SK11822001A3/sk unknown
- 2000-03-22 TR TR2001/02800T patent/TR200102800T2/xx unknown
- 2000-03-22 KR KR1020017012174A patent/KR20010108394A/ko not_active Withdrawn
- 2000-03-22 CZ CZ20013451A patent/CZ20013451A3/cs unknown
- 2000-03-22 AU AU41575/00A patent/AU4157500A/en not_active Abandoned
- 2000-03-22 PL PL00350904A patent/PL350904A1/xx not_active Application Discontinuation
- 2000-03-22 EP EP00921237A patent/EP1165545A1/en not_active Withdrawn
-
2001
- 2001-07-26 IS IS6024A patent/IS6024A/is unknown
- 2001-09-17 NO NO20014518A patent/NO20014518D0/no unknown
-
2003
- 2003-01-09 US US10/339,261 patent/US6946478B2/en not_active Expired - Fee Related
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