JP2007513957A5 - - Google Patents
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- Publication number
- JP2007513957A5 JP2007513957A5 JP2006543943A JP2006543943A JP2007513957A5 JP 2007513957 A5 JP2007513957 A5 JP 2007513957A5 JP 2006543943 A JP2006543943 A JP 2006543943A JP 2006543943 A JP2006543943 A JP 2006543943A JP 2007513957 A5 JP2007513957 A5 JP 2007513957A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- carbon atoms
- halogen
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C1=C(*)*C(N(*)*)=B*1 Chemical compound *C1=C(*)*C(N(*)*)=B*1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52848603P | 2003-12-11 | 2003-12-11 | |
| PCT/US2004/041068 WO2005061458A2 (en) | 2003-12-11 | 2004-12-10 | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513957A JP2007513957A (ja) | 2007-05-31 |
| JP2007513957A5 true JP2007513957A5 (https=) | 2008-01-17 |
Family
ID=34710083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006543943A Pending JP2007513957A (ja) | 2003-12-11 | 2004-12-10 | Ｎ−置換ジアリールアミン類縁体を含む，ホスホジエステラーゼ４阻害剤本出願は，参照によりその全開示がここに導入されている２００３年１２月１１日に提出した米国仮出願番号６０／５２８，４８６の利益を請求するものである。 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050222207A1 (https=) |
| EP (1) | EP1692109B1 (https=) |
| JP (1) | JP2007513957A (https=) |
| KR (1) | KR20060128909A (https=) |
| CN (1) | CN1922144A (https=) |
| AR (1) | AR046789A1 (https=) |
| AT (1) | ATE478049T1 (https=) |
| AU (1) | AU2004303855A1 (https=) |
| BR (1) | BRPI0417110A (https=) |
| CA (1) | CA2548824A1 (https=) |
| DE (1) | DE602004028754D1 (https=) |
| MX (1) | MXPA06006557A (https=) |
| MY (1) | MY141255A (https=) |
| RU (1) | RU2388750C2 (https=) |
| TW (1) | TW200602322A (https=) |
| WO (1) | WO2005061458A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030149052A1 (en) * | 2002-01-22 | 2003-08-07 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| RU2354648C2 (ru) | 2002-07-19 | 2009-05-10 | Мемори Фармасьютиклз Корпорейшн | Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4 |
| ES2445208T3 (es) | 2002-07-29 | 2014-02-28 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias |
| BRPI0413018B8 (pt) | 2003-07-30 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, e, uso de um composto |
| DE602006010979D1 (de) | 2005-01-19 | 2010-01-21 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2006135828A2 (en) * | 2005-06-10 | 2006-12-21 | Memory Pharmaceuticals Corporation | Trisubstituted amines as phosphodiesterase 4 inhibitors |
| WO2007048846A1 (de) * | 2005-10-27 | 2007-05-03 | Neuraxo Biopharmaceuticals Gmbh | Verwendung von eisen chelatisierenden verbindungen, zyklisches adenosinmonophosphat erhöhende verbindungen oder kombinationen davon zur behandlung von axonalen läsionen im zns |
| WO2007056457A2 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| US8067607B2 (en) * | 2006-02-01 | 2011-11-29 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| CA2642229C (en) | 2006-02-24 | 2015-05-12 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| FI3632488T3 (fi) * | 2006-12-22 | 2023-05-25 | Roche Diabetes Care Gmbh | Laite terapeuttisen nesteen pitkäaikaiseen jakeluun |
| ES2544482T3 (es) * | 2007-02-27 | 2015-08-31 | National University Corporation Okayama University | Compuesto rexinoide que tiene un grupo alcoxi |
| TW200902025A (en) * | 2007-04-11 | 2009-01-16 | Alcon Res Ltd | Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| TWI443090B (zh) | 2007-05-25 | 2014-07-01 | Abbvie Deutschland | 作為代謝性麩胺酸受體２（ｍｇｌｕ２ 受體）之正向調節劑之雜環化合物 |
| EP2070913A1 (en) * | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
| EP2110375A1 (en) * | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| WO2010003084A2 (en) * | 2008-07-02 | 2010-01-07 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| WO2010041449A1 (ja) * | 2008-10-09 | 2010-04-15 | 国立大学法人 岡山大学 | Rxr作動性物質を有効成分とする抗アレルギー剤 |
| US20100113608A1 (en) * | 2008-11-04 | 2010-05-06 | Alberte Randall S | Tryptase Enzyme Inhibiting Aminothiophenols |
| US20110082145A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| UA111861C2 (uk) | 2011-11-15 | 2016-06-24 | Такеда Фармасьютікал Компані Лімітед | Ароматична гетероциклічна сполука дигідрокси |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| WO2014081617A1 (en) * | 2012-11-20 | 2014-05-30 | Merck Sharp & Dohme Corp. | Substituted pyridone derivatives as pde10 inhibitors |
| GB201222711D0 (en) | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
| MX370188B (es) * | 2013-03-14 | 2019-12-04 | Dart Neuroscience Cayman Ltd | Compuestos de piridina y pirazina sustituidos como inhibidores de pde4. |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
| NZ777336A (en) | 2018-12-28 | 2026-02-27 | Regeneron Pharma | Treatment of respiratory disorders with arachidonate 15-lipoxygenase (alox15) inhibitors |
Family Cites Families (56)
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|---|---|---|---|---|
| US3259623A (en) * | 1963-06-14 | 1966-07-05 | Olin Mathieson | Process for preparing 2-(secondary amino)-halogenopyrimidines |
| GB1337389A (en) * | 1969-12-10 | 1973-11-14 | Ici Ltd | Pyrimidine derivatives |
| CH593266A5 (https=) * | 1973-09-20 | 1977-11-30 | Delalande Sa | |
| ZA865090B (en) * | 1985-07-22 | 1988-02-24 | Riker Laboratories Inc | Substituted di-t-butylphenols |
| JPH01118957A (ja) | 1987-10-31 | 1989-05-11 | Sharp Corp | 販売管理装置 |
| GB9311281D0 (en) * | 1993-06-01 | 1993-07-21 | Rhone Poulenc Rorer Ltd | Novel composition of matter |
| US5698711A (en) * | 1991-01-28 | 1997-12-16 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| US5935978A (en) * | 1991-01-28 | 1999-08-10 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| US6096768A (en) * | 1992-01-28 | 2000-08-01 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| TW229142B (https=) * | 1992-04-15 | 1994-09-01 | Nissan Detrochem Corp | |
| JP3634861B2 (ja) | 1992-06-15 | 2005-03-30 | セルテック リミテッド | 選択的ホスホジエステラーゼｉｖ阻害剤としての三置換フェニル誘導体 |
| US5679696A (en) * | 1992-07-28 | 1997-10-21 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group |
| US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
| TW263495B (https=) | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
| US5622977A (en) * | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| PL313973A1 (en) * | 1993-10-12 | 1996-08-05 | Du Pont Merck Pharma | 1 n-alkyl-n-arylopyrimidin amines and their derivatives |
| GB9326699D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| DE69433594T2 (de) * | 1993-12-22 | 2004-08-05 | Celltech R&D Ltd., Slough | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
| GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| US6245774B1 (en) * | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412571D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412573D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| ATE251141T1 (de) * | 1995-03-10 | 2003-10-15 | Berlex Lab | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| AU5772196A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| FR2735777B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| GB9603723D0 (en) * | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
| US5710170A (en) * | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
| GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| CN1080260C (zh) * | 1996-06-25 | 2002-03-06 | 美国辉瑞有限公司 | 取代的吲哚衍生物以及它们作为iv型磷酸二酯酶(pde)和肿瘤坏死因子(tnf)抑制剂的用途 |
| JPH1072415A (ja) | 1996-06-26 | 1998-03-17 | Nikken Chem Co Ltd | ３−アニリノ−２−シクロアルケノン誘導体 |
| US6262040B1 (en) * | 1996-09-04 | 2001-07-17 | Pfizer Inc | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) |
| GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19705012A1 (de) * | 1997-02-11 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Herbizide 3-Arylamino-6-trifluormethyluracile |
| EP0994100B1 (en) * | 1997-06-24 | 2006-08-30 | Nikken Chemicals Company, Limited | 3-anilino-2-cycloalkenone derivates |
| US5919937A (en) * | 1997-10-29 | 1999-07-06 | Merck & Co., Inc. | Process for phosphodiesterase IV inhibitors |
| WO1999026616A1 (en) * | 1997-11-25 | 1999-06-03 | Warner-Lambert Company | Benzenesulfonamide inhibitors of pde-iv and their therapeutic use |
| AU764005B2 (en) * | 1999-02-25 | 2003-08-07 | Merck Frosst Canada & Co. | PDE IV inhibiting compounds, compositions and methods of treatment |
| US6180650B1 (en) * | 1999-04-23 | 2001-01-30 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE 4 inhibitors |
| US6200993B1 (en) * | 1999-05-05 | 2001-03-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE4 inhibitors |
| WO2000071536A1 (en) * | 1999-05-20 | 2000-11-30 | E.I. Du Pont De Nemours And Company | Heteroaryloxypyrimidine insecticides and acaricides |
| US6699890B2 (en) * | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| WO2002074726A2 (en) * | 2001-01-22 | 2002-09-26 | Memory Pharmaceuticals Corporation | Aniline derivatives useful as phosphodiesterase 4 inhibitors |
| FR2827288B1 (fr) * | 2001-07-12 | 2003-10-31 | Servier Lab | Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20030149052A1 (en) * | 2002-01-22 | 2003-08-07 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| EP1500643A4 (en) * | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | benzamidine |
| EP1539697A1 (en) * | 2002-07-19 | 2005-06-15 | Memory Pharmaceutical Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| AU2003295656B2 (en) * | 2002-11-19 | 2010-11-11 | Memory Pharmaceuticals Corporation | Pyridine N-oxide compounds as phosphodiesterase 4 inhibitors |
-
2004
- 2004-12-08 MY MYPI20045068A patent/MY141255A/en unknown
- 2004-12-09 AR ARP040104598A patent/AR046789A1/es not_active Application Discontinuation
- 2004-12-10 CA CA002548824A patent/CA2548824A1/en not_active Abandoned
- 2004-12-10 WO PCT/US2004/041068 patent/WO2005061458A2/en not_active Ceased
- 2004-12-10 AT AT04813392T patent/ATE478049T1/de not_active IP Right Cessation
- 2004-12-10 DE DE602004028754T patent/DE602004028754D1/de not_active Expired - Lifetime
- 2004-12-10 BR BRPI0417110-1A patent/BRPI0417110A/pt not_active IP Right Cessation
- 2004-12-10 EP EP04813392A patent/EP1692109B1/en not_active Expired - Lifetime
- 2004-12-10 CN CNA2004800412769A patent/CN1922144A/zh active Pending
- 2004-12-10 US US11/008,775 patent/US20050222207A1/en not_active Abandoned
- 2004-12-10 KR KR1020067013876A patent/KR20060128909A/ko not_active Ceased
- 2004-12-10 TW TW093138511A patent/TW200602322A/zh unknown
- 2004-12-10 JP JP2006543943A patent/JP2007513957A/ja active Pending
- 2004-12-10 RU RU2006124518/04A patent/RU2388750C2/ru not_active IP Right Cessation
- 2004-12-10 MX MXPA06006557A patent/MXPA06006557A/es unknown
- 2004-12-10 AU AU2004303855A patent/AU2004303855A1/en not_active Abandoned
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