JP2002531527A5 - - Google Patents
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- Publication number
- JP2002531527A5 JP2002531527A5 JP2000586368A JP2000586368A JP2002531527A5 JP 2002531527 A5 JP2002531527 A5 JP 2002531527A5 JP 2000586368 A JP2000586368 A JP 2000586368A JP 2000586368 A JP2000586368 A JP 2000586368A JP 2002531527 A5 JP2002531527 A5 JP 2002531527A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9826882.4A GB9826882D0 (en) | 1998-12-07 | 1998-12-07 | Organic compounds |
| GB9826882.4 | 1998-12-07 | ||
| GB9904934.8 | 1999-03-04 | ||
| GBGB9904934.8A GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
| PCT/EP1999/009521 WO2000033878A2 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005106512A Division JP5043308B2 (ja) | 1998-12-07 | 2005-04-01 | マクロライドの安定化 |
| JP2005378514A Division JP5165199B2 (ja) | 1998-12-07 | 2005-12-28 | マクロライドの安定化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531527A JP2002531527A (ja) | 2002-09-24 |
| JP2002531527A5 true JP2002531527A5 (https=) | 2005-12-22 |
| JP3805625B2 JP3805625B2 (ja) | 2006-08-02 |
Family
ID=26314797
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586368A Expired - Lifetime JP3805625B2 (ja) | 1998-12-07 | 1999-12-06 | マクロライドの安定化 |
| JP2005106512A Expired - Lifetime JP5043308B2 (ja) | 1998-12-07 | 2005-04-01 | マクロライドの安定化 |
| JP2005378514A Expired - Lifetime JP5165199B2 (ja) | 1998-12-07 | 2005-12-28 | マクロライドの安定化 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005106512A Expired - Lifetime JP5043308B2 (ja) | 1998-12-07 | 2005-04-01 | マクロライドの安定化 |
| JP2005378514A Expired - Lifetime JP5165199B2 (ja) | 1998-12-07 | 2005-12-28 | マクロライドの安定化 |
Country Status (38)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
| MXPA04007847A (es) | 2002-02-13 | 2005-02-24 | Biogal Gyogyszergyar | Metodo para extraer un macrolido de biomateria. |
| NZ537829A (en) | 2002-07-30 | 2006-09-29 | Wyeth Corp | Parenteral formulations containing a rapamycin hydroxyester |
| TR200500302T3 (tr) * | 2003-03-31 | 2005-04-21 | Biogal Gyogyszergyar Rt. | Makrolidlerin kristalizasyonu ve saflaştırılması. |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| TW200523266A (en) | 2003-07-24 | 2005-07-16 | Biogal Gyogyszergyar | Method of purifying macrolides |
| CA2539324A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
| CN1889994A (zh) * | 2003-12-10 | 2007-01-03 | 艾克若克斯Dds有限公司 | 伴随透皮或局部药物输送的不希望的效果的治疗方法 |
| US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
| US20060094744A1 (en) * | 2004-09-29 | 2006-05-04 | Maryanoff Cynthia A | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| JP4974903B2 (ja) | 2005-02-09 | 2012-07-11 | 参天製薬株式会社 | 疾患または状態を処置するための液体処方物 |
| BRPI0619592A2 (pt) * | 2005-12-07 | 2016-09-06 | Wyeth Corp | métodos para medir a qualidade da partícula de um composto de rapamicina, para determinar o tamanho de partícula médio de uma amostra e a cristalinidade de um composto de rapamicina, e para a purificação de rapamicina |
| US7700614B2 (en) * | 2005-12-14 | 2010-04-20 | Abbott Laboratories | One pot synthesis of tetrazole derivatives of rapamycin |
| RU2008121713A (ru) * | 2005-12-20 | 2010-01-27 | Вайет (Us) | Контроль стабильности лекарственной формы cci-779 посредством контроля примесей лекарственныхого вещества |
| WO2007092620A2 (en) * | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| PL2001466T3 (pl) | 2006-03-23 | 2016-06-30 | Santen Pharmaceutical Co Ltd | Rapamycyna w małej dawce do leczenia chorób związanych z przepuszczalnością naczyń |
| WO2011151704A2 (en) | 2010-06-02 | 2011-12-08 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of rapamycin esters |
| WO2011156025A1 (en) * | 2010-06-07 | 2011-12-15 | Telik, Inc. | Crystalline Ezatiostat Hydrochloride Ansolvate |
| EP2601201B1 (en) * | 2010-08-04 | 2014-09-24 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties" |
| WO2012066502A1 (en) | 2010-11-19 | 2012-05-24 | Biocon Limited | Processes for preparation of everolimus and intermediates thereof |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| WO2013022201A1 (en) * | 2011-08-11 | 2013-02-14 | Dong-A Pharm. Co., Ltd. | Process of preparing a stabilized and solubilized formulation of sirolimus derivatives |
| US9610385B2 (en) | 2013-03-07 | 2017-04-04 | Abbott Cardiovascular Systems Inc. | Method of fabricating an implantable medical device comprising a rapamycin derivative |
| IN2013MU02532A (https=) | 2013-07-31 | 2015-06-26 | Sahajanand Medical Technologies Pvt Ltd | |
| CN104721158B (zh) * | 2013-12-24 | 2018-01-30 | 正大天晴药业集团股份有限公司 | 一种稳定的依维莫司片剂 |
| CN104892632B (zh) * | 2015-06-03 | 2017-12-26 | 道中道（菏泽）制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
| US10383860B2 (en) | 2015-07-28 | 2019-08-20 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof, and method for producing the same |
| JP6793651B2 (ja) * | 2015-08-28 | 2020-12-02 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| WO2017047618A1 (ja) * | 2015-09-18 | 2017-03-23 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| WO2017129772A1 (en) | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Stable pharmaceutical compositions of temsirolimus |
| JP6855470B2 (ja) | 2016-05-27 | 2021-04-07 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| KR102051806B1 (ko) * | 2018-01-12 | 2019-12-04 | 주식회사 종근당 | 에베로리무스를 포함하는 안정화된 약제학적 제제 |
| CN119431400A (zh) * | 2020-03-27 | 2025-02-14 | 波士顿科学国际有限公司 | 用于使药物结晶的方法 |
| JP2023028473A (ja) * | 2021-08-19 | 2023-03-03 | 日本マイクロバイオファーマ株式会社 | エベロリムスの製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3996355A (en) | 1975-01-02 | 1976-12-07 | American Home Products Corporation | Permanent suspension pharmaceutical dosage form |
| US4049128A (en) | 1976-11-18 | 1977-09-20 | Westinghouse Air Brake Company | Control system for automatic railway car coupler |
| AU543727B2 (en) * | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
| CA1338150C (en) † | 1988-02-18 | 1996-03-12 | Edward George Howard, Jr. | Ceramic/distillable binder compositions |
| GB8803836D0 (en) | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
| KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| FI97472C (fi) | 1991-05-07 | 1996-12-27 | American Home Prod | Menetelmä terapeuttisesti käyttökelpoisten rapamysiinijohdannaisten valmistamiseksi anti-inflammatorisina ja antifungaalisina aineina |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| EP1266900A1 (en) | 1992-10-13 | 2002-12-18 | Wyeth | Carbamates of rapamycin |
| RU2181054C2 (ru) * | 1994-11-02 | 2002-04-10 | Новартис Аг | Микроэмульсионный предконцентрат |
| EP0833828B1 (en) | 1995-06-09 | 2002-11-20 | Novartis AG | Rapamycin derivatives |
| BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| EP1208847B8 (en) * | 1996-07-30 | 2007-02-14 | Novartis AG | Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions |
| US6362264B1 (en) * | 1996-12-20 | 2002-03-26 | Ck Witco Corporation | Stabilizer for food contact and medical grade PVC |
| WO1998033482A1 (en) | 1997-02-04 | 1998-08-06 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
-
1998
- 1998-12-07 GB GBGB9826882.4A patent/GB9826882D0/en not_active Ceased
-
1999
- 1999-03-04 GB GBGB9904934.8A patent/GB9904934D0/en not_active Ceased
- 1999-11-29 CO CO99074905A patent/CO4980847A1/es unknown
- 1999-12-02 IT IT1999MI002520A patent/IT1319701B1/it active
- 1999-12-03 AR ARP990106171A patent/AR026102A1/es active IP Right Grant
- 1999-12-03 PE PE1999001209A patent/PE20001333A1/es not_active IP Right Cessation
- 1999-12-03 FR FR9915256A patent/FR2786771B1/fr not_active Expired - Lifetime
- 1999-12-04 TW TW094104943A patent/TWI270550B/zh not_active IP Right Cessation
- 1999-12-04 TW TW088121250A patent/TWI248938B/zh not_active IP Right Cessation
- 1999-12-06 SG SG200302502-0A patent/SG151072A1/en unknown
- 1999-12-06 CA CA2351580A patent/CA2351580C/en not_active Expired - Lifetime
- 1999-12-06 TR TR2001/01416T patent/TR200101416T2/xx unknown
- 1999-12-06 AU AU16573/00A patent/AU759219B2/en not_active Expired
- 1999-12-06 JP JP2000586368A patent/JP3805625B2/ja not_active Expired - Lifetime
- 1999-12-06 KR KR1020017007009A patent/KR100695834B1/ko not_active Expired - Lifetime
- 1999-12-06 KR KR1020067017352A patent/KR20060096477A/ko not_active Ceased
- 1999-12-06 RU RU2001118266/15A patent/RU2243769C2/ru active
- 1999-12-06 EP EP10179096A patent/EP2279751A3/en not_active Withdrawn
- 1999-12-06 HK HK02100663.4A patent/HK1038889B/en not_active IP Right Cessation
- 1999-12-06 ID IDW00200101156A patent/ID29250A/id unknown
- 1999-12-06 ES ES99959381T patent/ES2288033T5/es not_active Expired - Lifetime
- 1999-12-06 CA CA2732620A patent/CA2732620C/en not_active Expired - Lifetime
- 1999-12-06 HU HU0104489A patent/HU228939B1/hu unknown
- 1999-12-06 SK SK766-2001A patent/SK286688B6/sk not_active IP Right Cessation
- 1999-12-06 WO PCT/EP1999/009521 patent/WO2000033878A2/en not_active Ceased
- 1999-12-06 CZ CZ20012001A patent/CZ303006B6/cs not_active IP Right Cessation
- 1999-12-06 BR BR9915986-4A patent/BR9915986A/pt not_active Application Discontinuation
- 1999-12-06 CZ CZ20050170A patent/CZ302210B6/cs not_active IP Right Cessation
- 1999-12-06 EP EP06122628A patent/EP1743657A3/en not_active Ceased
- 1999-12-06 TR TR2002/01428T patent/TR200201428T2/xx unknown
- 1999-12-06 PL PL380082A patent/PL208854B1/pl unknown
- 1999-12-06 IL IL14309299A patent/IL143092A0/xx not_active IP Right Cessation
- 1999-12-06 SI SI9930985T patent/SI1137439T2/sl unknown
- 1999-12-06 EP EP10179099A patent/EP2269651A3/en not_active Withdrawn
- 1999-12-06 AT AT99959381T patent/ATE365051T1/de active
- 1999-12-06 DE DE69936352T patent/DE69936352T3/de not_active Expired - Lifetime
- 1999-12-06 PL PL348333A patent/PL196627B1/pl unknown
- 1999-12-06 CA CA002651609A patent/CA2651609A1/en not_active Abandoned
- 1999-12-06 HU HU1300289A patent/HU230174B1/hu unknown
- 1999-12-06 SK SK5032-2008A patent/SK287325B6/sk not_active IP Right Cessation
- 1999-12-06 EP EP99959381A patent/EP1137439B2/en not_active Expired - Lifetime
- 1999-12-06 CN CNB998141240A patent/CN1261163C/zh not_active Expired - Lifetime
- 1999-12-06 CN CN2006100798040A patent/CN1876657B/zh not_active Expired - Lifetime
- 1999-12-06 DK DK99959381.7T patent/DK1137439T4/da active
- 1999-12-06 NZ NZ511936A patent/NZ511936A/en not_active IP Right Cessation
- 1999-12-06 PT PT99959381T patent/PT1137439E/pt unknown
- 1999-12-07 BE BE9900799A patent/BE1012869A3/fr not_active IP Right Cessation
- 1999-12-07 MY MYPI20043386A patent/MY127579A/en unknown
- 1999-12-07 MY MYPI99005309A patent/MY120594A/en unknown
-
2001
- 2001-05-16 NO NO20012424A patent/NO332698B1/no not_active IP Right Cessation
- 2001-05-28 ZA ZA200104360A patent/ZA200104360B/en unknown
- 2001-05-29 US US09/866,977 patent/US6605613B2/en not_active Expired - Lifetime
-
2003
- 2003-03-21 US US10/393,795 patent/US6852729B2/en not_active Expired - Lifetime
- 2003-08-25 NZ NZ527781A patent/NZ527781A/en not_active IP Right Cessation
-
2004
- 2004-12-23 US US11/020,860 patent/US7297703B2/en not_active Expired - Lifetime
-
2005
- 2005-02-28 AR ARP050100744A patent/AR048073A2/es active IP Right Grant
- 2005-04-01 JP JP2005106512A patent/JP5043308B2/ja not_active Expired - Lifetime
- 2005-12-28 JP JP2005378514A patent/JP5165199B2/ja not_active Expired - Lifetime
-
2006
- 2006-05-04 AR ARP060101807A patent/AR054444A2/es active IP Right Grant
-
2007
- 2007-09-14 CY CY20071101192T patent/CY1106870T1/el unknown
- 2007-10-11 US US11/973,927 patent/US7572804B2/en not_active Expired - Fee Related
-
2009
- 2009-07-06 US US12/497,728 patent/US7741338B2/en not_active Expired - Fee Related
-
2012
- 2012-10-01 NO NO20121113A patent/NO334612B1/no not_active IP Right Cessation