GB9826882D0 - Organic compounds - Google Patents
Organic compoundsInfo
- Publication number
- GB9826882D0 GB9826882D0 GBGB9826882.4A GB9826882A GB9826882D0 GB 9826882 D0 GB9826882 D0 GB 9826882D0 GB 9826882 A GB9826882 A GB 9826882A GB 9826882 D0 GB9826882 D0 GB 9826882D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- organic compounds
- compounds
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Priority Applications (63)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9826882.4A GB9826882D0 (en) | 1998-12-07 | 1998-12-07 | Organic compounds |
| GBGB9904934.8A GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
| CO99074905A CO4980847A1 (es) | 1998-12-07 | 1999-11-29 | Procesos para estabilizar macrolidos de polieno y un macrolido obtenido en forma cristalina |
| IT1999MI002520A IT1319701B1 (it) | 1998-12-07 | 1999-12-02 | Procedimento per stabilizzare un macrolide polienicoed ed unparticolare macrolide ottenuto in forma cristallina |
| ARP990106171A AR026102A1 (es) | 1998-12-07 | 1999-12-03 | Un proceso para estabilizar un mocrolido de polietileno, una mezcla de forma solida, una composicion farmaceutica, un derivado de rapamicina y un procesopara su purificacion |
| FR9915256A FR2786771B1 (fr) | 1998-12-07 | 1999-12-03 | Procede de stabilisation d'un macrolide poly-ene et composition pharmaceutique contenant un tel compose |
| PE1999001209A PE20001333A1 (es) | 1998-12-07 | 1999-12-03 | Proceso para estabilizar macrolidos de polieno |
| TW088121250A TWI248938B (en) | 1998-12-07 | 1999-12-04 | Macrolides |
| TW094104943A TWI270550B (en) | 1998-12-07 | 1999-12-04 | Macrolides |
| CA2351580A CA2351580C (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| CNB998141240A CN1261163C (zh) | 1998-12-07 | 1999-12-06 | 大环内酯的稳定化 |
| EP10179099A EP2269651A3 (en) | 1998-12-07 | 1999-12-06 | Stabilisation of macrolides |
| TR2001/01416T TR200101416T2 (tr) | 1998-12-07 | 1999-12-06 | Makrolidlerin stabilizasyonu |
| SK5032-2008A SK287325B6 (sk) | 1998-12-07 | 1999-12-06 | Zmes obsahujúca 40-O-(2-hydroxy)etylrapamycín a antioxidant a farmaceutická kompozícia s obsahom tejto zmesi |
| AT99959381T ATE365051T1 (de) | 1998-12-07 | 1999-12-06 | Stabilisierung von rapamycinen oder rapamycinderivaten |
| PL348333A PL196627B1 (pl) | 1998-12-07 | 1999-12-06 | Stała mieszanina zawierająca rapamycynę albo pochodną rapamycyny oraz sposób stabilizowania rapamycyny albo pochodnej rapamycyny |
| AU16573/00A AU759219B2 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| CA2732620A CA2732620C (en) | 1998-12-07 | 1999-12-06 | Crystalline form of 40-o-(2-hydroxy-ethyl) rapamycin and process for preparation thereof |
| PL380082A PL208854B1 (pl) | 1998-12-07 | 1999-12-06 | Forma krystaliczna 40-O-(-hydroksy)etylo-rapamycyny, kompozycja farmaceutyczna ją zawierająca oraz sposób oczyszczania 40-O-(2-hydroksy)etylo-rapamycyny |
| HU0104489A HU228939B1 (en) | 1998-12-07 | 1999-12-06 | Stabilization of derivative of rapamicin |
| IL14309299A IL143092A0 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| HK02100663.4A HK1038889B (en) | 1998-12-07 | 1999-12-06 | Stabilization of rapamycins or derivatives of rapamycins |
| IDW00200101156A ID29250A (id) | 1998-12-07 | 1999-12-06 | Stabilisasi makrolida |
| KR1020017007009A KR100695834B1 (ko) | 1998-12-07 | 1999-12-06 | 마크로리드의 안정화 방법 |
| SG200302502-0A SG151072A1 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| HU1300289A HU230174B1 (hu) | 1998-12-07 | 1999-12-06 | Rapamycin-származékot tartalmazó ömlesztett keverék |
| BR9915986-4A BR9915986A (pt) | 1998-12-07 | 1999-12-06 | Estabilização de macrolìdios |
| NZ511936A NZ511936A (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| SI9930985T SI1137439T2 (sl) | 1998-12-07 | 1999-12-06 | Stabilizacija rapamicinov ali derivatov rapamicinov |
| KR1020067017352A KR20060096477A (ko) | 1998-12-07 | 1999-12-06 | 마크로리드의 안정화 방법 |
| JP2000586368A JP3805625B2 (ja) | 1998-12-07 | 1999-12-06 | マクロライドの安定化 |
| TR2002/01428T TR200201428T2 (tr) | 1998-12-07 | 1999-12-06 | Makrolidlerin stabilizasyonu |
| PCT/EP1999/009521 WO2000033878A2 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
| CZ20012001A CZ303006B6 (cs) | 1998-12-07 | 1999-12-06 | Zpusob stabilizace 40-O-(2-hydroxy)ethylrapamycinu, který má imunosupresivní vlastnosti, a smes obsahující 40-O-(2-hydroxy)ethylrapamycin a antioxidant |
| RU2001118266/15A RU2243769C2 (ru) | 1998-12-07 | 1999-12-06 | Стабилизация макролидов |
| EP06122628A EP1743657A3 (en) | 1998-12-07 | 1999-12-06 | Stabilisation of macrolides |
| DE69936352T DE69936352T3 (de) | 1998-12-07 | 1999-12-06 | Stabilisierung von rapamycinen oder rapamycinderivaten |
| DK99959381.7T DK1137439T4 (da) | 1998-12-07 | 1999-12-06 | Stabilisering af rapamyciner eller rapamycinderivater |
| EP99959381A EP1137439B2 (en) | 1998-12-07 | 1999-12-06 | Stabilization of rapamycins or derivatives of rapamycins |
| EP10179096A EP2279751A3 (en) | 1998-12-07 | 1999-12-06 | Stabilisation of macrolides |
| PT99959381T PT1137439E (pt) | 1998-12-07 | 1999-12-06 | Estabilização de rapamicinas ou de derivados de rapamicinas |
| CN2006100798040A CN1876657B (zh) | 1998-12-07 | 1999-12-06 | 大环内酯的稳定化 |
| SK766-2001A SK286688B6 (sk) | 1998-12-07 | 1999-12-06 | Spôsob stabilizácie rapamycínu alebo rapamycínového derivátu |
| CA002651609A CA2651609A1 (en) | 1998-12-07 | 1999-12-06 | Crystalline form of 40-o- (2-hydroxy-ethyl) rapamycin and process for preparation thereof |
| CZ20050170A CZ302210B6 (cs) | 1998-12-07 | 1999-12-06 | Nesolvatovaná@krystalická@forma@@@@O@@@@hydroxyethyl@@rapamycinu@@zpusob@její@prípravy@a@farmaceutická@kompozice@obsahující@tuto@krystalickou@formu |
| ES99959381T ES2288033T5 (es) | 1998-12-07 | 1999-12-06 | Estabilización de rapamicinas o de derivados de rapamicinas |
| BE9900799A BE1012869A3 (fr) | 1998-12-07 | 1999-12-07 | Procede de stabilisation d'un macrolide poly-ene et composition pharmaceutique contenant un tel compose. |
| MYPI99005309A MY120594A (en) | 1998-12-07 | 1999-12-07 | Stabilization of macrolides |
| MYPI20043386A MY127579A (en) | 1998-12-07 | 1999-12-07 | Stabilization of macrolides |
| NO20012424A NO332698B1 (no) | 1998-12-07 | 2001-05-16 | Fremgangsmate for stabilisering av rapamycinderivat |
| ZA200104360A ZA200104360B (en) | 1998-12-07 | 2001-05-28 | Stabilization of macrolides. |
| US09/866,977 US6605613B2 (en) | 1998-12-07 | 2001-05-29 | Macrolides |
| US10/393,795 US6852729B2 (en) | 1998-12-07 | 2003-03-21 | Macrolides |
| NZ527781A NZ527781A (en) | 1998-12-07 | 2003-08-25 | Crystalline rapamycin |
| US11/020,860 US7297703B2 (en) | 1998-12-07 | 2004-12-23 | Macrolides |
| ARP050100744A AR048073A2 (es) | 1998-12-07 | 2005-02-28 | 40-o-(2-hidroxi-etil)-rapamicina, proceso para su produccion y composicion farmaceutica que la contiene |
| JP2005106512A JP5043308B2 (ja) | 1998-12-07 | 2005-04-01 | マクロライドの安定化 |
| JP2005378514A JP5165199B2 (ja) | 1998-12-07 | 2005-12-28 | マクロライドの安定化 |
| ARP060101807A AR054444A2 (es) | 1998-12-07 | 2006-05-04 | Mezcla en forma solida de rapamicina o un derivado se rapamicina y un antioxidante |
| CY20071101192T CY1106870T1 (el) | 1998-12-07 | 2007-09-14 | Σταθεροποιηση ραπαμυκινης ή παραγωγων ραπαμυκινης |
| US11/973,927 US7572804B2 (en) | 1998-12-07 | 2007-10-11 | Macrolides |
| US12/497,728 US7741338B2 (en) | 1998-12-07 | 2009-07-06 | Macrolides |
| NO20121113A NO334612B1 (no) | 1998-12-07 | 2012-10-01 | Stabilisering av makrolider |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9826882.4A GB9826882D0 (en) | 1998-12-07 | 1998-12-07 | Organic compounds |
| GBGB9904934.8A GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB9826882D0 true GB9826882D0 (en) | 1999-01-27 |
Family
ID=26314797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB9826882.4A Ceased GB9826882D0 (en) | 1998-12-07 | 1998-12-07 | Organic compounds |
| GBGB9904934.8A Ceased GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB9904934.8A Ceased GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
Country Status (38)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| MXPA04007847A (es) | 2002-02-13 | 2005-02-24 | Biogal Gyogyszergyar | Metodo para extraer un macrolido de biomateria. |
| US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
| AR040693A1 (es) * | 2002-07-30 | 2005-04-13 | Wyeth Corp | Formulaciones parenterales |
| WO2004089958A2 (en) * | 2003-03-31 | 2004-10-21 | TEVA Gyógyszergyár Részvénytársaság | Crystallization and purification of macrolides |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| PL1558622T3 (pl) | 2003-07-24 | 2008-06-30 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Sposób oczyszczania makrolidów |
| KR20060085246A (ko) | 2003-09-18 | 2006-07-26 | 마커사이트, 인코포레이티드 | 경공막 전달 |
| US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
| KR20060126701A (ko) * | 2003-12-10 | 2006-12-08 | 애크럭스 디디에스 피티와이 리미티드 | 경피 또는 국소 약물 전달에 따른 원치않는 효과의치료방법 |
| US8551512B2 (en) * | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
| MX2007003731A (es) * | 2004-09-29 | 2007-08-14 | Johnson & Johnson | Formas de dosis farmaceuticas de compuestos similares a rapamicina amorfos estables. |
| DK1848431T3 (en) | 2005-02-09 | 2016-04-18 | Santen Pharmaceutical Co Ltd | LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS |
| WO2007067566A2 (en) * | 2005-12-07 | 2007-06-14 | Wyeth | Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry |
| US7700614B2 (en) * | 2005-12-14 | 2010-04-20 | Abbott Laboratories | One pot synthesis of tetrazole derivatives of rapamycin |
| US20070142422A1 (en) * | 2005-12-20 | 2007-06-21 | Wyeth | Control of CCI-779 dosage form stability through control of drug substance impurities |
| KR20140093764A (ko) * | 2006-02-09 | 2014-07-28 | 산텐 세이야꾸 가부시키가이샤 | 안정한 제제와 그 제조 및 사용 방법 |
| ES2563288T3 (es) | 2006-03-23 | 2016-03-14 | Santen Pharmaceutical Co., Ltd | Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular |
| JP2013527223A (ja) | 2010-06-02 | 2013-06-27 | フレゼニウス・カビ・オンコロジー・リミテッド | ラパマイシンエステルの安定な医薬組成物 |
| CN103025753A (zh) * | 2010-06-07 | 2013-04-03 | 泰立克公司 | 晶体盐酸依泽替米贝非溶剂化物 |
| WO2012017449A1 (en) * | 2010-08-04 | 2012-02-09 | Meril Life Sciences Pvt. Ltd | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties" |
| ES2753529T3 (es) | 2010-11-19 | 2020-04-13 | Biocon Ltd | Procesos para la preparación de everolimús y productos intermedios del mismo |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| WO2013022201A1 (en) * | 2011-08-11 | 2013-02-14 | Dong-A Pharm. Co., Ltd. | Process of preparing a stabilized and solubilized formulation of sirolimus derivatives |
| US9610385B2 (en) | 2013-03-07 | 2017-04-04 | Abbott Cardiovascular Systems Inc. | Method of fabricating an implantable medical device comprising a rapamycin derivative |
| IN2013MU02532A (https=) | 2013-07-31 | 2015-06-26 | Sahajanand Medical Technologies Pvt Ltd | |
| CN104721158B (zh) * | 2013-12-24 | 2018-01-30 | 正大天晴药业集团股份有限公司 | 一种稳定的依维莫司片剂 |
| CN104892632B (zh) * | 2015-06-03 | 2017-12-26 | 道中道(菏泽)制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
| EP3329916A4 (en) | 2015-07-28 | 2019-03-20 | Nippon Kayaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF, AND PROCESS FOR PRODUCING THE SAME |
| JP6793651B2 (ja) * | 2015-08-28 | 2020-12-02 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| US20190038605A1 (en) * | 2015-09-18 | 2019-02-07 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof |
| WO2017129772A1 (en) | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Stable pharmaceutical compositions of temsirolimus |
| WO2017204215A1 (ja) | 2016-05-27 | 2017-11-30 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| KR102051806B1 (ko) * | 2018-01-12 | 2019-12-04 | 주식회사 종근당 | 에베로리무스를 포함하는 안정화된 약제학적 제제 |
| EP4126882A1 (en) * | 2020-03-27 | 2023-02-08 | Boston Scientific Scimed Inc. | Methods for crystallization of drugs |
| JP2023028473A (ja) * | 2021-08-19 | 2023-03-03 | 日本マイクロバイオファーマ株式会社 | エベロリムスの製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3996355A (en) | 1975-01-02 | 1976-12-07 | American Home Products Corporation | Permanent suspension pharmaceutical dosage form |
| US4049128A (en) | 1976-11-18 | 1977-09-20 | Westinghouse Air Brake Company | Control system for automatic railway car coupler |
| AU543727B2 (en) * | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
| GB8803836D0 (en) | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
| JPH01249651A (ja) † | 1988-02-18 | 1989-10-04 | E I Du Pont De Nemours & Co | セラミツク/蒸留可能な結合剤組成物 |
| KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| FI97472C (fi) * | 1991-05-07 | 1996-12-27 | American Home Prod | Menetelmä terapeuttisesti käyttökelpoisten rapamysiinijohdannaisten valmistamiseksi anti-inflammatorisina ja antifungaalisina aineina |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| SG47580A1 (en) | 1992-10-13 | 1998-04-17 | American Home Prod | Carbamates of rapamycin |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| RU2181054C2 (ru) * | 1994-11-02 | 2002-04-10 | Новартис Аг | Микроэмульсионный предконцентрат |
| US5985890A (en) | 1995-06-09 | 1999-11-16 | Novartis Ag | Rapamycin derivatives |
| FR2736550B1 (fr) * | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| PT956034E (pt) * | 1996-07-30 | 2002-12-31 | Novartis Ag | Composicoes farmaceuticas para o tratamento da rejeicao de transplantes estados inflamatorios ou auto-imunes compreendendo ciclosporina a e 40-o-(2-hidroxietil)-rapamicina |
| US6362264B1 (en) * | 1996-12-20 | 2002-03-26 | Ck Witco Corporation | Stabilizer for food contact and medical grade PVC |
| CA2279259A1 (en) | 1997-02-04 | 1998-08-06 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
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1998
- 1998-12-07 GB GBGB9826882.4A patent/GB9826882D0/en not_active Ceased
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1999
- 1999-03-04 GB GBGB9904934.8A patent/GB9904934D0/en not_active Ceased
- 1999-11-29 CO CO99074905A patent/CO4980847A1/es unknown
- 1999-12-02 IT IT1999MI002520A patent/IT1319701B1/it active
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- 1999-12-06 RU RU2001118266/15A patent/RU2243769C2/ru active
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- 1999-12-06 EP EP10179096A patent/EP2279751A3/en not_active Withdrawn
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- 1999-12-06 KR KR1020067017352A patent/KR20060096477A/ko not_active Ceased
- 1999-12-06 PL PL380082A patent/PL208854B1/pl unknown
- 1999-12-06 BR BR9915986-4A patent/BR9915986A/pt not_active Application Discontinuation
- 1999-12-06 TR TR2002/01428T patent/TR200201428T2/xx unknown
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2001
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