JP2002531488A5 - - Google Patents
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- Publication number
- JP2002531488A5 JP2002531488A5 JP2000586306A JP2000586306A JP2002531488A5 JP 2002531488 A5 JP2002531488 A5 JP 2002531488A5 JP 2000586306 A JP2000586306 A JP 2000586306A JP 2000586306 A JP2000586306 A JP 2000586306A JP 2002531488 A5 JP2002531488 A5 JP 2002531488A5
- Authority
- JP
- Japan
- Prior art keywords
- mecamylamine
- nicotine
- drug
- hour
- period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000010410 layer Substances 0.000 description 22
- IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 description 18
- 229960002525 mecamylamine Drugs 0.000 description 18
- 239000003814 drug Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 14
- 229960002715 nicotine Drugs 0.000 description 14
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 14
- 229940079593 drug Drugs 0.000 description 12
- 239000013464 silicone adhesive Substances 0.000 description 7
- 239000003522 acrylic cement Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 206010057852 Nicotine dependence Diseases 0.000 description 4
- 208000025569 Tobacco Use disease Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 3
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 3
- 229960003946 selegiline Drugs 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11128598P | 1998-12-07 | 1998-12-07 | |
| US60/111,285 | 1998-12-07 | ||
| PCT/US1999/028697 WO2000033812A2 (en) | 1998-12-07 | 1999-12-07 | Transdermal patch for delivering volatile liquid drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531488A JP2002531488A (ja) | 2002-09-24 |
| JP2002531488A5 true JP2002531488A5 (enExample) | 2006-12-28 |
Family
ID=22337613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586306A Pending JP2002531488A (ja) | 1998-12-07 | 1999-12-07 | 揮発性液体薬剤を送出するための経皮パッチ |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1137406B2 (enExample) |
| JP (1) | JP2002531488A (enExample) |
| KR (1) | KR100885235B1 (enExample) |
| AT (1) | ATE264098T1 (enExample) |
| AU (1) | AU778992B2 (enExample) |
| CA (1) | CA2380391A1 (enExample) |
| DE (1) | DE69916492T3 (enExample) |
| NZ (2) | NZ525878A (enExample) |
| WO (1) | WO2000033812A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| WO2000041538A2 (en) | 1999-01-14 | 2000-07-20 | Noven Pharmaceuticals, Inc. | Dermal compositions |
| JP2005504002A (ja) | 2001-02-13 | 2005-02-10 | ガバメント オブ ザ ユナイテッド ステイツ、 アズ リプリゼンティッド バイ ザ セクレタリィ オブ ジ アーミイ | 経皮免疫感作のためのワクチン |
| DE10110391A1 (de) | 2001-03-03 | 2002-09-26 | Lohmann Therapie Syst Lts | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
| CN1516595A (zh) * | 2001-03-19 | 2004-07-28 | Iomai公司 | 用于经皮免疫的贴剂 |
| US7099713B2 (en) | 2002-06-28 | 2006-08-29 | Battelle Memorial Institute | Skin conduction and transport systems |
| US20040086551A1 (en) | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl |
| CA2518385A1 (en) * | 2003-03-14 | 2004-09-23 | Agi Therapeutics Ltd. | Treatment of intestinal conditions with n-2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine |
| US20070224284A1 (en) | 2004-03-12 | 2007-09-27 | John Devane | Methods and compositions comprising at least one alpha3 beta4 nAChR antagonist or pharmaceutically acceptable salt thereof |
| WO2005025549A2 (en) | 2003-09-10 | 2005-03-24 | Noven Pharmaceuticals, Inc. | Multi-layer transdermal drug delivery device |
| JP2007509951A (ja) * | 2003-10-28 | 2007-04-19 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | 経皮的なドラッグデリバリーシステムにおける医薬品の損失及び送達を制御するための組成物及び方法 |
| ITMI20041697A1 (it) * | 2004-09-03 | 2004-12-03 | Bouty S P A | Sistema terapeutico a rilascio controllato per uso topico in forma di cerotto multistrato |
| US8343538B2 (en) | 2004-10-08 | 2013-01-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems |
| WO2006041911A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Device transdermal administration of drugs including acrylic polymers |
| IL177071A0 (en) | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| ES2499067T3 (es) | 2005-10-13 | 2014-09-26 | Nitto Denko Corporation | Preparación transdérmica de nicotina y método de producción de la misma |
| DE102006054733A1 (de) | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit |
| CN102164601A (zh) * | 2008-09-30 | 2011-08-24 | 帝国制药美国公司 | 经皮延长给药多奈哌齐组合物及其使用方法 |
| EP2298277A1 (en) * | 2009-09-09 | 2011-03-23 | Labtec GmbH | Transdermal patch formulation |
| US9017723B2 (en) | 2010-04-30 | 2015-04-28 | Teikoku Pharma Usa, Inc. | Propynylaminoindan transdermal compositions |
| WO2012129429A2 (en) | 2011-03-24 | 2012-09-27 | Teikoku Pharma Usa, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
| WO2013070526A1 (en) | 2011-11-09 | 2013-05-16 | Teikoku Pharma Usa, Inc. | Methods for the treatment of skin neoplasms |
| NZ706590A (en) | 2012-11-02 | 2016-02-26 | Teikoku Pharma Usa Inc | Propynylaminoindan transdermal compositions |
| DE102013013397A1 (de) | 2013-08-13 | 2015-03-12 | Epinamics Gmbh | Aerosolspender für transdermal wirkende pharmazeutische Zusammensetzungen |
| DE102013020633A1 (de) | 2013-12-16 | 2015-06-18 | Epinamics Gmbh | Dermale und/oder transdermale pharmazeutische Zusammensetzung enthaltend eine terpenoide Verbindung |
| DE102020112143B4 (de) | 2020-05-05 | 2022-03-17 | Lts Lohmann Therapie-Systeme Ag | Nicotin - Corona |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4717568A (en) * | 1985-08-09 | 1988-01-05 | Alza Corporation | Laminar arrangement for increasing delivery of beneficial agent from dispenser |
| US5316759A (en) † | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| DE3629304A1 (de) † | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| CH674618A5 (enExample) * | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| GB8807504D0 (en) † | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
| DE3908432A1 (de) * | 1989-03-14 | 1990-09-27 | Lohmann Therapie Syst Lts | Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung |
| DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
| JPH09505028A (ja) † | 1993-07-09 | 1997-05-20 | シグナス，インコーポレイテッド | 経皮的／経頬的にニコチン置換治療を提供する方法およびデバイス |
| DE4332094C2 (de) † | 1993-09-22 | 1995-09-07 | Lohmann Therapie Syst Lts | Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung |
| JP3021661B2 (ja) * | 1994-03-07 | 2000-03-15 | セラテック・インコーポレーテッド | 薬剤含有接着複合体の経皮放出デバイス |
| IL122484A0 (en) * | 1995-06-07 | 1998-06-15 | Noven Pharma | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| US5691365A (en) * | 1995-07-18 | 1997-11-25 | University Of Kentucky Research Foundation | Nicotinic receptor antagonists in the treatment of neuropharmacological disorders |
| JPH09301853A (ja) * | 1996-05-14 | 1997-11-25 | Nitto Denko Corp | 貼付剤および貼付製剤 |
-
1999
- 1999-12-07 JP JP2000586306A patent/JP2002531488A/ja active Pending
- 1999-12-07 EP EP99968461A patent/EP1137406B2/en not_active Expired - Lifetime
- 1999-12-07 AT AT99968461T patent/ATE264098T1/de not_active IP Right Cessation
- 1999-12-07 AU AU25877/00A patent/AU778992B2/en not_active Ceased
- 1999-12-07 NZ NZ52587899A patent/NZ525878A/xx not_active IP Right Cessation
- 1999-12-07 KR KR1020017007132A patent/KR100885235B1/ko not_active Expired - Fee Related
- 1999-12-07 DE DE69916492T patent/DE69916492T3/de not_active Expired - Lifetime
- 1999-12-07 NZ NZ512788A patent/NZ512788A/en not_active IP Right Cessation
- 1999-12-07 WO PCT/US1999/028697 patent/WO2000033812A2/en not_active Ceased
- 1999-12-07 CA CA002380391A patent/CA2380391A1/en not_active Abandoned
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