JP2016502989A5 - - Google Patents
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- Publication number
- JP2016502989A5 JP2016502989A5 JP2015547016A JP2015547016A JP2016502989A5 JP 2016502989 A5 JP2016502989 A5 JP 2016502989A5 JP 2015547016 A JP2015547016 A JP 2015547016A JP 2015547016 A JP2015547016 A JP 2015547016A JP 2016502989 A5 JP2016502989 A5 JP 2016502989A5
- Authority
- JP
- Japan
- Prior art keywords
- buprenorphine
- transdermal therapeutic
- therapeutic system
- hours
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960001736 buprenorphine Drugs 0.000 claims 103
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 102
- 230000001225 therapeutic effect Effects 0.000 claims 76
- 239000010410 layer Substances 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 23
- 239000011159 matrix material Substances 0.000 claims 22
- 229920000642 polymer Polymers 0.000 claims 15
- 239000012790 adhesive layer Substances 0.000 claims 13
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 10
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 229940040102 levulinic acid Drugs 0.000 claims 6
- 150000001735 carboxylic acids Chemical class 0.000 claims 5
- -1 buprenorphine carboxylate Chemical class 0.000 claims 4
- 239000000853 adhesive Substances 0.000 claims 3
- 230000001070 adhesive effect Effects 0.000 claims 3
- 230000001186 cumulative effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 239000011149 active material Substances 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 238000010030 laminating Methods 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261736342P | 2012-12-12 | 2012-12-12 | |
| US61/736,342 | 2012-12-12 | ||
| PCT/EP2013/076325 WO2014090921A1 (en) | 2012-12-12 | 2013-12-12 | Transdermal delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016502989A JP2016502989A (ja) | 2016-02-01 |
| JP2016502989A5 true JP2016502989A5 (enExample) | 2017-01-19 |
Family
ID=49816915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547016A Abandoned JP2016502989A (ja) | 2012-12-12 | 2013-12-12 | 経皮送達システム |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20150306093A1 (enExample) |
| EP (1) | EP2931263A1 (enExample) |
| JP (1) | JP2016502989A (enExample) |
| KR (1) | KR20150096460A (enExample) |
| CN (1) | CN105007906A (enExample) |
| AP (1) | AP2015008525A0 (enExample) |
| AR (1) | AR093940A1 (enExample) |
| AU (1) | AU2013205080B2 (enExample) |
| BR (1) | BR112015013660A2 (enExample) |
| CA (1) | CA2894960A1 (enExample) |
| CL (1) | CL2015001577A1 (enExample) |
| CR (1) | CR20150360A (enExample) |
| DE (1) | DE112013005945T5 (enExample) |
| EA (1) | EA201591124A1 (enExample) |
| GB (1) | GB2523715A (enExample) |
| HK (1) | HK1215677A1 (enExample) |
| IL (1) | IL239223A0 (enExample) |
| MX (1) | MX2015007348A (enExample) |
| NZ (1) | NZ628092A (enExample) |
| PE (1) | PE20151147A1 (enExample) |
| PH (1) | PH12015501169A1 (enExample) |
| SG (1) | SG11201504286VA (enExample) |
| TN (1) | TN2015000201A1 (enExample) |
| TW (1) | TW201438765A (enExample) |
| WO (1) | WO2014090921A1 (enExample) |
| ZA (1) | ZA201504964B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| EA201491164A1 (ru) | 2011-12-12 | 2014-10-30 | ЭлТиЭс ЛОМАНН ТЕРАПИ-ЗЮСТЕМ АГ | Трансдермальная система доставки |
| WO2014195352A1 (en) | 2013-06-04 | 2014-12-11 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
| CA2977732C (en) | 2015-03-10 | 2021-02-23 | Rhodes Technologies | Acetate salt of buprenorphine and methods for preparing buprenorphine |
| US20180256562A1 (en) * | 2015-09-14 | 2018-09-13 | Amneal Pharmaceuticals Llc | Transdermal Delivery System |
| KR101695603B1 (ko) * | 2016-11-08 | 2017-01-12 | 이창우 | 병목 하단 밀착 구조의 점탄성 연결캡을 포함하는 니들 디스크 롤러 장치 |
| WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
| EP3764997A1 (en) * | 2018-03-13 | 2021-01-20 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| BR112020017484A2 (pt) * | 2018-03-13 | 2020-12-22 | Lts Lohmann Therapie-Systeme Ag | Sistema terapêutico transdérmico para a administração transdérmica de buprenorfina compreendendo um polímero híbrido de acrílico e silicone |
| CN111971032A (zh) * | 2018-03-13 | 2020-11-20 | 罗曼治疗系统股份公司 | 包含有机硅丙烯酸杂化聚合物的透皮治疗系统 |
| CN111867569A (zh) * | 2018-03-13 | 2020-10-30 | 罗曼治疗系统股份公司 | 包含有机硅丙烯酸杂化聚合物的透皮治疗系统 |
| GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
| US20220241215A1 (en) * | 2019-07-09 | 2022-08-04 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising an active agent-containing layer comprising a silicone-containing polymer and a skin contact layer comprising a silicone gel adhesive |
| CN113952319A (zh) * | 2021-11-30 | 2022-01-21 | 烟台大学 | 一种含丁丙诺啡的骨架型透皮贴剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| DE60322102D1 (de) * | 2002-12-13 | 2008-08-21 | Euro Celtique Sa | Transdermales buprenorphin-dosierschema zwecks schmerzstillung |
| CN1943576A (zh) * | 2006-10-27 | 2007-04-11 | 哈尔滨健迪医药技术有限公司 | 丁丙诺啡和/或盐酸丁丙诺啡贴剂基质及其贴剂的制备方法 |
| DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| CN101612141B (zh) * | 2009-07-29 | 2012-10-03 | 考司美德制药株式会社 | 丁丙诺啡贴剂 |
-
2013
- 2013-04-13 AU AU2013205080A patent/AU2013205080B2/en not_active Ceased
- 2013-12-12 EP EP13810924.4A patent/EP2931263A1/en not_active Withdrawn
- 2013-12-12 JP JP2015547016A patent/JP2016502989A/ja not_active Abandoned
- 2013-12-12 HK HK16103661.4A patent/HK1215677A1/zh unknown
- 2013-12-12 NZ NZ628092A patent/NZ628092A/en not_active IP Right Cessation
- 2013-12-12 BR BR112015013660A patent/BR112015013660A2/pt active Search and Examination
- 2013-12-12 WO PCT/EP2013/076325 patent/WO2014090921A1/en not_active Ceased
- 2013-12-12 CA CA2894960A patent/CA2894960A1/en not_active Abandoned
- 2013-12-12 PE PE2015000906A patent/PE20151147A1/es not_active Application Discontinuation
- 2013-12-12 US US14/650,451 patent/US20150306093A1/en not_active Abandoned
- 2013-12-12 MX MX2015007348A patent/MX2015007348A/es unknown
- 2013-12-12 DE DE112013005945.2T patent/DE112013005945T5/de not_active Withdrawn
- 2013-12-12 SG SG11201504286VA patent/SG11201504286VA/en unknown
- 2013-12-12 TW TW102145867A patent/TW201438765A/zh unknown
- 2013-12-12 KR KR1020157018513A patent/KR20150096460A/ko not_active Withdrawn
- 2013-12-12 AR ARP130104652A patent/AR093940A1/es unknown
- 2013-12-12 EA EA201591124A patent/EA201591124A1/ru unknown
- 2013-12-12 GB GB1512243.5A patent/GB2523715A/en not_active Withdrawn
- 2013-12-12 CN CN201380071638.8A patent/CN105007906A/zh active Pending
- 2013-12-12 AP AP2015008525A patent/AP2015008525A0/xx unknown
-
2015
- 2015-05-22 TN TNP2015000201A patent/TN2015000201A1/fr unknown
- 2015-05-26 PH PH12015501169A patent/PH12015501169A1/en unknown
- 2015-06-04 IL IL239223A patent/IL239223A0/en unknown
- 2015-06-08 CL CL2015001577A patent/CL2015001577A1/es unknown
- 2015-07-09 CR CR20150360A patent/CR20150360A/es unknown
- 2015-07-10 ZA ZA2015/04964A patent/ZA201504964B/en unknown
-
2018
- 2018-03-08 US US15/915,369 patent/US20180193333A1/en not_active Abandoned
-
2020
- 2020-04-30 US US16/863,584 patent/US20200253957A1/en not_active Abandoned
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