AR093940A1 - Sistema de liberacion transdermica, metodo de preparacion - Google Patents
Sistema de liberacion transdermica, metodo de preparacionInfo
- Publication number
- AR093940A1 AR093940A1 ARP130104652A ARP130104652A AR093940A1 AR 093940 A1 AR093940 A1 AR 093940A1 AR P130104652 A ARP130104652 A AR P130104652A AR P130104652 A ARP130104652 A AR P130104652A AR 093940 A1 AR093940 A1 AR 093940A1
- Authority
- AR
- Argentina
- Prior art keywords
- buprenorphine
- layer
- acid
- base
- patient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se relaciona con un método de tratamiento del dolor en un paciente al aplicar un sistema terapéutico transdérmico para la administración transdérmica de buprenorfina por 7 días sobre la piel de un paciente, dicho sistema terapéutico transdérmico comprendiendo una estructura de capa autoadhesiva conteniendo buprenorfina que comprende A) una capa de respaldo impermeable a la buprenorfina, y B) una capa matricial conteniendo buprenorfina sobre dicha capa de respaldo impermeable a la buprenorfina, la capa matricial comprendiendo a) una base polimérica, b) buprenorfina, y c) un ácido carboxílico seleccionado del grupo consistente de ácido oleico, ácido linoleico, ácido linolénico, ácido levulínico y mezclas de los mismos, en una cantidad suficiente para que dicha buprenorfina sea solubilizada en él para formar una mezcla, y la mezcla ácido carboxílico buprenorfina forme depósitos dispersos en la base polimérica, y C) una capa de contacto con la piel sobre dicha capa matricial conteniendo buprenorfina que comprende un adhesivo sensible a la presión de base polimérica, y opcionalmente donde la estructura de capa autoadhesiva conteniendo buprenorfina contiene dicha buprenorfina en una cantidad de menos de 0,8 mg/cm² base de buprenorfina o una cantidad equimolar de una sal farmacéuticamente aceptable de la misma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261736342P | 2012-12-12 | 2012-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093940A1 true AR093940A1 (es) | 2015-07-01 |
Family
ID=49816915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104652A AR093940A1 (es) | 2012-12-12 | 2013-12-12 | Sistema de liberacion transdermica, metodo de preparacion |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20150306093A1 (es) |
| EP (1) | EP2931263A1 (es) |
| JP (1) | JP2016502989A (es) |
| KR (1) | KR20150096460A (es) |
| CN (1) | CN105007906A (es) |
| AP (1) | AP2015008525A0 (es) |
| AR (1) | AR093940A1 (es) |
| AU (1) | AU2013205080B2 (es) |
| BR (1) | BR112015013660A2 (es) |
| CA (1) | CA2894960A1 (es) |
| CL (1) | CL2015001577A1 (es) |
| CR (1) | CR20150360A (es) |
| DE (1) | DE112013005945T5 (es) |
| EA (1) | EA201591124A1 (es) |
| GB (1) | GB2523715A (es) |
| HK (1) | HK1215677A1 (es) |
| IL (1) | IL239223A0 (es) |
| MX (1) | MX2015007348A (es) |
| NZ (1) | NZ628092A (es) |
| PE (1) | PE20151147A1 (es) |
| PH (1) | PH12015501169A1 (es) |
| SG (1) | SG11201504286VA (es) |
| TN (1) | TN2015000201A1 (es) |
| TW (1) | TW201438765A (es) |
| WO (1) | WO2014090921A1 (es) |
| ZA (1) | ZA201504964B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| PE20142341A1 (es) | 2011-12-12 | 2015-01-17 | Lohmann Therapie Syst Lts | Sistema de administracion transdermica |
| SG11201509218SA (en) | 2013-06-04 | 2015-12-30 | Lohmann Therapie Syst Lts | Transdermal delivery system |
| SG11201707350TA (en) | 2015-03-10 | 2017-10-30 | Rhodes Tech | Acetate salt of buprenorphine and methods for preparing buprenorphine |
| JP2018526415A (ja) * | 2015-09-14 | 2018-09-13 | アムニール ファーマシューティカルズ エルエルシー | 経皮送達システム |
| KR101695603B1 (ko) * | 2016-11-08 | 2017-01-12 | 이창우 | 병목 하단 밀착 구조의 점탄성 연결캡을 포함하는 니들 디스크 롤러 장치 |
| WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
| US20210008000A1 (en) * | 2018-03-13 | 2021-01-14 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| EP3764998A1 (en) * | 2018-03-13 | 2021-01-20 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| WO2019175096A1 (en) * | 2018-03-13 | 2019-09-19 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system for the transdermal administration of buprenorphine comprising a silicone acrylic hybrid polymer |
| WO2019175101A1 (en) * | 2018-03-13 | 2019-09-19 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
| BR112021024461A2 (pt) * | 2019-07-09 | 2022-01-18 | Lts Lohmann Therapie Systeme Ag | Sistema terapêutico transdérmico compreendendo uma camada contendo agente ativo compreendendo um polímero contendo silicone e uma camada de contato com a pele compreendendo um adesivo de gel de silicone |
| CN113952319A (zh) * | 2021-11-30 | 2022-01-21 | 烟台大学 | 一种含丁丙诺啡的骨架型透皮贴剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| WO2004054553A1 (en) * | 2002-12-13 | 2004-07-01 | Euro-Celtique S.A. | Transdermal buprenorphine dosage regimen for analgesia |
| CN1943576A (zh) * | 2006-10-27 | 2007-04-11 | 哈尔滨健迪医药技术有限公司 | 丁丙诺啡和/或盐酸丁丙诺啡贴剂基质及其贴剂的制备方法 |
| DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| CN101612141B (zh) * | 2009-07-29 | 2012-10-03 | 考司美德制药株式会社 | 丁丙诺啡贴剂 |
-
2013
- 2013-04-13 AU AU2013205080A patent/AU2013205080B2/en not_active Ceased
- 2013-12-12 EP EP13810924.4A patent/EP2931263A1/en not_active Withdrawn
- 2013-12-12 CA CA2894960A patent/CA2894960A1/en not_active Abandoned
- 2013-12-12 AR ARP130104652A patent/AR093940A1/es unknown
- 2013-12-12 BR BR112015013660A patent/BR112015013660A2/pt active Search and Examination
- 2013-12-12 KR KR1020157018513A patent/KR20150096460A/ko not_active Application Discontinuation
- 2013-12-12 SG SG11201504286VA patent/SG11201504286VA/en unknown
- 2013-12-12 DE DE112013005945.2T patent/DE112013005945T5/de not_active Withdrawn
- 2013-12-12 US US14/650,451 patent/US20150306093A1/en not_active Abandoned
- 2013-12-12 EA EA201591124A patent/EA201591124A1/ru unknown
- 2013-12-12 GB GB1512243.5A patent/GB2523715A/en not_active Withdrawn
- 2013-12-12 TW TW102145867A patent/TW201438765A/zh unknown
- 2013-12-12 AP AP2015008525A patent/AP2015008525A0/xx unknown
- 2013-12-12 CN CN201380071638.8A patent/CN105007906A/zh active Pending
- 2013-12-12 PE PE2015000906A patent/PE20151147A1/es not_active Application Discontinuation
- 2013-12-12 NZ NZ628092A patent/NZ628092A/en not_active IP Right Cessation
- 2013-12-12 MX MX2015007348A patent/MX2015007348A/es unknown
- 2013-12-12 JP JP2015547016A patent/JP2016502989A/ja not_active Abandoned
- 2013-12-12 WO PCT/EP2013/076325 patent/WO2014090921A1/en active Application Filing
-
2015
- 2015-05-22 TN TNP2015000201A patent/TN2015000201A1/fr unknown
- 2015-05-26 PH PH12015501169A patent/PH12015501169A1/en unknown
- 2015-06-04 IL IL239223A patent/IL239223A0/en unknown
- 2015-06-08 CL CL2015001577A patent/CL2015001577A1/es unknown
- 2015-07-09 CR CR20150360A patent/CR20150360A/es unknown
- 2015-07-10 ZA ZA2015/04964A patent/ZA201504964B/en unknown
-
2016
- 2016-03-30 HK HK16103661.4A patent/HK1215677A1/zh unknown
-
2018
- 2018-03-08 US US15/915,369 patent/US20180193333A1/en not_active Abandoned
-
2020
- 2020-04-30 US US16/863,584 patent/US20200253957A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TN2015000201A1 (en) | 2016-10-03 |
| SG11201504286VA (en) | 2015-06-29 |
| PH12015501169A1 (en) | 2015-08-10 |
| BR112015013660A2 (pt) | 2017-07-11 |
| CR20150360A (es) | 2015-08-21 |
| PE20151147A1 (es) | 2015-08-06 |
| MX2015007348A (es) | 2016-01-20 |
| ZA201504964B (en) | 2017-11-29 |
| CA2894960A1 (en) | 2014-06-19 |
| TW201438765A (zh) | 2014-10-16 |
| US20150306093A1 (en) | 2015-10-29 |
| EP2931263A1 (en) | 2015-10-21 |
| US20180193333A1 (en) | 2018-07-12 |
| DE112013005945T5 (de) | 2015-08-27 |
| GB2523715A (en) | 2015-09-02 |
| US20200253957A1 (en) | 2020-08-13 |
| GB201512243D0 (en) | 2015-08-19 |
| KR20150096460A (ko) | 2015-08-24 |
| AU2013205080B2 (en) | 2016-07-07 |
| JP2016502989A (ja) | 2016-02-01 |
| HK1215677A1 (zh) | 2016-09-09 |
| NZ628092A (en) | 2017-01-27 |
| AU2013205080A1 (en) | 2014-06-26 |
| EA201591124A1 (ru) | 2015-11-30 |
| AP2015008525A0 (en) | 2015-06-30 |
| WO2014090921A1 (en) | 2014-06-19 |
| CN105007906A (zh) | 2015-10-28 |
| CL2015001577A1 (es) | 2015-10-02 |
| IL239223A0 (en) | 2015-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |