BR0313092A - Sistema de liberação transdérmica aperfeiçoado - Google Patents
Sistema de liberação transdérmica aperfeiçoadoInfo
- Publication number
- BR0313092A BR0313092A BR0313092-4A BR0313092A BR0313092A BR 0313092 A BR0313092 A BR 0313092A BR 0313092 A BR0313092 A BR 0313092A BR 0313092 A BR0313092 A BR 0313092A
- Authority
- BR
- Brazil
- Prior art keywords
- drug
- amino
- matrix
- release system
- functional
- Prior art date
Links
- 239000003814 drug Substances 0.000 abstract 7
- 229940079593 drug Drugs 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- 239000011159 matrix material Substances 0.000 abstract 5
- 239000000853 adhesive Substances 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SISTEMA DE LIBERAçãO TRANSDéRMICA APERFEIçOADO". é provido um Sistema de Liberação Transdérmica (TDS) aperfeiçoado compreendendo uma camada de fundo inerte aos componentes da matriz, uma matriz auto-adesiva contendo uma droga amino funcional e uma lâmina ou folha protetora a ser removida antes da utilização, caracterizado pelo fato da matriz auto-adesiva consistir de um polímero semi-permeável sólido ou semi-sólido (1) em que foi incorporada uma droga amino funcional em sua forma de base livre, (2) que é saturado com a droga amino funcional e contém a dita droga como uma pluralidade de micro-reservatórios no interior da matriz, (3) que é altamente permeável à base livre da droga amino funcional, (4) que é impermeável à forma protonada da droga amino funcional, (5) em que o diâmetro máximo dos micro-reservatórios é menor que a espessura da matriz. O dito TDS provê um fluxo aumentado da droga amino funcional através da interface TDS/pele.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02016864A EP1386604A1 (en) | 2002-07-30 | 2002-07-30 | Improved transdermal delivery system |
PCT/EP2003/008319 WO2004012719A1 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313092A true BR0313092A (pt) | 2005-06-21 |
Family
ID=30011092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313092-4A BR0313092A (pt) | 2002-07-30 | 2003-07-28 | Sistema de liberação transdérmica aperfeiçoado |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP1386604A1 (pt) |
JP (1) | JP4837915B2 (pt) |
KR (1) | KR101016914B1 (pt) |
CN (1) | CN100558350C (pt) |
AT (1) | ATE343380T1 (pt) |
AU (1) | AU2003266252B2 (pt) |
BR (1) | BR0313092A (pt) |
CA (1) | CA2490573C (pt) |
CY (1) | CY1105878T1 (pt) |
DE (1) | DE60309329T2 (pt) |
DK (1) | DK1524971T3 (pt) |
ES (1) | ES2273042T3 (pt) |
HK (1) | HK1083458A1 (pt) |
IL (1) | IL165917A (pt) |
MX (1) | MXPA05000349A (pt) |
NO (1) | NO334187B1 (pt) |
NZ (1) | NZ537476A (pt) |
PL (1) | PL376999A1 (pt) |
PT (1) | PT1524971E (pt) |
SI (1) | SI1524971T1 (pt) |
WO (1) | WO2004012719A1 (pt) |
ZA (1) | ZA200500255B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
DE10361258A1 (de) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
DE102004014841B4 (de) | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
JP5546013B2 (ja) * | 2008-02-27 | 2014-07-09 | 久光製薬株式会社 | 貼付剤及び包装体 |
ES2536206T3 (es) * | 2008-02-27 | 2015-05-21 | Hisamitsu Pharmaceutical Co., Inc. | Parche medicinal |
ES2679800T3 (es) * | 2009-12-22 | 2018-08-31 | Lts Lohmann Therapie-Systeme Ag | Polivinilpirrolidona para la estabilización de una dispersión sólida de la forma no cristalina de rotigotina |
DE102011090178A1 (de) | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
ES2694662T3 (es) | 2013-07-03 | 2018-12-26 | Lts Lohmann Therapie-Systeme Ag | Sistema terapéutico transdérmico con componente electrónico |
EP4238580A3 (en) | 2014-05-20 | 2023-10-25 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system including an interface mediator |
CA2948220C (en) | 2014-05-20 | 2023-06-20 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system containing rotigotine |
CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
FI3854388T3 (fi) | 2020-01-24 | 2023-11-27 | Luye Pharma Switzerland Ag | Transdermaalinen hoitojärjestelmä, jossa on vaikuttava aine rotigotiini ja ainakin yksi ei-amiiniresistentti silikoniliima |
EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736577A (en) * | 1995-01-31 | 1998-04-07 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
DE19814083C2 (de) * | 1998-03-30 | 2002-02-07 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
FR2792529B1 (fr) * | 1999-04-26 | 2001-09-28 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines |
IT1311696B1 (it) * | 1999-06-22 | 2002-03-19 | Zanussi Elettromecc | Compressore del fluido frigorigeno azionato da un motore elettricoa frequenza di alimentazione variabile |
JP2002045699A (ja) * | 2000-08-08 | 2002-02-12 | Mitsubishi Electric Corp | 排ガス浄化用層状電気化学触媒 |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
ATE364380T1 (de) * | 2001-03-16 | 2007-07-15 | Alza Corp | Transdermales pflaster zur verabreichung von fentanyl |
EP1372614A4 (en) * | 2001-03-16 | 2007-10-31 | Andrx Pharmaceuticals Llc | SULPHONYL UREA FORMULATION WITH CONTROLLED RELEASE |
DK1256340T3 (da) * | 2001-05-08 | 2003-12-01 | Sanol Arznei Schwarz Gmbh | Forbedret transdermalt, terapeutisk system til behandlingen af Parkinsons sygdom |
EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
-
2002
- 2002-07-30 EP EP02016864A patent/EP1386604A1/en not_active Withdrawn
-
2003
- 2003-07-28 BR BR0313092-4A patent/BR0313092A/pt not_active Application Discontinuation
- 2003-07-28 EP EP03766330A patent/EP1524971B1/en not_active Expired - Lifetime
- 2003-07-28 AT AT03766330T patent/ATE343380T1/de active
- 2003-07-28 NZ NZ537476A patent/NZ537476A/en not_active IP Right Cessation
- 2003-07-28 PL PL376999A patent/PL376999A1/pl not_active Application Discontinuation
- 2003-07-28 AU AU2003266252A patent/AU2003266252B2/en not_active Expired
- 2003-07-28 KR KR1020057001101A patent/KR101016914B1/ko active IP Right Grant
- 2003-07-28 DK DK03766330T patent/DK1524971T3/da active
- 2003-07-28 MX MXPA05000349A patent/MXPA05000349A/es active IP Right Grant
- 2003-07-28 WO PCT/EP2003/008319 patent/WO2004012719A1/en active IP Right Grant
- 2003-07-28 CA CA2490573A patent/CA2490573C/en not_active Expired - Lifetime
- 2003-07-28 ES ES03766330T patent/ES2273042T3/es not_active Expired - Lifetime
- 2003-07-28 CN CNB038184397A patent/CN100558350C/zh not_active Expired - Lifetime
- 2003-07-28 PT PT03766330T patent/PT1524971E/pt unknown
- 2003-07-28 DE DE60309329T patent/DE60309329T2/de not_active Expired - Lifetime
- 2003-07-28 JP JP2004525348A patent/JP4837915B2/ja not_active Expired - Lifetime
- 2003-07-28 SI SI200330559T patent/SI1524971T1/sl unknown
-
2004
- 2004-12-22 IL IL165917A patent/IL165917A/en active IP Right Grant
-
2005
- 2005-01-11 ZA ZA2005/00255A patent/ZA200500255B/en unknown
- 2005-02-11 NO NO20050770A patent/NO334187B1/no not_active IP Right Cessation
-
2006
- 2006-03-20 HK HK06103512.7A patent/HK1083458A1/xx not_active IP Right Cessation
- 2006-12-21 CY CY20061101845T patent/CY1105878T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI1524971T1 (sl) | 2007-02-28 |
IL165917A (en) | 2007-07-24 |
ZA200500255B (en) | 2006-01-25 |
NO20050770L (no) | 2005-02-11 |
DE60309329T2 (de) | 2008-04-17 |
HK1083458A1 (en) | 2006-07-07 |
EP1386604A1 (en) | 2004-02-04 |
MXPA05000349A (es) | 2005-03-31 |
WO2004012719A1 (en) | 2004-02-12 |
AU2003266252B2 (en) | 2008-11-20 |
PT1524971E (pt) | 2007-01-31 |
EP1524971A1 (en) | 2005-04-27 |
KR101016914B1 (ko) | 2011-02-22 |
KR20050025638A (ko) | 2005-03-14 |
PL376999A1 (pl) | 2006-01-23 |
DE60309329D1 (de) | 2006-12-07 |
IL165917A0 (en) | 2006-01-15 |
CY1105878T1 (el) | 2011-02-02 |
AU2003266252A1 (en) | 2004-02-23 |
ES2273042T3 (es) | 2007-05-01 |
CN1671365A (zh) | 2005-09-21 |
JP2005535686A (ja) | 2005-11-24 |
CN100558350C (zh) | 2009-11-11 |
NZ537476A (en) | 2007-08-31 |
JP4837915B2 (ja) | 2011-12-14 |
ATE343380T1 (de) | 2006-11-15 |
EP1524971B1 (en) | 2006-10-25 |
DK1524971T3 (da) | 2007-02-19 |
CA2490573C (en) | 2011-06-07 |
NO334187B1 (no) | 2014-01-13 |
CA2490573A1 (en) | 2004-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 9/70, A61K 31/38, A61P 25/16 Ipc: A61K 9/70 (2011.01), A61K 31/38 (2011.01), A61P 25 |
|
B25D | Requested change of name of applicant approved |
Owner name: UCB PHARMA GMBH (DE) Free format text: NOME ALTERADO DE: SCHWARZ PHARMA AG |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |