JP2002531441A5 - - Google Patents
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- Publication number
- JP2002531441A5 JP2002531441A5 JP2000585220A JP2000585220A JP2002531441A5 JP 2002531441 A5 JP2002531441 A5 JP 2002531441A5 JP 2000585220 A JP2000585220 A JP 2000585220A JP 2000585220 A JP2000585220 A JP 2000585220A JP 2002531441 A5 JP2002531441 A5 JP 2002531441A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- cycloalkyl
- embedded image
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 38
- 125000000217 alkyl group Chemical group 0.000 description 26
- 125000000753 cycloalkyl group Chemical group 0.000 description 16
- 125000003710 aryl alkyl group Chemical group 0.000 description 13
- 125000005843 halogen group Chemical group 0.000 description 13
- 150000002148 esters Chemical class 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000004350 aryl cycloalkyl group Chemical group 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 9
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 description 9
- 125000004475 heteroaralkyl group Chemical group 0.000 description 8
- -1 -CF 3 Chemical group 0.000 description 7
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 0 *[C@](CNC(c1ccc(CN(Cc2nc3ccccc3[n]2)C(N*)=O)cc1)=O)NC(OCc1ccccc1)=O Chemical compound *[C@](CNC(c1ccc(CN(Cc2nc3ccccc3[n]2)C(N*)=O)cc1)=O)NC(OCc1ccccc1)=O 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 102100035140 Vitronectin Human genes 0.000 description 2
- 108010031318 Vitronectin Proteins 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- QLSUPPMUIKILHM-SANMLTNESA-N CCCNC(N(Cc1nc2ccccc2[nH]1)Cc(cc1)ccc1C(NC[C@@H](C(O)=O)NC(OCc1ccccc1)=O)=O)=O Chemical compound CCCNC(N(Cc1nc2ccccc2[nH]1)Cc(cc1)ccc1C(NC[C@@H](C(O)=O)NC(OCc1ccccc1)=O)=O)=O QLSUPPMUIKILHM-SANMLTNESA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- IRAFVKKZYWAUDC-MHZLTWQESA-N OC([C@H](CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(N2CCOCC2)=O)cc1)=O)NC(OCc1ccccc1)=O)=O Chemical compound OC([C@H](CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(N2CCOCC2)=O)cc1)=O)NC(OCc1ccccc1)=O)=O IRAFVKKZYWAUDC-MHZLTWQESA-N 0.000 description 1
- YGYAODXUYBGWIQ-UMSFTDKQSA-N OC([C@H](CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(Nc(cc2)ccc2-c2ccccc2)=O)cc1)=O)NC(OC1c2ccccc12)=O)=O Chemical compound OC([C@H](CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(Nc(cc2)ccc2-c2ccccc2)=O)cc1)=O)NC(OC1c2ccccc12)=O)=O YGYAODXUYBGWIQ-UMSFTDKQSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
- 206010038923 Retinopathy Diseases 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20161198A | 1998-11-30 | 1998-11-30 | |
| US09/201611 | 1998-11-30 | ||
| PCT/US1999/026023 WO2000032578A1 (en) | 1998-11-30 | 1999-11-29 | Benzimidazole compounds that are vitronectin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531441A JP2002531441A (ja) | 2002-09-24 |
| JP2002531441A5 true JP2002531441A5 (https=) | 2006-11-16 |
| JP4480117B2 JP4480117B2 (ja) | 2010-06-16 |
Family
ID=22746536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000585220A Expired - Lifetime JP4480117B2 (ja) | 1998-11-30 | 1999-11-29 | ビトロネクチンレセプターアンタゴニストであるベンズイミダゾール化合物 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1135374B9 (https=) |
| JP (1) | JP4480117B2 (https=) |
| CN (1) | CN1161340C (https=) |
| AR (1) | AR021427A1 (https=) |
| AT (1) | ATE338751T1 (https=) |
| AU (1) | AU1908400A (https=) |
| CA (1) | CA2353063C (https=) |
| CO (1) | CO5140112A1 (https=) |
| DE (1) | DE69933135T2 (https=) |
| ES (1) | ES2273517T3 (https=) |
| PE (1) | PE20001427A1 (https=) |
| WO (1) | WO2000032578A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148349C (zh) * | 1999-04-07 | 2004-05-05 | 参天制药株式会社 | N-取代-N′-取代脲衍生物及其用作TNF-α生成抑制剂的用途 |
| DE60023492T2 (de) * | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
| FR2809396B1 (fr) * | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO2008148845A2 (en) | 2007-06-07 | 2008-12-11 | Novozymes A/S | Method of preparing a dough-based product |
| EP2595488B1 (en) | 2010-07-21 | 2019-12-04 | Novozymes A/S | Process for preparing a baked product with anti-staling amylase and peptidase |
| EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
| US9951027B2 (en) | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| CN104694290A (zh) * | 2014-05-07 | 2015-06-10 | 宁波职业技术学院 | 一种洗脚皂 |
| WO2016062677A1 (en) | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| JP6672288B2 (ja) | 2014-10-23 | 2020-03-25 | バイエル・ファルマ・アクティエンゲゼルシャフト | 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール |
| EP3303302B1 (en) | 2015-06-08 | 2019-03-20 | Bayer Pharma Aktiengesellschaft | N-menthylbenzimidazoles as midh1 inhibitors |
| JP6824954B2 (ja) | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール |
| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| WO2021176045A1 (en) | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Imidazotriazines acting on cancer via inhibition of cdk12 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10501222A (ja) * | 1994-05-27 | 1998-02-03 | メルク エンド カンパニー インコーポレーテッド | 破骨細胞仲介骨吸収を抑制するための化合物 |
| NZ290008A (en) * | 1994-06-29 | 1998-08-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists, comprising a fibrinogen antagonist analogue linked to a heterocycle |
-
1999
- 1999-09-29 CN CN99815842.9A patent/CN1161340C/zh not_active Expired - Fee Related
- 1999-11-29 CA CA002353063A patent/CA2353063C/en not_active Expired - Fee Related
- 1999-11-29 AR ARP990106061A patent/AR021427A1/es unknown
- 1999-11-29 AU AU19084/00A patent/AU1908400A/en not_active Abandoned
- 1999-11-29 JP JP2000585220A patent/JP4480117B2/ja not_active Expired - Lifetime
- 1999-11-29 ES ES99962691T patent/ES2273517T3/es not_active Expired - Lifetime
- 1999-11-29 WO PCT/US1999/026023 patent/WO2000032578A1/en not_active Ceased
- 1999-11-29 EP EP99962691A patent/EP1135374B9/en not_active Expired - Lifetime
- 1999-11-29 DE DE69933135T patent/DE69933135T2/de not_active Expired - Lifetime
- 1999-11-29 AT AT99962691T patent/ATE338751T1/de not_active IP Right Cessation
- 1999-11-30 CO CO99075257A patent/CO5140112A1/es unknown
- 1999-11-30 PE PE1999001198A patent/PE20001427A1/es not_active Application Discontinuation
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