JP2005503434A5 - - Google Patents
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- Publication number
- JP2005503434A5 JP2005503434A5 JP2003530656A JP2003530656A JP2005503434A5 JP 2005503434 A5 JP2005503434 A5 JP 2005503434A5 JP 2003530656 A JP2003530656 A JP 2003530656A JP 2003530656 A JP2003530656 A JP 2003530656A JP 2005503434 A5 JP2005503434 A5 JP 2005503434A5
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- JP
- Japan
- Prior art keywords
- group
- compound
- pharmaceutical composition
- formula
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 125000002252 acyl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- 208000001132 Osteoporosis Diseases 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010017076 Fracture Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 206010038433 renal dysplasia Diseases 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 239000011647 vitamin D3 Substances 0.000 claims 2
- 229940021056 vitamin d3 Drugs 0.000 claims 2
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 229940124325 anabolic agent Drugs 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- -1 phosphine oxide compound Chemical class 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32395701P | 2001-09-21 | 2001-09-21 | |
| US32387001P | 2001-09-21 | 2001-09-21 | |
| PCT/EP2002/010233 WO2003027065A1 (en) | 2001-09-21 | 2002-09-12 | 3-desoxy-vitamin d3 analog esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503434A JP2005503434A (ja) | 2005-02-03 |
| JP2005503434A5 true JP2005503434A5 (https=) | 2005-12-08 |
Family
ID=26984180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530656A Pending JP2005503434A (ja) | 2001-09-21 | 2002-09-12 | ３−デスオキシ−ビタミンｄ３類似体 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1430026A1 (https=) |
| JP (1) | JP2005503434A (https=) |
| KR (1) | KR100628586B1 (https=) |
| CN (1) | CN1285573C (https=) |
| AU (1) | AU2002338672B2 (https=) |
| BR (1) | BR0212719A (https=) |
| CA (1) | CA2459789A1 (https=) |
| MX (1) | MXPA04002640A (https=) |
| PA (1) | PA8554901A1 (https=) |
| PE (1) | PE20030429A1 (https=) |
| PL (1) | PL370352A1 (https=) |
| RU (1) | RU2296121C2 (https=) |
| UY (1) | UY27448A1 (https=) |
| WO (1) | WO2003027065A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL376148A1 (en) * | 2002-10-23 | 2005-12-27 | Leo Pharma A/S | Vitamin d analogues, compositions comprising said analogues and their use |
| WO2006036813A2 (en) * | 2004-09-24 | 2006-04-06 | Bioxell S.P.A. | 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof |
| CA2586679A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| CN102124301B (zh) | 2008-08-22 | 2014-04-02 | Nxp股份有限公司 | 基于位置的服务 |
| CN110339205B (zh) * | 2019-08-19 | 2021-08-24 | 山东德信生物科技有限公司 | 富氢水组合物在抑制六价铬诱导的df-1细胞内质网应激及自噬中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
| WO1999012894A1 (en) * | 1997-09-08 | 1999-03-18 | F. Hoffmann-La Roche Ag | 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs |
| US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
-
2002
- 2002-09-12 MX MXPA04002640A patent/MXPA04002640A/es active IP Right Grant
- 2002-09-12 WO PCT/EP2002/010233 patent/WO2003027065A1/en not_active Ceased
- 2002-09-12 PL PL02370352A patent/PL370352A1/xx not_active Application Discontinuation
- 2002-09-12 AU AU2002338672A patent/AU2002338672B2/en not_active Ceased
- 2002-09-12 CA CA002459789A patent/CA2459789A1/en not_active Abandoned
- 2002-09-12 JP JP2003530656A patent/JP2005503434A/ja active Pending
- 2002-09-12 CN CNB028185285A patent/CN1285573C/zh not_active Expired - Fee Related
- 2002-09-12 RU RU2004112217/04A patent/RU2296121C2/ru not_active IP Right Cessation
- 2002-09-12 BR BR0212719-9A patent/BR0212719A/pt not_active IP Right Cessation
- 2002-09-12 KR KR1020047004110A patent/KR100628586B1/ko not_active Expired - Fee Related
- 2002-09-12 EP EP02777075A patent/EP1430026A1/en not_active Withdrawn
- 2002-09-18 PA PA20028554901A patent/PA8554901A1/es unknown
- 2002-09-19 PE PE2002000921A patent/PE20030429A1/es not_active Application Discontinuation
- 2002-09-20 UY UY27448A patent/UY27448A1/es not_active Application Discontinuation
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