CN1285573C - 3－脱氧－维生素d3类似物酯 - Google Patents

3－脱氧－维生素d3类似物酯 Download PDF

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Publication number
CN1285573C
CN1285573C CNB028185285A CN02818528A CN1285573C CN 1285573 C CN1285573 C CN 1285573C CN B028185285 A CNB028185285 A CN B028185285A CN 02818528 A CN02818528 A CN 02818528A CN 1285573 C CN1285573 C CN 1285573C
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CN
China
Prior art keywords
compound
formula
group
acyl
compounds
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028185285A
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English (en)
Chinese (zh)
Other versions
CN1556795A (zh
Inventor
米兰·罗多耶·乌斯科科维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1556795A publication Critical patent/CN1556795A/zh
Application granted granted Critical
Publication of CN1285573C publication Critical patent/CN1285573C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028185285A 2001-09-21 2002-09-12 3－脱氧－维生素d3类似物酯 Expired - Fee Related CN1285573C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32395701P 2001-09-21 2001-09-21
US32387001P 2001-09-21 2001-09-21
US60/323,870 2001-09-21
US60/323,957 2001-09-21

Publications (2)

Publication Number Publication Date
CN1556795A CN1556795A (zh) 2004-12-22
CN1285573C true CN1285573C (zh) 2006-11-22

Family

ID=26984180

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028185285A Expired - Fee Related CN1285573C (zh) 2001-09-21 2002-09-12 3－脱氧－维生素d3类似物酯

Country Status (14)

Country Link
EP (1) EP1430026A1 (https=)
JP (1) JP2005503434A (https=)
KR (1) KR100628586B1 (https=)
CN (1) CN1285573C (https=)
AU (1) AU2002338672B2 (https=)
BR (1) BR0212719A (https=)
CA (1) CA2459789A1 (https=)
MX (1) MXPA04002640A (https=)
PA (1) PA8554901A1 (https=)
PE (1) PE20030429A1 (https=)
PL (1) PL370352A1 (https=)
RU (1) RU2296121C2 (https=)
UY (1) UY27448A1 (https=)
WO (1) WO2003027065A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL376148A1 (en) * 2002-10-23 2005-12-27 Leo Pharma A/S Vitamin d analogues, compositions comprising said analogues and their use
WO2006036813A2 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
CN102124301B (zh) 2008-08-22 2014-04-02 Nxp股份有限公司 基于位置的服务
CN110339205B (zh) * 2019-08-19 2021-08-24 山东德信生物科技有限公司 富氢水组合物在抑制六价铬诱导的df-1细胞内质网应激及自噬中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs

Also Published As

Publication number Publication date
KR20040035853A (ko) 2004-04-29
JP2005503434A (ja) 2005-02-03
PA8554901A1 (es) 2003-12-10
CA2459789A1 (en) 2003-04-03
EP1430026A1 (en) 2004-06-23
RU2004112217A (ru) 2005-07-10
KR100628586B1 (ko) 2006-09-26
UY27448A1 (es) 2003-03-31
PL370352A1 (en) 2005-05-16
CN1556795A (zh) 2004-12-22
AU2002338672B2 (en) 2006-03-09
PE20030429A1 (es) 2003-05-15
BR0212719A (pt) 2004-08-03
RU2296121C2 (ru) 2007-03-27
MXPA04002640A (es) 2004-06-07
WO2003027065A1 (en) 2003-04-03

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee