JP2005503434A - ３−デスオキシ−ビタミンｄ３類似体 - Google Patents

３−デスオキシ−ビタミンｄ３類似体 Download PDF

Info

Publication number
JP2005503434A
JP2005503434A JP2003530656A JP2003530656A JP2005503434A JP 2005503434 A JP2005503434 A JP 2005503434A JP 2003530656 A JP2003530656 A JP 2003530656A JP 2003530656 A JP2003530656 A JP 2003530656A JP 2005503434 A JP2005503434 A JP 2005503434A
Authority
JP
Japan
Prior art keywords
compound
group
formula
alkyl
desoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003530656A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005503434A5 (https=
Inventor
ウスココヴィック，ミラン・ラドージェ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2005503434A publication Critical patent/JP2005503434A/ja
Publication of JP2005503434A5 publication Critical patent/JP2005503434A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2003530656A 2001-09-21 2002-09-12 ３−デスオキシ−ビタミンｄ３類似体 Pending JP2005503434A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32395701P 2001-09-21 2001-09-21
US32387001P 2001-09-21 2001-09-21
PCT/EP2002/010233 WO2003027065A1 (en) 2001-09-21 2002-09-12 3-desoxy-vitamin d3 analog esters

Publications (2)

Publication Number Publication Date
JP2005503434A true JP2005503434A (ja) 2005-02-03
JP2005503434A5 JP2005503434A5 (https=) 2005-12-08

Family

ID=26984180

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003530656A Pending JP2005503434A (ja) 2001-09-21 2002-09-12 ３−デスオキシ−ビタミンｄ３類似体

Country Status (14)

Country Link
EP (1) EP1430026A1 (https=)
JP (1) JP2005503434A (https=)
KR (1) KR100628586B1 (https=)
CN (1) CN1285573C (https=)
AU (1) AU2002338672B2 (https=)
BR (1) BR0212719A (https=)
CA (1) CA2459789A1 (https=)
MX (1) MXPA04002640A (https=)
PA (1) PA8554901A1 (https=)
PE (1) PE20030429A1 (https=)
PL (1) PL370352A1 (https=)
RU (1) RU2296121C2 (https=)
UY (1) UY27448A1 (https=)
WO (1) WO2003027065A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503880A (ja) * 2002-10-23 2006-02-02 レオ・ファーマ・アクティーゼルスカブ ビタミンｄ類似体、該類似体を含んで成る組成物およびその使用
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
CN102124301B (zh) 2008-08-22 2014-04-02 Nxp股份有限公司 基于位置的服务
CN110339205B (zh) * 2019-08-19 2021-08-24 山东德信生物科技有限公司 富氢水组合物在抑制六价铬诱导的df-1细胞内质网应激及自噬中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503880A (ja) * 2002-10-23 2006-02-02 レオ・ファーマ・アクティーゼルスカブ ビタミンｄ類似体、該類似体を含んで成る組成物およびその使用
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法

Also Published As

Publication number Publication date
KR20040035853A (ko) 2004-04-29
PA8554901A1 (es) 2003-12-10
CA2459789A1 (en) 2003-04-03
EP1430026A1 (en) 2004-06-23
RU2004112217A (ru) 2005-07-10
KR100628586B1 (ko) 2006-09-26
UY27448A1 (es) 2003-03-31
PL370352A1 (en) 2005-05-16
CN1556795A (zh) 2004-12-22
AU2002338672B2 (en) 2006-03-09
PE20030429A1 (es) 2003-05-15
BR0212719A (pt) 2004-08-03
RU2296121C2 (ru) 2007-03-27
CN1285573C (zh) 2006-11-22
MXPA04002640A (es) 2004-06-07
WO2003027065A1 (en) 2003-04-03

Similar Documents

Publication Publication Date Title
JP4493340B2 (ja) １α−ヒドロキシ−２−メチレン−１９−ノル−プレグナカルシフェロール及びその使用
JP2004509853A (ja) 骨強度を増加するための２α−メチル−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用
US5872113A (en) Fluorinated vitamin D3 analogs
JP2004505022A (ja) 骨強度を増加するための２−メチレン−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用
EP1015423B1 (en) 1,3-dihydroxy-20,20-dialkyl-vitamin d 3? analogs
HRP980224A2 (en) Vitamin d3 analogs with bis c-20 side chains
JP2007530421A (ja) （２０Ｓ）−１α−ヒドロキシ−２−メチレン−１９−ノル−ビタミンＤ３及びその使用
KR100351490B1 (ko) 비스 씨-20 측쇄를 갖는 비타민 디3 유사체
JP2005503434A (ja) ３−デスオキシ−ビタミンｄ３類似体
US6559138B1 (en) 3-Desoxy-vitamin D3 analog esters
CA2205315C (en) Fluorinated vitamin d3 analogs
AU2002338672A1 (en) 3-desoxy-vitamin D3 analog esters
US7491711B2 (en) Methods of treatment using 3-desoxy vitamin D3 analogs
RU2223953C2 (ru) Аналоги витамина D, фармацевтическая композиция, соединения
US5696103A (en) Method for treating osteoporosis
JP4619360B2 (ja) ２−メチレン−１９−ノル−２０（Ｓ）−２５−メチル−１α−ヒドロキシカルシフェロール及びその使用
HK1004619A (en) Fluorinated vitamin d3 analogs
JPWO2004067525A1 (ja) ビタミンｄ３ラクトン誘導体
HK1026705B (en) Vitamin d3 analogs with bis c-20 side chains

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070410

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070709

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070717

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071211