JP4480117B2 - ビトロネクチンレセプターアンタゴニストであるベンズイミダゾール化合物 - Google Patents
ビトロネクチンレセプターアンタゴニストであるベンズイミダゾール化合物 Download PDFInfo
- Publication number
- JP4480117B2 JP4480117B2 JP2000585220A JP2000585220A JP4480117B2 JP 4480117 B2 JP4480117 B2 JP 4480117B2 JP 2000585220 A JP2000585220 A JP 2000585220A JP 2000585220 A JP2000585220 A JP 2000585220A JP 4480117 B2 JP4480117 B2 JP 4480117B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- resin
- cycloalkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CCOC([C@](*)NC(N(Cc1nc2ccccc2[n]1)Cc(cc1)ccc1C(NC[C@@](C(O)=O)NC(OCc1ccccc1)=O)=O)=O)=O Chemical compound CCOC([C@](*)NC(N(Cc1nc2ccccc2[n]1)Cc(cc1)ccc1C(NC[C@@](C(O)=O)NC(OCc1ccccc1)=O)=O)=O)=O 0.000 description 9
- IOLQGYBIBBUCCW-UHFFFAOYSA-N CCC1NC(CCC=C2)=C2C(C)=C1 Chemical compound CCC1NC(CCC=C2)=C2C(C)=C1 IOLQGYBIBBUCCW-UHFFFAOYSA-N 0.000 description 1
- XYUAXZDQSDTCHO-UHFFFAOYSA-N O=S(c1ccccc1)=O Chemical compound O=S(c1ccccc1)=O XYUAXZDQSDTCHO-UHFFFAOYSA-N 0.000 description 1
- DIKIZNRMEAHRFH-UHFFFAOYSA-N OC(C(CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(NC2CCCCC2)=O)cc1)=O)NC(OCC1C=CC=CC1)=O)=O Chemical compound OC(C(CNC(c1ccc(CN(Cc2nc3ccccc3[nH]2)C(NC2CCCCC2)=O)cc1)=O)NC(OCC1C=CC=CC1)=O)=O DIKIZNRMEAHRFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20161198A | 1998-11-30 | 1998-11-30 | |
| US09/201611 | 1998-11-30 | ||
| PCT/US1999/026023 WO2000032578A1 (en) | 1998-11-30 | 1999-11-29 | Benzimidazole compounds that are vitronectin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531441A JP2002531441A (ja) | 2002-09-24 |
| JP2002531441A5 JP2002531441A5 (https=) | 2006-11-16 |
| JP4480117B2 true JP4480117B2 (ja) | 2010-06-16 |
Family
ID=22746536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000585220A Expired - Lifetime JP4480117B2 (ja) | 1998-11-30 | 1999-11-29 | ビトロネクチンレセプターアンタゴニストであるベンズイミダゾール化合物 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1135374B9 (https=) |
| JP (1) | JP4480117B2 (https=) |
| CN (1) | CN1161340C (https=) |
| AR (1) | AR021427A1 (https=) |
| AT (1) | ATE338751T1 (https=) |
| AU (1) | AU1908400A (https=) |
| CA (1) | CA2353063C (https=) |
| CO (1) | CO5140112A1 (https=) |
| DE (1) | DE69933135T2 (https=) |
| ES (1) | ES2273517T3 (https=) |
| PE (1) | PE20001427A1 (https=) |
| WO (1) | WO2000032578A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148349C (zh) * | 1999-04-07 | 2004-05-05 | 参天制药株式会社 | N-取代-N′-取代脲衍生物及其用作TNF-α生成抑制剂的用途 |
| DE60023492T2 (de) * | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
| FR2809396B1 (fr) * | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO2008148845A2 (en) | 2007-06-07 | 2008-12-11 | Novozymes A/S | Method of preparing a dough-based product |
| EP2595488B1 (en) | 2010-07-21 | 2019-12-04 | Novozymes A/S | Process for preparing a baked product with anti-staling amylase and peptidase |
| EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
| US9951027B2 (en) | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| CN104694290A (zh) * | 2014-05-07 | 2015-06-10 | 宁波职业技术学院 | 一种洗脚皂 |
| WO2016062677A1 (en) | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| JP6672288B2 (ja) | 2014-10-23 | 2020-03-25 | バイエル・ファルマ・アクティエンゲゼルシャフト | 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール |
| EP3303302B1 (en) | 2015-06-08 | 2019-03-20 | Bayer Pharma Aktiengesellschaft | N-menthylbenzimidazoles as midh1 inhibitors |
| JP6824954B2 (ja) | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール |
| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| WO2021176045A1 (en) | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Imidazotriazines acting on cancer via inhibition of cdk12 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10501222A (ja) * | 1994-05-27 | 1998-02-03 | メルク エンド カンパニー インコーポレーテッド | 破骨細胞仲介骨吸収を抑制するための化合物 |
| NZ290008A (en) * | 1994-06-29 | 1998-08-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists, comprising a fibrinogen antagonist analogue linked to a heterocycle |
-
1999
- 1999-09-29 CN CN99815842.9A patent/CN1161340C/zh not_active Expired - Fee Related
- 1999-11-29 CA CA002353063A patent/CA2353063C/en not_active Expired - Fee Related
- 1999-11-29 AR ARP990106061A patent/AR021427A1/es unknown
- 1999-11-29 AU AU19084/00A patent/AU1908400A/en not_active Abandoned
- 1999-11-29 JP JP2000585220A patent/JP4480117B2/ja not_active Expired - Lifetime
- 1999-11-29 ES ES99962691T patent/ES2273517T3/es not_active Expired - Lifetime
- 1999-11-29 WO PCT/US1999/026023 patent/WO2000032578A1/en not_active Ceased
- 1999-11-29 EP EP99962691A patent/EP1135374B9/en not_active Expired - Lifetime
- 1999-11-29 DE DE69933135T patent/DE69933135T2/de not_active Expired - Lifetime
- 1999-11-29 AT AT99962691T patent/ATE338751T1/de not_active IP Right Cessation
- 1999-11-30 CO CO99075257A patent/CO5140112A1/es unknown
- 1999-11-30 PE PE1999001198A patent/PE20001427A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000032578A1 (en) | 2000-06-08 |
| WO2000032578A8 (en) | 2002-02-07 |
| CA2353063C (en) | 2009-06-16 |
| ATE338751T1 (de) | 2006-09-15 |
| CA2353063A1 (en) | 2000-06-08 |
| EP1135374A1 (en) | 2001-09-26 |
| EP1135374B1 (en) | 2006-09-06 |
| AU1908400A (en) | 2000-06-19 |
| DE69933135T2 (de) | 2007-08-09 |
| CN1161340C (zh) | 2004-08-11 |
| DE69933135D1 (de) | 2006-10-19 |
| PE20001427A1 (es) | 2000-12-18 |
| JP2002531441A (ja) | 2002-09-24 |
| ES2273517T3 (es) | 2007-05-01 |
| CN1333755A (zh) | 2002-01-30 |
| AR021427A1 (es) | 2002-07-17 |
| EP1135374B9 (en) | 2007-02-21 |
| CO5140112A1 (es) | 2002-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4480117B2 (ja) | ビトロネクチンレセプターアンタゴニストであるベンズイミダゾール化合物 | |
| EP1009758B1 (en) | Meta-benzamidine derivatives as serine protease inhibitors | |
| US4952562A (en) | Anti-thrombotic peptides and pseudopeptides | |
| TW397825B (en) | Aroyl-piperidine derivatives | |
| EP0502926B1 (en) | Anti-thrombotic peptides and pseudopeptides | |
| US7928137B2 (en) | Meta-benzamidine derivatives as serine protease inhibitors | |
| JP2000510098A (ja) | 桂皮酸誘導体 | |
| EP0655439A2 (en) | 5,6-Bicyclic glycoprotein IIb IIIa antagonists useful in inhibition of platelet aggregation | |
| JP2000507952A (ja) | ｍｅｔａ―置換フェニレンスルホンアミド誘導体 | |
| JPH10101565A (ja) | 胃腸血行障害を治療および予防するための医薬製剤を製造するためのベンズアゼピン−ｎ−酢酸誘導体の使用 | |
| JP2000513375A (ja) | フィブリノーゲンレセプター拮抗薬プロドラッグ | |
| HRP20000574A2 (en) | Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists | |
| US6204282B1 (en) | Benzimidazole compounds that are vitronectin receptor antagonists | |
| JPH10512581A (ja) | 血小板凝集阻害剤 | |
| JP2004524264A (ja) | ビフェニル誘導体およびインテグリン阻害剤としてのその使用 | |
| JP2000514427A (ja) | フィブリノーゲンレセプター拮抗薬プロドラッグ | |
| US6172256B1 (en) | Chiral-β-amino acid compounds and derivatives thereof | |
| MXPA01005395A (en) | Benzimidazole compounds that are vitronectin receptor antagonists | |
| WO2000061545A1 (en) | Methods for solid phase combinatorial synthesis of integrin inhibitors | |
| HRP980216A2 (en) | Therapeutic 1,2,3,4-tetrahydroisoquinolines | |
| JP2002520393A (ja) | 抗血栓剤としてのビスピペリジン | |
| JPH04504130A (ja) | メルカプト―アシルアミノ酸 | |
| JP2002522497A (ja) | Ｃ３ａ受容体リガンド | |
| CZ20014089A3 (cs) | Deriváty spiroimidazolidinu, jejich příprava a pouľití, a farmaceutické prostředky, které je obsahují | |
| JPH0681722B2 (ja) | 抗トリプシン剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060927 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060927 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20091228 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100106 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100212 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100310 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100315 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130326 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |