DE69933135D1 - Benzimidazolderivate mit vitronectinrezeptor-antagonistischer wirkung - Google Patents

Benzimidazolderivate mit vitronectinrezeptor-antagonistischer wirkung

Info

Publication number
DE69933135D1
DE69933135D1 DE69933135T DE69933135T DE69933135D1 DE 69933135 D1 DE69933135 D1 DE 69933135D1 DE 69933135 T DE69933135 T DE 69933135T DE 69933135 T DE69933135 T DE 69933135T DE 69933135 D1 DE69933135 D1 DE 69933135D1
Authority
DE
Germany
Prior art keywords
vitamin
receptor activity
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69933135T
Other languages
English (en)
Other versions
DE69933135T2 (de
Inventor
R Neustadt
M Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69933135D1 publication Critical patent/DE69933135D1/de
Publication of DE69933135T2 publication Critical patent/DE69933135T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69933135T 1998-11-30 1999-11-29 Benzimidazolderivate mit vitronectinrezeptor antagonistischer wirkung Expired - Lifetime DE69933135T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20161198A 1998-11-30 1998-11-30
US201611 1998-11-30
PCT/US1999/026023 WO2000032578A1 (en) 1998-11-30 1999-11-29 Benzimidazole compounds that are vitronectin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69933135D1 true DE69933135D1 (de) 2006-10-19
DE69933135T2 DE69933135T2 (de) 2007-08-09

Family

ID=22746536

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933135T Expired - Lifetime DE69933135T2 (de) 1998-11-30 1999-11-29 Benzimidazolderivate mit vitronectinrezeptor antagonistischer wirkung

Country Status (12)

Country Link
EP (1) EP1135374B9 (de)
JP (1) JP4480117B2 (de)
CN (1) CN1161340C (de)
AR (1) AR021427A1 (de)
AT (1) ATE338751T1 (de)
AU (1) AU1908400A (de)
CA (1) CA2353063C (de)
CO (1) CO5140112A1 (de)
DE (1) DE69933135T2 (de)
ES (1) ES2273517T3 (de)
PE (1) PE20001427A1 (de)
WO (1) WO2000032578A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061552A1 (fr) * 1999-04-07 2000-10-19 Santen Pharmaceutical Co., Ltd. DERIVE D'UREE N-SUBSTITUE-N'-SUBSTITUE, ET SON UTILISATION COMME INHIBITEUR DE LA PRODUCTION DE TNF-$g(a)
MXPA01011757A (es) * 1999-05-17 2002-06-04 Novo Nordisk As Antagonistas / agonistas inversos del glucagon.
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
DK2527430T3 (en) 2007-06-07 2015-04-13 Novozymes As A process for preparing a dough-based product
US10390538B2 (en) 2010-07-21 2019-08-27 Novozymes A/S Process for preparing a baked product with anti-staling amylase and peptidase
MX2016010474A (es) 2014-02-11 2016-10-31 Bayer Pharma AG Benzimidazol-2-aminas como inhibidores de midh1.
CA2939021C (en) 2014-02-11 2022-07-12 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as midh1 inhibitors
CN104694290A (zh) * 2014-05-07 2015-06-10 宁波职业技术学院 一种洗脚皂
WO2016062677A1 (en) 2014-10-23 2016-04-28 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as midh1 inhibitors
JP6672288B2 (ja) 2014-10-23 2020-03-25 バイエル・ファルマ・アクティエンゲゼルシャフト 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール
JP6830909B2 (ja) 2015-06-08 2021-02-17 ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ ｍＩＤＨ１阻害剤としてのＮ−メンチルベンズイミダゾール
CN108026052B (zh) 2015-07-16 2021-10-08 德国癌症研究公共权益基金会 作为mIDH1抑制剂的5-羟烷基苯并咪唑类
TW202146416A (zh) 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
JP2023517034A (ja) 2020-03-06 2023-04-21 バイエル アクチェンゲゼルシャフト Ｃｄｋ１２の阻害を介してがんに作用するイミダゾトリアジン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701776B2 (en) * 1994-05-27 1999-02-04 Merck & Co., Inc. Compounds for inhibiting osteoclast-mediated bone resorption
PL318199A1 (en) * 1994-06-29 1997-05-26 Smithkline Beecham Corp Antagonists of vitronectin receptors

Also Published As

Publication number Publication date
CA2353063A1 (en) 2000-06-08
JP2002531441A (ja) 2002-09-24
ES2273517T3 (es) 2007-05-01
DE69933135T2 (de) 2007-08-09
AR021427A1 (es) 2002-07-17
EP1135374B1 (de) 2006-09-06
EP1135374A1 (de) 2001-09-26
WO2000032578A1 (en) 2000-06-08
WO2000032578A8 (en) 2002-02-07
CO5140112A1 (es) 2002-03-22
CN1333755A (zh) 2002-01-30
EP1135374B9 (de) 2007-02-21
CN1161340C (zh) 2004-08-11
PE20001427A1 (es) 2000-12-18
AU1908400A (en) 2000-06-19
ATE338751T1 (de) 2006-09-15
JP4480117B2 (ja) 2010-06-16
CA2353063C (en) 2009-06-16

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